

| Benched | QB | Matthew Stafford LAR | Owner | Tue Nov 11 9:27pm ET |
| Benched | RB | Aaron Jones MIN | Owner | Tue Nov 11 9:27pm ET |
| Benched | D/ST | Buffalo Bills BUF | Owner | Tue Nov 11 9:27pm ET |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 11 9:27pm ET |
| Started | RB | Javonte Williams DAL | Owner | Tue Nov 11 9:27pm ET |
| Started | D/ST | Los Angeles Rams LAR | Owner | Tue Nov 11 9:27pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 11 6:20pm ET |
| Benched | K | Michael Badgley IND | Owner | Tue Nov 11 6:20pm ET |
| Benched | D/ST | Detroit Lions DET | Owner | Tue Nov 11 6:20pm ET |
| Started | WR | Tez Johnson TB | Owner | Tue Nov 11 6:20pm ET |
| Started | D/ST | Pittsburgh Steelers PIT | Owner | Tue Nov 11 6:20pm ET |
| Benched | QB | Justin Fields NYJ | Owner | Tue Nov 11 9:46pm ET |
| Benched | WR | Rome Odunze CHI | Owner | Tue Nov 11 9:46pm ET |
| Started | QB | Joe Flacco CIN | Owner | Tue Nov 11 9:46pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 11 9:46pm ET |
| No starting lineup changes performed this week. |
| Benched | QB | Jordan Love GB | Owner | Tue Nov 11 1:32pm ET |
| Benched | RB | Jeremy McNichols WAS | Owner | Tue Nov 11 1:32pm ET |
| Benched | WR | Josh Downs IND | Owner | Tue Nov 11 1:32pm ET |
| Started | QB | Dak Prescott DAL | Owner | Tue Nov 11 1:32pm ET |
| Started | RB | Chase Brown CIN | Owner | Tue Nov 11 1:32pm ET |
| Started | WR | Malik Washington MIA | Owner | Tue Nov 11 1:32pm ET |
| Benched | WR | Davante Adams LAR | Owner | Tue Nov 11 4:25pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 11 4:25pm ET |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Nov 11 12:31pm ET |
| Benched | TE | Greg Dulcich MIA | Owner | Tue Nov 11 12:31pm ET |
| Benched | D/ST | Indianapolis Colts IND | Owner | Tue Nov 11 12:31pm ET |
| Started | WR | George Pickens DAL | Owner | Tue Nov 11 12:31pm ET |
| Started | TE | Travis Kelce KC | Owner | Tue Nov 11 12:31pm ET |
| Benched | QB | Jared Goff DET | Owner | Tue Nov 11 7:49pm ET |
| Started | TE | Cade Otton TB | Owner | Tue Nov 11 7:49pm ET |
| Started | WR | Rashee Rice KC | Owner | Tue Nov 11 7:49pm ET |
| Started | WR | CeeDee Lamb DAL | Owner | Tue Nov 11 7:49pm ET |
| Started | QB | Patrick Mahomes KC | Owner | Tue Nov 11 7:49pm ET |
| Benched | K | Matt Prater BUF | Owner | Tue Nov 11 7:49pm ET |
| Benched | TE | Dalton Kincaid BUF | Owner | Tue Nov 11 7:49pm ET |
| Benched | WR | Keenan Allen LAC | Owner | Tue Nov 11 7:49pm ET |
| Benched | RB | J.K. Dobbins DEN | Owner | Tue Nov 11 7:49pm ET |
| Started | K | Brandon Aubrey DAL | Owner | Tue Nov 11 7:49pm ET |
| Benched | WR | Tetairoa McMillan CAR | Owner | Tue Nov 11 5:54pm ET |
| Started | WR | Jauan Jennings SF | Owner | Tue Nov 11 5:54pm ET |
| Benched | WR | Troy Franklin DEN | Owner | Tue Nov 11 11:33pm ET |
| Started | TE | Jake Ferguson DAL | Owner | Tue Nov 11 11:33pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | Jonathan Taylor IND | Owner | Tue Nov 11 2:29pm ET |
| Started | WR | Jameson Williams DET | Owner | Tue Nov 11 2:29pm ET |