After a hot stretch in the middle of the campaign, Pittsburgh Steelers running back Najee Harris has quieted down in recent weeks with fewer than 70 rushing yards in three straight contests. He could struggle again in Week 13 in a tough divisional matchup against the Cincinnati Bengals. The Bengals give up plenty of points to opposing teams but have been shutting down the running game for most of the season. It is worth noting, however, that Cincinnati has surrendered the fifth-most rushing touchdowns to running backs. With Jaylen Warren mixing in to split touches with Harris, it's difficult to project Harris for a lot of yardage on Sunday, so fantasy managers may be disappointed with his output unless he falls into the end zone. Because of this, Harris should be viewed as just a low-end RB2 in most formats.

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Pittsburgh Steelers quarterback Russell Wilson has struggled over the past two weeks and will hope to bounce back against the Cincinnati Bengals in Week 13. In addition to surrendering the fifth-most points in the NFL, Cincinnati allows the third-most fantasy points per game to opposing quarterbacks. Although AFC North matchups involving Pittsburgh tend to be low-scoring defensive battles, this contest is projected for a healthy amount of points with a 47.5-point over/under. Wilson hasn't been consistent enough as a starter this season to warrant consideration in single-quarterback fantasy formats, but he is certainly a viable QB2 with upside in superflex leagues.

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New England Patriots running back Rhamondre Stevenson is coming off one of his worst games this season, as he rushed just eight times for 13 yards and failed to catch a pass last Sunday. Stevenson was inefficient, unproductive, and relatively uninvolved in the Patriots' loss to Miami. However, he has a chance to bounce back in a big way this week against the Indianapolis Colts. The Colts have struggled to slow down opposing backfields, allowing the eighth-most receptions, fourth-most rushing yards, and fourth-most fantasy points to running backs in 2024. The 26-year-old's fantasy ranking drops to the RB3 tier this week, but he's still worth deploying in most leagues given his favorable matchup at home.

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New England Patriots quarterback Drake Maye remains an intriguing fantasy option ahead of Sunday's Week 13 game against the Indianapolis Colts. While Maye is coming off his second consecutive loss, the rookie has maintained solid fantasy production, ranking as the overall fantasy QB11 since he took over as the team's starter back in Week 6. This week, Maye gets one of his best matchups yet, facing a Colts defense that has allowed the third-most completions, fifth-most passing yards, and 12th-most fantasy points to opposing quarterbacks. This year's No. 3 overall pick ranks just inside the top 12 fantasy quarterbacks heading into this week's battle against an underperforming Colts squad.

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If the San Francisco 49ers plan to knock off the Buffalo Bills in Orchard Park on Sunday night, the team will likely need tight end George Kittle to continue his run of production. In each game he's played since a disappointing Week 1, Kittle has outperformed half-PPR projections, culminating in last week's six-target, six reception, 90-yard, one-touchdown game in Green Bay. After spending all of 2023 as the epitome of a boom/bust fantasy asset, this season Kittle has flipped the script and become the 49ers' steadiest offensive producer. The Bills are the 13th-best in the league at limiting fantasy tight end half-PPR points per game. With starting quarterback Brock Purdy (shoulder) on the good side of questionable, San Francisco's offense still has an uphill battle as they'll be missing All-Pro left tackle Trent Williams (ankle) for the second-straight game and left guard Aaron Banks (concussion). A loud, cold, and maybe snowy environment will also make things tougher offensively. Kittle should considered a mid-high TE1 in Week 13, and a must-start even if Purdy can't go.

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Tennessee Titans quarterback Will Levis is coming off arguably his best showing of the 2024-25 campaign, throwing for 278 yards, two touchdowns, and one pick in the Week 12 win over the Texans. He also completed 75% of his throws in that one. Although the signal-caller is beginning to show signs of life, he has a long way to go before he earns the trust of fantasy managers. With every team in the National Football League playing in Week 13, there are safer options available for fantasy managers. However, Levis is still worth considering for multi-QB fantasy setups in Week 13 versus the Washington Commanders.

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Tennessee Titans running back Tony Pollard is coming off one of his best performances of the season, amassing 119 yards and a touchdown off 24 carries, adding three catches for 10 yards in the win over the Houston Texans. After a few rough weeks, fantasy managers were certainly thrilled to see him turn things around. However, Pollard has had some uneventful showings during the 2024-25 campaign, so he's far from a sure thing from a fantasy standpoint. Still, the 27-year-old should be considered a starting fantasy option in nearly any fantasy format imaginable for the Week 13 matchup versus the Washington Commanders.

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Tennessee Titans wide receiver Nick Westbrook-Ikhine had a quiet start to the 2024-25 campaign. However, things have gone in a different direction, with the 27-year-old finding the end zone in six of his previous seven appearances. Granted, it would be nice if he had more catches, especially for those participating in PPR formats. Still, Westbrook-Ikhine appears to have a good thing going with Will Levis, so he warrants consideration for fantasy lineups. With that in mind, he's still a risky fantasy option in Week 13 versus the Commanders.

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Buffalo Bills tight end Dawson Knox will be atop the depth chart on Sunday night when the team hosts the San Francisco 49ers. Starter Dalton Kincaid (knee) will be inactive for the second consecutive game. Knox logged a season-high mark in targets (six) and receptions (four) for 40 yards in place of Kincaid before the team's bye week. The 49ers are the sixth-best defense against fantasy football tight ends this season. With all 32 teams in action, Knox is outside of streaming consideration.

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Buffalo Bills running back Ray Davis has remained in a reserve role since Week 6 but holds value as a bench stash entering Week 13. The rookie only averaged five touches per game over the last four contests. If anything happens to starter James Cook, Davis would be the most valuable waiver-wire addition. Fantasy managers, especially those rostering Cook, can get ahead by adding Davis to benches. He should not be started against the San Francisco 49ers.

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San Francisco 49ers wide receiver Deebo Samuel Sr. will attempt to break out of a four-game touchdown-less slump when the team goes to Buffalo to face the Bills in Week 13. The sixth-year pro's performance in Green Bay last week was ugly. Samuel Sr. was targeted four times by backup quarterback Brandon Allen, catching only one pass for 21 yards. Two of those unfulfilled targets should have been caught. He had no rushing attempts. Amid speculation that Samuel Sr. is looking a little "thicker" lately, his most explosive play in recent memory was an 87-yard kick return at Lambeau called back for holding. It could be rough-going again in a loud, cold, and maybe snowy Orchard Park, as the Bills have allowed the eighth-fewest half-PPR points to opposing wide receivers. Significantly, San Francisco's offensive line is banged up, with All-Pro left tackle Trent Williams (ankle) set to miss a second-straight game and starting left guard Aaron Banks (concussion) also out. Still, Samuel Sr. likely offers at least a modest rebound from last week with starting quarterback Brock Purdy (shoulder) expected to play. Samuel Sr. is a WR3/FLEX this week, with a downgrade to WR4 if Purdy can't go.

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Los Angeles Rams running back Kyren Williams began the year by recording at least one touchdown in seven straight contests. However, after not scoring in meetings with the Seahawks, Dolphins, and Patriots, the 24-year-old finally got back in the end zone in the Week 12 loss to the Philadelphia Eagles. With Puka Nacua and Cooper Kupp healthy, Williams has a lot less on his plate. Still, he will remain involved. Although Williams' success for fantasy managers is often contingent on whether he runs it in for six points, his outlook is promising for Sunday's matchup versus a Saints defense that has allowed 12 rushing touchdowns during the 2024-25 campaign, the third-worst mark in the NFL. Keep him starting in Week 13.

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Los Angeles Rams wide receiver Cooper Kupp is coming off another strong performance, catching eight of his 11 targets for 60 yards and a touchdown in the Week 12 loss to the Eagles. Although he missed time this season due to injury, he's been relatively consistent in most of his appearances during the 2024-25 campaign. With a favorable matchup on the horizon versus a Saints defense that has surrendered nearly 2,000 yards to opposing wideouts this season, the fifth-worse mark in the NFL, Kupp's ceiling is higher than usual.

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Los Angeles Rams wide receiver Puka Nacua has been on a roll. Although the 23-year-old only has one touchdown this season, he's combined for 25 catches for 338 yards in his previous three appearances. Without question, Matthew Stafford should continue to look in his direction in the Week 13 showdown against New Orleans, and his outlook is more promising than normal versus a Saints defense that has allowed 1,959 yards to opposing receivers this season, the fifth-worst total in the National Football League.

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Buffalo Bills wide receiver Amari Cooper (wrist) does not carry an injury designation into the weekend after fully participating in practice all week. His route participation may increase against San Francisco. He's been a part-time player since his arrival in Buffalo before Week 7 but had the bye week to better acclimate to the Bills system. Fellow outside wide receiver Keon Coleman (wrist) will be inactive. However, the San Francisco pass defense is above average against fantasy football wide receivers. Sunday Night Football also has weather concerns (snow, wind). Cooper is considered a risky start in Week 13.

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Buffalo Bills quarterback Josh Allen enters Week 13 as a model of consistency for fantasy football. He's scored at least 20 fantasy points in six straight games and is the QB5 in fantasy points per game this season. In Week 13, the Buffalo Bills host the reeling San Francisco 49ers. The defense is generally strong against quarterbacks but there are injuries to a few key players, including All-Pro pass rusher Nick Bosa. There's a chance of snow in the forecast, which could hamper offensive production. Nevertheless, Allen has been too good to fade and should be in all starting lineups this weekend.

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Buffalo Bills running back James Cook projects to see plenty of usage on Sunday night against the San Francisco 49ers. The 49ers are fairly weak against fantasy football running backs this season, allowing the 10th-most points per game. Most recently, Josh Jacobs ran for 106 yards and three touchdowns against them. Cook can beat defenses on the ground or through the passing game. With the potential for hazardous weather in Buffalo, Cook may hear his name called more often. He's ranked as a high-end RB2 in Week 13.

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Los Angeles Rams quarterback Matthew Stafford has played well in the last month. After tossing only three touchdowns in the Rams' first six games of the 2024-25 campaign, the 36-year-old signal-caller has 12 in the last five contests. Los Angeles needs some wins to keep the team's postseason hopes alive. Fantasy managers will likely see Stafford extra-motivated in Sunday's meeting with the Saints, and he'll have a good chance to produce versus a New Orleans defense that has allowed 23.6 points per game this season, one of the worst marks in the National Football League. With that in mind, Stafford deserves consideration in all fantasy formats, although he's a must-start in two-QB setups.

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Buffalo Bills wide receiver Khalil Shakir has five straight games with at least six receptions as the slot receiver for quarterback Josh Allen. He has 18 more catches than the next Buffalo Bill. As Allen's go-to receiver, Shakir ranks as a WR3 against San Francisco. However, the 49ers are one of the best defenses against slot receivers this season. Plus, Shakir hasn't scored a touchdown since Week 3. Shakir should still see plenty of targets but there are some reasons to be concerned about him matching his typical stat line.

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San Francisco 49ers wide receiver Jauan Jennings faces the Bills in Orchard Park for Week 13's Sunday night matchup. Last week in Green Bay -- and catching passes from backup quarterback Brandon Allen -- Jennings led the 49ers in targets with seven, finishing with five receptions for 40 yards. Fortunately, starter Brock Purdy (shoulder) is expected to play in Buffalo, but the encouraging news ends there. Buffalo's pass defense has been the eighth-toughest on fantasy wide receivers and should have a nice home-field advantage as a significant winter storm is expected to bleed into the first quarter. Most significantly, San Francisco will be missing All-Pro left tackle Trent Williams (ankle) and starting left guard Aaron Banks (concussion). Consider Jennings a risky WR3/FLEX with a significant downgrade into WR4 territory if Purdy is held out again.

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