San Francisco 49ers defensive end Nick Bosa (hip) and offensive tackle Trent Williams (ankle) will not suit up in Week 13 to face the Buffalo Bills, according to Eric Branch of the San Francisco Chronicle. Both Bosa and Williams will now miss their second-straight contest. Through ten games, Bosa has tallied 36 tackles (24 solos), seven tackles with one pass deflection, while Williams has been a mainstay on the San Francisco offensive line. As a result, fantasy managers should expect Jaylon Moore to get the nod at left tackle, while Sam Okuayinou, Yetur Gross-Matos, and Leonard Floyd will see an uptick in playing time on the defensive line. Without Williams, the San Francisco offense could be in trouble, especially if they do not have their starting QB, Brock Purdy (shoulder), who is also listed as questionable.

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San Francisco 49ers quarterback Brock Purdy (shoulder) is listed as questionable for Sunday's game, according to Eric Branch of the San Francisco Chronicle. Fantasy managers should pay close attention to his status during the weekend, as he could be a game-time decision. Last weekend, Brandon Allen got the starting nod and went 17-for-29 with 199 yards, a score, and an interception. Purdy has enjoyed another strong fantasy campaign, averaging 23.4 PPR points through ten games. If Purdy can play, fantasy managers should view him as a low-end QB1, as he will face a tough Buffalo defense in a potentially unfavorable weather setting. If Allen gets the nod for the second-straight week, he would be viewed as a low-end QB2.UPDATE: Purdy practiced in full on Friday, and head coach Kyle Shanahan expects him to play on Sunday. "Lots of things can happen between now and then," but as of now, the Niners expect him to be active against Buffalo.

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New York Jets running back Breece Hall (knee) is listed as questionable but should be "good to go" according to Rich Cimini of ESPN. The star running back was able to log a full practice for the first time this week, which puts him in a great position heading into the weekend. Hall opened the week as a non-participant but was updated to a limited participant on Thursday. Despite New York's offensive struggles, Hall has still continued to produce solid RB1 production as he has averaged 16.8 PPR points per game with 57.5 rushing and 36.5 receiving yards per game. If he can suit up on Sunday, fantasy managers should lock him into all lineups despite him facing the Seattle Seahawks, who have allowed the 12th-fewest PPR points this season to opposing RBs.

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Seattle Seahawks wide receiver Tyler Lockett (knee) does not carry an injury designation into Sunday's match against the New York Jets. The veteran wideout was unable to practice on Wednesday and Thursday but was able to turn in a full session on Friday. The 32-year-old has taken a step back this season, as he has only averaged 45.0 yards per game and is on pace to have one of the lowest yardage totals of his career. Over the past two weeks, he has tallied just 49 combined yards and caught just two passes in each game. Facing a tough Jets secondary that has allowed the fewest PPR points, fantasy managers should only view Lockett as a desperation flex play in PPR formats.

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Seattle Seahawks wide receiver DK Metcalf (shoulder) is off the injury report and good to go for Sunday's matchup against the New York Jets. Metcalf was unable to participate in practice on Wednesday and Thursday with a shoulder injury but was able to log a full session on Friday. As a result, fantasy managers should feel comfortable locking him into all lineups this weekend, as he should see his typical snap count operating as the lead wideout in the Seattle passing attack. Through nine games this season, Metcalf has averaged a solid 14.9 PPR points per game with 77.4 yards per contest. Despite facing a tough New York secondary that has allowed the fewest PPR points to opposing wideouts, Metcalf should still be viewed as a solid WR2 in all formats.

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Washington Commanders defensive back Marshon Lattimore (hamstring) is listed as doubtful for Sunday's game against the Tennessee Titans, according to Mike Garafolo of the NFL Network. Lattimore has yet to make his Washington debut as he remains sidelined with this hamstring injury. However, Lattimore was able to log three consecutive limited practice sessions this week, which suggests that he could be on his way to returning following their Week 14 bye. Earlier this season, Lattimore tallied 30 tackles (22 solo), eight assists, and two pass deflections through seven games with New Orleans. As a result, Mike Sainristil and Benjamin St-Juste will see most of the snaps on Sunday if Lattimore cannot suit up.

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Washington Commanders running back Brian Robinson Jr. (ankle) logged a full practice on Friday and does not carry an injury designation for this Sunday's game against the Tennessee Titans, according to John Keim of ESPN. Robinson sustained this ankle injury last weekend during their loss to the Dallas Cowboys. The Alabama product was only able to log five carries before exiting early. Even though Robinson missed time earlier this season, fantasy managers should feel confident locking him in as a solid RB2 as he has found the end zone seven times through eight games. In addition, No. 2 running back Austin Ekeler (concussion) will not suit up, which will open up even more opportunities for Robinson, which could make him a low-end RB1 despite facing a tough Tennessee rushing defense.

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Washington Commanders running back Austin Ekeler (concussion) will not suit up this weekend when the Washington Commanders host the Tennessee Titans. Ekeler suffered this concussion (his second of the season) during last weekend's loss to the Dallas Cowboys. Before exiting the game tallied 22 yards on nine rushing attempts. Ekeler has enjoyed a solid debut campaign in the DMV, as he has averaged 11.6 PPR points per game, operating primarily as a third-down option. As a result, fantasy managers should expect Brian Robinson Jr. to see the majority of snaps, while Jeremy McNichols could mix in as a change-of-pace option. Even though the Titans have allowed the 11th-fewest PPR points to opposing RBs, Robinson could have top-12 upside, given the increased workload.

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New England Patriots safety Kyle Dugger (ankle) is listed as questionable to play against the visiting Indianapolis Colts on Sunday in Week 13. In addition to Dugger, safety Jabrill Peppers (knee), linebackers Christian Elliss (knee), Anfernee Jennings (knee) and Sione Takitaki (knee), and defensive tackle Jaquelin Roy (neck) are questionable for the Pats defense. The 28-year-old Dugger has played through limited tags each of the last two weeks, so barring a setback on Saturday, he should be active on Sunday for New England's secondary. Dugger has only played in eight games so far in 2024 due to injury and has compiled 44 tackles (30 solo), one sack, five tackles for loss, three pass breakups and a forced fumble. At best, he'll be a low-end starting option at defensive back for those in IDP fantasy formats.

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Philadelphia Eagles wide receiver DeVonta Smith (hamstring) is listed as questionable for Sunday's game against the Baltimore Ravens, according to Jonathan Jones of CBS. Fantasy managers should continue to pay close attention to his status throughout the weekend, as he could be a game-time decision. Smith sat out last weekend with this injury and opened the week as a non-participant in practice. He was then able to upgrade to a limited participant on Thursday and Friday. Throughout the season, Smith has shown flashes of his elite upside but has struggled to produce consistently. If he can play this weekend, fantasy managers should view him as a WR2 with upside facing a weak Baltimore secondary that has allowed the most PPR points to opposing wideouts this season. If he cannot play, A.J. Brown and Dallas Goedert could see a significant uptick in targets.

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New England Patriots wide receiver DeMario Douglas (ankle) has been listed as questionable to play this Sunday against the visiting Indianapolis Colts in Week 13. Douglas was limited in practice this week and is now up in the air to play this weekend. If the 23-year-old is ruled out, it would be a serious downgrade for New England's offense, as he's been one of quarterback Drake Maye's favorite target through the air. Douglas entered Week 13 leading the team's receiving corps in receptions (48), receiving yards (477) and targets (66) while scoring one touchdown in 12 games in his second season in the NFL. Because of his injury, Douglas becomes more of a shaky WR4/5 option for fantasy managers this weekend. If he's unable to get the green light to play on Sunday morning, Kendrick Bourne and Kayshon Boutte will likely be the top receivers, with tight ends Hunter Henry and Austin Hooper also seeing more work.

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Philadelphia Eagles wide receiver DeVonta Smith (hamstring) practiced for the second straight day on Friday, but he said after practice that he's unsure if he will be able to play on Sunday against the Baltimore Ravens in Week 13. Smith said the final decision on whether he'll play isn't up to him, but if it were, he said, "I still don't know." The 26-year-old missed practice all of last week and sat out the Sunday night win over the Los Angeles Rams. Then he missed Wednesday's practice before being limited on Thursday. Smith appears to be making progress, but he's likely to be listed as questionable on Friday's final injury report, and he could end up being a game-time decision. That will make the decision to sit or start Smith more difficult for fantasy managers in Week 13 with Philly's game coming in the later window on Sunday. If Smith misses another game, Jahan Dotson will operate as the WR2 for the Eagles.

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Los Angeles Chargers running back J.K. Dobbins (knee) has officially been ruled out for Week 13's contest against the hosting Atlanta Falcons on Sunday after he was unable to practice all week. Dobbins sprained his left MCL in the Monday night loss to the Baltimore Ravens, so it's not a surprise that he won't be available this weekend. Depending on how he recovers, fantasy managers could be without LA's lead back again next week when the Chargers head on the road to Kansas City to take on the division-rival Chiefs for the second time this year. The Bolts will likely play it safe with Dobbins, considering his lengthy injury history. With Dobbins out this Sunday, Gus Edwards should lead the LA backfield in touches, with rookie Kimani Vidal and Hassan Haskins battling for change-of-pace work. Fantasy managers should view Edwards as a touchdown-dependent RB3/flex this week.

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The Houston Texans defense/special teams is in the middle of the pack when it comes to points allowed, but they have been among the most disruptive which could mean another productive fantasy day in Week 13 against Jacksonville. In their past three games, the Texans have forced 10 turnovers, compiled 13 sacks, and scored two touchdowns, making them a force in fantasy lineups. The potential return of Jags quarterback Trevor Lawrence (shoulder) would be a major upgrade for their offense, but Jacksonville still ranks 27th in scoring percentage and has turned over the ball on 13% of its possessions. Houston is a starting option in this matchup.

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Tampa Bay Buccaneers left tackle Tristan Wirfs (knee, foot) is currently listed as questionable ahead of the Week 13 matchup against the Carolina Panthers. Wirfs sat out of last week's win over the New York Giants. He continues to be limited in practice which gives him a questionable tag ahead of Sunday's game. Wirfs is an All-Pro tackle and is extremely important to this offensive unit. His presence is important for both the run game and for the protection of quarterback Baker Mayfield. His absence would likely mean Justin Skule gets the start at left tackle given he's listed as the second string on the depth chart.

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Philadelphia Eagles wide receiver DeVonta Smith (hamstring) was seen on the field during Friday's practice. Smith sat out of practice to start the week, but has been back on the field for the last two days. Smith sat out last week's win over the Los Angeles Rams, but appears to be heading in the right direction now. The expectation is that Smith will likely be considered questionable heading into the Week 13 matchup against the Baltimore Ravens. When healthy, Smith has been solid this season, so fantasy managers should get him back in their lineups if he's able to play.

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Kansas City Chiefs running back Isiah Pacheco (leg) is officially back ahead of Friday's Week 13 matchup against the Las Vegas Raiders. Pacheco is back on the field for the first time since Week 2. It was uncertain coming into this game if Pacheco would be limited or not considering he hasn't played in months. The Chiefs have said that Pacheco will be a full-go for Friday's game. Fantasy managers should feel good about getting Pacheco back in their lineups for this favorable matchup. Kareem Hunt will see his value take a hit with Hunt back in the mix. It remains to be seen how much Hunt will be involved going forward.

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Atlanta Falcons wide receiver Darnell Mooney (hamstring) is good to go ahead of the Week 13 matchup against the Los Angeles Chargers. Mooney suffered a hamstring injury during last week's loss to the Denver Broncos. As a result, Mooney was limited in practice on Wednesday, but has now been cleared to play in Week 13. Prior to last week, Mooney had posted three straight 80-plus receiving yard games. The Chargers secondary has been solid this season which should push Mooney into WR3 territory for Week 13.

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New York Jets running back Breece Hall (knee) is hopeful to get on the field for the Week 13 matchup against the Seattle Seahawks. Hall missed Wednesday's practice but was able to get back on field during Thursday's session. Interim head coach Jeff Ulbrich said Hall is trending in the right direction ahead of this weekend's game. Hall tweaked his knee in Week 11 and has been experiencing soreness during the team's Week 12 bye. Braelon Allen figures to take over as the lead back if Hall is unable to play. Allen should be rostered in 12-team formats ahead of this Week 13 matchup.

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Atlanta Falcons wide receiver Drake London (hip) is ready to go ahead of the Week 13 matchup against the Los Angeles Chargers. London landed on the injury report on Thursday due to what appears to be a minor hip issue. Despite that, head coach Raheem Morris has cleared London ahead of this weekend. London has 11 receptions for 158 yards over his last two games. Fantasy managers should feel safe plugging him back into lineups this weekend. However, London could have some issues against a tough Chargers secondary.

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