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San Francisco 49ers running back Brian Robinson Jr. may see an uptick in usage when the team faces the Saints on Sunday. With quarterback Brock Purdy (toe, shoulder) out, wide receiver Jauan Jennings (shoulder) questionable, and tight end George Kittle (hamstring) on injured reserve, San Francisco is short on playmakers. In Week 2, San Francisco may prefer to grind things out on the ground now that Mac Jones is under center. If that's the case, Robinson should mix in regularly in order to avoid overworking Christian McCaffrey (31 touches in Week 1). Robinson projects as an RB4 in Week 2. While he is not a must-start, he is a viable flex in deeper leagues and should be rostered in most leagues.

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The Philadelphia Eagles just traded for Tank Bigsby on Monday, and the former Jaguar is currently listed as the third running back on the depth chart. He was far outpaced by Travis Etienne Jr. in Jacksonville's first game, and was splitting touches with Bhayshul Tuten as well. Bigsby only managed 12 yards on five carries against the Panthers in Week 1, which clearly didn't impress the Jaguars front office enough to keep him on the roster. Eagles backup RB Will Shipley (rib) is officially out for the upcoming contest against Kansas City, clearing the runway a bit for Bigsby, but probably not enough for any real fantasy production. Shipley and AJ Dillon combined for 13 snaps on offense against Dallas last week, while Saquon Barkley totaled 50. With a star like Barkley ahead of him, Bigsby should not be considered for lineups in Week 2.

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Philadelphia Eagles wide receiver A.J. Brown had fantasy managers second-guessing whether they should have taken him so high in their drafts with his performance against the Cowboys, hauling in just one catch for eight yards on one target. However, with the Chiefs on the horizon in Week 2, Brown looks to cement his spot once again as the top wideout in Philly's offense. Kansas City allowed four players to achieve 50 or more receiving yards last week against the Chargers, and Brown caught a touchdown last time he faced off against this defense in Super Bowl LIX. He's due for a bounceback showing, and despite his lack of looks in Week 1, Brown is still a WR1 in fantasy.

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Eagles wide receiver DeVonta Smith fell victim to a strange week for the Philadelphia passing game against the Cowboys, being targeted just three times for three catches and 16 yards. Saquon Barkley and Dallas Goedert led the team in targets in Week 1, and Jahan Dotson had the most receiving yards in what was a bit of an anomaly. Philly will likely get back to their normal ways eventually, which favors Smith in this upcoming contest against the Chiefs as the Eagles' typical second option in the passing game. In their Super Bowl LIX clash, Smith led his team in receiving yards (69) and caught a touchdown against Kansas City. He's a player that's known to be up-and-down in fantasy, so managers have to bank on this being an up week for Smith in a favorable matchup-especially with Goedert (knee) being unavailable. The Chiefs let the Chargers pass all over them last Friday, so Smith is a solid WR2 for Week 2 in hopes that his offense can do something similar.

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Philadelphia Eagles rookie wide receiver Darius Cooper failed to get any targets in the opening game of the season against the Cowboys. While Cooper did have a solid preseason showing against the Bengals, he was bound to struggle for looks in the regular season with the amount of talent surrounding him. He is currently listed as the fifth wideout on the Philly depth chart and was on the field for only two offensive snaps in Week 1. In an upcoming faceoff against the Chiefs, this undrafted rookie will likely have a similar workload. Cooper isn't worth looking at in fantasy for Week 2.

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Philadelphia Eagles tight end Kylen Granson could see an uptick in targets in Week 2 with Dallas Goedert (knee) officially being ruled out. In Philly's season opener against the Cowboys, Granson was the only other tight end besides Goedert to tally any targets, though it was just one which resulted in a one-yard catch. The Eagles' other option as a replacement is former sixth-round draft pick Grant Calcaterra, who did see more snaps (37) last week than Granson (17). With uncertainty at the position, neither of Philadelphia's backups seem like reliable fantasy options this week against Kansas City. Only consider them for deeper leagues.

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Atlanta Falcons quarterback Michael Penix Jr. performed well in Week 1, completing 27 of 42 passes for 298 yards and a touchdown without throwing an interception, while also adding six rushes for 21 yards and a score. In Week 2, he'll have a road matchup with the Minnesota Vikings, who were tough against the run last season, allowing the second-fewest rush yards per game (93.2), and who only allowed 61 rush yards to non-quarterbacks in Week 1. It likely means the Falcons will lean on the pass again in this matchup, and the 25-year-old will have a full complement of receivers as Drake London (shoulder) and Darnell Mooney (shoulder) were both full participants in practice on Friday. The Vikings defense will be without a couple of pieces on Sunday, namely Andrew Van Ginkel (concussion), who nearly led the team in sacks in 2024 with 11.5, so the former first-round draft pick shapes up as a mid-range QB2 this week whose arrow is pointing up.

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Philadelphia Eagles kicker Jake Elliott impressed in his season debut, going perfect for the game by making his sole field goal attempt of 58 yards and all three of his extra points. In Week 2 Elliott will travel to Kansas City for a matchup against the Chiefs, who allowed 27 points to the Chargers last week in a loss. The Chiefs gave up five scores on seven drives-excluding the final time Los Angeles had the ball when they ran the clock out. Facing a weak defense and having long range, Elliott should remain in fantasy lineups this week.

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Philadelphia Eagles quarterback Jalen Hurts looks to speed past another defense this week as he faces the Chiefs at Arrowhead. Hurts led his team on the ground last week, racking up 62 rushing yards and two touchdowns on 14 attempts. He also broke the Super Bowl record for most rushing yards by a QB against Kansas City back in February. Last week, the Chiefs let Justin Herbert do basically whatever he wanted, as he threw for 318 yards and three touchdowns in a Chargers win. All signs point to Hurts being poised for a big game on Sunday, especially in what could turn into a high-scoring, revenge-fueled matchup. He remains a top option at his position in fantasy for Week 2.

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Philadelphia Eagles running back Saquon Barkley tied for the sixth-most rushing attempts in the league last week (18), once again proving that he has one of the most reliably-heavy workloads in the NFL. He also made PPR managers happy with his four receptions on five targets-both good for second-most on the team. In Week 2 Barkley faces a Chiefs defense that held Omarion Hampton to just 48 yards on 15 attempts last Friday, but that was a rookie, and this is Saquon Barkley. After leading Philly in targets and receptions in their last meeting against Kansas City in the Super Bowl, expect Barkley to have a prominent role in the passing game again this week. He's a top-tier RB1 as per usual.

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San Francisco 49ers running back Christian McCaffrey is not listed on the team's final injury report for Week 2. McCaffrey did not practice on Wednesday with his injury description listed as both calf and resting, but practiced in full on Thursday and Friday. The 29-year-old carried a questionable tag into the season opener but logged 31 touches for 162 scrimmage yards in the 49ers' 17-13 win over the Seahawks. With quarterback Brock Purdy (toe, shoulder) ruled out and tight end George Kittle (hamstring) on injured reserve, the offense can be expected to run through McCaffrey once again when the 49ers face the Saints on Sunday. A weekly favorite for an RB1 finish, he is a must-start for Week 2.

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In the season opener, Pittsburgh Steelers kicker Chris Boswell picked up right where he left off in 2024, drilling two field goals and four extra points. Most notably, he set a franchise record with a 60-yarder that gave Pittsburgh a 34-32 lead with just over a minute left in the fourth quarter. Boswell will look to carry this momentum into a Week 2 meeting with the Seattle Seahawks, who fared well against fantasy kickers last season. Despite the matchup and modest projected point total, Boswell's consistency keeps him in play as a reliable starter across all formats.

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Kansas City Chiefs wide receiver Tyquan Thornton had two catches for 41 yards in the Week 1 loss to the Chargers. With Xavier Worthy (shoulder), who was injured early in the opener, doubtful for the Week 2 Super Bowl rematch with the Eagles, there is room for others to benefit. Marquise Brown, who had 10 catches (16 targets) for 99 yards against Los Angeles, has the best chance of remaining the No. 1 wideout. Travis Kelce should also continue to get attention from Patrick Mahomes. With that in mind, Mahomes can spread the ball around, so it's hard to predict if Thornton will stay involved enough to justify a spot as a fantasy starter. Although the 25-year-old should have a role in Week 2, fantasy managers will be rolling the dice if utilizing his services for streaming purposes against Philly.

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Pittsburgh Steelers tight end Pat Freiermuth saw three targets last week and will look to build on his chemistry with quarterback Aaron Rodgers in Week 2 against the Seattle Seahawks. Seattle was middle-of-the-road against opposing tight ends last season, but surrendered plenty of fantasy points to the position in its season opener against the San Francisco 49ers. Unfortunately for Freiermuth, new addition Jonnu Smith appears to have a more significant role in Pittsburgh's offense. Smith led the Steelers' tight end room in snaps, targets, and receptions in Week 1. Freiermuth has proven to be a productive player over his five-year career, so while he is sure to have some big games this season, it will be difficult to predict them so long as the team's weapons stay healthy. He should be rostered in dynasty formats, but Freiermuth can remain on waiver wires in most redraft leagues.

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Baltimore Ravens tight end Mark Andrews had only one catch for five yards in the upset loss to the Bills. While that statistical line was disappointing, his one target was even more troubling for fantasy managers. Fresh off a loss, Baltimore will look to pick up a win over the Browns in Week 2. Andrews has played extremely well versus Cleveland throughout his career (14 games), totaling 59 catches for 755 yards and 11 touchdowns. Still, after a disastrous Week 1 effort, he's hard to trust, especially with so many options on the offensive side of the ball for the Ravens. Without question, Andrews can get hot, so there's rarely a time when he isn't featured in a fantasy lineup. However, there is some risk involved, which is something fantasy managers need to consider.

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Los Angeles Chargers wide receiver Keenan Allen had seven catches for 68 yards in the Week 1 win over the Chiefs. While he wasn't as productive as Ladd McConkey and Quentin Johnston, the veteran wideout had a team-high 10 targets while finding the end zone in the third quarter off of an 11-yard throw from Justin Herbert. With a win in the books, Los Angeles will face Las Vegas in Week 2 in another AFC West showdown. Geno Smith played well in the win over the Patriots. However, the defense still struggled at times, especially defending the pass. Not much is expected to change on that front on Monday night. It's apparent Allen and Herbert still have strong on-field chemistry. With that in mind, the 33-year-old appears to have some gas left in the tank, making him worthy of a spot in all fantasy lineups in Week 2.

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San Francisco 49ers quarterback Mac Jones will get the start in Sunday's meeting with the Saints. With Brock Purdy (toe) out for the foreseeable future, the 49ers will now turn to Jones, who hasn't exactly had the best track record since entering the league in 2021. San Francisco will also be without George Kittle (hamstring). That may also be the case for Jauan Jennings (shoulder), who is listed as questionable. However, Christian McCaffrey is in the mix, which certainly helps take some pressure off of the signal-caller. Jones, who has thrown for 10,590 yards, 54 touchdowns, and 44 interceptions throughout his career, reportedly looked good during training camp. All things considered, Jones has a favorable matchup in Week 2 versus New Orleans, so he deserves consideration in SuperFlex formats. The 27-year-old should also see interest from DFS managers due to his rostering cost.

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Chicago Bears rookie wide receiver Luther Burden III opened his NFL career quietly, finishing with one catch for -3 yards in the Bears' 27-24 loss to the Vikings. As expected, Burden wasn't a starter in Week 1 under head coach Ben Johnson, instead rotating in behind Rome Odunze, D.J. Moore, and Olamide Zaccheaus. He logged a 27% snap share and a 22% route participation rate, both fourth among Chicago's wideouts. The matchup in Week 2 is favorable, as the Bears face a Lions defense that allowed the most receiving yards to wide receivers in 2024, but Burden remains firmly off the fantasy radar. Until he can leapfrog Zaccheaus and carve out a larger role, he's more of a developmental stash than a lineup option.

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Pittsburgh Steelers wide receiver Roman Wilson did not see the field much in the season opener and will hope for more involvement in Week 2 against the Seattle Seahawks. Wilson logged just 10 of a possible 56 offensive snaps in Week 1, well behind starting wideouts DK Metcalf and Calvin Austin III. With Wilson competing alongside Ben Skowronek and Scotty Miller for the WR3 role, and Pittsburgh showing a willingness to utilize multiple tight ends, his path to meaningful opportunities remains narrow. As a second-year player who struggled to stay healthy as a rookie, Wilson may emerge at some point, but he should only be viewed as a stash in dynasty formats and cannot be considered in redraft lineups this week.

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Chicago Bears rookie tight end Colston Loveland made his NFL debut in Week 1 but had a quiet outing, catching both of his targets for just 12 yards in the 27-24 loss to the Minnesota Vikings. As expected, Loveland operated behind starter Cole Kmet, playing 57% of the snaps compared to Kmet's 90%. In one-tight end sets, Kmet dominated the role with 77% of the snaps, while Loveland accounted for just 23%. The matchup is brutal in Week 2, as Loveland faces a Detroit Lions defense that allowed the fewest fantasy points to tight ends in 2024. Until he overtakes Kmet in the Bears' tight end rotation, Loveland remains a stash-only option for fantasy managers.

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