San Francisco 49ers left tackle Trent Williams (illness, toe) is "likely" to play in Week 4 versus the New England Patriots, per NFL Network's Ian Rapoport. Williams will still undergo pregame testing to ensure he's good to go, but it sounds like he's trending in the right direction. San Francisco would benefit from having Williams on the field in a huge way. He's widely regarded as the NFL's best offensive lineman, setting up numerous opportunities for Brock Purdy, Jordan Mason, George Kittle, Deebo Samuel Sr., Brandon Aiyuk, and others to make plays. A healthy Williams truly does bump Purdy and Mason up a spot or two in the weekly fantasy football rankings.

From RotoBaller

Dallas Cowboys defensive ends Micah Parsons (ankle) and DeMarcus Lawrence (foot) are expected to miss multiple games after suffering injuries during Thursday's win over the New York Giants. The Cowboys have already ruled out Parsons for Week 5 versus the Pittsburgh Steelers due to a high-ankle sprain. The superstar pass rusher could be sidelined as long as Week 8. Lawrence is expected to miss four games due to a foot sprain. The loss of both players is going to be a significant hit to this defensive unit. Chauncey Golston and Marshawn Kneeland are expected to fill in, but they aren't going to be able to give the same production as Parsons or Lawrence.

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Green Bay Packers running back Emanuel Wilson is coming off his best performance of the season during last week's win over the Tennessee Titans. Wilson rushed 12 times for 50 yards while hauling in two passes for an additional 25 yards with a touchdown as well. It's nice to see Wilson getting more involved after seeing only nine carries through the first two games of the season. Possibly, the Packers will trust him with a bigger role going forward. However, Josh Jacobs will remain the clear lead back in this offense, which is going to limit Wilson's upside. Wilson is worth rostering in deep and dynasty formats but probably not worth starting against the Minnesota Vikings in Week 4.

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Houston Texans RB Joe Mixon (ankle) is considered a game-time decision for Week 4's contest against the Jacksonville Jaguars, according to a source. He will test out the injury during pregame warmups to determine if he will be able to play.

Fantasy Spin: Mixon had been listed as questionable on the injury report after logging just one limited practice session during the week. RB Dameon Pierce (hamstring) has already been ruled out, so if Mixon is also held out of action today, RB Cam Akers would be in line for a heavy workload versus the Jaguars. In this scenario, Akers would be a decent flex option with upside in most fantasy formats. Keep checking back for updates on Mixon's status.

From TheHuddle

San Francisco 49ers running back Christian McCaffrey (knee) recently returned from seeing a specialist in Germany. It sounds like the plan is for McCaffrey to continue working on the ground, but he won't be back on the field anytime soon. The earliest McCaffrey can resume practicing with the team will be Week 6. Right now the plan is for McCaffrey to possibly return by early November. That isn't great news for fantasy managers, but at least the superstar back will only miss a handful of more games. In the meantime, Jordan Mason figures to continue being the lead back. Mason should be considered a RB1 in fantasy formats until McCaffrey returns.

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New Orleans Saints RB Alvin Kamara (hip, ribs) is expected to play in Week 4's game against the Atlanta Falcons, according to a source.

Fantasy Spin: Kamara had been listed as questionable on the injury report after participating in two of the team's three practice sessions during the week on a limited basis. When healthy, he should be viewed as a must-start option in all fantasy formats.

From TheHuddle

Cleveland Browns running back Nick Chubb (knee) is expected to get back on the practice field this week. Chubb began the year on the PUP list while recovering from a torn ACL he suffered last season. Once Chubb begins practicing, he will get three weeks to get ready before the team must activate him. That being said, Chubb likely isn't going to get back into game action until closer to mid-season. It's uncertain how the team will manage his workload once Chubb is fully back in action. The star back figures to reclaim his role as the lead back in Cleveland, which means Jerome Ford will probably take a backseat here soon.

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Miami Dolphins wide receiver Odell Beckham Jr. (undisclosed) is expected to practice in Week 5 as he gets closer to returning from the PUP list, per NFL Network's Ian Rapoport. Beckham has been sidelined since early training camp due to an undisclosed issue, so even if he does practice this week, it could be a while longer before he plays in a game. It's been hard for the Dolphins to extract much production out of Tyreek Hill and Jaylen Waddle with Tua Tagovailoa (concussion) sidelined, so Beckham doesn't figure to have much fantasy value when he returns, either. He can be left on waivers in most leagues.

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New England Patriots wide receiver Kendrick Bourne (knee) is expected to practice in Week 5 as he gets closer to returning from the PUP list, according to NFL Network's Ian Rapoport. Bourne is recovering from an ACL tear that abruptly ended his promising 2023 season. Through just eight games, he had caught 37 passes for 406 yards and four touchdowns. That type of production put him on the fantasy radar as a FLEX play, but we're not sure he'll be able to replicate it when he returns this year given the state of New England's run-heavy offense led by Jacoby Brissett. Still, we can't discount the reliable, veteran presence he offers when on the field.

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Los Angeles Chargers wide receiver D.J. Chark (hip) has spent the first four weeks of the season on the PUP list and is expected to resume practicing ahead of Week 5 when the team is on its bye, according to NFL Network's Ian Rapoport. The Chargers' early bye week is convenient for Chark as it gives him extra time to practice while (potentially) missing no more than the minimum four games. Once activated, Chark figures to command a few looks per game in an offense where the other top wide receivers are Ladd McConkey, Quentin Johnston, and Josh Palmer. Still, Chark is off the fantasy radar ahead of his eventual return.

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Kansas City Chiefs running back Clyde Edwards-Helaire (illness) is expected to practice in Week 5 as he prepares to return from the non-football injury list, according to NFL Network's Ian Rapoport. Edwards-Helaire was placed on the NFI list coming out of the preseason as he dealt with personal mental health issues, including PTSD. This move forced him to miss the first four games of the 2024 season, at a minimum. After the Chiefs' Week 4 game against the Los Angeles Chargers, Edwards-Helaire will be eligible to return. He's expected to practice right away as the Chiefs get ready for Week 5, and he could immediately slot into the starting running back role with Isiah Pacheco (fibula) on IR. He would rank as a fantasy RB3 while operating alongside rookie standout Carson Steele and veteran pass-catching specialist Samaje Perine.

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Cleveland Browns running back Nick Chubb (knee) is expected to have his practice window opened on Wednesday in Week 5, according to ESPN's Adam Schefter. Chubb opened 2024 on the PUP list as he continued to recover from two surgeries to repair ligaments in his left knee that were torn against the Steelers on Sept. 18, 2023. Once his practice window is opened, the star running back will be allowed to practice with the team for 21 days without counting toward the 53-man roster. Before those 21 days expire, the Browns must elevate him to the active roster. If they don't, he'll be ineligible to play this season. We don't know an exact timetable for Chubb's return, and while Cleveland has no interest in rushing him back before he's ready, it sounds like he's ahead of schedule in his recovery. Chubb was a solid fantasy RB1 when healthy but will likely drop the low-end RB2 tier when he returns to the mix.

From RotoBaller

Minnesota Vikings tight end T.J. Hockenson (knee) is almost ready for the team to trigger his 21-day practice window, according to ESPN's Adam Schefter. Hockenson tore his ACL and MCL in Week 16 last year but has made a speedy recovery and hopes to return within the next few weeks. It's important to note that once the Vikings designate Hockenson to practice, he'll have 21 days where he can practice with the team while not counting toward the 53-man roster. Once those 21 days go by, the team must activate him from injured reserve or rule him out for the remainder of the season. Schefter notes that the former is more likely for Hockenson, with Week 7 or 8 being his target for a return. Once he's back on the field, Hockenson will rank as a high-end fantasy TE1.

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Houston Texans running back Joe Mixon (ankle) "has worked hard to be back and even though it seems to be an uphill climb to play, he hasn't given up trying," according to NFL Network's Ian Rapoport. Mixon will test his injury pregame to see whether he can suit up on Sunday afternoon. The veteran hasn't played since Week 2 when he was on the receiving end of a hip-drop tackle. He was able to finish the game but then was sidelined for Week 3. Through two games, he has 228 scrimmage yards and one touchdown. Houston would benefit from having him available on Sunday against the Jaguars, but they also won't rush him back before he's ready. If Mixon can't play this week, Cam Akers would lead the Texans' backfield for the second consecutive game, ranking as a fantasy RB3.

From RotoBaller

New Orleans Saints wide receiver Chris Olave (hamstring) is anticipated to play versus Atlanta. The wideout is listed as questionable, with his official availability not expected until near opening kick. However, barring a setback, he should be good to get on the field in Week 4. Olave was relatively quiet during the first two contests of the season. Yet, he finished the Week 3 loss to the Eagles by catching all six targets for 86 yards and a touchdown. With that in mind, Olave is one of the best receivers in the National Football League. As such, he should be featured in all fantasy lineups despite a challenging matchup with the Falcons on the horizon. Olave's likely presence could also mean fewer targets for Rashid Shaheed, although he's at least a flex option after finding the end zone in two of the Saints' three games.

From RotoBaller

San Francisco 49ers wide receiver Deebo Samuel Sr. (calf) is expected to play in Sunday's showdown with the Patriots. Although the wideout was expected to be out longer, it appears he is ready to roll. While there is a chance he could see fewer snaps than usual, he remains a starting fantasy option in any format. On the other hand, Jauan Jennings, coming off a three-touchdown performance in Week 3, will now go from a must-start to a borderline flex option, especially with George Kittle (hamstring) also anticipated to suit up. Kittle and Samuel's impending returns could also mean Brandon Aiyuk may continue to struggle.

From RotoBaller

Tampa Bay Buccaneers running back Bucky Irving (hamstring) is expected to play on Sunday versus the Eagles. The rookie was limited in a few practices throughout the week while missing Thursday's session altogether. Fortunately, the Bucs should have him on the field, barring a setback. Despite Irving seeing considerably fewer snaps than Rachaad White (illness), who is also anticipated to suit up, he has been more productive on the ground. Still, both men are hard to trust, although White still has a higher fantasy ceiling. With that in mind, if the workload changes moving ahead, Irving's value could shift, meaning he's worth stashing for now.

From RotoBaller

Tampa Bay Buccaneers running back Rachaad White (illness) is expected to play against the Eagles. He had a case of food poisoning, resulting in his name being added to the Bucs' injury report. Fortunately, it appears he's feeling better. White has struggled throughout the first three games of the year, running for 66 yards off 31 carries and adding 12 catches for 98 yards. Even worse, he hasn't found the end zone. With that said, despite the added involvement of Bucky Irving (hamstring), who is also in line to play in Week 4, White remains a flex option versus Philly.

From RotoBaller

Jacksonville Jaguars wide receiver Gabe Davis (shoulder) is expected to be on the field for Sunday's showdown against the Houston Texans. It doesn't appear the shoulder injury will be enough to keep him out of the lineup for Week 4. However, the 25-year-old has only eight catches for 123 yards throughout the first three games of the 2024-25 campaign. But, he has at least logged more snaps than any of the other Jags' wideouts, so he has that going for him. Still, Davis is hard to trust from a fantasy standpoint, although he remains a flex option, especially with Evan Engram (hamstring) sidelined again.

From RotoBaller

Chicago Bears wide receiver Keenan Allen (heel) is expected to play in Sunday's matchup versus the Rams. He's missed the last two games because of a heel injury. Fortunately, it appears the issue is behind him. While Allen had just four receptions in the Week 1 win over the Titans, he was targeted 11 times. As such, he's a starting fantasy wideout in any format, with his presence likely resulting in fewer targets for Rome Odunze, who had a six-catch, 112-yard, one-touchdown outing in Week 3 against the Colts.

From RotoBaller