San Francisco 49ers quarterback Brock Purdy is expected to play one to two series in the team's preseason opener against the Las Vegas Raiders, making his debut for the 2025 season. The outing will allow Purdy to get game reps and build chemistry with receivers following the offseason departure of star wideout Deebo Samuel. San Francisco's injury woes continue as well, with wide receiver Jauan Jennings (calf) and running backs Isaac Guerendo (shoulder) and rookie Jordan James (finger) all sidelined. Purdy is coming off a 2024 campaign where he threw for 3,864 yards, 20 touchdowns, and 12 interceptions.

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San Francisco 49ers tight end George Kittle is expected to make his preseason debut in the team's matchup against the Las Vegas Raiders. The veteran is entering his ninth professional season at 31 years old after a stellar 2024 campaign in which he hauled in 78 receptions for 1,106 yards and eight touchdowns, solidifying his status as one of the league's best tight ends. Kittle, considered a stalwart and the heart of the team, will look to get some valuable reps ahead of the regular season.

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San Francisco 49ers wide receiver Ricky Pearsall is set to make his preseason debut after impressing at camp this offseason. The 24-year-old and 2024 first-round pick from Florida missed some early time with a hamstring tweak but is now considered one of the few starters not currently sidelined by injury. Pearsall is entering his second season, looking to build on a rookie campaign that saw him record 31 catches for 400 yards and three touchdowns in 11 games.

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ESPN's Courtney Cronin reports that the Chicago Bears are still seeking clarity at the starting left tackle position, responsible for protecting quarterback Caleb Williams' blindside. While some of Williams' rookie mistakes were linked to last season's offensive line play, the unit is expected to improve significantly with the offseason additions of Pro Bowler Joe Thuney and center Drew Dalman. PFF has ranked it as the fourth-best offensive line in the NFL. Despite this, the starting left tackle spot remains an open race between incumbent Braxton Jones, rookies Ozzy Trapilo and Kiran Amegadjie, and former practice squad player Theo Benedet. Head coach Ben Johnson said that while the team hopes to find "the right guy" soon, the competition might extend into the regular season. Jones, a 2022 fifth-round pick, is working to re-establish himself after missing spring workouts due to a fractured ankle, while Benedet has impressed in recent practices, earning first-team reps.

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New England Patriots wide receiver Stefon Diggs (knee) is inactive for the team's second preseason game against the Vikings on Saturday. The veteran wideout avoided the Physically Unable to Perform (PUP) list in training camp as he continues to recover from a torn ACL he suffered last October. Diggs, who will turn 32 in November, is entering his 11th professional season after a 2024 campaign with the Houston Texans that saw him post 47 catches for 496 yards and three touchdowns before his season-ending injury. He'll look to continue his comeback in the coming weeks and, barring any setbacks, he should be ready for Week 1.

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New Orleans Saints head coach Kellen Moore announced rookie Tyler Shough will start Sunday's preseason matchup against the Jaguars. Shough and Spencer Rattler are locked in one of the league's closest quarterback battles, but Shough may be gaining the edge after leading last week's lone touchdown drive, a 54-yard strike to Mason Tipton. The rookie has the arm talent and supporting weapons to make noise if he secures the job. While he's off the radar in most formats, Shough could emerge as a sneaky QB2 in deeper leagues should he win the starting role.

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Carolina Panthers quarterback Andy Dalton (elbow) exited Saturday's preseason matchup with Houston and will not return. The 37-year-old veteran served as Bryce Young's backup last season and is expected to remain in that role for 2025. Dalton provides Carolina with experience and insurance should Young go down, but his 7-6 touchdown-to-interception ratio from 2024 underscores his limited fantasy value. Even if pressed into action, Dalton would be a low-upside option, keeping him off the radar in all fantasy formats.

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Indianapolis Colts running back Tyler Goodson (elbow) left Saturday's preseason matchup with Green Bay and will not return. The 24-year-old has carved out a role on special teams while contributing 240 rushing yards on 45 career carries. Entering 2025, Goodson is competing with rookie DJ Giddens for the backup role behind Jonathan Taylor. With Giddens impressing in camp and Goodson now sidelined, his fantasy outlook takes a hit. Unless he secures the No. 2 role, Goodson should be avoided in fantasy drafts outside of the deepest formats.

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Washington Commanders quarterback Marcus Mariota (lower leg) will not play in Monday's preseason matchup with Cincinnati, as head coach Dan Quinn is resting several veterans. Mariota, entering his 11th NFL season, is locked in as the backup behind Jayden Daniels. While the veteran brings mobility and experience, he has no standalone fantasy value. Should Daniels miss time, however, Mariota would be a priority free-agent pickup thanks to his rushing upside. For now, fantasy managers can safely leave him off draft boards.

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Carolina Panthers wide receiver Jalen Coker (illness) will not play in Saturday's preseason matchup against the Houston Texans. The second-year wideout posted 32 catches for 478 yards and two touchdowns as a rookie but faces tougher competition for snaps this year. With rookie Tetairoa McMillan entering the fold and Xavier Legette already locked in as a starter, Coker will need to maximize his preseason reps to secure a role in Carolina's rotation. For now, he's off the fantasy radar outside of the deepest formats, but his development will be worth monitoring.

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Washington Commanders tight end Zach Ertz will sit out Monday's preseason matchup with the Bengals. While he's not listed on the injury report, the team is expected to rest the 33-year-old veteran as a precaution. Ertz has secured the starting role and should remain a steady option for quarterback Jayden Daniels this season. The veteran played all 17 games last year, his first full campaign since 2021. Ertz projects as a low-end TE2 in fantasy and is unlikely to be drafted outside of deeper formats, but he remains a reliable security blanket in Washington's offense.

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Green Bay Packers running back MarShawn Lloyd (groin) is expected to make his preseason debut Sunday against the Colts. The 2024 rookie appeared in just one game before suffering an ankle injury and later required an emergency appendectomy that ended his season. Lloyd enters 2025 healthy and projects as the primary change-of-pace option behind starter Josh Jacobs. For fantasy purposes, Lloyd is an intriguing handcuff with upside, particularly in deeper formats. If Jacobs were to miss time, Lloyd's explosiveness and versatility could give him immediate flex appeal.

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Green Bay Packers running back Josh Jacobs will not play in Saturday's second preseason game against the Indianapolis Colts, according to Packers beat writer Mike Spofford. Jacobs will take a seat after playing just one offensive snap in the preseason opener last week against the New York Jets. Most of the team's key starters won't feature this weekend, including quarterback Jordan Love (thumb) and receivers Jayden Reed (knee), Dontayvion Wicks (calf) and Romeo Doubs (back). In his first year in Green Bay in 2024, Jacobs topped 1,000 rushing yards for the fourth time in his six NFL seasons and scored a career-high 15 rushing touchdowns on 301 carries. Jacobs should again be the workhorse in the Packers' backfield this year, but fantasy managers should expect TD regression, making him more of a low-end RB1 target in fantasy.

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The Houston Texans will play several starters on Saturday in their second preseason game against the Carolina Panthers, including quarterback C.J. Stroud, according to Aaron Wilson of KPRC 2 Sports. Wide receiver Nico Collins will also get a few series on offense with Stroud this weekend, while running back Dameon Pierce will be held out. This will be Stroud's first preseason action this summer after he sat out of the opener last week against the Minnesota Vikings. The 23-year-old took a step back in 2024 in his sophomore season, throwing for 3,727 yards, 20 touchdowns and 12 interceptions while being sacked 52 times in 17 regular-season starts. Stroud showed in his rookie campaign that he can put up numbers, but a bounce-back in 2025 will depend on whether his offensive line can protect him. Treat him as a low-end QB2 in fantasy with upside.

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Philadelphia Eagles quarterback Jalen Hurts is not expected to play in the team's second preseason game on Saturday against the Cleveland Browns, according to Tim McManus of ESPN. Tanner McKee also isn't expected to suit up, paving the way for Dorian Thompson-Robinson to make his first start of the preseason. Kyle McCord should also see reps under center. Hurts also sat out last week's preseason opener, so his last chance to play in the preseason will come next Friday against the New York Jets. The 27-year-old didn't crack 3,000 passing yards in 2024 for the first time as a starter, but it didn't help that he sat out two games due to injury. The Eagles relied more on the ground with running back Saquon Barkley tearing it up, but Hurts still scored double-digit touchdowns on the ground for the fourth straight year. For his rushing TD prowess alone, he should be considered a top-five fantasy QB.

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Cleveland Browns wide receiver Jerry Jeudy and running back Jerome Ford are not expected to play in the team's second preseason game on Saturday against the Philadelphia Eagles, according to Browns beat writer Kelsey Russo. In addition, the Browns are expected to hold out rookie RB Dylan Sampson. Jeudy's last chance to play in the preseason will come next Saturday against the Los Angeles Rams, as he also didn't play in the preseason opener last week. In regards to the RB situation, the Browns are being mindful not to thin out their RB room even more with rookie second-rounder Quinshon Judkins still unsigned as he deals with legal matters. Jeudy will be the unquestioned WR1 again in 2025, although his fantasy upside will remain limited with veteran quarterback Joe Flacco running the offense. Ford figures to have an elevated backfield role if Judkins is not ready for the start of the season.

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Washington Commanders rookie running back Jacory Croskey-Merritt (shoulder) was wearing a non-contact jersey in Saturday's training camp practice, according to Ben Standig. Croskey-Merritt only took part in individual drills at practice as he works through a minor shoulder injury. The 24-year-old seventh-rounder suffered the shoulder injury in the preseason opener last week against the New England Patriots, when he carried the ball seven times for 24 yards while catching his only target for eight yards. He has been impressive during camp as he competes for a depth role in Washington's backfield behind Austin Ekeler and Brian Robinson Jr. Croskey-Merritt's primary competition for a 53-man roster spot this summer are Jeremy McNichols and Chris Rodriguez Jr. From all accounts, Croskey-Merritt has done enough so far to make the team.

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Atlanta Falcons placekicker Younghoe Koo was a perfect2-for-2 on field goal attempts and 2-for-2 on extra points in Friday's 23-20 loss to the Titans. The 31-year-old hit from 39 and 42 yards out, but is coming off a rough 2024 in which he converted just74 percent of his field goal attempts before missing the final three games of 2024 with a hip injury. Lenny Krieg handled kicking duties in the team's first preseason matchup and is presumably in the mix to compete for the starting job. Krieg hit from 57 yards and missed from 53 in that first game while converting his lone extra point. Regardless of who wins the job, after Koo's struggles and the Falcons' murky offensive outlook, there are better options to choose from at kicker in 12-team fantasy leagues.

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Alex Brasky of SI.com writes that Buffalo Bills wide receiver Keon Coleman "has dominated training camp" this summer, and it continued with a couple of touchdown catches during Friday's joint practice with the Chicago Bears. The 22-year-old former second-rounder (33rd overall) in 2024 appears to be taking the next step heading into his sophomore campaign after disappointing with 29 catches, 556 yards and four touchdowns on 57 targets in 13 regular-season games (12 starts) a year ago. Coleman has taken advantage of top wideout Khalil Shakir missing time in camp with an ankle injury. With Joshua Palmer now in town to serve as a deep threat down the field, the hope is that Coleman's route tree expands and he becomes a more versatile pass-catcher. If that's the case and he continues to ascend, Coleman will end up being an excellent value pick in fantasy drafts in the later rounds.

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Cleveland Browns rookie quarterback Dillon Gabriel (hamstring) is expected to start Saturday's game against the Philadelphia Eagles, according to the team. With the Browns battling injuries under center, the rookie third-round pick from Oregon will take the reins in a meeting with the defending Super Bowl champions. Expected Week 1 starter Joe Flacco is resting, while Kenny Pickett (hamstring) is limited with a hamstring injury, and fifth-round rookie Shedeur Sanders (oblique) suffered an oblique strain earlier this week. Sanders turned heads in a preseason-opening 30-10 win over the Carolina Panthers last week. Gabriel didn't play in that game as a result of a hamstring injury, but he'll have his chance to stand out on Saturday. He and veteran Tyler Huntley are expected to be the only available Cleveland QBs.

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