Indianapolis Colts running back Trey Sermon (collarbone) has been cleared to play in Week 6 against the division-rival Tennessee Titans and will serve as the team's primary RB for the second straight week with Jonathan Taylor (ankle) being ruled out. Sermon missed practice on Wednesday but was a full-go on both Thursday and Friday. The 25-year-old saw 10 carries for 38 yards and his second rushing touchdown of the year in last week's loss to the division-rival Jacksonville Jaguars, adding six receptions for another 25 yards. For the added volume alone with JT out again, fantasy managers should consider Sermon an RB3/flex this weekend. However, the matchup against the Titans on the road isn't nearly as good, as they've allowed the 22nd-most half-PPR points to opposing backs through five weeks this year.

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Indianapolis Colts wide receiver Josh Downs (toe) was listed as questionable on the team's final injury report for Week 6 against the division-rival Tennessee Titans. Downs was unable to practice on Wednesday or Thursday, but he appears to be tracking in the right direction to play on Sunday after putting in a full practice on Friday. Fellow wideout Michael Pittman Jr. (back) did the exact same this week, but he appears to be much more up in the air due to a back injury that reportedly could keep him out multiple weeks. Downs' fantasy stock has risen after he put up 17 receptions (21 targets) for 151 yards and a touchdown the last two weeks. However, his status is in question this weekend against a very stingy Tennessee secondary, and his fantasy upside could actually tank if quarterback Anthony Richardson (oblique) returns to action. The 23-year-old is lining up as a shaky WR3/flex if he's active. If both he and Pittman are ruled out, Alec Pierce will be Indy's WR1.

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Green Bay Packers kicker Brayden Narveson looks to continue building up some momentum as the Packers host the Arizona Cardinals in Week 6. After Narveson's brutal showing in Week 4 where he missed two field goals, the Packers stuck with him and Narveson made his only field goal attempt and booted home three extra point attempts in their win against the Los Angeles Rams in Week 5. Starting Narveson in fantasy lineups this week is a bet on the game environment being filled with points, which is definitely on the table with the scoring potential of both the Packers and Cardinals. Consider Narveson a fringe starting option this week in Week 6.

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Washington Commanders running back Jeremy McNichols could move up the depth chart on Sunday afternoon if Brian Robinson Jr. (knee) is unable to suit up. Robinson entered last weekend with a questionable status but was able to play. Fantasy managers should continue to monitor his status throughout the weekend. McNichols has shined in the few opportunities he has gotten this season. In Week 4 with Austin Ekeler sidelined with a concussion, McNichols tallied 68 yards and two scores on eight attempts. Late into the fourth quarter last weekend when the Commanders had a sizeable lead, the 28-year-old received seven carries and totaled 44 yards and another score. If Robinson is unable to play, McNichols becomes a viable flex option in deeper formats and should share the backfield with Ekeler.

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Tampa Bay Buccaneers kicker Chase McLaughlin has been one of the more consistent options early in the season. Last week, McLaughlin was perfect on all six of his kicks during the overtime loss to the Atlanta Falcons. The veteran kicker is a perfect 10-for-10 on field goal attempts heading into the Week 6 matchup against the New Orleans Saints. McLaughlin has connected on two field goals or more in every game, but one this season. The Bucs offense continues to give McLaughlin plenty of work on a weekly basis which gives him solid streaming value for this Week 6 divisional matchup.

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Washington Commanders wide receiver Terry McLaurin has topped double-digit PPR points in each of the past three weeks and remains a high-end WR2 in Week 6 when he faces the Baltimore Ravens. Since tallying just 39 yards in the first two games of the season, McLaurin has hit the century mark in two out of the past three games and averaged an impressive 88.0 yards with eight targets per game in this stretch. In addition, he has found the end zone twice during this span. Facing a Baltimore Ravens defense that has allowed the most points to opposing wideouts this season makes McLaurin a high-upside play in all formats and should be locked into all starting lineups.

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New Orleans Saints tight end Taysom Hill (rib) missed practice all week and has officially been ruled out for the Week 6 divisional clash on Sunday against the Tampa Bay Buccaneers. This will be Hill's third missed game of the year and his second in a row due to fractured ribs that he suffered in the Week 4 loss to the division-rival Atlanta Falcons. The 34-year-old can do it all on the football field, but it's impossible to predict when he'll be heavily utilized when he's healthy. For now, Hill should remain on the waiver wire in most fantasy formats. When he does return, Hill could see more action out of the backfield as a passer or runner if he's able to return before quarterback Derek Carr (oblique) does. The Saints have a quick turnaround in Week 7 next Thursday against the Denver Broncos, so Hill may be fighting an uphill battle to return by then.

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Washington Commanders wide receiver Noah Brown (groin) was held out of last weekend's game but is expected to return to the field this weekend and could be worth a look as a high-risk, high-upside play in DFS format. Since making his Commanders debut in Week 2, Brown has logged more snaps and ran more routes every week, highlighted by a season-high in Week 4 with 26 routes, the second-most on the team. During this stretch, Brown has caught three passes in each game. Brown logged three limited practice sessions this week and is expected to suit up this weekend. With how well Jayden Daniels has performed in the NFL, Brown's breakout performance could be right around the corner and facing one of the worst pass defenses in football could be the recipe for success.

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Tampa Bay Buccaneers tight end Cade Otton has picked up his performance over the last few weeks. Otton started off slow with two duds, but has played better over the last two weeks. The third-year tight end has 44 receiving yards or more over each of the last three games. It's also worth noting that the Bucs could be without Rachaad White (foot), Jalen McMillan (hamstring), and Trey Palmer (concussion) for Sunday's game against the New Orleans Saints. That means, Otton could be pushed up the pecking order with the Bucs having less options on offense. Otton has done enough lately to be a playable option as a TE2 for this Week 6 matchup.

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Washington Commanders tight end Zach Ertz caught a season-low two passes for ten yards last weekend but has a great opportunity to bounce-back facing the Baltimore Ravens. Even though Ertz had his worst game on the scoresheet, he saw eight targets. From Weeks 1 to 4, Ertz averaged four targets in each game with a solid 37.5 yards. With the Commanders lacking a proven No.2 option in the passing attack, Ertz should continue to remain productive every week. Facing a Ravens defense that has allowed the 26th-most points to opposing tight ends makes Ertz a low-end TE1 with upside.

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Washington Commanders kicker Austin Seibert has remained perfect since joining the DMV in Week 2 and has entered streaming territory heading into Week 6. Seibert's leg has not been tested outside of 50+ yards, but he has produced double-digit fantasy points in three of his four games. This weekend, their matchup against the Ravens holds the highest projected point total of the week at an incredible 51.5 which suggests that both teams will be in scoring positions often, making Seibert a safe play with upside in all standard formats.

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Green Bay Packers tight end Tucker Kraft (groin) popped up on the injury report with limited practices on Thursday and Friday, but is good to go for Week 6 as the Packers square off against the Cardinals. Kraft has no injury designation heading into the weekend, so he should be able to continue his excellent run of production in recent weeks. Kraft has been fantasy football's top tight end the last two weeks and had his best game of the season last week where he caught four balls for 88 yards for two touchdowns, including a 66-yard catch and run. With the Packers returning Romeo Doubs to the lineup and the possibility of Christian Watson (ankle) returning, the targets for Kraft may be more limited than in previous weeks, but Kraft will be on the field a ton (83% snap rate for the season). Fantasy managers should still start Kraft in most formats as a TE1 this week.

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Green Bay Packers wide receiver Jayden Reed should be targeted plenty in the Packers' upcoming matchup in Week 6 where they'll host the Arizona Cardinals. Reed has been a big play waiting to happen for Green Bay this season and has emerged as the Packers' unquestioned top target and playmaker in their offense. With a four-catch, 78-yard effort along with 19 rushing yards last week against the Los Angeles Rams, that stat line represented his worst game of the three games with Jordan Love starting at quarterback. With other receivers returning to the lineup like Romeo Doubs and potentially Christian Watson (ankle) who is listed as questionable in the injury report, Reed's targets may shift slightly, but Reed is still in a great position heading into Week 6. He's become a must-start wide receiver for fantasy managers and should be universally started.

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New Orleans Saints running back Alvin Kamara (hand, hip) was removed from Friday's final injury report and will play in Week 6 against the division-rival Tampa Bay Buccaneers. Kamara picked up a DNP on Wednesday but was limited in practice on Thursday and Friday. Meanwhile, Kendre Miller (hamstring) practiced in full all week and is questionable to make his season debut. The 29-year-old Kamara played a season-high 90% of the offensive snaps in last week's loss to the Kansas City Chiefs on Monday night and remains a workhorse for this offense. Expect another heavy workload for Kamara in rookie quarterback Spencer Rattler's first career start, which makes Kamara a must-start RB1 for fantasy managers. However, with QB Derek Carr (oblique) out, the Saints' offense could struggle to move the ball effectively, which could be an overall downgrade for Kamara's upside.

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New Orleans Saints wide receiver Rashid Shaheed (hip) was removed from Friday's injury report and will be active on Sunday in Week 6 against the division-rival Tampa Bay Buccaneers. Shaheed did not practice on Wednesday but returned to limited sessions on both Thursday and Friday. The 26-year-old is in the midst of a breakout season in 2024 and enters Week 6 as the No. 14 fantasy wideout in half-PPR scoring thanks to 19 receptions for 338 yards and three touchdowns. He has had some nice chemistry on the deep ball with quarterback Derek Carr (oblique), but with Carr likely out multiple weeks, Shaheed's fantasy value could take a big tumble while taking passes from rookie QB Spencer Rattler, who will be making his first start this weekend. Shaheed should be viewed as a much more volatile WR3/flex in Week 6.

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Tampa Bay Buccaneers wide receiver Sterling Shepard could be asked to take on a bigger role during Sunday's matchup against the New Orleans Saints. The Bucs could be shorthanded at wideout with Jalen McMillan (hamstring) and Trey Palmer (concussion) both uncertain heading into this game. That being said, Shepard could be asked to step in and be the third receiver behind Mike Evans and Chris Godwin. His best performance came in Week 3 when he hauled in three receptions for 51 yards. It's hard to imagine Shepard being a viable streaming option even if he gets the nod as the third wideout.

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Washington Commanders rookie quarterback Jayden Daniels looks to win his fifth straight game on Sunday as he takes on the Baltimore Ravens. After losing his first professional game, Daniels has averaged an impressive 24.2 PPR points per game with 951 total passing yards, 212 rushing yards, and six scores. The LSU standout has only turned the ball over twice and completed a remarkable 78.5% of his passes. This weekend, he faces a Baltimore defense that has allowed the 28th-most points to opposing quarterbacks. Daniels should be locked into all lineups this weekend as this game could become quite high-scoring given the projected 51.5-point total, which is the highest of the slate.

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Washington Commanders running back Austin Ekeler should be viewed as a solid flex option in PPR formats this weekend as they will face the Baltimore Ravens in what could be a very high-scoring affair. After missing Week 4 with a concussion, Ekeler looked strong in Week 5 as he ran for a season-high 67 yards on six carries. He added 30 yards on two receptions. Ekeler has seen at least two targets in every game and ran double-digit routes in three out of the four games he has played in. In addition, Brian Robinson Jr. (knee) is listed as questionable for Sunday's game, which could further increase Ekeler's opportunities. If Robinson is unable to play, Ekeler should be viewed as a high-end RB2.

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Green Bay Packers running back Josh Jacobs looks to keep his solid run going when the Packers host the Arizona Cardinals in Week 6. Jacobs scored his first touchdown as a Packer last week and totaled 94 total yards in their win over the Rams in Week 5. Jacobs should find many more running lanes against the Cardinals, who are a bottom-six defense in EPA/rush attempt on the season. Arizona has given up at least 80 yards rushing to four running backs in the last three weeks, so Jacobs should be in line for a quality day with the safe and solid volume he gets each week. Fantasy managers should feel secure in slotting Jacobs into their lineups as a RB1 option in most weeks and that doesn't change in Week 6.

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Las Vegas Raiders running back Zamir White (groin) is listed as questionable for Sunday's contest against the visiting Pittsburgh Steelers in Week 6. White missed the Week 5 loss to the division-rival Denver Broncos and is in danger of missing his second straight game. The 25-year-old was unable to practice on Wednesday or Thursday before returning to a limited session on Friday. Even if White suits up this weekend against Pittsburgh, fantasy managers should only consider him for a starting lineup spot if they are in dire straights at the RB position. He's been a huge disappointment through the first five weeks of the season, averaging a career-low 3.1 yards per carry on 49 rushing attempts (152 yards and no scores) in four games. Alexander Mattison will see the majority of backfield work for Vegas if White sits out again, putting him in play as an RB3/flex in fantasy in a tough matchup.

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