San Francisco 49ers running back Christian McCaffrey (Achilles) is officially active for Week 10 against the Tampa Bay Buccaneers. He had been listed as questionable but was widely expected to play after the Niners activated him from injured reserve on Saturday. The star running back has not yet appeared in a game this season, so Sunday represents his much-anticipated return. Many fantasy managers who selected McCaffrey with the 1.01 pick in fantasy drafts felt betrayed by his long absence, but now, he has a chance to make it up with a strong stretch throughout the second half of the season. In case he has a reduced workload, McCaffrey ranks as a low-end RB1 in his first game back. In future weeks, though, he'll likely rank among the top three running backs, joining the conversation with Saquon Barkley and Derrick Henry.

From RotoBaller

San Francisco 49ers wide receiver Deebo Samuel Sr. (rib, oblique) is officially active for Week 10 against the Tampa Bay Buccaneers. He had been listed as questionable after logging three limited practices in a row. Samuel has delivered modest production so far this season, catching just 24 passes for 406 yards and one touchdown through seven games. Fantasy managers should still deploy him, given his talent, role, and usage, but his days of being a surefire WR1 are over. For now, he's a riskier WR2 play.

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San Francisco 49ers defensive end Nick Bosa (hip) is officially active for Sunday's game against the Tampa Bay Buccaneers. He had been questionable heading into Week 10 after logging three limited practices in a row. Bosa continues to be one of the most effective defenders in his age-27 season, registering 28 tackles, 4.5 sacks, one forced fumble, one fumble recovery, and one interception through eight games this year. This week, Bosa will be tasked with taking down Baker Mayfield and the rest of his Buccaneers teammates.

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Buffalo Bills wide receiver Amari Cooper (wrist) will miss a second straight game while recovering from a wrist injury in Week 10 versus the Indianapolis Colts. With rookie Keon Coleman (wrist) also out, Buffalo's receiving corps will be noticeably thin on Sunday at Lucas Oil Stadium, with Khalil Shakir to serve as the No. 1 pass-catcher for quarterback Josh Allen. In addition to Shakir, tight ends Dalton Kincaid and Dawson Knox should see more run in Buffalo's passing attack, while veterans Mack Hollins and Curtis Samuel should serve in starting three-receiver sets alongside Shakir. With Cooper out last week, Shakir caught six of seven targets for 50 yards and also had his first 100-yard game the week prior. Cooper's next chance to return will be for a Week 11 showdown on Nov. 17 against the Super Bowl-champion Kansas City Chiefs.

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Atlanta Falcons wide receiver Drake London (hip) is officially active for Sunday's game against the New Orleans Saints. He had been listed as questionable after being limited in practice ahead of Week 10. London has been quite productive this season, catching 50 passes for 552 yards and six touchdowns while ranking as the overall WR6 in PPR leagues. The 23-year-old remains a strong fantasy option heading into Week 10. His matchup against the Saints is particularly favorable given that New Orleans traded away cornerback Marshon Lattimore last Tuesday.

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Miami Dolphins WR Tyreek Hill (wrist) is considered a game-time decision for Week 10's game against the Los Angeles Rams.

Fantasy Spin: Hill had been listed as questionable on the injury report after missing Miami's final two practice sessions of the week due to a wrist injury that he initially sustained during training camp but aggravated a few days ago. He will participate during pregame warmups Monday, Nov. 11, before a final decision is made about his status. Fantasy owners should make alternate plans in the event that Hill is held out of action.

From TheHuddle

The Washington Commanders have declared CB Marshon Lattimore, PK Austin Seibert, OT Cornelius Lucas, QB Jeff Driskel, S Darrick Forrest Jr., S Dominique Hampton and RB Brian Robinson Jr. inactive for Week 10.

From TheHuddle

The Buffalo Bills have declared WR Amari Cooper, LB Edefuan Ulofoshio, RB Reggie Gilliam, WR Keon Coleman, C Will Clapp and WR KJ Hamler inactive for Week 10.

From TheHuddle

Tampa Bay Buccaneers wide receiver Mike Evans (hamstring) said he felt "close" to being available for Week 10 against the San Francisco 49ers. However, he was ruled out and is instead eyeing a Week 12 return. That timetable would give Evans an extra week to get healthy during the bye before suiting up against the New York Giants on November 24. Evans has been sidelined since Week 7, the same week Tampa Bay also lost Chris Godwin (ankle) to a season-ending injury. As a result, Tampa Bay's passing attack has been forced to funnel through players like Cade Otton, Trey Palmer, and Jalen McMillan (hamstring). Evans' return will give Tampa Bay a reliable top receiver once again.

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Dallas Cowboys quarterback Dak Prescott (hamstring) is expected to undergo season-ending surgery after testing revealed a partial tear of his hamstring tendon. The veteran quarterback is set to meet with a doctor on Monday to get a final opinion. Prescott won't play in Week 10 and is likely going to elect surgery to address the issue. This would certainly be a frustrating end to Prescott's season, but the team needs to do what is best for his health. Cooper Rush will start under center in Week 10 and figures to remain the starter going forward, assuming Prescott elects the surgery.

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Dallas Cowboys pass rusher Micah Parsons (ankle) is set to make his return to the field ahead of the Week 10 matchup against the Philadelphia Eagles. Parsons will take the field for the first time since suffering an ankle injury in Week 4. His return to the field is a welcoming sight for this defensive unit. Parsons was able to get in three limited practice sessions this week. That being said, Parsons is expected to be on a snap count for this first game back. The Cowboys don't want to push Parsons too hard considering he has missed quite a bit of time.

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Carolina Panthers running back Miles Sanders (foot, ankle) is considered doubtful to return for Sunday's Week 10 matchup against the New York Giants. It appears Sanders suffered some type of leg injury during the first half of this game. After further evaluation it sounds like the Panthers are likely going to hold him out for the rest of the game. Before exiting, Sanders rushed the ball twice as the primary backup to Chuba Hubbard. The absence of Sanders should mean a few more snaps for Hubbard during the second half of this game.

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Houston Texans wide receiver Nico Collins (hamstring) has been activated from the Injured Reserve ahead of the Week 10 matchup against the Detroit Lions. Collins missed the minimum four games on the IR after suffering a hamstring injury in Week 4. The Texans could desperately use Collins on the field with Stefon Diggs (knee) done for the season. Currently, Collins is listed as questionable and considered a game-time decision for Sunday's game. Fellow wideout Tank Dell (back) is also banged up, but is expected to play. If active, Collins would likely be on a snap count and could be a risky option for Week 10.

From RotoBaller

San Francisco 49ers running back Christian McCaffrey (Achilles) will suit up for the Week 10 matchup against the Tampa Bay Buccaneers. McCaffrey is set to make his season debut after missing the few first months due to a lingering Achilles issue. The return of McCaffrey should mean that Jordan Mason falls into the backup role which will decrease his value. There was uncertainty around how many snaps McCaffrey would play during his first game. It doesn't sound like he's going to be limited, so fantasy managers can get McCaffrey back in their lineups ahead of this Week 10 matchup.

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Buffalo Bills kicker Tyler Bass struggled early in the season, but has cleaned it up over the last few weeks. In fact, Bass has six straight field goals and 9-of-10 extra point attempts over the last three games. The 27-year-old knocked down a 61-yard field goal during last week's win over the Miami Dolphins. It appears the early struggles for Bass are behind him. Fantasy managers should restore faith in him ahead of the Week 10 against the Indianapolis Colts.

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Minnesota Vikings running back Cam Akers appears to have moved into the primary backup role in the backfield. Last week, Akers rushed six times for 46 yards in the win over the Indianapolis Colts. Fellow back Ty Chandler appears to have moved into the third string role now. That means, Akers should see a handful of carries behind Aaron Jones most weeks. Akers is unlikely to have reliable value while being the backup, but is worth holding in deep leagues and dynasty formats as he's only one injury away from being the starter. The 25-year-old can be avoided for Week 10, but is worth a stash.

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Miami Dolphins wide receiver Tyreek Hill (wrist) is being considered a game-time decision ahead of the Week 10 matchup against the Los Angeles Rams. Hill re-aggravated a wrist injury earlier in the week and was held out of practice on Friday and Saturday. Now, Hill's status is currently up in the air as they will likely wait until warmups before making a final decision on him. Jaylen Waddle figures to be the primary receiving option if Hill is unable to play. Both Odell Beckham Jr. and Malik Washington see should more snaps as well, but they aren't exactly reliable fantasy options. It sounds like fantasy managers are going to be forced to wait until Monday to know Hill's final injury status.

From RotoBaller

Miami Dolphins wide receiver Odell Beckham Jr. could see a decent dose of targets if Tyreek Hill (wrist) is ruled out for Monday night's game against the Los Angeles Rams. Beckham could be a vocal point against his former team if this game turns into a shootout. The Rams defense ranks 23rd in fantasy points allowed per game to wide receivers and allow the 12th most yards per game. Despite Beckham's highest target count being three in any game this season, he could be considered a streaming option if you have any bye week or injury issues. If Hill plays, Beckham likely won't be a fantasy factor. Monitor the status of Hill leading up to Monday Night's contest.

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Tampa Bay Buccaneers kicker Chase McLaughlin has been one of the more reliable kicking options in the league this season. The veteran kicker has connected on a career-best 93.3 percent of his field goal this season. McLaughlin has only missed one field goal and one extra point heading into the Week 10 matchup against the San Francisco 49ers. The 28-year-old has made three extra points and one field goal in each of the last two games. The Bucs will have a tough challenge against the 49ers defense this weekend. Despite that, McLaughlin is still worth a look as a streaming option for Week 10.

From RotoBaller

Pittsburgh Steelers LB Preston Smith will make his debut with the team in Week 10's game against the Washington Commanders. He had been acquired in a trade with the Green Bay Packers Tuesday, Nov. 5.

From TheHuddle