Houston Texans running back Joe Mixon (ankle) is expected to play on Sunday according to Jordan Schultz of FOX Sports. Mixon has been sidelined since suffering an ankle injury in their Week 2 victory over the Chicago Bears. After opening the week missing practice on Wednesday, Mixon was able to log a limited session on both Thursday and Friday which is also a very good sign. Fantasy managers should continue to monitor his status ahead of kickoff in case he faces a setback. The 28-year-old looked sharp in his Houston debut as he ran for 159 yards and a score on 30 attempts and should be locked into all lineups as a solid RB2 facing the New England Patriots.

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Jacksonville Jaguars tight end Evan Engram (hamstring) is expected to play on Sunday according to Jordan Schultz of FOX Sports. Engram has been sidelined since Week 2 after suffering a hamstring injury during warmups of that week. The tight end was able to log three consecutive limited practice sessions this week. Fantasy managers should continue to monitor his status ahead of kickoff in case he faces a setback. Engram enjoyed a career-year last season as he caught an impressive 114 receptions for 963 yards and four touchdowns. Engram remains a solid TE1 when he travels to Tottenham and faces the Chicago Bears who have allowed the 10th-fewest points to opposing tight ends this season.

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Buffalo Bills rookie wide receiver Keon Coleman should be viewed as a low-end flex option this week as he faces the New York Jets on Monday evening. Coleman saw a season-high five targets last weekend but was only able to bring in one of them for a 49-yard TD reception. Since scoring 0.0 PPR points in Week 2, Coleman has gone on to score at least 8.0 PPR points in each of the past three weeks. On Monday, the Bills could be without No.1 wideout Khalil Shakir (ankle) as he did not practice on Thursday and Friday. If Shakir is unable to play, Coleman could be worth a look as a flex option in all standard formats facing a tough New York defense who has allowed the seventh-fewest points to opposing wide receivers.

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New England Patriots wide receiver Kendrick Bourne (knee) is expected to play on Sunday according to Andrew Callahan of the Boston Herald. Bourne opened the campaign on the PUP list and made his season debut last weekend against the Miami Dolphins. In this game, the 29-year-old logged only 15 total snaps, which was the lowest among New England wideouts. This week, Bourne was a limited participant during all three practice sessions. Fantasy managers should leave Bourne out of their lineups this weekend until he is able to emerge as a proven starter in the passing attack.

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Buffalo Bills rookie running back Ray Davis could see increased usage on Monday evening. No.1 running back James Cook (toe) did not practice on Thursday and Friday and could be in danger of missing Monday's game depending on his practice status on Saturday. Fantasy managers should pay close attention to the injury report as it could provide clarity on Cook's injury designation. From Weeks 2 through 4, the rookie saw at least seven carries in each game. However, last weekend, Davis did not see an attempt but did catch his lone target. If Cook is unable to suit up, fantasy managers should expect Davis and Ty Johnson to split backfield duties with Johnson likely seeing more pass-catching work and Davis seeing the short-yardage opportunities.

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Buffalo Bills quarterback Josh Allen remains a high-end QB1 despite the difficult matchup on Monday evening against the New York Jets who have allowed the second-fewest points to opposing quarterbacks this season. Allen got off to a hot start this season as he topped 30.0 PPR points in two of the first three games. During this span he scored nine total touchdowns. However, over the past two weeks, Allen has been in a bit of a slump as he has averaged just 13.6 PPR points per game with just one total score. In addition, he could be without running back James Cook (toe) and No.1 wideout Khalil Shakir (ankle) who did not practice on Thursday and Friday. Despite this, fantasy managers should feel confident starting Allen in all formats given his incredible track record.

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Pittsburgh Steelers rookie wide receiver Roman Wilson is expected to be active in Week 6 on Sunday on the road against the Las Vegas Raiders, according to source, which will be his NFL debut. An ankle injury slowed Wilson to start the year, but he'll rejoin them now and give quarterback Justin Fields another option in the passing game moving forward. Despite not being on the injury report, Wilson was a healthy scratch in the last three contests after being out with his ankle injury in the first two weeks of his rookie season. The 23-year-old third-rounder has an opportunity in Pittsburgh's thin receiving corps, but for now he'll likely be mixed in as depth behind George Pickens, Van Jefferson and Calvin Austin III. Eventually, Wilson profiles as a medium-volume deep threat for a Steelers offense that doesn't really stretch the field much, at least with Fields under center. At best, Wilson is a watch-list candidate in 12-team fantasy leagues right now. Stash him in dynasty formats.

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The Indianapolis Colts signed running back Evan Hull from the practice squad to the 53-man active roster on Saturday with Jonathan Taylor (ankle) missing his second straight game due to a high-ankle sprain this Sunday against the division-rival Tennessee Titans. The Colts need extra RB depth this weekend behind Trey Sermon, who will be starting for the second straight week, and Tyler Goodson. The 23-year-old was on the active roster last week as well in the Week 5 loss to the division-rival Jacksonville Jaguars but didn't play a single offensive snap. The former fifth-round selection in 2023 out of Northwestern played in just one game in his rookie campaign and had one carry for one yard and caught his only target for a gain of six yards. Hull remains well off the fantasy radar and may only play if one of Sermon or Goodson get injured on Sunday against the Titans.

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The New York Giants will place linebacker Kayvon Thibodeaux (wrist) on Injured Reserve on Saturday, according to source. Thibodeaux broke the scaphoid bone in his wrist in last week's win over the Seattle Seahawks and will now miss at least the next four games. A source said Thibodeaux has a four- to six-week timeline. If he only misses the required four games, Thibodeaux could return for a Week 10 date against the Carolina Panthers. But with the Giants having their bye in Week 11, there's a better chance that we don't see him again until Week 12 versus the Tampa Bay Buccaneers. The 23-year-old had surgery on his wrist on Wednesday. The former fifth overall pick in 2022 out of Oregon had only 12 tackles (eight solo), two sacks, three tackles for loss and seven QB hits in five games into his third NFL season before getting injured. Azeez Ojulari and Patrick Johnson will be expected to step up with bigger workloads with Thibodeaux out for the G-Men.

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Pittsburgh Steelers running back/kick returner Cordarrelle Patterson (ankle) missed practice all week and was ruled out for the Week 6 contest this Sunday against the Las Vegas Raiders at Allegiant Stadium. Patterson hurt his ankle in the Week 4 loss to the Indianapolis Colts and missed the Week 5 loss to the Dallas Cowboys. The 33-year-old hasn't practiced in the last two weeks, so he could be in danger of missing another game in Week 7 against the New York Jets. His absence will be felt more for Pittsburgh on special teams than it will on offense, and the backfield will be getting a boost with Jaylen Warren (knee) returning after sitting out last week. Patterson, a four-time Pro Bowl kick returner, has seen only 16 carries in four games this season in his first year in Pittsburgh for 92 rushing yards, also catching five passes for 34 yards. He belongs on the waiver wire in most fantasy formats.

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Buffalo Bills Pro Bowl running back James Cook (toe) will practice on Saturday despite his toe injury and plans to play on Monday night against the division-rival New York Jets in Week 6, according to his agency LAA. Head coach Sean McDermott said that Cook will be listed as questionable on the final injury report. As long as the 25-year-old doesn't suffer a setback at practice on Saturday, it's looking like fantasy managers will be able to keep him in their starting lineups. Cook didn't practice on Thursday and Friday and was looking more likely to miss the Week 6 contest before this news. It's good news that he's expected to play, but fantasy managers should expect more bust potential from Cook this week, as both Ty Johnson and rookie Ray Davis could spell him more often, and the matchup against a tough Jets defense doesn't help matters.

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Buffalo Bills head coach Sean McDermott said that wide receiver Khalil Shakir (ankle) will be listed as questionable for the Week 6 divisional showdown on Monday night against the New York Jets. Shakir was unable to practice on Thursday and Friday, so he's apparently going to return to the practice field on Saturday in order to give himself a shot at suiting up in primetime on Monday. The 24-year-old pass-catcher injured his ankle in the Week 4 loss to the Baltimore Ravens and sat out of the Week 5 loss to the Houston Texans. It's good news that he's made some progress, but he's firmly in danger of missing his second straight game and is an extremely volatile fantasy option this weekend with Buffalo's game being on Monday night. If Shakir misses another game, rookie Keon Coleman, Mack Hollins and Curtis Samuel will be more involved in the passing game, as well as tight end Dalton Kincaid against a stout Jets defense.

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Atlanta Falcons kicker Younghoe Koo ranks near the top in fantasy points at the position so far in 2024, with his last seven makes coming from 40 yards or more. The Atlanta offense really got rolling last week and gets another favorable matchup in Week 6 against the Carolina Panthers. The Panthers have been terrible against both the pass and run, so the Falcons should have no problem moving the ball down the field which should provide Koo with plenty of opportunity. The drawback perhaps is that Carolina has been too forgiving, which could lead to touchdowns and only extra points for the 30-year-old kicker, but with one of the higher projected totals on the board (46.5) and beautiful weather conditions projected in Charlotte, this game sets up nicely for the seven-year veteran.

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Atlanta Falcons running back Tyler Allgeier has yet to accumulate double-digit rush attempts in a game this season, but with Bijan Robinson popping up on Thursday's injury report with a hamstring injury, perhaps this is the week he helps spell Robinson a few extra snaps. The Falcons will square off with the Carolina Panthers in Week 6, a defense that has yielded a league-worst nine touchdowns on the ground through five weeks. In addition to Robinson's injury, albeit minor, Atlanta is favored by six points in this contest, so if the Falcons are playing with a lead late in the game, Allgeier could stand to benefit. The 24-year-old has shown in the past that he's a capable back, and with 5.4 yards per rush on average this season it shows he still is, but while he's a strong handcuff for Robinson managers, without more opportunities the BYU product is merely a low-end FLEX play this week.

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New York Jets wide receiver Mike Williams had been trending up in recent weeks but he took a step back in Week 5, catching just two balls for 25 yards in a loss to the Minnesota Vikings. He will look to bounce back at home against the Buffalo Bills in Week 6's Monday night game. It isn't a great matchup for Williams, however, as the Bills are allowing the seventh-fewest fantasy points per game to wide receivers this year. Williams could benefit from the extra defensive attention paid to Garrett Wilson and, to a lesser extent, Allen Lazard, but he is still not a strong fantasy option heading into Week 6. Treat him as a WR5 this weekend.

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Atlanta Falcons wide receiver Ray-Ray McCloud III corralled six passes for the second consecutive game in last week's clash with Tampa Bay, and in Week 6 he's gifted the Carolina defense that has allowed a league-high 11 scores through the air. McCloud is Atlanta's No. 3 wideout and registers just a 7.5 aDOT but has managed to turn his looks into 229 yards receiving, which is more than higher-rostered players like Courtland Sutton (224) and Amari Cooper (208). The 27-year-old has yet to find the endzone, which limits his production, but he is also somewhat involved in the run game (two rushes for 23 yards), and the Panthers are charitable on the ground as well. The Clemson product can also provide points in the kick return game for leagues that reward those stats. The five-foot-nine receiver should be viewed as a FLEX option this week with WR3 upside, especially in PPR formats.

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New York Jets kicker Greg Zuerlein has made six of his eight field-goal attempts in 2024, working out to an average of just 1.6 attempts per game. He will look for more work heading into a Week 6 matchup against the Buffalo Bills on Monday night. The Bills have been tough on kickers this season, allowing just the 26th-most fantasy points per game to the position through five games. Zuerlein isn't seeing enough volume to be trusted as a top-15 fantasy option heading into Week 6.

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New York Jets wide receiver Allen Lazard has been a pleasant surprise in 2024, catching 20 balls for 240 yards and four touchdowns over five games. He will look to keep it going against the Buffalo Bills in Week 6's Monday night game. The Bills may cool him off, however, as their secondary is allowing the seventh-fewest fantasy points per game to receivers this season. This downgrades the entire New York passing attack for Week 6, leaving Lazard as a boom/bust flex option heading into Monday night.

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Green Bay Packers tight end Luke Musgrave (ankle) was placed on the injured reserve according to Adam Schefter of ESPN. As a result, Musgrave will be sidelined for at least the next four games due to an ankle injury. The 24-year-old has had a slow start to the campaign catching only five passes across the first four weeks with just 22 yards. Fantasy managers should expect 23-year-old Tucker Kraft to see the majority of opportunities at the position going forward. Kraft has enjoyed a nice breakout campaign and has caught ten passes for 141 yards and three scores over the past two weeks. Kraft remains a TE1 going forward and has a favorable matchup this weekend against a week Arizona secondary.

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Tampa Bay Buccaneers wide receiver Trey Palmer (concussion) will miss his second straight game this weekend due to a concussion. The sophomore wideout was unable to participate in any team practices this week and will now set his sights on returning in Week 7. After catching only one pass through the first three weeks of the season, Palmer enjoyed a nice bounce-back performance in Week 4 when he caught three passes for 26 yards and a score. Fantasy managers should expect rookie wideout Jalen McMillan (hamstring) to serve as the No.3 option this weekend if he is able to suit up. If not, veteran Sterling Shepard will take that role and could be worth a look as a high-risk option in DFS as he found the end zone last week.

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