Arizona Cardinals quarterback Kyler Murray was sensational in the Cardinals' 31-6 victory over the New York Jets. Murray's official stat line was 22/24 for 266 passing yards and one passing touchdown while adding 21 rushing yards and two rushing touchdowns. Murray had very few negative plays and operated the Cardinals' offense with elite efficiency, helping to end the game early. Murray and rookie wide receiver Marvin Harrison Jr. got back on track, connecting for a 9-yard touchdown reception. With the Cardinals' offense firing on all cylinders and a favorable upcoming schedule, Kyler Murray is a must-start for the foreseeable future. However, fantasy managers must look to other options in Week 11, when the Cardinals are on a bye.

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Detroit Lions tight end Sam LaPorta (shoulder) suffered a shoulder injury in the Sunday night game against the Houston Texans and is considered questionable to return in the second half. The good news for LaPorta's fantasy managers is that the 23-year-old second-year tight end already had a season-high 66 receiving yards on three receptions with his third touchdown of the season before injuring his shoulder. The Texans' defense has made it a point to limit top Lions wideout Amon-Ra St. Brown on Sunday night, which has led to LaPorta being wide open for several big gains on the evening. It's unclear how serious LaPorta's injury is or if it will put him in danger of missing the Week 11 contest next Sunday against the Jacksonville Jaguars. If LaPorta ends up missing any time with his shoulder injury, Brock Wright and Shane Zylstra will see more snaps, with Wright being the better pass-catching option.

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Indianapolis Colts wide receiver Adonai Mitchell capitalized on the absence of Michael Pittman Jr. in Week 10, snaring all six of his targets for 71 yards in Sunday's 30-20 loss to the Bills. The six catches and the yardage total were both easily season-highs for the rookie wideout who had two catches or less in eight of nine games coming into Sunday. The Colts selected him in the second round of this year's draft and after this performance, another solid week could be in the cards for the 22-year-old should Pittman miss another week. It could be tough to replicate though in Week 11 as the Colts face the Jets in the Meadowlands next Sunday, a pass defense that has been superb at limiting production to pass catchers. The product out of the University of Texas should be on the WR4/5 map if Pittman misses another week.

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Philadelphia Eagles wide receiver DeVonta Smith reeled in 2-of-3 targets for 14 yards in the team's 34-6 victory over the Dallas Cowboys. Smith wasn't called on to do much in this one -- nor was much of the Eagles' offense -- as no other pass-catcher but fellow wideout A.J. Brown recorded more than 27 yards receiving. Quarterback Jalen Hurts combined for four total touchdowns on the afternoon while the Cowboys could not muster an iota of offense. If fantasy managers can find any solace in the subpar performance, the Alabama product was tied for second on the team in targets with tight end Dallas Goedert. Smith should be used more frequently his next time out when Philadelphia faces off against their division-rival Washington Commanders at home this Thursday night.

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Tampa Bay Buccaneers wide receiver Jalen McMillan was banged up heading into this game, but ended up being active ahead of this Week 10 contest. However, fantasy managers might not have noticed McMillan was active given his performance. The rookie wideout finished with a goose egg as he wasn't targeted in the loss to the San Francisco 49ers. This is not a good sign given the Bucs are already limited at the wideout spot. It shows that the Bucs don't have much faith in their third-round rookie. Fantasy managers in dynasty leagues should hold McMillan, but he looks like a drop-candidate everywhere else.

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Indianapolis Colts wide receiver Alec Pierce caught two garbage-time passes on the Colts' final drive, including a 10-yard touchdown reception, giving him four catches for 81 yards and a score in Sunday's 30-20 loss to the Bills. In Michael Pittman Jr.'s (back) absence, Pierce tied a season-high in targets with seven, and the TD was his fourth of the season -- although just his first since Week 5. As of now, Pittman is considered week-to-week, so keep an eye on his status, as that could again mean a few extra targets for Pierce in Week 11 should Pittman miss another game. Regardless, Pierce is always a threat to score on a deep ball given his speed, but in Week 11, the 24-year-old will have to do it against a strong Jets pass defense, putting him in the WR4/5 range again.

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The New York Jets defense was blown out by the Arizona Cardinals in a 31-6 loss in Week 10 on Sunday. New York managed just one sack and was unable to force any turnovers as they fell down 24-6 at halftime. The Jets got their lone sack from Quincy Williams in the blowout loss. New York's defense will look to bounce back against the Indianapolis Colts in Week 11.

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New York Jets wide receiver Garrett Wilson caught five of his six targets for 41 yards in a 31-6 loss to the Arizona Cardinals in Week 10. Wilson and the rest of the New York passing attack struggled against the Arizona secondary in the blowout loss as Aaron Rodgers passed for just 151 yards on 35 attempts. The slow outing for Wilson breaks a streak of five straight games with at least 61 receiving yards. Wilson now has 65 catches for 704 yards and five touchdowns through 10 games. He has a good shot at bouncing back against the Indianapolis Colts in Week 11.

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Tampa Bay Buccaneers tight end Cade Otton has been unbelievable over the last few weeks, but was finally held in check on Sunday. Otton hauled in five of his eight targets for 35 yards in what ended up being a loss to the San Francisco 49ers. Well, Otton's tremendous run had to end at some point, but at least he was still able to do some damage here. Fantasy managers will have to look elsewhere for help next week with the Bucs on a bye week. After that, wide receiver Mike Evans (hamstring) is expected to make his return to the field. If that happens, Otton could lose some fantasy value heading into the Week 12 matchup against the New York Giants.

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New York Jets wide receiver Davante Adams caught six of his 13 targets for 31 yards in a 31-6 loss to the Arizona Cardinals in Week 10. Adams struggled to get anything going downfield despite drawing 13 targets as he averaged just 5.2 yards per catch in the blowout loss. That being said, the workload was encouraging as Adams has now drawn 24 targets over his past two games. Adams will be a strong fantasy play against the Indianapolis Colts in Week 11.

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Philadelphia Eagles wide receiver A.J. Brown hauled in 5-of-7 targets for 109 yards in Sunday's 34-6 win over the Dallas Cowboys. Brown had receptions of 14, 18, 30, and 44 yards on the day as Philadelphia dismantled a Cooper Rush-led Cowboys squad. It's the third time in six outings this season that the Ole Miss alum has eclipsed the century mark, and he's recorded at least 84 yards in all but one contest. Ho-hum. He led the team in receiving by a wide margin, as no other Eagles pass-catcher notched more than 27 yards. Brown would have likely had an even more significant performance if the game were more competitive, but Philly benched their starters just minutes into the final frame. The team will line up for a second consecutive divisional clash this Thursday when they host the visiting Washington Commanders. The 27-year-old will again be a top-flight WR play.

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New York Jets kicker Spencer Shrader made both of his field-goal attempts in a 31-6 loss to the Arizona Cardinals in Week 10. Shrader was elevated from the practice squad on Saturday after the Jets cut Riley Patterson earlier in the week. They also had veteran Anders Carlson on their roster but opted to give kicking duties to Shrader, who hit three extra points as a member of the Indianapolis Colts earlier in the season. That being said, Shrader will take on those same Colts in Week 11.

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New York Jets quarterback Aaron Rodgers completed 22 of his 35 passes for 151 yards but failed to throw any touchdowns in a 31-6 loss to the Arizona Cardinals in Week 10. Rodgers and the entire Jets offense came up short in what appeared to be a decent matchup against the Arizona defense on paper. He got off to an especially painful start, throwing for just 40 yards in the first half. Things picked up a bit after halftime but it was still a disappointing performance for the entire New York offense. Rodgers will hope to bounce back heading into a Week 11 matchup against the Indianapolis Colts.

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New York Jets running back Breece Hall carried the ball 10 times for 52 yards and caught all four of his targets for 31 yards in a 31-6 loss to the Arizona Cardinals in Week 10. Hall performed well when he got the ball, averaging 5.2 yards per carry, but the Jets fell behind early and went pass-heavy after halftime. He managed to bolster his fantasy outing with another strong showing in the passing game as he has 39 catches for 358 yards through nine games. The explosive running back has now failed to find the end zone in three straight games. He will look to bounce back in Week 11 against the Indianapolis Colts.

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Philadelphia Eagles running back Saquon Barkley (arm) rushed 14 times for 66 yards and brought in his sole target for an additional 12 receiving yards in the team's 34-6 win over their division-rival Dallas Cowboys. The long-time New York Giant wasn't needed much in this one, as Dallas had trouble getting anything going with Cooper Rush calling signals for the Cowboys offense. It's worth mentioning that Barkley missed a drive late in the first half after coughing up a fumble on a Micah Parsons tackle the drive before. Zach Berman of the team noted that the 27-year-old had a sizeable bandage on his "left wrist/forearm area" that went up to his elbow after coming out of the locker room for the start of the second half. However, he would remain in the game and rack up another eight touches until the Eagles benched their starters early in the fourth quarter. With a quick turnaround on tap for Philadelphia in a home matchup against the Washington Commanders on Thursday Night Football, fantasy managers should monitor the superstar RBs practice status through Wednesday.

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Tampa Bay Buccaneers running back Rachaad White was once again sluggish on the ground, but was able to salvage his fantasy value with his ability as a receiver. On Sunday, White rushed the ball 10 times for 31 yards on the ground. It was another lackluster game for White on the ground against a tough San Francisco 49ers defense. Luckily, White was able to save his value by hauling in six of his seven targets for 39 yards and a touchdown in the loss. The Bucs now head into a bye week, but White could lose some steam after that. Wide receiver Mike Evans (hamstring) is expected to return in Week 12 which could take away some of the targets for White going forward. That might make White fall into the flex conversation for the Week 12 matchup against the New York Giants.

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New York Jets running back Braelon Allen carried the ball seven times for 27 yards and caught his lone target for seven yards in a 31-6 loss to the Arizona Cardinals in Week 10. Allen mixed in behind starter Breece Hall, notching seven carries to Hall's 10 in the blowout loss. The Jets have been inconsistent in their touch distribution for Allen this season as he saw just four carries in Week 9 and two in Week 7. Allen remains a high-end handcuff in fantasy behind Hall but is tough to trust in starting lineups. He will face off against the Indianapolis Colts in Week 11.

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Tampa Bay Buccaneers quarterback Baker Mayfield was held in check by the San Francisco 49ers defense on Sunday. Mayfield has been incredible throughout most of the season, but didn't have the same success this weekend. He completed 18-of-29 passing attempts for 116 yards and one touchdown in the three-point loss. Mayfield showed heart in this game and even stiff armed his way to giving his team the lead with less than a minute left. Fantasy managers shouldn't get frustrated by this performance. Mayfield is likely to get wide receiver Mike Evans (hamstring) back after the bye week. The expectation is that Mayfield will resume his QB1 ways in Week 12 against the New York Giants.

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Indianapolis Colts wide receiver Josh Downs led his team in targets and receptions in Sunday's 30-20 loss to the Bills, hauling in seven of 10 passes thrown his way for 72 yards. While it was productive and what fantasy managers have grown accustomed to from him, it could have been better had he not dropped what would have been an easy score early on in the game. Still, it was the third straight game in which the former third-round pick has recorded at least nine targets and sixth time in eight games that he's reached that level, affording him plenty of opportunities for receptions and a solid weekly floor. The 23-year-old will have a more difficult task in Week 11 as the Colts take on a Jets defense that has been great at limiting fantasy points to opposing receivers. Downs likely projects as a fringe WR2 next Sunday so long as Joe Flacco remains under center.

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Tampa Bay Buccaneers running back Bucky Irving was able to put together a solid performance on the ground during Sunday's game against the San Francisco 49ers. The rookie back rushed the ball 13 times for 73 yards and a touchdown in the loss. He also hauled in all three of his targets for 14 additional yards through the air. Irving has been impressive this season, but his ceiling is limited with Rachaad White splitting up the carries with him in the backfield. Despite that, Irving should remain a fine flex option for the Week 12 matchup against the New York Giants.

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