Indianapolis Colts wide receiver Josh Downs (toe) is expected to be active for the team's Week 6 road matchup against the Tennessee Titans. Despite logging two DNPs this week and being listed as questionable, the second-year wideout will reportedly suit up, according to Stephen Holder of The Athletic. Teammate Michael Pittman Jr. (back) traveled with the team and also plans to play in the contest against the Titans. Downs has been a PPR monster over the last two weeks, racking up 17 catches, 151 yards, and a touchdown on 21 targets. However, it's worth noting that most of this production came with veteran quarterback Joe Flacco under center in stead of second-year QB Anthony Richardson (oblique). Richardson is also slated to be active for Sunday's outing, so the 23-year-old wideout could return to a lower-volume role. Still, he could see more work than usual with Pittman dinged up. Regardless, the Titans' defense has been one of the more staunch units against opposing offenses, so look for Indy's unit to have their hands full.

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The Detroit Lions and running back David Montgomery have agreed to a two-year $18.25 million extension, locking the veteran RB up through the 2027 season, per Adam Schefter. Montgomery had two years remaining on the three-year $18 million deal he inked in 2023, but the team saw fit to extend an integral part of their offense. The new contract includes $10.5 million in new guaranteed money, and Detroit handcuffs him and backfield mate Jahmyr Gibbs for the foreseeable future. Since 2019, the former third-round pick's 43 rushing scores are good for ninth-most in the league. The 27-year-old has been one of the more consistent fantasy backs this season despite fluctuating yardage outputs, scoring a touchdown in each of his first four outings. He'll look to keep that streak going in Week 6 on the road against the Cowboys.

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Cleveland Browns running back Nick Chubb (knee) is scheduled to make his 2024 debut next Sunday when his team hosts the Cincinnati Bengals in a home matchup, per Mary Kay Cabot of Cleveland.com. It will be his first regular-season action since Week 2 of last season when he was forced from the Browns' contest against the Pittsburgh Steelers after suffering a gruesome, complex knee injury. It's unclear what capacity that will be in, and it is fair to wonder whether or not he'll be on a snap count, but it's a remarkable feat for the 28-year-old. For one more week, it will be running backs D'Onta Foreman and Jerome Ford shouldering the load in the backfield before the former second-round pick's return. When that comes to pass, Chubb will likely make this backfield a three-man rotation until he is healthy -- or effective -- enough to siphon touches away from his teammates. That duo will face an Eagles squad in Week 6 that's let up the eighth-fewest yards on the ground to opposing defenses (515) but the third-most yards per carry (5.0).

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Indianapolis Colts rookie wide receiver Adonai Mitchell caught four of his seven targets for 38 yards in the team's Week 5 loss to the Jacksonville Jaguars. Despite a decent target share, Mitchell saw a very low snap share, playing a total of just 19 in the game. With Michael Pittman Jr. (back) and Josh Downs (toe) trending to play, Mitchell will likely see a similar snap share again in Week 6. On top of that, Mitchell and the Colts will be up against the Titans' secondary, a unit that's allowed the lowest receiving yards/game as well as the fewest fantasy points to opposing WRs. Mitchell is better left on the bench in Week 6.

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Indianapolis Colts quarterback Joe Flacco had an outstanding Week 5 performance, completing 33 of his 44 passes for 359 yards in the team's loss. Flacco's starting status for Week 6 against the Titans is up in the air, with QB Anthony Richardson (oblique) tracking to play but still a game-time decision. If Flacco were to start, he would make for a deeper streaming option, with the Titans secondary allowing the fewest passing yards this season at a 124/game average. Fantasy managers in 2QB/Superflex leagues should stay up to date on the news on Sunday morning, should they need a last-minute replacement.

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Indianapolis Colts wide receiver Alec Pierce popped in the team's Week 5 loss, grabbing all three of his targets for 134 yards and a touchdown. He'll now gear up for a Week 6 matchup against the Tennessee Titans, the team allowing the fewest points to opposing WRs this season. While Pierce has led the team in yards with 386, he comes in fourth in total target share at 12.1%. On top of that, reports suggest that the Colts will be starting QB Anthony Richardson (oblique) in Week 6, which may lower the team's passing volume as opposed to if they were to start QB Joe Flacco. While there remains the possibility that Pierce can catch a few deep shots like he has in weeks past, it's a hard thing to bank on in such a tough matchup. Fantasy managers can view Pierce as a WR4/5 option in Week 6, with him currently slated as the WR46 in our staff's half-PPR rankings.

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Indianapolis Colts running back Tyler Goodson ran the ball five times for 26 yards in Week 5, also grabbing three targets for 31 yards through the air. Goodson was involved in the absence of Jonathan Taylor (ankle) but played a secondary role to RB Trey Sermon in last week's loss. With Taylor out again in Week 6, Goodson will remain involved in the backfield once again. He is in for a tougher matchup, facing a Titans defense that has allowed the 11th-fewest fantasy points to opposing RBs this season. While Goodson may see an increase in volume after a nice showing last week, it's too much of a speculation to start him with confidence in most formats. He is currently the RB48 in this week's staff's half-PPR rankings.

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Indianapolis Colts running back Trey Sermon ran the ball ten times for 38 yards and a touchdown in the team's Week 5 loss. He also reeled in six catches for another 25 yards through the air. Sermon is slated to be Indy's lead back once again when they face the Tennessee Titans on Sunday. Although he has replaced Jonathan Taylor (ankle) in his absence, running back Tyler Goodson has also seen a sizable role, getting five carries in the team's Week 5 loss. Sermon will face a tougher defense in Tennessee, as they have allowed the 11th least fantasy points to opposing RBs this season. Given the tougher matchup, and what could potentially be a split in opportunities with Goodson, Sermon doesn't make for a strong start in Week 6. Fantasy managers replacing Taylor can look his way, but he should otherwise be viewed as a RB3 option. He is currently the RB31 in our staff's half-PPR weekly rankings.

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Denver Broncos wide receiver Josh Reynolds (finger) has been placed on the injured reserve ahead of the Week 6 matchup against the Los Angeles Chargers. The organization was hopeful that Reynolds would only miss one game after having a minor finger surgery. Clearly that wasn't the case as Reynolds will now sit out the next four weeks. The absence of Reynolds should mean more playing time for Lil' Jordan Humphrey, Marvin Mims Jr. and Troy Franklin. Between the trio, Humphrey has the biggest upside after a 48-yard performance last week.

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Los Angeles Chargers running back Gus Edwards (ankle) has been placed on the injured reserve ahead of their Week 6 matchup against the Denver Broncos. Edwards hasn't practiced all week and it doesn't sound like his injury is going to get better anytime soon. That being said, Edwards will head to the IR and miss the next four games. Edwards has taken a backseat to J.K. Dobbins over the last two weeks. The first two weeks Edwards saw 29 carries, but only had nine rushing attempts over the last two games. Dobbins has run away with the lead back gig, which means Edwards' absence won't make a huge impact. Hassan Haskins and Kimani Vidal could see a few touches, but Dobbins is going to be the primary running back going forward.

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Carolina Panthers wide receiver Diontae Johnson (ankle) is currently listed as questionable ahead of the Week 6 matchup against the Atlanta Falcons. Despite that, Johnson is expected to suit up for this divisional matchup. He has been limited in practice all week and played through the ankle injury last week. He finished with three receptions for 23 yards last week, so the ankle issue could've hindered his performance. The injury doesn't seem to be serious enough to force him out of action, but his value could take a hit if he's not 100 percent healthy. Fantasy managers should put him in the WR3 range if he does suit up this weekend. Otherwise, Xavier Legette and Jonathan Mingo will see more involvement in the offense.

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Tennessee Titans wide receiver DeAndre Hopkins faces the Indianapolis Colts in a Week 6 matchup. After an incredibly slow start to the season - likely due to lasting effects from a knee injury - Hopkins has lead the Titans in receiving yards and targets for the last two weeks. That hasn't translated to a ton of fantasy production since this passing offense has been in flux, but it has a massive opportunity ahead of them now facing one of the worst secondaries in the NFL. The Colts have allowed the fourth most yards to WRs this season, and were just gashed by Trevor Lawrence, who threw for a career high 371 yards last week. If the Titans are not able to have success through the air in this one, the outlook of Hopkins will be bleak for the rest of the season, unless he is traded. The former Texans star should be a fine WR3 or flex option in this juicy matchup.

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Washington Commanders running back Brian Robinson Jr. (knee) has been ruled out for the Week 6 matchup against the Baltimore Ravens. This seemed likely to happen considering Robinson wasn't able to practice all week. Robinson will sit out at least one game after suffering a knee injury during last week's win. The Commanders will likely split up the backfield duties between Austin Ekeler and Jeremy McNichols. Ekeler has been pretty quiet this season, but did rush for 67 yards on six carries last week. However, McNichols has been seeing more redzone work with three touchdowns over the last two games. The assumption is Ekeler does more of the passing catching while McNicols gets the early work on the ground. The Ravens have done a good job at slowing down running backs on the ground, so Ekeler has more upside between the two.

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New York Giants running back Devin Singletary (groin) has been ruled out for the Week 6 matchup against the Cincinnati Bengals. Singletary will miss his second straight game after being limited in practice all week. His absence will mean that Tyrone Tracy Jr. will serve as the lead back once again. Last week, Tracy rushed 18 times for 129 yards in the win over the Seattle Seahawks. He figures to once again see heavy usage with the Giants being limited on viable options on offense. Fantasy managers should be able to trust Tracy as a RB2 for Week 6.

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New York Jets tight end Tyler Conklin (hip) is listed as questionable on the team's final injury report heading into a Week 6 matchup against the Buffalo Bills on Monday night. Conklin practiced on a limited basis all week and could be headed for a game-time decision, meaning fantasy managers counting on him might want to have a backup plan in place. If Conklin does play, he will go up against a Buffalo defense that is allowing the fifth-fewest fantasy points per game to opposing tight ends. Due to the injury and the tough matchup, Conklin lands as a mid-range TE2 in fantasy heading into Week 6.

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New York Jets quarterback Aaron Rodgers (ankle) was removed from the injury report and will play in Week 6's Monday night game against the Buffalo Bills. After injuring his ankle in a Week 5 loss, Rodgers practiced on a limited basis on Thursday and Friday before getting upgraded to a full session on Saturday. He will draw a tough matchup against a Buffalo defense that is allowing the fifth-fewest fantasy points per game to the quarterback position this season. Rodgers has been a very mediocre fantasy quarterback this season and the tough matchup does not help. Treat him as a mid-range QB2 in fantasy heading into Week 6.

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Las Vegas Raiders wide receiver Jakobi Meyers (ankle) is listed as doubtful ahead of the Week 6 matchup against the Pittsburgh Steelers. This is bad news for the Raiders offense with Davante Adams (hamstring) already being ruled out. It could be an extremely busy day for tight end Brock Bowers. The absence of both Adams and Meyers would turn Tre Tucker into the WR1 on this roster. He figures to see heavy usage as well, so he should be a solid streaming choice. DJ Turner and Tyreik McAllister would be behind Tucker and Bowers on the pecking order.

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Houston Texans running back Joe Mixon (ankle) is expected to play on Sunday according to Jordan Schultz of FOX Sports. Mixon has been sidelined since suffering an ankle injury in their Week 2 victory over the Chicago Bears. After opening the week missing practice on Wednesday, Mixon was able to log a limited session on both Thursday and Friday which is also a very good sign. Fantasy managers should continue to monitor his status ahead of kickoff in case he faces a setback. The 28-year-old looked sharp in his Houston debut as he ran for 159 yards and a score on 30 attempts and should be locked into all lineups as a solid RB2 facing the New England Patriots.

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Jacksonville Jaguars tight end Evan Engram (hamstring) is expected to play on Sunday according to Jordan Schultz of FOX Sports. Engram has been sidelined since Week 2 after suffering a hamstring injury during warmups of that week. The tight end was able to log three consecutive limited practice sessions this week. Fantasy managers should continue to monitor his status ahead of kickoff in case he faces a setback. Engram enjoyed a career-year last season as he caught an impressive 114 receptions for 963 yards and four touchdowns. Engram remains a solid TE1 when he travels to Tottenham and faces the Chicago Bears who have allowed the 10th-fewest points to opposing tight ends this season.

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Buffalo Bills rookie wide receiver Keon Coleman should be viewed as a low-end flex option this week as he faces the New York Jets on Monday evening. Coleman saw a season-high five targets last weekend but was only able to bring in one of them for a 49-yard TD reception. Since scoring 0.0 PPR points in Week 2, Coleman has gone on to score at least 8.0 PPR points in each of the past three weeks. On Monday, the Bills could be without No.1 wideout Khalil Shakir (ankle) as he did not practice on Thursday and Friday. If Shakir is unable to play, Coleman could be worth a look as a flex option in all standard formats facing a tough New York defense who has allowed the seventh-fewest points to opposing wide receivers.

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