Kansas City Chiefs quarterback Patrick Mahomes will take on the Denver Broncos in Week 10. Mahomes is coming off his best fantasy performance of the season, passing for 291 yards and three touchdowns against the Tampa Bay Buccaneers. The Buccaneers defense has allowed huge performances to opposing offenses all season, so this week will be more challenging for the Chiefs quarterback. The Denver Broncos rank sixth in fantasy points allowed to opposing quarterbacks this season, making them one of the toughest matchups. Mahomes has been trending up in the past few weeks, and that trend could continue as he builds more chemistry with DeAndre Hopkins. Mahomes found himself on the injury report earlier this week with an ankle injury but practiced fully all week and does not have an injury designation for the game. Mahomes is ranked QB10 in our RotoBaller rankings this week, making him a low-end QB1 in this matchup. Given his recent success, fantasy managers should start Mahomes this week but temper expectations in a difficult matchup.

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Kansas City Chiefs tight end Travis Kelce will take on the Denver Broncos in Week 10. Kelce is coming off a season-best performance against the Tampa Bay Buccaneers in Week 9. The veteran tight end had 14 catches on 16 targets for 100 yards in the 30-24 overtime win. Kelce will transition from facing one of the most favorable matchups to one of the toughest. The Broncos rank 10th in fantasy points allowed to opposing tight ends this season, so Kelce will have his work cut out for him. That said, Kelce is among the few elite tight ends with a strong guaranteed workload every week. Kelce is ranked TE2 in our RotoBaller Half-PPR rankings this week in a difficult matchup, but fantasy managers should feel great about starting him every week.

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San Francisco 49ers rookie wide receiver Ricky Pearsall is in Tampa for a Week 10 matchup against the Buccaneers on Sunday. The 31st-overall pick in the 2024 draft will be playing in just his third game as a pro after an impressively short recovery from being shot in the chest as the victim of an armed robbery. Pearsall has a bright future but will be running as a third receiver this week with Deebo Samuel Sr. (rib/oblique) and Jauan Jennings (hip) expected to play. The 49ers are also welcoming back Christian McCaffrey (Achilles), and tight end George Kittle is healthy so targets will be hard to come by. Tampa Bay's pass defense hasn't been good, so the matchup is there for deeper-league managers looking to strike gold, but Pearsall should be considered a WR4 on Sunday, considering San Francisco's expected hierarchy.

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The New England Patriots defense remains an unreliable fantasy option heading into Week 10 against the Chicago Bears and their No. 1 pick quarterback, Caleb Williams. The Patriots' defense has several playmakers, but the unit's productivity has been underwhelming so far. New England has forced just five turnovers through nine weeks while allowing an average of 23.4 points per game. Even against the Bears and Williams, who has seven turnovers this year, the Patriots' defense cannot be trusted to make a real impact. They've tallied the eight-fewest fantasy points among D/ST units and remains off the radar this Sunday.

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New England Patriots tight end Hunter Henry has been quite productive lately and, as a result, is firmly positioned on the fantasy radar for Week 10 against the Chicago Bears. Over the last four weeks, with most of his targets coming from Drake Maye, the veteran tight end is averaging 5.8 catches, 58.5 receiving yards, and 0.3 touchdowns per game. The Patriots haven't had a whole lot of scoring opportunities, but their tendency to play from behind has created extra opportunities and targets for the team's pass catchers, including Henry. He's a firm TE1 option slated to command a large target share once again on Sunday.

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New England Patriots quarterback Drake Maye has struggled with ball security lately, totaling four interceptions and two lost fumbles during his three full games under center. Despite turnover issues, Maye has maintained his role among the top 12 fantasy quarterbacks, throwing for six touchdown passes and rushing for 209 yards so far this year. This week, he faces the Bears, whose secondary has been quite impressive in 2024. Chicago has allowed the fewest passing touchdowns and the fewest fantasy points to opposing quarterbacks. Nevertheless, Maye's rushing upside and touchdown tendencies make up for his tough matchup and poor ball security. He remains a low-end fantasy QB1 versus Chicago.

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San Francisco 49ers wide receiver Jauan Jennings (hip) will return from a two-game absence when the team takes on the Buccaneers in Tampa on Sunday. In his last time on the field -- in Seattle -- Jennings was targeted five times, finishing with three receptions for 27 yards. The targets tied Deebo Samuel Sr. for the wide receiver team lead, even with a pre-injury Brandon Aiyuk on the field. With Aiyuk out for the season, Jennings has a golden opportunity in front of him to become a fantasy contributor down the stretch. The matchup for 49ers receivers this week is good as the Bucs have allowed the seventh-most WR fantasy points this season. Consider Jennings a viable WR3/FLEX option in Week 10.

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New England Patriots kicker Joey Slye cannot be trusted in fantasy football ahead of his Week 10 matchup versus the Chicago Bears. Slye had a brief stretch of solid performances early in the year, but he has settled back into mediocrity while struggling with accuracy here and there. All in all, he is 13-for-13 on extra points and 12-for-15 on field goals. He missed a kick as recently as last week. In general, scoring opportunities have been tough to come by for the Patriots, and Slye is no exception. Even in a relatively favorable matchup against the Bears, Slye belongs on fantasy waivers.

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New England Patriots wide receiver DeMario Douglas hasn't been the most consistent contributor this season, but he has generally been trending in the right direction ever since the team installed rookie Drake Maye as its starting quarterback. Douglas has six-plus catches in four of his last seven games, including a seven-catch, 35-yard showing just last Sunday against the Tennessee Titans. Douglas isn't a major yardage producer, but he has trustworthy hands and commands plenty of volume within the Patriots' offense. Although the 23-year-old is trending up, he gets a very unfavorable matchup this week in the form of the Bears. Chicago has allowed the fourth-fewest fantasy points per game to opposing slot receivers like Douglas, so even if New England finds itself playing from behind, the receiver could have trouble overcoming strong coverage from the Bears' secondary. Douglas has volume-based WR3 upside in PPR leagues, but his floor is also quite low.

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San Francisco 49ers running back Jordan Mason will return to a backup role in Week 10 when the team takes on the Buccaneers in Tampa. The undrafted third-year pro did an impressive job filling in for All-Pro Christian McCaffrey (Achilles) over the 49ers' first five games, averaging 15.9 half-PPR points before suffering a lingering shoulder sprain in Week 6 and ceding much of his subsequent work to rookie Isaac Guerendo. While Mason won't be completely locked out of action with the return of McCaffrey on Sunday since San Francisco is likely to ease the latter back into action to some degree, the Niners have established a preference for using their RB1 almost exclusively. As long as CMC remains healthy, Mason reverts to a top handcuff/stash, while Guerendo falls off the fantasy map entirely. Hang on to Mason if at all possible, but leave him on the bench in Week 10.

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San Francisco 49ers quarterback Brock Purdy will be in Tampa for a Week 10 showdown against the Buccaneers on Sunday. The last time we saw Purdy, he earned a Week 8 30-24 victory over the Dallas Cowboys at home. The former Iowa State Cyclone looked sharp in that game, posting 26.3 fantasy points. Purdy has a juicy matchup coming out of the bye, as Tampa Bay's defense is ranked dead-last in QB fantasy points allowed in Yahoo default scoring. Though Purdy will be without Brandon Aiyuk (knee) for the remainder of the year, there are no other excuses for San Francisco's passing attack to stall in this one, as Christian McCaffrey (Achilles), Deebo Samuel (rib/oblique), and Jauan Jennings (hip) are all likely to play. The Bucs are leading the NFL in rushing touchdowns allowed to quarterbacks -- part of why they've been such a friendly matchup -- and Purdy has been on a bit of a ground-game heater. He's averaging 26.3 yards per game this season, nearly triple 2023's mark, and has rushed for three touchdowns in his last two games. However, McCaffrey's return is likely to stymie that trend. Regardless, Purdy is a solid fantasy starter in Week 10.

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New York Giants wide receiver Wan'Dale Robinson will look to break out of a recent slump as the team heads to Munich to face the Carolina Panthers in Week 10. Robinson has struggled over the past three weeks, including a three-catch, 10-yard outing in Week 9, resulting in diminished fantasy production (he did have a touchdown called back on a penalty). With 51 receptions on 76 targets but averaging only 6.7 yards per catch, Robinson has been used primarily in short-yardage situations, limiting his upside. Facing a Panthers defense ranked 12th against fantasy WRs but vulnerable in the red zone with 18 passing touchdowns allowed this season, Robinson's potential for a bounce-back remains low, making him a risky WR4 play in deeper leagues for Week 10.

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Indianapolis Colts running back Jonathan Taylor was held in check in Week 9 against a stout Vikings rush defense, but Week 10 brings a much more favorable matchup. The Buffalo Bills have allowed the second-most fantasy points to the RB position, and it hasn't just been on the ground. Running backs have scored four receiving TDs against them as well, in addition to the six rushing TDs they've yielded. Taylor is certainly a capable receiver, even receiving a season-high five targets in Week 9 with Joe Flacco under center. Although the 25-year-old missed a few weeks with an ankle injury, when he returned in Week 8, Taylor eclipsed 100-plus rushing and receiving yards for the fourth consecutive week. With Flacco struggling through the air last week and the Bills tougher against the pass, along with the expected absence of WR Michael Pittman Jr., the Colts could lean a bit heavier on the ground game in Week 10, which sets Jonathan Taylor up as a back-end RB1 on Sunday with some upside.

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New York Giants wide receiver Malik Nabers remains the team's top weapon heading into Week 10's matchup against the Carolina Panthers in Munich. Last week, Nabers led the Giants with nine receptions, though he was held to just 59 yards as the Commanders contained his big-play ability. This week, he faces a Panthers defense that ranks 12th against fantasy WRs and has allowed 18 passing touchdowns this season, despite limiting overall passing yards to 232.6 per game. Nabers' steady target volume and six end-zone targets make him a reliable fantasy option, and against Carolina's vulnerable red-zone defense, he has a solid chance to add to his three touchdowns this season, making him a high-floor WR1 for Week 10.

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Buffalo Bills wide receiver Mack Hollins (shoulder) was removed from the injury report heading into Sunday's matchup with the Colts. He practiced in full on Wednesday. However, there were some doubts regarding his availability after logging limited sessions on Thursday and Friday. Fortunately, he's good to go against Indianapolis. The 31-year-old is coming off his best game of the 2024-25 campaign, catching all five targets for 30 yards and a touchdown. With Keon Coleman (wrist) out and Amari Cooper (wrist) questionable, there could be opportunities for others on the offensive end. While Khalil Shakir should remain Josh Allen's preferred receiving option, Hollins could gain streaming potential in deep league fantasy formats if Cooper doesn't suit up.

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New York Giants running back Tyrone Tracy Jr. heads into Week 10 against the Carolina Panthers with momentum after a solid 66-yard rushing performance in Week 9, further asserting himself as the team's lead back with a 68.3% timeshare. Tracy has been productive since becoming the starter in Week 5, averaging 14.76 fantasy points per game, ranking him 22nd among RBs in that span. Facing a struggling Panthers run defense that ranks last in both overall and fantasy RB defense, allowing 159.3 rushing yards per game, Tracy has a prime opportunity for a breakout game in Munich. With his 5.0 yards-per-carry average, Tracy could see strong fantasy value against Carolina's generous defensive front.

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Tennessee Titans wide receiver Tyler Boyd (shoulder) was removed from the injury report ahead of the Week 10 matchup with the Chargers. The veteran was limited in practice on Wednesday and Thursday. But he was a full-go for Friday's session. With DeAndre Hopkins now a Kansas City Chief, others had a chance to step up. While Calvin Ridley and Nick Westbrook-Ikhine have been useful for fantasy managers, Boyd remains irrelevant on the offensive end for the Titans. That's not expected to change anytime soon, so he shouldn't draw any attention from fantasy managers, especially with a difficult game on the horizon.

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New York Giants quarterback Daniel Jones heads into Week 10 against the Carolina Panthers looking to build on a solid performance in Week 9, where he rushed for his first touchdown of the season and threw for two scores in a 27-22 loss to the Commanders. Jones has tallied 1,880 passing yards, eight touchdowns, and five interceptions this season, but he's still without a 300-yard game. Facing Carolina's 25th-ranked pass defense, which allows 232.6 passing yards per game and has surrendered 18 touchdown passes on the season, Jones has a favorable matchup for fantasy production. Although Jones ranks 27th in fantasy points per game (16.21), the Panthers' defense has allowed an average of 19.28 points per game to opposing quarterbacks, suggesting a potential opportunity for Jones to deliver a strong fantasy outing in Munich.

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Arizona Cardinals running back James Conner (finger) is a high-end RB2 in Week 10 when the Cardinals host the New York Jets. Conner has been dealing with a finger injury that limited his practice participation earlier in the week; however, he practiced in full on Friday and appears to be good to go for Sunday. Conner is a workhorse back, and his volume has translated into a high number of touchdown opportunities. While there are concerns that his volume might decrease due to the injury and the emergence of rookie running back Trey Benson, his snap count should remain high enough to warrant RB2 consideration. Conner still possesses significant touchdown upside and should receive enough volume to remain a solid RB2 in Week 10 against the Jets.

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Pittsburgh Steelers wide receiver Mike Williams will make his first appearance for the team in a Week 10 showdown with the 7-2 Washington Commanders. Williams was unable to get on the same page as quarterback Aaron Rodgers in New York but will hope to quickly establish chemistry with Russell Wilson. The Steelers have been linked to Williams since the offseason and should be eager to get him on the field to work opposite George Pickens. While the veteran's role in the offense will be worth monitoring, Williams cannot be expected to immediately garner more opportunities than fellow wideouts Van Jefferson and Calvin Austin III. Fantasy managers would be wise to leave Williams on the waiver wire in most redraft formats for the time being.

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