Los Angeles Chargers offensive coordinator Greg Roman hinted that rookie first-round running back Omarion Hampton (ankle) could split backfield touches with Kimani Vidal when he returns from Injured Reserve, according to Alex Insdorf. "We'll play that one by ear. I feel really good about both of them. I'm sure you'll see some sort of 1-2 punch there," Roman said when asked about Hampton's snap numbers with Vidal also in the fold. The 22-year-old Hampton is hoping to come off IR to play in Week 13 against the division-rival Las Vegas Raiders, but nothing is official. If Hampton does return this Sunday, it sounds like he could see more of a timeshare in L.A.'s backfield, at least as the Bolts work him back into the fold for the first time since he injured his ankle in Week 5. Hampton will be a lot more volatile in fantasy football lineups if he's back on Sunday, even in a plus matchup, but eventually, he should regain lead-back duties for the Chargers by season's end.

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The Cincinnati Bengals announced on Wednesday that they officially activated quarterback Joe Burrow (toe) from Injured Reserve, and he will make his return on Thursday against the division-rival Baltimore Ravens on Thanksgiving Day. Burrow has finally recovered from surgery to fix a turf-toe injury that he suffered in Week 2. The 28-year-old franchise QB was very close to returning last weekend, but he was held out of the Week 12 loss to the New England Patriots. Cincy's offense will receive a big boost as they look to keep their faint playoff hopes alive. Burrow has been practicing in full and will take on a Ravens defense that has been much better of late as they have gotten healthier. He will be without receiver Tee Higgins (concussion), but All-Pro wideout Ja'Marr Chase is returning from a one-game suspension. Even with the long layoff, Burrow will be in play as at least a low-end QB1 option for fantasy managers in his return.

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Green Bay Packers wide receiver Jayden Reed (foot, shoulder) was not activated from injured reserve on Wednesday and has been ruled out for Thursday's matchup against the Detroit Lions, according to Matt Schneidman of The Athletic. Head coach Matt LaFleur refused to rule out Reed for the Thanksgiving game earlier in the week, saying "you'll find out Thursday," but the third-year wideout's return will wait at least another week. The 25-year-old practiced for the first time last Friday since suffering a broken collarbone during Green Bay's Week 2 win over the Washington Commanders. He was also limited on Monday and Tuesday this week, and should have a good chance of returning in Week 14 against the Chicago Bears.

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Tampa Bay Buccaneers offensive coordinator Josh Grizzard compared the workload for running back Bucky Irving (foot, shoulder) in his potential Week 13 return to how the team handled wide receiver Chris Godwin in his return against the Rams last week, Scott Smith of Buccaneers.com reports. Godwin was limited in Week 12, playing just 25 of 70 offensive snaps (36%). Irving has missed seven straight games after suffering injuries to both his foot and shoulder in Week 4 against the Philadelphia Eagles, but looked "fine" in practice Wednesday and is expected to play in Week 13 against the Arizona Cardinals. The second-year back will operate as part of a committee, with Sean Tucker and Rachaad White to stay involved. Irving's expected return is a great sign for his fantasy managers, but on a snap count, expectations should be tempered.

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Houston Texans quarterback C.J. Stroud (concussion) is practicing on Wednesday and continues to take steps toward being cleared from concussion protocol this week, per Aaron Wilson of KPRC 2. Stroud has missed three consecutive games since taking a shot to the head during Houston's Week 9 loss to the Denver Broncos. The third-year quarterback remained in concussion protocol to begin the week, but the Texans are hopeful that he will return in Week 13 for a big divisional matchup against the Indianapolis Colts. Stroud was playing well before going down, throwing for 318 yards in Week 8 against the 49ers, his first 300-yard game since Week 5 of last season. He would be back in play as a potential streamer in Week 13 if he is able to play.

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Arizona Cardinals running back Trey Benson (knee) was seen participating in Wednesday's practice session, according to Darren Urban of AZCardinals.com. The Cardinals opened Benson's 21-day practice window last week, and he was limited in practice every day before ultimately being ruled out for Week 12. Head coach Jonathan Gannon did not have an update on the second-year back's status for Week 13 against the Tampa Bay Buccaneers, so his chances of returning are still up in the air. The Arizona backfield continues to be a headache for fantasy managers and is also riddled with injury, as Emari Demercado (ankle) missed Week 12, and Bam Knight was on the injury report last week with an ankle injury as well. There should be more word on Benson's game status in the coming days, and he remains a solid stash for his eventual return.

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Arizona Cardinals wide receiver Marvin Harrison Jr. (appendix) was back at practice on Wednesday after missing the last two games due to appendix surgery, according to Darren Urban of AZCardinals.com. Harrison should have a good chance to return to action in Week 13 against the Tampa Bay Buccaneers, assuming everything goes well in practice this week. His status will continue to be monitored in the next two days. Michael Wilson has emerged as a fantasy stud during Harrison's absence, recording a whopping 25 receptions for 303 yards on 33 targets in the past two games. Wilson should continue to get more opportunities, which creates an interesting conversation about what Harrison's fantasy value could look like when he returns. There has been plenty of pass volume in Arizona with Jacoby Brissett at quarterback, so Harrison could still be relied on as a WR3 in Week 13.

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Philadelphia Eagles wide receiver DeVonta Smith (chest, shoulder) is missing a second straight day of practice on Wednesday with chest and shoulder injuries, according to Jeff Neiburg of the Philadelphia Inquirer. Smith played 95% of the offensive snaps in the Week 12 loss to the Dallas Cowboys on Sunday and caught six of his 11 targets for 89 yards in a busy day, but he's now in danger of sitting out on a short week this Friday against the Chicago Bears. The 27-year-old will need to get back on the practice field on Thursday to have a shot at playing in Week 13. If Smith is inactive or limited at all this week, A.J. Brown figures to be peppered with targets. Tight end Dallas Goedert would also have a much higher fantasy ceiling. Jahan Dotson would most likely operate as the team's WR2.

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The Seattle Seahawks are signing free-agent running back Cam Akers to their active 53-man roster on Wednesday, sources told Jordan Schultz of FOX Sports. Akers, 26, spent time with the Minnesota Vikings this season and will now join the 8-3 Seahawks for RB depth. The Seahawks are facing the Vikings in Week 13 this Sunday. Akers appeared in only three games for Minnesota this year, carrying the ball five times for 19 yards while also completing a 32-yard pass on a trick play. The six-year NFL veteran will give Seattle some more backfield depth, with George Holani (hamstring) a candidate to land on Injured Reserve. Akers probably won't have any fantasy value as long as both Kenneth Walker III and Zach Charbonnet stay healthy.

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Tampa Bay Buccaneers head coach Todd Bowles said on Wednesday that quarterback Teddy Bridgewater will get most of the practice reps this week to prepare him in case Baker Mayfield (shoulder) is unable to play on Sunday against the visiting Arizona Cardinals, according to Greg Auman of FOX Sports. Mayfield has a chance to play in Week 13 after suffering a mild AC joint sprain in his left (non-throwing) shoulder in the Sunday night loss to the Los Angeles Rams, but nothing is certain. The 33-year-old Bridgewater went 8-for-15 passing for 62 yards after taking over for the injured Mayfield on Sunday. He'll have a much better matchup against Arizona with time to prepare this weekend if he makes his first start of the season, but Bridgewater should still be considered a low-upside QB2 streamer, at best, in superflex leagues if he gets the nod.

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Atlanta Falcons head coach Raheem Morris said on Wednesday that quarterback Michael Penix Jr. (knee) had successful surgery on his knee on Tuesday, according to D. Orlando Ledbetter of The Atlanta Journal-Constitution. Penix had full reconstructive surgery to fix a partially torn ACL in his left knee, which will keep him out for the rest of this season and possibly for the start of the 2026 season next fall. The 25-year-old second-year signal-caller is facing a nine-month recovery, which will force Atlanta to rethink its long-term plan at the QB position this offseason. This is Penix's third ACL reconstruction in his career after he had two knee surgeries in college. Kirk Cousins will start the rest of the year under center for the Falcons, but depending on how he finishes the season, the Falcons could opt out of the final two seasons of his four-year deal.

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New York Giants interim head coach Mike Kafka said that rookie quarterback Jaxson Dart (concussion) will be a full participant in practice on Wednesday, according to ESPN's Jordan Raanan. It sounds as if both Dart and Jameis Winston will take first-team reps. Raanan points out that Dart is still officially in the league's concussion protocol after missing the last two games. It's good news that the 22-year-old Ole Miss product is practicing in full, but he still needs final clearance from the concussion protocol in order to be cleared to play on Monday night against the New England Patriots. Winston nearly led the G-Men to an upset of the Detroit Lions in Week 12, but if cleared, New York is fully expected to go back to Dart to close out the season after they traded into the first round of the 2025 draft to select him. If Dart is cleared to play on Monday, he'll immediately be in play as a QB1 again in fantasy due to his dual-threat abilities under center.

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Washington Commanders head coach Dan Quinn said on Wednesday that wide receiver Terry McLaurin (quadriceps) will practice this week, according to Tashan Reed of The Athletic. McLaurin looks to have made some progress coming out of the team's bye week and could make his return on Sunday Night Football versus the Denver Broncos in Week 13. The 30-year-old's status for this week will depend on how much he can do in practice, though. Scary Terry has played in only four games in 2025 due to his quad injury, but he could return just in time for the fantasy football playoffs in several weeks. If McLaurin does make his return in Week 13, he'll be coming back to an offense that is still being run by veteran backup quarterback Marcus Mariota as Jayden Daniels recovers from a gruesome dislocated left elbow. We'll be keeping a close eye on McLaurin's practice statuses this week.

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Buffalo Bills head coach Sean McDermott said that wide receiver Keon Coleman being a healthy scratch in last Thursday night's loss to the Houston Texans was not discipline-related but was due to the short run-up to the game, according to Joe Buscaglia of The Athletic. McDermott said the Bills will "take things one day at a time" with Coleman. McDermott didn't exactly clarify if Coleman will be active for this Sunday's game against the Pittsburgh Steelers, but it would be a surprise if the second-year wideout was not back on the field after being held out the last two games. The 22-year-old was a healthy scratch in Week 11 after being late to a team meeting that Friday. Coleman has been a big disappointment for the Bills and fantasy managers in 2025, catching 32 passes for 330 yards and three touchdowns on 49 targets. He'll be pretty hard to trust as a WR4/flex play in fantasy in Week 13 if he's active.

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The Kansas City Chiefs have ruled out tight end Noah Gray (concussion) for Thursday's Thanksgiving Day game against the hosting Dallas Cowboys, according to ESPN's Adam Schefter. Gray will not have enough time to clear the league's concussion protocol on a short week. His next chance to play will come in Week 14 against the Houston Texans on Sunday, Dec. 7. Travis Kelce will continue to operate as one of quarterback Patrick Mahomes' top options in the passing game, but with Gray out on Thursday, both Robert Tonyan and Jared Wiley will have a chance to see the field more. The 26-year-old Gray has not been on the fantasy football radar in most leagues in 2025, catching 16 of his 28 targets for 132 yards and no touchdowns in 11 games played.

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Buffalo Bills head coach Sean McDermott said "there's a chance" that tight end Dalton Kincaid (hamstring) returns to play this Sunday against the Pittsburgh Steelers in Week 13, according to The Athletic's Joe Buscaglia. However, Kincaid will not be at practice with the rest of the team on Wednesday. Kincaid is slowly improving, but he has not played since injuring his hamstring back in Week 10, and he's up in the air to return this weekend. Without the 26-year-old on the field, Dawson Knox has failed to take advantage of his increased opportunities, catching only four passes on seven targets for 40 yards in the last two weeks. Kincaid is one of Buffalo's top pass-catchers this year, so they could really use him back for an important game against Pittsburgh, but he's going to need to get back on the practice field first. If Kincaid returns in Week 13, he'll be immediately back on the TE1 radar in fantasy.

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The Buffalo Bills released veteran wide receiver Elijah Moore on Wednesday after signing veteran receiver Brandin Cooks on Tuesday, according to Adam Schefter of ESPN. Moore failed to capitalize with Buffalo despite second-year wideout Keon Coleman being a healthy scratch the last two games for disciplinary reasons, and now he'll be searching for a new team to close out the 2025 season. The 25-year-old former second-round pick of the New York Jets in 2021 out of Mississippi was a non-factor in fantasy football in his nine games in Buffalo, catching only nine passes on 17 targets for 112 yards and no touchdowns. Cooks, 32, caught 19 of his 25 targets for 165 yards and no scores in 10 games with the New Orleans Saints before joining Buffalo. He'll provide the Bills' struggling offense with an experienced deep threat to help stretch the field.

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Tampa Bay Buccaneers wide receiver Jalen McMillan (neck) has been on Injured Reserve for the entirety of the 2025 regular season after suffering a neck injury in preseason action. While McMillan has yet to have his IR activation window opened by the team, Greg Auman of Fox Sports reports that McMillan "seems close" heading into Tampa Bay's Week 13 matchup against the Arizona Cardinals. Across 13 games as a rookie in 2024, McMillan recorded 37 catches for 461 yards and eight touchdowns on 58 targets. While 2025 appears likely to be a mostly lost year for the 23-year-old, Auman's reporting indicates that McMillan has a chance to get back on the field before the end of the regular season. If he can return, McMillan would join a crowded Tampa Bay wide receiver room that includes Emeka Egbuka, Chris Godwin, and Tez Johnson, and could be getting Mike Evans (collarbone) as well. It's unclear how heavily the team would lean on McMillan, particularly given the long injury layoff.

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Indianapolis Colts head coach Shane Steichen said that quarterback Daniel Jones (leg) will be listed as limited for Wednesday's walkthrough practice, but he will be good to go for Sunday's divisional game against the Houston Texans, according to Mike Chappell of FOX 59. Jones was also on last week's injury report with a fibula injury, but he eventually returned to a full practice and played in Sunday's overtime loss to the Kansas City Chiefs, going 19-for-31 passing for 181 yards, two touchdowns, and no interceptions. The 28-year-old has been a front-runner for Comeback Player of the Year in 2025 in his first year in Indy, having thrown for 2,840 yards, 17 touchdowns, and seven interceptions in 11 games. Jones will be more of a low-end QB2 option in fantasy football this weekend, though, against the No. 1 defense in the NFL.

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Atlanta Falcons head coach Raheem Morris said Wednesday that he thinks wide receiver Drake London (knee) is "doubtful" to play in his team's Week 13 matchup against the New York Jets, per D. Orlando Ledbetter of the Atlanta Journal-Constitution. London suffered a PCL injury in Week 11 that appears likely to sideline him for at least two games. Across nine games this season, the star wideout has recorded 60 catches for 810 yards and six touchdowns on 94 targets. In his absence in Week 12 against the New Orleans Saints, Falcons wideouts David Sills V and Dylan Drummond both saw an increase in playing time. Wide receiver Darnell Mooney and tight end Kyle Pitts Sr. may be the most likely beneficiaries from a target perspective if London remains out against the Jets.

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