The Indianapolis Colts elevated wide receiver Laquon Treadwell from the practice squad to the active roster for Sunday's game against the Buffalo Bills after the team ruled out Michael Pittman Jr. (back) for Week 10. It will be the first week that Treadwell has been active for the Colts in 2024, and he'll be unlikely to make any noise in fantasy as receiver depth for Indy. With Pittman inactive, Josh Downs should serve as quarterback Joe Flacco's favorite target, with Alec Pierce and rookie Adonai Mitchell also seeing more opportunities. Treadwell, 29, only played in five games last year with the Baltimore Ravens and caught just one of three targets for a 16-yard gain. The previous year he caught six of 10 targets for 42 scoreless yards in six contests with the Seattle Seahawks.

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Miami Dolphins right tackle Austin Jackson (knee) will not play in the Monday night game against the Los Angeles Rams in Week 10. Head coach Mike McDaniel said Jackson popped up with a knee injury after the Week 9 loss to the division-rival Buffalo Bills. It's unknown if Jackson will need surgery, but thankfully his injury doesn't appear to be season-ending. With Jackson sidelined on Monday, veteran Kendall Lamm and rookie Patrick Paul are both options to replace him on the right side of the offensive line against the Rams. Miami comes into Week 10 action riding a three-game losing streak despite quarterback Tua Tagovailoa back in the starting role under center the last two weeks. The Dolphins currently sit at 2-6 and are 2.5 games behind the Denver Broncos for the seventh seed in the AFC.

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San Francisco 49ers running back Christian McCaffrey (Achilles), who is listed as questionable to play in Week 10 against the Tampa Bay Buccaneers, said he feels great and is ready to make his 2024 debut on Sunday. McCaffrey missed the first eight games with bilateral Achilles tendonitis but completed his first full week of practice and will be activated from Injured Reserve on Saturday. CMC also dealt with a calf strain in early August and missed most of training camp in the summer. Now that the reigning Offensive Player of the Year is back, fantasy managers want to know how effective he'll be against Tampa and how much work he'll get. While McCaffrey should operate as San Fran's lead back on Sunday, he'll more than likely have his workload monitored, which will make him a more risky RB1. Jordan Mason will now lose most of his fantasy value as he reverts to a backup role.

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Although the move isn't yet official, the Dallas Cowboys will put quarterback Dak Prescott (hamstring) on Injured Reserve, which means he'll be required to miss at least the next four games, according to executive vice president Stephen Jones. Multiple sources said Prescott is expected to need six to eight weeks of recovery for the partial avulsion of his hamstring that he suffered in the Week 9 loss to the Falcons. If he need surgery, Prescott would miss the rest of the regular season. If he doesn't have surgery and recovers quickly, Prescott would be eligible to return on Dec. 9 against the Bengals in Week 14. However, the prevailing sentiment is that Prescott will likely need more time than that to recover. It's a huge blow to the already disappointing 3-5 Cowboys. Their offense will now be led by backup QB Cooper Rush, who will be no better than a low-end QB2 in superflex fantasy leagues moving forward.

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Miami Dolphins wide receiver Tyreek Hill (wrist) is "doing everything possible" in order to play on Monday night against the Los Angeles Rams after he was added to the Week 10 injury report after missing practice on Friday, according to head coach Mike McDaniel. The head coach said Hill's wrist injury has been "heating up," and the team wants to give it a chance to "cool down." Miami is taking things day-to-day with Hill, who sounds likely to get a questionable tag on Saturday's final injury report. For what it's worth, McDaniel is optimistic Hill will be able to play. The Cheetah leads all Dolphins players with 446 receiving yards in 2024, but he has just one TD and it's his worst statistical start since coming to Miami in 2022. The good news is he has averaged 76 yards in the last two games with quarterback Tua Tagovailoa back. If Hill can't play, it will put Jaylen Waddle in the No. 1 role against LA.

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The Denver Broncos defense/special teams unit is tied for third in the league with the Chicago Bears in overall fantasy points, but they represent a shaky fantasy option as they head into a tough Week 10 matchup against the undefeated Kansas City Chiefs and Patrick Mahomes. While KC's offense hasn't been as explosive as in years past, they are definitely more dangerous now after trading for receiver DeAndre Hopkins. And while Denver's D has been one of the stingier units in 2024 -- they're allowing the third-fewest points per game (17.9) -- the Ravens proved last week that they can still be dominated. The Chiefs offense hasn't been perfect with 12 giveaways on the season, but they also haven't been an ideal matchup for opposing defenses, allowing only 5.0 fantasy points per game. There just isn't a ton of upside for Denver's D/ST on the road against the defending Super Bowl champs.

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Denver Broncos rookie wide receiver Devaughn Vele probably isn't going to break out in the team's Week 10 matchup on the road against the division-rival Kansas City Chiefs, a defense that has allowed the eighth-fewest half-PPR fantasy points to opposing receivers this year. The seventh-round pick out of Utah has some intriguing long-term upside working with quarterback Bo Nix in Denver, but he's just not anywhere near the fantasy radar in single-year leagues. In just five games played in his first year in the NFL, Vele has 18 catches on 23 targets for 176 yards and no touchdowns. Courtland Sutton, the clear WR1 in Denver, is really the only fantasy relevant receiver that the Broncos have to offer in 2024. Even with Josh Reynolds (finger) on Injured Reserve, Vele just hasn't managed to stand out while competing for targets with Lil'Jordan Humphrey and fellow rookie Troy Franklin.

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Fantasy managers should be able to find more reliable kicking options in Week 10 than Denver Broncos kicker Wil Lutz, who has been disappointing each of the last two weeks. Lutz checks in as the No. 7 kicker in overall fantasy points entering a Week 10 showdown against the undefeated Kansas City Chiefs, but he's managed just one field goal and five extra points in Weeks 8 and 9 against the Carolina Panthers and Baltimore Ravens, respectively. The 30-year-old has been one of the most accurate in the league, missing just one of his 19 field-goal attempts on the year while making all 17 of his extra points, but volume may be hard to come by on Sunday in a hostile environment against a KC defense that has allowed just 18.4 points per game, fourth-fewest in the NFL. Lutz has been money when given opportunities in 2024, but there's minimal fantasy upside for him this weekend.

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Denver Broncos wide receiver Lil'Jordan Humphrey simply cannot be trusted in fantasy for a Week 10 divisional matchup this Sunday on the road against the 9-0 Kansas City Chiefs. Humphrey ranks third on the Broncos in targets (32), receptions (21) and receiving yards (188), but the lack of production speaks for itself, and he has yet to get into the end zone in nine games played. The 26-year-old does have some impressive yards-after-the-catch skills, but he's only gone over four catches in a game once this year and still has yet to eclipse 50 yards in a game. Denver's offense could struggle to move the ball for the second straight week against a Chiefs defense that has allowed the eighth-fewest half-PPR points to opposing pass-catchers this season. There's no reason for Humphrey to be rostered in 12-team fantasy leagues.

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Jacksonville Jaguars kicker Cam Little isn't a great option this week in fantasy against the Minnesota Vikings. The Jaguars are dealing with a lot of injuries on offense, including quarterback Trevor Lawrence, who seems likely to be replaced by Mac Jones. With the offense's upside lower than usual, the already mid-tier fantasy kicker is even worse of a fantasy option than he has been this season. To top it all off, the Vikings defense has been one of the best defenses in fantasy against kickers. If all of the banged up receiving options, such as Brian Thomas Jr. and Gabe Davis, are healthy, he could have a decent day, but the upside for fantasy points is extremely limited. Unless fantasy managers believe in Mac Jones, Little is best left out of lineups in Week 10.

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Jacksonville Jaguars wide receiver Parker Washington will be tasked with stepping up once again against the Minnesota Vikings. In Week 9, Washington had just three catches for 41 yards on six targets last week in relief of Christian Kirk and Gabe Davis. Brian Thomas Jr. was a game-time decision but played. Kirk is out for the rest of the season and Davis and Thomas Jr. are questionable once again, so Washington should have a similar role against the Minnesota Vikings. His main competition is tight end Evan Engram, the healthiest receiving option currently on the team. Washington will have to deal with Mac Jones potentially taking over for Trevor Lawrence as well this week due to an injury of his own, but the two did play together a bit during preseason. It's risky, but Washington is a potential deep league flex play once again in Week 10.

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The Chicago Bears' defense and special teams are looking to rebound in Week 10 as they face off against the New England Patriots. After a somewhat strong showing in Week 9, where they kept things competitive despite a tough loss to the Arizona Cardinals, the Bears now turn their attention to rookie quarterback Drake Maye. Maye has been impressed, managing a solid performance despite working with a below-average group of skill players. The Bears' defense will need to key in on Hunter Henry, his top weapon in the passing game if they hope to neutralize the Patriots' attack. Rhamondre Stevenson will be a key focus on the ground, especially after the Bears were gashed by the Cardinals' rushing attack last week. While the Bears' defense is still a startable fantasy option in Week 10, their floor is lower than expected, and fantasy managers should be cautious, given the potential for big plays from Stevenson and Henry. With Maye showing poise and the Patriots having some weapons, the Bears could be in for a more challenging outing than anticipated.

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The New York Jets defense/special teams will head on the road to take on the Arizona Cardinals in Week 10. New York's pass rush was a problem in a Week 9 win over the Houston Texans as they notched eight sacks in the win. They will look to keep it going against Kyler Murray and company this weekend. The Cardinals have been a tough matchup for fantasy defenses this season, however, as they are allowing the 12th-fewest fantasy points per game to the position thus far. The Jets settle in as a top-15 fantasy defense heading into Week 10.

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Jacksonville Jaguars running back Tank Bigsby will have to hold off Travis Etienne Jr. once again against the Minnesota Vikings. He was limited in practice all week due to an ankle injury but is fully off the injury report after Friday's practice. Bigsby had a big Week 7 against the New England Patriots with Etienne Jr. out but had a down week in Week 9 against the Philadelphia Eagles with Etienne Jr. back. This week could be a bit different, as with the receiving core banged up and Mac Jones replacing Trevor Lawrence, the running backs could be relied on more than usual both on the ground and in the passing game. Especially with a blitz-heavy defense from Brian Flores, the short passing game specifically could be a large part of the game plan. Bigsby serves as an interesting flex play in Week 10.

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Jacksonville Jaguars tight end Evan Engram should still be viewed as a TE1 in Week 10 but should be slightly downgraded against the Vikings. That is due to starting quarterback Trevor Lawrence likely being out due to injury this Sunday, and Mac Jones potentially being at the helm instead. While it's possible Engram is fine with a different QB, the change would make him a riskier fantasy option than usual. Given the volatile nature of the tight end position in fantasy, managers shouldn't bench him, but expectations should be tempered slightly. He had 10 targets last week, but only caught five of them for 45 yards. That is around the level he should be at against the Vikings in what should be a similar game script. Engram is still a starting fantasy tight end but has less upside than usual in Week 10.

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Jacksonville Jaguars running back Travis Etienne Jr. will look to take back control of the backfield in Week 10 against the Minnesota Vikings. He was questionable earlier in the week due to a hamstring injury but is no longer on the injury report after Friday's practice. Etienne Jr. only earned 31% of the snaps and five touches last week after missing the previous two games. He came into the season as the clear lead back, but due to a combination of underwhelming play and the emergence of backup Tank Bigsby, the backfield situation in Jacksonville is now at best an even split. However, with Trevor Lawrence and the receiving core banged up, both Etienne Jr. and Bigsby could be more involved than usual against the Vikings. Etienne Jr. should be viewed as a solid flex option in Week 10.

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Jacksonville Jaguars quarterback Mac Jones seems likely to start this Sunday against the Minnesota Vikings in place of the injured Trevor Lawrence. Lawrence is dealing with a left shoulder injury from last week's matchup with the Philadelphia Eagles and practiced in a limited fashion all week. The former first round pick of the New England Patriots has a decent matchup against the Vikings, who have been hit or miss against offenses in fantasy so far. Brian Flores, who also happens to be a former New England Patriot, loves to blitz, which can be difficult for quarterbacks who aren't ready for it, but can also mean great fantasy games for those who are ready for it. Fantasy owners should definitely hold off on starting Jones unless they are desperate given Week 10 would be his first start of the season.

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Jacksonville Jaguars wide receiver Brian Thomas Jr. (chest) is officially questionable to play against the Minnesota Vikings on Sunday. He had been listed as a limited participant during all three days of practice this week. Thomas has exceeded expectations in his rookie season, catching 35 passes for 595 yards and five touchdowns through nine games. He ranks as the overall WR10 in terms of fantasy points this season, which is an impressive feat for someone catching passes in a 2-7 offense. Fantasy managers will hope that the LSU product suits up this week. He's a solid WR2 option despite a matchup against the Vikings' strong defense.

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Jacksonville Jaguars wide receiver Gabe Davis (shoulder) is officially questionable to play against the Minnesota Vikings on Sunday. He had been listed as a limited participant in practice all week long. Davis picked up the shoulder issue in Week 9, ultimately exiting the game early and finishing without a catch. In total, through nine games this year, he has 18 receptions for 217 yards and two touchdowns. That comes out to an average of just two catches and 24 receiving yards per game, which is certainly not good enough to keep him on the fantasy radar. Even with fellow receiver Christian Kirk (collarbone) done for the year, Davis' role is unappealing. He can be dropped in most leagues.

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The New Orleans Saints will place wide receiver Chris Olave (concussion) on injured reserve Saturday, according to NFL Network's Ian Rapoport. Olave has suffered two concussions this season and four throughout his young career, prompting him to meet with specialists and potentially re-evaluate his future in the NFL. The Saints do expect Olave will return to the field this season, but his placement on IR rules him out for a minimum of four games. New Orleans has already lost Rashid Shaheed (knee) for the rest of the season, so Olave being sidelined once again will create significant opportunities for depth receivers like Cedrick Wilson Jr., Mason Tipton, and Marquez Valdes-Scantling.

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