Jose Ramirez hit two home runs, including the first of three straight in a five-run fourth inning, to power the Cleveland Guardians to a 10-4 victory over the Los Angeles Angels on Friday night in Anaheim, Calif.

Ramirez hit a two-run homer in the third inning off Angels starter Patrick Sandoval, then another two-run homer in the fourth. Josh Naylor followed Ramirez with a solo homer off Sandoval, who was removed after the blast. David Fry completed the hat trick with a homer off Jose Suarez.

The Guardians finished with 10 hits, including two each from Ramirez, Fry, Andres Gimenez and Gabriel Arias. Six different Guardians hitters had at least one RBI, led by four from Ramirez.

It was another disappointing performance by Sandoval (2-7), who gave up eight runs, six hits and four walks in 3 2/3 innings.

Guardians left-hander Logan Allen (6-2) benefitted from all the offense to get the win, giving up three runs on seven hits and two walks in 5 2/3 innings. He struck out seven and threw 99 pitches.

The Angels got three hits from Luis Rengifo, including a home run. Logan O'Hoppe and Jo Adell also homered in the loss. For Adell, it was his 10th of the season, tying Mike Trout and Taylor Ward for the team lead.

All three Angels homers came with the bases empty, but they went hitless (0 for 4) with runners in scoring position.

Rengifo's home run off Allen in the first inning gave the Angels an early 1-0 lead. But Cleveland scored twice in the second inning. Arias hit an RBI single and Johnathan Rodriguez scored from third on a wild pitch.

Ramirez's two-run homer in the third made it 4-1 before the Angels pushed across a run in the bottom of the inning.

Cleveland, though, answered with the five runs in the fourth, essentially sealing the win.