San Francisco Giants left-hander Kyle Harrison was scratched from his start on Sunday and placed on the 15-day injured list with a right ankle sprain, retroactive to Thursday.

With Harrison out, the Giants selected right-hander Spencer Bivens from Triple-A Sacramento and released right-hander Nick Avila.

Harrison, 22, is 4-3 with a 3.96 ERA in 14 starts this season. The Giants' third-round pick in 2020 is 5-4 with a 4.02 ERA in 21 starts since making his major league debut last season.

Bivens, 29, signed with the Giants as an undrafted free agent in 2022 and has yet to pitch in the major leagues.

This season at Triple-A, Bivens is 4-0 with a 2.81 ERA in 21 relief appearances and was named Pacific Coast League pitcher of the month in May. In three seasons in the minors, he is 15-6 with a 3.54 ERA in 81 games (four starts).

Bivens could make his debut as soon as Sunday, with rookie left-hander Erik Miller scheduled to serve as the Giants' opener in a bullpen game against the visiting Los Angeles Angels.

Avila, 26, was a 26th-round pick of the Giants in 2019 and made his debut this season, going 1-0 with an 8.49 ERA over eight relief appearances.