Tampa Bay Buccaneers wide receiver Jalen McMillan (hamstring) is officially active for Sunday's game against the San Francisco 49ers. He had been listed as questionable. McMillan missed two consecutive practices before returning in a limited capacity on Friday, so his availability for Week 10 is notable at the very least. The 22-year-old has appeared in six games this season, catching 10 passes for 109 yards and one touchdown. His best game came in Week 8 when he started with Mike Evans (hamstring) and Chris Godwin (ankle). In that contest, he played 81 percent of the offensive snaps, turning seven targets into a career-high four catches and 35 yards. He'll look to build on that stat line this week with Evans still sidelined and Godwin done for the year.

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Kansas City Chiefs running back Clyde Edwards-Helaire is a healthy inactive yet again on Sunday in a Week 10 divisional matchup against the visiting Denver Broncos. It's the fourth straight game that Edwards-Helaire has been a healthy scratch for the Chiefs, with Kareem Hunt, Samaje Perine and rookie Carson Steele ahead of him on the RB depth chart. The 25-year-old was on the Non-Football Illness list earlier this season due to personal issues and is well off the fantasy radar, especially Isiah Pacheco (leg) hoping to return from a broken leg before the end of the season. CEH has been one of the few Chiefs' draft busts in recent years after they took him 32nd overall in the first round in 2020 out of LSU. Edwards-Helaire has yet to see the field in 2024.

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New Orleans Saints running back Jamaal Williams (groin) is officially inactive for Week 10 against the Atlanta Falcons. He had been listed as questionable. The veteran running back logged two limited practices before downgrading to a non-participant Friday. He has appeared in eight games this season, tallying just 124 rushing yards and 21 receiving yards. With Williams sidelined and Kendre Miller (hamstring) on injured reserve, the Saints will call upon a combination of Taysom Hill and Jordan Mims to back up Alvin Kamara on Sunday. Kamara is the only Saints running back currently on the fantasy radar.

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Jacksonville Jaguars quarterback Trevor Lawrence (shoulder), as expected, is officially inactive in Week 10 against the Minnesota Vikings on Sunday. Lawrence was never expected to play this weekend after suffering an AC joint sprain in his left (non-throwing) shoulder in the Week 9 loss to the Philadelphia Eagles. It was reported on Sunday morning that Lawrence could also be in danger of missing the rest of the season because of his shoulder injury. It's just the second time in the 25-year-old's four-year career that he'll be missing a game, paving the way for backup Mac Jones to make his first start of 2024. The Jaguars have a bye in Week 12, so Lawrence will probably sit out the Week 11 contest against the Detroit Lions. With Jones now leading a struggling Jaguars offense, fantasy managers should downgrade all of the Jaguars' pass-catchers.

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San Francisco 49ers running back Christian McCaffrey (Achilles) is officially active for Week 10 against the Tampa Bay Buccaneers. He had been listed as questionable but was widely expected to play after the Niners activated him from injured reserve on Saturday. The star running back has not yet appeared in a game this season, so Sunday represents his much-anticipated return. Many fantasy managers who selected McCaffrey with the 1.01 pick in fantasy drafts felt betrayed by his long absence, but now, he has a chance to make it up with a strong stretch throughout the second half of the season. In case he has a reduced workload, McCaffrey ranks as a low-end RB1 in his first game back. In future weeks, though, he'll likely rank among the top three running backs, joining the conversation with Saquon Barkley and Derrick Henry.

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San Francisco 49ers wide receiver Deebo Samuel Sr. (rib, oblique) is officially active for Week 10 against the Tampa Bay Buccaneers. He had been listed as questionable after logging three limited practices in a row. Samuel has delivered modest production so far this season, catching just 24 passes for 406 yards and one touchdown through seven games. Fantasy managers should still deploy him, given his talent, role, and usage, but his days of being a surefire WR1 are over. For now, he's a riskier WR2 play.

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San Francisco 49ers defensive end Nick Bosa (hip) is officially active for Sunday's game against the Tampa Bay Buccaneers. He had been questionable heading into Week 10 after logging three limited practices in a row. Bosa continues to be one of the most effective defenders in his age-27 season, registering 28 tackles, 4.5 sacks, one forced fumble, one fumble recovery, and one interception through eight games this year. This week, Bosa will be tasked with taking down Baker Mayfield and the rest of his Buccaneers teammates.

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Buffalo Bills wide receiver Amari Cooper (wrist) will miss a second straight game while recovering from a wrist injury in Week 10 versus the Indianapolis Colts. With rookie Keon Coleman (wrist) also out, Buffalo's receiving corps will be noticeably thin on Sunday at Lucas Oil Stadium, with Khalil Shakir to serve as the No. 1 pass-catcher for quarterback Josh Allen. In addition to Shakir, tight ends Dalton Kincaid and Dawson Knox should see more run in Buffalo's passing attack, while veterans Mack Hollins and Curtis Samuel should serve in starting three-receiver sets alongside Shakir. With Cooper out last week, Shakir caught six of seven targets for 50 yards and also had his first 100-yard game the week prior. Cooper's next chance to return will be for a Week 11 showdown on Nov. 17 against the Super Bowl-champion Kansas City Chiefs.

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Atlanta Falcons wide receiver Drake London (hip) is officially active for Sunday's game against the New Orleans Saints. He had been listed as questionable after being limited in practice ahead of Week 10. London has been quite productive this season, catching 50 passes for 552 yards and six touchdowns while ranking as the overall WR6 in PPR leagues. The 23-year-old remains a strong fantasy option heading into Week 10. His matchup against the Saints is particularly favorable given that New Orleans traded away cornerback Marshon Lattimore last Tuesday.

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Miami Dolphins WR Tyreek Hill (wrist) is considered a game-time decision for Week 10's game against the Los Angeles Rams.

Fantasy Spin: Hill had been listed as questionable on the injury report after missing Miami's final two practice sessions of the week due to a wrist injury that he initially sustained during training camp but aggravated a few days ago. He will participate during pregame warmups Monday, Nov. 11, before a final decision is made about his status. Fantasy owners should make alternate plans in the event that Hill is held out of action.

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The Washington Commanders have declared CB Marshon Lattimore, PK Austin Seibert, OT Cornelius Lucas, QB Jeff Driskel, S Darrick Forrest Jr., S Dominique Hampton and RB Brian Robinson Jr. inactive for Week 10.

From TheHuddle

The Buffalo Bills have declared WR Amari Cooper, LB Edefuan Ulofoshio, RB Reggie Gilliam, WR Keon Coleman, C Will Clapp and WR KJ Hamler inactive for Week 10.

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Tampa Bay Buccaneers wide receiver Mike Evans (hamstring) said he felt "close" to being available for Week 10 against the San Francisco 49ers. However, he was ruled out and is instead eyeing a Week 12 return. That timetable would give Evans an extra week to get healthy during the bye before suiting up against the New York Giants on November 24. Evans has been sidelined since Week 7, the same week Tampa Bay also lost Chris Godwin (ankle) to a season-ending injury. As a result, Tampa Bay's passing attack has been forced to funnel through players like Cade Otton, Trey Palmer, and Jalen McMillan (hamstring). Evans' return will give Tampa Bay a reliable top receiver once again.

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Dallas Cowboys quarterback Dak Prescott (hamstring) is expected to undergo season-ending surgery after testing revealed a partial tear of his hamstring tendon. The veteran quarterback is set to meet with a doctor on Monday to get a final opinion. Prescott won't play in Week 10 and is likely going to elect surgery to address the issue. This would certainly be a frustrating end to Prescott's season, but the team needs to do what is best for his health. Cooper Rush will start under center in Week 10 and figures to remain the starter going forward, assuming Prescott elects the surgery.

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Dallas Cowboys pass rusher Micah Parsons (ankle) is set to make his return to the field ahead of the Week 10 matchup against the Philadelphia Eagles. Parsons will take the field for the first time since suffering an ankle injury in Week 4. His return to the field is a welcoming sight for this defensive unit. Parsons was able to get in three limited practice sessions this week. That being said, Parsons is expected to be on a snap count for this first game back. The Cowboys don't want to push Parsons too hard considering he has missed quite a bit of time.

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Carolina Panthers running back Miles Sanders (foot, ankle) is considered doubtful to return for Sunday's Week 10 matchup against the New York Giants. It appears Sanders suffered some type of leg injury during the first half of this game. After further evaluation it sounds like the Panthers are likely going to hold him out for the rest of the game. Before exiting, Sanders rushed the ball twice as the primary backup to Chuba Hubbard. The absence of Sanders should mean a few more snaps for Hubbard during the second half of this game.

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Houston Texans wide receiver Nico Collins (hamstring) has been activated from the Injured Reserve ahead of the Week 10 matchup against the Detroit Lions. Collins missed the minimum four games on the IR after suffering a hamstring injury in Week 4. The Texans could desperately use Collins on the field with Stefon Diggs (knee) done for the season. Currently, Collins is listed as questionable and considered a game-time decision for Sunday's game. Fellow wideout Tank Dell (back) is also banged up, but is expected to play. If active, Collins would likely be on a snap count and could be a risky option for Week 10.

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San Francisco 49ers running back Christian McCaffrey (Achilles) will suit up for the Week 10 matchup against the Tampa Bay Buccaneers. McCaffrey is set to make his season debut after missing the few first months due to a lingering Achilles issue. The return of McCaffrey should mean that Jordan Mason falls into the backup role which will decrease his value. There was uncertainty around how many snaps McCaffrey would play during his first game. It doesn't sound like he's going to be limited, so fantasy managers can get McCaffrey back in their lineups ahead of this Week 10 matchup.

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Buffalo Bills kicker Tyler Bass struggled early in the season, but has cleaned it up over the last few weeks. In fact, Bass has six straight field goals and 9-of-10 extra point attempts over the last three games. The 27-year-old knocked down a 61-yard field goal during last week's win over the Miami Dolphins. It appears the early struggles for Bass are behind him. Fantasy managers should restore faith in him ahead of the Week 10 against the Indianapolis Colts.

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Minnesota Vikings running back Cam Akers appears to have moved into the primary backup role in the backfield. Last week, Akers rushed six times for 46 yards in the win over the Indianapolis Colts. Fellow back Ty Chandler appears to have moved into the third string role now. That means, Akers should see a handful of carries behind Aaron Jones most weeks. Akers is unlikely to have reliable value while being the backup, but is worth holding in deep leagues and dynasty formats as he's only one injury away from being the starter. The 25-year-old can be avoided for Week 10, but is worth a stash.

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