Philadelphia Eagles quarterback Jalen Hurts will take on the Dallas Cowboys in Week 10. There was some concern that the 26-year-old was dealing with a surprise ankle injury after head coach Nick Sirianni let it slip that his missed practice on Wednesday was more than rest, but Hurts was left off of the final injury report and is a full go for Sunday's divisional matchup against the Cowboys. A.J. Brown (knee) and DeVonta Smith (hamstring) were a concern heading into the weekend, but both were full participants Friday and carry no injury designation. Dallas is reeling at the moment, with multiple injuries on offense and defense. Their defense could be getting Micah Parsons (ankle) back, but the team allows the fifth-most fantasy points per game to quarterbacks. With all his weapons at full health, Hurts is a smash start in Week 10.

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Detroit Lions wide receiver Amon-Ra St. Brown will have to earn his output in Week 10 against a Houston Texans defense that has been generally strong this season. St. Brown continued his efficiency last week, catching all seven targets for 56 yards and a touchdown, marking his sixth consecutive game with a score. As one of the steadiest WRs in the league, he ranks as a Top-12 fantasy option at receiver this season across scoring formats. Though his volume may be slightly lower than some top WRs, his reliability and scoring streak make him a must-start WR1 in Week 10.

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Philadelphia Eagles running back Saquon Barkley will face off against the division-rival Dallas Cowboys in Week 10. The 27-year-old has dealt with some back soreness this past week and has been given some rest during practice, but he is not on the final injury report and is a full go for Sunday. The matchup can not get much better. Dallas is missing pieces on both sides of the ball and is currently allowing the third-most fantasy points per game to running backs. After gaining nearly 200 total yards last week against Jacksonville, Barkley is in line for another strong performance against a struggling Cowboys defense.

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Detroit Lions running back Jahmyr Gibbs remains a strong fantasy option heading into Week 10, despite a challenging matchup against the Houston Texan's top-five run defense. Though his volume is considerably less than most RB1s, Gibbs has been one of the league's most efficient backs all year long. Though he shares the backfield with David Montgomery, Gibbs' explosive play style has led to consistent scoring, including five games with a touchdown and two multi-touchdown performances. The Texans allow an average of just 14 fantasy points per week to running backs, but the Lions will look to establish their dual-front offensive attack as early as possible. Fantasy managers should have no problem leaning on Gibbs' big-play potential as an RB1 until proven otherwise.

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Pittsburgh Steelers quarterback Russell Wilson is 2-0 with four total touchdowns and no interceptions as a starter this season. He'll face what could be his toughest challenge yet in keeping up with the Washington Commanders in Week 10. The Commanders are among the highest-scoring offenses in the league while limiting opposing teams to the fifth-fewest passing yards per contest. Still, Washington has given up a fair amount of passing touchdowns, so Wilson could certainly find success on Sunday. Pittsburgh added veteran wide receiver Mike Williams ahead of the NFL trade deadline to give Wilson another weapon and hopefully improve the team's aerial attack. Although the 35-year-old shouldn't be trusted in single-quarterback formats, Wilson projects as a fine QB2 option in superflex leagues this week.

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Detroit Lions running back David Montgomery faces a challenging matchup in Week 10 against a stingy Houston Texans run defense. Montgomery, a Top-15 back in fantasy points per game, has been reliablefinding the endzone in six of eight games, ranking sixth in both red zone touches and total touchdowns. He's averaging 15.9 touches and 81.1 total yards per game, and he ranks 13th among qualifying backs in missed tackles forced per attempt. Houston's defense has been tough on running backs, allowing just under 115 rushing yards per game. They also rank fifth in lowest rushing success rate and third in fewest missed tackles. If Detroit can establish their ground game early, they'll likely lean heavily on their backfield as they have much of this season. He remains a touchdown-dependent RB2 in this matchup.

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Although he hasn't found the end zone as a pass-catcher, Denver Broncos wide receiver Courtland Sutton has had his best two games of the season in the last two weeks, combining for 15 catches (21 targets) for 222 yards while also throwing a touchdown pass to quarterback Bo Nix on a trick play last week. He's seen double-digit targets the last two weeks for the first time since Week 3 and only the fourth time in 2024. The 29-year-old ranks 11th among all wideouts with 68 targets but is tied for 19th with 36 receptions and averages 10 half-PPR fantasy points per game -- tied with Nick Westbrook-Ikhine for 36th. It might be difficult for Sutton to extend his streak of 100-yard games to three in Week 10 against the division-rival Kansas City Chiefs, a team allowing the eighth-fewest fantasy points per game to receivers. Sutton should be considered a WR3/flex in fantasy this Sunday on the road.

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Denver Broncos running back Jaleel McLaughlin's fantasy stock is down heading into a tough Week 10 divisional matchup on the road against the undefeated Kansas City Chiefs. McLaughlin hasn't really been a realistic starting option for fantasy managers all year, but he's especially off the radar going up against a Chiefs defense that has allowed the fewest half-PPR points to RBs in nine games. He had just eight touches for 20 yards in the Week 9 loss to the Baltimore Ravens and saw rookie Audric Estime handle just as many carries while being more productive. Head coach Sean Payton said he wants to get Estime more involved moving forward, which is most likely going to come at the expense of McLaughlin. The second-year back has taken a step back in 2024 and is averaging just 5.7 half-PPR points this year, which ranks him 50th among all RBs in the league.

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Denver Broncos rookie quarterback Bo Nix threw for a season-high 284 yards and three touchdowns in the Week 8 win over the Carolina Panthers before coming back down to Earth in the Week 9 blowout loss on the road to the Baltimore Ravens, when he threw for 223 yards, no touchdowns and his first interception since Week 6. While Nix has looked much better in recent weeks than he did at the start of his rookie campaign, things won't get any easier in Week 10 on the road against the undefeated and division-rival Kansas City Chiefs. KC's defense has allowed just over 200 passing yards per game in nine games in 2024 and have been middle of the pack in terms of fantasy points allowed to opposing QBs. Nix actually checks in as the QB11 in overall fantasy points entering Week 10, but he should be considered more of a low-end QB2 on the road against the reigning Super Bowl champions.

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Indianapolis Colts wide receiver Josh Downs has been one of the lone bright spots on offense regardless of who has been under center for Indy, accruing nine or more targets in five of the seven games he's played and nabbing six or more receptions in four of them. One of those instances came just last week when he hauled in six of nine targets for 60 yards from Joe Flacco, who will once again be quarterbacking his squad in Week 10. While their opponent, the Buffalo Bills, has been good against the pass by allowing the sixth-fewest points to WRs, the Colts will be without Michael Pittman Jr. on Sunday, so Downs should be the unquestioned No.1 receiver. With a 6.58 aDOT, Downs' receptions will likely be of the short variety, but he does offer solid YAC (yards after catch) ability, and as four-point underdogs on their own turf, the Colts could be playing catch-up all game, so Downs should be dependably involved. As such, the 23-year-old is a solid WR2 this week.

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Denver Broncos running back Javonte Williams will be facing a Kansas City Chiefs defense in Week 10 that has allowed the fewest PPR points per game to the running back position through nine weeks of the 2024 season. That won't give fantasy managers much confidence in Williams, who has produced double-digit half-PPR points just twice in nine games this year, with one of those games being his two-touchdown breakout in Week 7 against the New Orleans Saints. Williams hasn't scored in any other game and will need to be much more efficient than he's been this year to return any kind of value in Week 10. The only good news is that Williams has seen at least 17 touches in four of the last six games as Denver's clear lead back. The 24-year-old enters Week 10 as a low-upside RB3/flex and has averaged 9.6 half-PPR points this year, which ranks 32nd among RBs.

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Detroit Lions quarterback Jared Goff enters Week 10 against the Houston Texans offering reliable but modest upside as a fantasy play. Goff ranks second among qualifying quarterbacks in yards per attempt and seventh in fantasy points per dropback, showcasing solid efficiency throughout the season. However, Houston's pass defense has been tough at times over the last few weeks, which could encourage Detroit to lean even more on their run game. That said, the Texans have struggled with pass touchdowns, ranking 32nd in pass touchdown rate allowed and giving up the 10th-most fantasy points per game to quarterbacks. With Jameson Williams back from suspension (PED violation), Goff has a versatile set of playmakers to leverage, keeping him in the low-end QB1/QB2 mix this weekespecially helpful with four teams on bye.

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After being a limited participant in practice on Wednesday and Thursday, Atlanta Falcons tight end Kyle Pitts (hamstring) was a full participant on Friday and is expected to play this weekend against the Saints. The 24-year-old seemed to hit his stride in Weeks 5 through 8, averaging five catches and 79 yards per game over that stretch but was limited to just one catch on one target for 11 yards in Week 9 against the Cowboys. Week 10 brings a rematch with New Orleans, the same team that held him without a catch back in Week 4, however, they are missing some key pieces on defense this time and are losers of seven straight, with the Falcons 3.5-point favorites in this one. The Saints have been generally good against tight ends though, having allowed the 15th-fewest fantasy points to the position, so even though Atlanta throws the ball on almost 56% of its plays, Pitts projects to continue as a volatile TE1 in this matchup.

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Los Angeles Chargers running back Gus Edwards (ankle) is officially listed as questionable to return from Injured Reserve and play in Week 10 against the visiting Tennessee Titans. Edwards was limited in practice on Wednesday and Thursday before upgrading to full on Friday. The former Baltimore Ravens RB has not played since getting injured in the Week 4 loss to the division-rival Kansas City Chiefs. If Edwards is activated from IR on Saturday and plays on Sunday, he'll most likely be eased in as J.K. Dobbins' backup. In the four games that Edwards played in before his injury, he took a clear back seat to Dobbins in LA's backfield and was averaging a career-low 3.0 yards per carry on 38 rushing attempts. Edwards' impending return will mean less playing time for rookie Kimani Vidal as a change-of-pace option behind Dobbins.

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Los Angeles Chargers outside linebackers Joey Bosa (hip) and Khalil Mack (groin) are both listed as questionable to face off against the Tennessee Titans in Week 10 on Sunday. In addition, cornerback Kristian Fulton (hamstring) is doubtful and linebacker Denzel Perryman (toe) is questionable. Bosa was limited in practice all week, while Mack didn't practice at all, so Bosa has the much better shot at being active this weekend in a juicy matchup against quarterback Will Levis (shoulder), who is returning after missing the last three games. Given their injuries, both Bosa and Mack are risky IDP fantasy options in Week 10. The 29-year-old Bosa played in the Week 9 win over the Browns but didn't record a single tackle. If one or both of Bosa and Mack are ruled inactive on Sunday afternoon, expect to see Bud Dupree take on a bigger pass-rushing role.

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Miami Dolphins wide receiver Tyreek Hill (wrist) was added to the Week 10 injury report on Friday with a wrist injury and was unable to practice. Mid-week additions to the injury report usually are never good, but Hill has one more day to get back on the practice field before the team releases their final injury report for their Week 10 contest against the Los Angeles Rams on Monday night. Fantasy managers should have a better idea on Saturday as to whether Hill's injury is serious enough to put his Monday status in questionable, and they'll also have a tough decision to make if Hill is a game-time decision. If Hill is unable to go against the Rams, Jaylen Waddle would be the top receiving for Miami and would be a must-start. Hill has not scored since Week 1 but has been more productive the last two weeks with quarterback Tua Tagovailoa back, catching 10 of his 14 targets for 152 yards.

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Houston Texans running back Dameon Pierce (groin) was unable to practice all week and was officially ruled out on Friday for the Week 10 game versus the Detroit Lions on Sunday night. Pierce will miss his second straight game with a groin injury, which will allow Dare Ogunbowale and J.J. Taylor to see more change-of-pace work this weekend behind starter Joe Mixon. The 24-year-old Pierce also missed four straight games from Weeks 2-5 due to injury and has seen only 14 rushing attempts for 98 yards and a touchdown in the four games he's been active in. Pierce does have an impressive 7.0 yard-per-carry average, but he hasn't been very healthy and has had a minimal role when active behind Mixon in 2024. Pierce should be found on the waiver wire in most fantasy leagues and is nothing more than a handcuff option for Mixon in deep leagues.

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Houston Texans defensive end Will Anderson Jr. (ankle) was unable to practice all week and was officially ruled out on Friday to play in the Week 10 showdown on Sunday night against the Detroit Lions. Anderson injured his ankle in the Week 9 loss to the New York Jets last Thursday night and wasn't able to make enough progress to play this weekend. It's a big blow to Houston's pass rush against a high-octane Lions offense. In addition, the Detroit offensive line has been stingy allowing opposing pass-rushers to get their hands on quarterback Jared Goff in 2024. With Anderson out at least one game, Derek Barnett will be counted on more across from defensive end Danielle Hunter. Fantasy managers should be looking to fade the Texans defense/special teams unit in a bad matchup this Sunday evening.

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San Francisco 49ers wide receiver Deebo Samuel Sr. (oblique, ribs) is officially listed as questionable to play in the Week 10 matchup versus the Tampa Bay Buccaneers this Sunday, per head coach Kyle Shanahan. Samuel was limited in the first two practices of the week before shedding his non-contact jersey on Friday, so he's on the right side of questionable this weekend and should play after having last week's bye to heal up. In addition to Samuel likely being active against Tampa, Jauan Jennings (hip) and Chris Conley (ankle) have been cleared, which will make it more difficult for rookie Ricky Pearsall to stand out from a fantasy perspective. With Brandon Aiyuk (knee) out for the year, Samuel should be one of quarterback Brock Purdy's top targets going forward, making him a must-start in fantasy. Samuel caught four passes for 71 yards and carried the ball four times for 15 yards in Week 9.

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The San Francisco 49ers listed defensive end Nick Bosa (hip) as questionable to play in Week 10 on Sunday against the Tampa Bay Buccaneers, according to head coach Kyle Shanahan. Bosa came down with a hip-pointer injury in practice on Wednesday and was very limited in the final practice of the week on Friday, leaving his availability up in the air this weekend. Losing the 27-year-old former first-rounder, who is one of the best pass-rushers in the game, would make San Fran's defense even more vulnerable in Week 10. However, the Niners' defense/special teams unit should be considered a top-10 option this week, regardless of whether Bosa plays, in a matchup against a Bucs team that could be down their top four receivers. Bosa is shaping up as a shaky starter in IDP fantasy leagues in Week 10. If Bosa is inactive on Sunday, both Robert Beal and Sam Okuayinonu should see more snaps.

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