

| Benched | WR | Marvin Harrison Jr. ARI | Owner | Wed Nov 12 9:57am ET |
| Started | WR | Rashee Rice KC | Owner | Wed Nov 12 9:57am ET |
| Benched | QB | Daniel Jones IND | Owner | Tue Nov 11 8:46pm ET |
| Started | QB | Patrick Mahomes KC | Owner | Tue Nov 11 8:46pm ET |
| Benched | QB | Trevor Lawrence JAX | Owner | Wed Nov 12 12:14am ET |
| Started | QB | Dak Prescott DAL | Owner | Wed Nov 12 12:14am ET |
| Benched | D/ST | Buffalo Bills BUF | Owner | Tue Nov 11 9:21am ET |
| Started | D/ST | Pittsburgh Steelers PIT | Owner | Tue Nov 11 9:21am ET |
| No starting lineup changes performed this week. |
| Benched | K | Cam Little JAX | Owner | Tue Nov 11 6:31pm ET |
| Benched | D/ST | Denver Broncos DEN | Owner | Tue Nov 11 6:31pm ET |
| Started | K | Brandon Aubrey DAL | Owner | Tue Nov 11 6:31pm ET |
| Started | D/ST | Green Bay Packers GB | Owner | Tue Nov 11 6:31pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Rome Odunze CHI | Owner | Wed Nov 12 10:38am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 12 10:38am ET |
| Benched | TE | Pat Freiermuth PIT | Owner | Tue Nov 11 3:13pm ET |
| Started | TE | Jake Ferguson DAL | Owner | Tue Nov 11 3:13pm ET |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Tue Nov 11 3:12pm ET |
| Benched | WR | Courtland Sutton DEN | Owner | Tue Nov 11 3:12pm ET |
| Started | RB | Travis Etienne JAX | Owner | Tue Nov 11 3:12pm ET |
| Started | WR | Tee Higgins CIN | Owner | Tue Nov 11 3:12pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Christian Watson GB | Owner | Tue Nov 11 7:08am ET |
| Started | WR | George Pickens DAL | Owner | Tue Nov 11 7:08am ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |