The Los Angeles Rams officially placed wide receiver Puka Nacua (knee) on Injured Reserve on Wednesday. The team announced early in the week that he would go on IR, but it is now official, and he must sit out at least the next four games. It's an unfortunate development for Nacua and his fantasy managers who took him in the first or second round of preseason fantasy drafts following a 105-catch, 1,486-yard, six-touchdown season as a rookie. He will be first eligible to return following Los Angeles' Week 6 bye leading up to the matchup with the Las Vegas Raiders in Week 7. While he's out, Cooper Kupp, who saw 21 targets in Week 1, should continue to dominate targets. However, wideouts Demarcus Robinson and Tyler Johnson and tight end Colby Parkinson will see increased opportunities. In deep leagues, Tutu Atwell might be worth stashing.

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Baltimore Ravens quarterback Lamar Jackson (soreness) was not at Monday's practice while dealing with general soreness. However, he is back on the practice field on Wednesday, which should ease any concerns that fantasy managers had early in the week. Jackson had a strong Week 1 performance against the Kansas City Chiefs, throwing for 273 yards and a touchdown and rushing 16 times for 122 yards. The two-time MVP remains a must-start fantasy option in all matchups, as he can pay off in fantasy football despite down weeks as a passer. Baltimore hosts the Las Vegas Raiders in Week 2, and he has overall QB1 upside.

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The Cleveland Browns placed safety Juan Thornhill (calf), linebacker Tony Fields II (ankle), defensive tackle Maurice Hurst (ankle), and linebacker Mohamoud Diabate (hip) on Injured Reserve on Wednesday. All four players will now have to miss at least the next four games, meaning they are ineligible to return until at least Week 6 ahead of the matchup with the Philadelphia Eagles. Thornhill is the biggest loss for the Cleveland defense that gave up 33 points in the Week 1 loss to the Dallas Cowboys. The team signed three defenders from its practice squad and signed two more players to the practice squad in corresponding moves. This is obviously not an ideal development, but Cleveland could still play strong defense with a healthy Myles Garrett and Denzel Ward.

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Chicago Bears rookie wide receiver Rome Odunze (knee) is not practicing on Wednesday and will be "day-to-day," according to head coach Matt Eberflus. Reports earlier this week had Odunze labeled as week-to-week due to an MCL sprain that he suffered in his NFL debut in the Week 1 win over the Tennessee Titans. This new report is much more optimistic, but fantasy managers should still consider the 22-year-old very questionable for the Week 2 game in Houston against the Texans. And with Keenan Allen (heel) also banged up, Chicago's deep receiving corps could suddenly be thin this weekend. Odunze played 77% of the offensive snaps in his first regular-season NFL game last Sunday but caught just one pass for an 11-yard gain. As long as both DJ Moore and Allen remain healthy, Odunze figures to be an inconsistent fantasy option on a weekly basis despite all of his upside.

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Washington Commanders head coach Dan Quinn said that they are "definitely trending in the right direction" to have wide receiver Noah Brown read to make his team debut in Week 2 in a divisional matchup versus the New York Giants this Sunday. Brown hasn't had enough time to learn the playbook after joining the Commanders recently, but it appears as though he could be active this weekend after being a healthy scratch in the Week 1 loss to the Tampa Bay Buccaneers. The 28-year-old could immediately compete for a role as the WR3 behind Terry McLaurin and Olamide Zaccheaus, which would be bad news for rookie Luke McCaffrey and Dyami Brown in the receiving pecking order. If Brown is active, don't expect him to play many offensive snaps in his first game. He can remain on the waiver wire in most fantasy leagues for now.

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Cincinnati Bengals head coach Zac Taylor said that wide receiver Tee Higgins (hamstring) is making strides in his recovery but deferred to the injury report that will come out later on Wednesday after practice. Higgins tweaked his hamstring in practice last Thursday and was ruled out of the season-opening upset loss to the New England Patriots on Sunday. It sounds like Higgins might be limited in practice on Wednesday, which still puts him up in the air to play in Week 2 versus the defending Super Bowl-champion Kansas City Chiefs. If the 25-year-old makes his season debut this weekend, he could also be on a pitch count, making him a shaky WR3/flex play. With Higgins out in Week 1, Andrei Iosivas played 100% of the offensive snaps but hauled in only three passes for 26 yards on six targets, which tied for the team lead with Ja'Marr Chase.

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New York Giants head coach Brian Daboll said on Wednesday that wide receiver Darius Slayton (concussion) is still in the league's concussion protocol and won't practice. Slayton suffered a concussion in the season-opening blowout loss to the Minnesota Vikings and had only three catches on four targets for 26 yards. Right now, he's on the wrong side of questionable as the team prepares for a Week 2 divisional matchup against the Washington Commanders. Even if Slayton returns to practice later this week and clears the NFL's concussion protocols by Sunday, fantasy managers should look to leave him out of their lineups in deeper leagues. He's currently rostered in only 2% of Yahoo leagues. If Slayton misses this weekend's contest, expect Jalin Hyatt to have the best shot at picking up more snaps in a bad offense behind rookie Malik Nabers and Wan'Dale Robinson.

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Indianapolis Colts kicker Matt Gay (hernia) is "good to go," head coach Shane Steichen said on Wednesday. It's unclear what Gay's practice status is to begin the week, but apparently he will be ready to make his 2024 debut this Sunday at Lambeau Field in Week 2 against the Green Bay Packers. Gay recently had surgery to fix a sports hernia and was unable to suit up in the Week 1 loss to the division-rival Houston Texans. With Gay out last weekend, rookie Spencer Shrader made his NFL debut and made all three of his extra-point attempts. The 25-year-old didn't attempt a single field goal. The 30-year-old Gay will be Indy's primary kicker in 2024 when healthy after making 80.5% of his 41 field-goal attempts in 17 games for the Colts a year ago. It's nice that Gay only had to miss one game, but fantasy managers should have better options at the position in Week 2.

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Kansas City Chiefs head coach Andy Reid said in his opening statement on Wednesday that wide receiver Marquise Brown (shoulder) will be the only player on the team that won't practice. However, Reid said it's still possible for Brown to be in uniform for his Chiefs debut in Week 2 against the Cincinnati Bengals. "He won't be out there today," Reid said. Hollywood suffered a sternoclavicular injury to his shoulder in the preseason opener in August and missed the season-opening win over the Baltimore Ravens last Thursday. The former Arizona Cardinals receiver is trending in the right direction and could play this Sunday if he can get back on the practice field on Thursday or Friday, but right now, consider him to be on the wrong side of questionable. With Brown out in Week 1, both Rashee Rice and rookie first-rounder Xavier Worthy feasted as quarterback Patrick Mahomes' primary weapons.

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Cleveland Browns quarterback Deshaun Watson's attorney, Rusty Hardin, released a statement on his client's behalf on Wednesday denying recent allegations of more sexual misconduct against him. "Deshaun strongly denies the allegations in the Jane Doe lawsuit filed Monday. We have asked him not to comment further while this matter works its way through the courts, but are comfortable he will ultimately be vindicated," Hardin wrote in the statement. "We will be ready to defend this case in court at the appropriate time, but don't intend to conduct our defense in the media. We would ask that people be patient while the legal process runs its course." In the meantime, the NFL doesn't plan to put Watson on the commissioner's exempt list, so he will be active as a QB2 in fantasy in Week 2 versus the Jacksonville Jaguars after a poor showing in the Week 1 loss to the Dallas Cowboys.

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Indianapolis Colts wide receiver Josh Downs (ankle) will be limited in practice on Wednesday, according to head coach Shane Steichen. Downs suffered a high-ankle sprain back on Aug. 7 and missed the team's Week 1 loss to the division-rival Houston Texans last weekend. However, the 23-year-old continues to make strong progress and said late last week that he felt he was close to making a return. If he can make more progress in practice on Thursday and Friday, there's a chance he could suit up in Week 2 this Sunday at Lambeau Field against the Green Bay Packers. When healthy, Downs could be the team's No. 2 wideout behind Michael Pittman Jr., which is bad news for those that just plucked Alec Pierce off the waiver wire after he went for over 100 yards and a touchdown in Week 1. Downs is worth scooping up off the waiver wire if he's available.

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Cleveland Browns tight end David Njoku (ankle) will miss Sunday's game against the Jacksonville Jaguars due to an ankle injury. Njoku suffered the ankle injury in Week 1 and is considered week-to-week. The 28-year-old limped off the field after being rolled up on by an opposing defender in Sunday's game against the Dallas Cowboys and was feared to have a high ankle sprain. He has a history of foot and ankle issues, which is concerning for his future production. However, there aren't many good options for fantasy at tight end, so he's a must-start when he plays. Fellow Browns tight end Jordan Akins is the only other TE on the depth chart, but he logged just three receptions in 2023, so Njoku managers should look elsewhere for a replacement this week.

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San Francisco 49ers RB Christian McCaffrey (Achilles, calf) feels like a long shot to play in Week 2, per sources on Wednesday, Sept. 11.

Fantasy Spin: It's not entirely surprising the Niners are being cautious with their star player with it being so early in the season, although it's a bummer for fantasy owners. If you have not already, go out and get Jordan Mason immediately. He's a locked-in RB1 as long as McCaffrey is sidelined.

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Free-agent CB Ahkello Witherspoon is signing with the Los Angeles Rams, per source on Wednesday, Sept. 11. The terms of the contract were not immediately disclosed.

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Cleveland Browns TE David Njoku (ankle) has been ruled out for Week 2, head coach Kevin Stefanski said on Wednesday, Sept. 11.

Fantasy Spin: The next man up on the depth chart is Jordan Akins, who does have some history with Deshaun Watson from their days together in Houston. However, with Watson's struggles, and with it being so early in the season, you can probably find a better option on the waiver wire.

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Buffalo Bills CB Taron Johnson (forearm) and DE Dawuane Smoot (toe) did not practice on Wednesday, Sept. 11, and were ruled out for Week 2. In addition, DE Javon Solomon (oblique) was limited and is doubtful, and QB Josh Allen (hand), RB Ty Johnson (knee), TE Quintin Morris (shoulder) and QB Mitchell Trubisky (knee) practiced in full and were removed from the injury report.

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Buffalo Bills CB Taron Johnson (forearm) and DE Dawuane Smoot (toe) have been ruled out for Week 2.

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Buffalo Bills QB Josh Allen (hand) will play Thursday, Sept. 12, against the Miami Dolphins in Week 2.

Fantasy Spin: Allen was the QB1 after Week 1, and while there should be some concern about the short week, he's still a top-flight play.

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Miami Dolphins RB Raheem Mostert (chest) has been ruled out for Week 2.

Fantasy Spin: De'Von Achane (ankle) is also a game-time decision Thursday night, which means Jeff Wilson Jr. and Jaylen Wright are worth picking up and could both be flex options.

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Miami Dolphins running back De'Von Achane (ankle) will be a game-time decision for Thursday Night Football against the Buffalo Bills. The second-year speedster is dealing with an ankle injury and did not practice on Monday or Tuesday. Veteran running back Raheem Mostert (chest) has already been ruled out. Fantasy managers should pay close attention up until Thursday, as we may not know if Achane will play or not until the team releases its official inactive report 90 minutes before kickoff on Thursday. If Achane is active, he's a risky starter, but the upside outweighs the risk. If he's out, Jeff Wilson Jr. and Jaylen Wright are both intriguing RB3 or flex options. Check your waiver wire now for Wilson Jr. or Wright. Wilson Jr. is likely the "safer" option, but Wright has more upside moving forward.

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