San Francisco 49ers running back Jordan Mason will return to a backup role in Week 10 when the team takes on the Buccaneers in Tampa. The undrafted third-year pro did an impressive job filling in for All-Pro Christian McCaffrey (Achilles) over the 49ers' first five games, averaging 15.9 half-PPR points before suffering a lingering shoulder sprain in Week 6 and ceding much of his subsequent work to rookie Isaac Guerendo. While Mason won't be completely locked out of action with the return of McCaffrey on Sunday since San Francisco is likely to ease the latter back into action to some degree, the Niners have established a preference for using their RB1 almost exclusively. As long as CMC remains healthy, Mason reverts to a top handcuff/stash, while Guerendo falls off the fantasy map entirely. Hang on to Mason if at all possible, but leave him on the bench in Week 10.

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San Francisco 49ers quarterback Brock Purdy will be in Tampa for a Week 10 showdown against the Buccaneers on Sunday. The last time we saw Purdy, he earned a Week 8 30-24 victory over the Dallas Cowboys at home. The former Iowa State Cyclone looked sharp in that game, posting 26.3 fantasy points. Purdy has a juicy matchup coming out of the bye, as Tampa Bay's defense is ranked dead-last in QB fantasy points allowed in Yahoo default scoring. Though Purdy will be without Brandon Aiyuk (knee) for the remainder of the year, there are no other excuses for San Francisco's passing attack to stall in this one, as Christian McCaffrey (Achilles), Deebo Samuel (rib/oblique), and Jauan Jennings (hip) are all likely to play. The Bucs are leading the NFL in rushing touchdowns allowed to quarterbacks -- part of why they've been such a friendly matchup -- and Purdy has been on a bit of a ground-game heater. He's averaging 26.3 yards per game this season, nearly triple 2023's mark, and has rushed for three touchdowns in his last two games. However, McCaffrey's return is likely to stymie that trend. Regardless, Purdy is a solid fantasy starter in Week 10.

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New York Giants wide receiver Wan'Dale Robinson will look to break out of a recent slump as the team heads to Munich to face the Carolina Panthers in Week 10. Robinson has struggled over the past three weeks, including a three-catch, 10-yard outing in Week 9, resulting in diminished fantasy production (he did have a touchdown called back on a penalty). With 51 receptions on 76 targets but averaging only 6.7 yards per catch, Robinson has been used primarily in short-yardage situations, limiting his upside. Facing a Panthers defense ranked 12th against fantasy WRs but vulnerable in the red zone with 18 passing touchdowns allowed this season, Robinson's potential for a bounce-back remains low, making him a risky WR4 play in deeper leagues for Week 10.

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Indianapolis Colts running back Jonathan Taylor was held in check in Week 9 against a stout Vikings rush defense, but Week 10 brings a much more favorable matchup. The Buffalo Bills have allowed the second-most fantasy points to the RB position, and it hasn't just been on the ground. Running backs have scored four receiving TDs against them as well, in addition to the six rushing TDs they've yielded. Taylor is certainly a capable receiver, even receiving a season-high five targets in Week 9 with Joe Flacco under center. Although the 25-year-old missed a few weeks with an ankle injury, when he returned in Week 8, Taylor eclipsed 100-plus rushing and receiving yards for the fourth consecutive week. With Flacco struggling through the air last week and the Bills tougher against the pass, along with the expected absence of WR Michael Pittman Jr., the Colts could lean a bit heavier on the ground game in Week 10, which sets Jonathan Taylor up as a back-end RB1 on Sunday with some upside.

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New York Giants wide receiver Malik Nabers remains the team's top weapon heading into Week 10's matchup against the Carolina Panthers in Munich. Last week, Nabers led the Giants with nine receptions, though he was held to just 59 yards as the Commanders contained his big-play ability. This week, he faces a Panthers defense that ranks 12th against fantasy WRs and has allowed 18 passing touchdowns this season, despite limiting overall passing yards to 232.6 per game. Nabers' steady target volume and six end-zone targets make him a reliable fantasy option, and against Carolina's vulnerable red-zone defense, he has a solid chance to add to his three touchdowns this season, making him a high-floor WR1 for Week 10.

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Buffalo Bills wide receiver Mack Hollins (shoulder) was removed from the injury report heading into Sunday's matchup with the Colts. He practiced in full on Wednesday. However, there were some doubts regarding his availability after logging limited sessions on Thursday and Friday. Fortunately, he's good to go against Indianapolis. The 31-year-old is coming off his best game of the 2024-25 campaign, catching all five targets for 30 yards and a touchdown. With Keon Coleman (wrist) out and Amari Cooper (wrist) questionable, there could be opportunities for others on the offensive end. While Khalil Shakir should remain Josh Allen's preferred receiving option, Hollins could gain streaming potential in deep league fantasy formats if Cooper doesn't suit up.

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New York Giants running back Tyrone Tracy Jr. heads into Week 10 against the Carolina Panthers with momentum after a solid 66-yard rushing performance in Week 9, further asserting himself as the team's lead back with a 68.3% timeshare. Tracy has been productive since becoming the starter in Week 5, averaging 14.76 fantasy points per game, ranking him 22nd among RBs in that span. Facing a struggling Panthers run defense that ranks last in both overall and fantasy RB defense, allowing 159.3 rushing yards per game, Tracy has a prime opportunity for a breakout game in Munich. With his 5.0 yards-per-carry average, Tracy could see strong fantasy value against Carolina's generous defensive front.

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Tennessee Titans wide receiver Tyler Boyd (shoulder) was removed from the injury report ahead of the Week 10 matchup with the Chargers. The veteran was limited in practice on Wednesday and Thursday. But he was a full-go for Friday's session. With DeAndre Hopkins now a Kansas City Chief, others had a chance to step up. While Calvin Ridley and Nick Westbrook-Ikhine have been useful for fantasy managers, Boyd remains irrelevant on the offensive end for the Titans. That's not expected to change anytime soon, so he shouldn't draw any attention from fantasy managers, especially with a difficult game on the horizon.

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New York Giants quarterback Daniel Jones heads into Week 10 against the Carolina Panthers looking to build on a solid performance in Week 9, where he rushed for his first touchdown of the season and threw for two scores in a 27-22 loss to the Commanders. Jones has tallied 1,880 passing yards, eight touchdowns, and five interceptions this season, but he's still without a 300-yard game. Facing Carolina's 25th-ranked pass defense, which allows 232.6 passing yards per game and has surrendered 18 touchdown passes on the season, Jones has a favorable matchup for fantasy production. Although Jones ranks 27th in fantasy points per game (16.21), the Panthers' defense has allowed an average of 19.28 points per game to opposing quarterbacks, suggesting a potential opportunity for Jones to deliver a strong fantasy outing in Munich.

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Arizona Cardinals running back James Conner (finger) is a high-end RB2 in Week 10 when the Cardinals host the New York Jets. Conner has been dealing with a finger injury that limited his practice participation earlier in the week; however, he practiced in full on Friday and appears to be good to go for Sunday. Conner is a workhorse back, and his volume has translated into a high number of touchdown opportunities. While there are concerns that his volume might decrease due to the injury and the emergence of rookie running back Trey Benson, his snap count should remain high enough to warrant RB2 consideration. Conner still possesses significant touchdown upside and should receive enough volume to remain a solid RB2 in Week 10 against the Jets.

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Pittsburgh Steelers wide receiver Mike Williams will make his first appearance for the team in a Week 10 showdown with the 7-2 Washington Commanders. Williams was unable to get on the same page as quarterback Aaron Rodgers in New York but will hope to quickly establish chemistry with Russell Wilson. The Steelers have been linked to Williams since the offseason and should be eager to get him on the field to work opposite George Pickens. While the veteran's role in the offense will be worth monitoring, Williams cannot be expected to immediately garner more opportunities than fellow wideouts Van Jefferson and Calvin Austin III. Fantasy managers would be wise to leave Williams on the waiver wire in most redraft formats for the time being.

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Chicago Bears safety Jaquan Brisker (concussion) has again been ruled inactive for Sunday's home matchup against the New England Patriots. Brisker hasn't appeared in a game since the team's Week 5 36-10 victory over the Carolina Panthers, missing the ensuing three outings. More so, -- and even more concerning -- the 25-year-old has yet to even sniff a practice since sustaining the injury, logging a DNP in each opportunity he's gotten. It's an unsettling development for the Penn State alum, as hopefully, he'll be able to at least get in a limited session ahead of Week 11. Safety Elijah Hicks will again get the start, filling in for the injured Brisker.

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Pittsburgh Steelers kicker Chris Boswell is a top-three fantasy scorer at his position this season and will hope to stay productive against the Washington Commanders in Week 10. It's worth noting that the Commanders' defense is much improved from last season and is surrendering the third-fewest fantasy points per contest to opposing kickers. Nonetheless, Boswell is one of the most consistent kickers in the NFL and offers more upside than he did to start the campaign with quarterback Russell Wilson now leading Pittsburgh's offense. Fantasy managers that held onto Boswell through the Steelers' Week 9 bye or managed to add him from free agency should feel confident putting him right back in starting lineups on Sunday.

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Los Angeles Rams wide receiver Demarcus Robinson (toe/hip) was listed as a limited participant in the team's Friday practice. Robinson picked up a toe injury in the team's thrilling 26-20 OT win over the Seattle Seahawks despite being the hero of the contest. Interestingly enough, he's listed with a hip ailment as well, but when and where that occurred is unclear. Head coach Sean McVay didn't seem too bothered about the 30-year-old wideout's status when asked about him on Thursday but did note they're being cautious with the veteran's toe. He'll have one more opportunity to elevate his practice status before Los Angeles must give him a designation for their Monday night home tilt against the Miami Dolphins. If Robinson can't go, teammates Tutu Atwell and Tyler Johnson project to pick up some extra snaps for the matchup on Monday Night Football. Keep an eye on his status.

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Tampa Bay Buccaneers tight end Cade Otton has been nearly unstoppable on the field over the last few weeks. Over the last three games, Otton has hauled in 25 receptions on 30 targets for 258 yards and three touchdowns. The Bucs don't have many reliable pass-catchers right now, so they continue to go to Otton and it's working. The expectation is that the San Francisco 49ers defense will plan around holding Otton in check, but fantasy managers should still play him as a TE1 for Week 10. Otton has been too great lately, so ride with him until he gives you reason not to trust him.

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Detroit Lions kicker Jake Bates remains a reliable, high-floor option in Week 10 against the Houston Texans. While Bates benefits from Detroit's high-scoring offense, he has limited upside as Lions head coach Dan Campbell often opts to go for it on fourth down in opposing team territory, reducing Bates' field goal attempts. However, he's attempted just 12 field goals this seasonmaking all of themwhile converting 30 of 31 extra points over eight games. Facing a Texans defense that allows the fifth-fewest fantasy points to kickers, Bates' scoring potential may be capped. However, his connection to Detroit's prolific offense keeps him streamable, especially in leagues with limited kicker options.

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Tampa Bay Buccaneers wide receiver Jalen McMillan (hamstring) is currently listed as questionable ahead of the Week 10 matchup against the San Francisco 49ers. The rookie wideout sat out during last week's loss to the Kansas City Chiefs. McMillan is still dealing with the same injury and is in danger of missing another game. If active, McMillan would be a shaky flex option given him and quarterback Baker Mayfield haven't been on the same page this season. There's decent upside with McMillan, but he's probably not worth the risk against the 49ers defense. Sterling Shepard and Trey Palmer figure to see more attention if McMillan is unable to play.

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Pittsburgh Steelers tight end Pat Freiermuth was a solid contributor to begin the season but has been incredibly quiet for fantasy since Week 6. He'll hope to get back on track against the Washington Commanders on Sunday. The Commanders allow the 14th-fewest fantasy points per game to opposing tight ends, making this a middle-of-the-road matchup for Freiermuth. He is yet to display much chemistry with quarterback Russell Wilson outside of a 30-yard reception the duo connected on in Week 7. Fantasy managers should not be relying on Freiermuth in most formats this week.

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Tampa Bay Buccaneers wide receiver Trey Palmer is an avoidable streaming option ahead of the Week 10 matchup against the San Francisco 49ers. The expectation was that Palmer would see increased involvement in the offense with the Bucs banged up at wideout. That hasn't really been the case as Palmer hauled in two of his four targets for 33 yards during last week's loss to the Kansas City Chiefs. He only played 49 percent of the offensive snaps and that's with fellow wideout Jalen McMillan (hamstring) sidelined as well. Palmer could be worth a stash in dynasty leagues, but isn't a starting option right now.

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Tampa Bay Buccaneers running back Bucky Irving (toe) has been cleared to play ahead of the Week 10 matchup against the San Francisco 49ers. Irving has been playing through a toe issue lately, but it doesn't seem to be something that is going to impact his performance. He rushed seven times for 24 yards while hauling in all three of his targets for 10 yards during last week's loss to the Kansas City Chiefs. The Bucs continue to use a committee approach in the backfield which is mainly Rachaad White and Irving. Neither of them are great fantasy options, but both are on the flex radar for Week 10.

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