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Buffalo Bills running back James Cook (hamstring) practiced in full on Friday and will not carry an injury designation into his team's Week 2 matchup against the New York Jets. Cook was limited in practice on Wednesday due to a hamstring injury, but he was able to log consecutive full practices to end the week. The 25-year-old recorded 102 yards from scrimmage and a touchdown on 18 touches in Week 1 against the Baltimore Ravens. Cook profiles as a high-end fantasy RB2 in Week 2.

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Kansas City Chiefs rookie wide receiver Jalen Royals (knee) will miss his second consecutive game in Week 2 against the Philadelphia Eagles. With top Chiefs wide receivers Rashee Rice (suspension) and Xavier Worthy (shoulder) both currently sidelined, Royals' injury is causing him to miss a golden opportunity to establish a role in the Kansas City offense. Without Royals in the mix, Marquise Brown, JuJu Smith-Schuster, and Tyquan Thornton appear set to anchor the team's wide receiver corps in Week 2.

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Kansas City Chiefs wide receiver Xavier Worthy (shoulder) is officially listed as doubtful for the team's Week 2 matchup against the Philadelphia Eagles. Worthy dislocated his shoulder in Kansas City's Week 1 loss to the Los Angeles Chargers, but was able to log limited practices on Thursday and Friday heading into Week 2. While Worthy appears unlikely to play against the Eagles, he could return quicker than initially expected after the injury was diagnosed. Without Worthy, Chiefs wide receivers Marquise Brown, JuJu Smith-Schuster, and Tyquan Thornton could also see expanded workloads.

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After a season-opening performance by the New York Giants' offense that was an abject disaster, the team is in search of solutions. While a change under center feels like an inevitability at some point this season, with rookie Jaxson Dart eventually taking over for Russell Wilson, some on the team seem to believe that a change in philosophy is also needed. Dating back to last season, multiple Giants players have suggested that an offense funneled entirely through one player, in this case, wide receiver Malik Nabers, is not sustainable. Nabers saw nine targets on Sunday, resulting in five catches for 71 yards. It was his 14th straight game seeing at least eight targets, and the Giants are 2-12 in those contests. Nabers himself told reporters that the team needs to do a better job of spreading the ball around. Based on the evidence we've seen on the field, fantasy managers should not fear a sudden decrease in targets. They should, however, hope for any change that can make those looks more valuable.

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Daniel Carlson kicked off his 2025 campaign with a solid Week 1 performance, tying for K8 with 11 fantasy points against the Patriots. The reliable Raiders specialist showcased his impressive leg strength by connecting from both 40 and 51 yards while adding a pair of extra points. Though he missed an ambitious 58-yard attempt before halftime, Carlson's powerful leg remains a valuable fantasy asset. Heading into Week 2, he faces a Chargers defense that surrendered 21 points to the Chiefs offense, suggesting ample scoring opportunities should be available. While not an elite option, Carlson's proven accuracy and favorable matchup position him as a dependable low-end starting kicker for managers seeking consistency from their special teams slot this weekend.

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Las Vegas Raiders running back Zamir White has secured the No. 2 role behind rookie Ashton Jeanty, but his Week 1 usage was minimal. White played just 14% of offensive snaps and managed only eight yards on three carries, serving strictly in a relief role. The positive takeaway is that he has clearly distanced himself above Raheem Mostert on the depth chart, but with Jeanty handling 86% of the snaps and dominating touches, White's value is strictly that of a handcuff. Unless Jeanty misses time, there's little path to standalone fantasy relevance for White this season.

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Green Bay Packers wide receiver Jayden Reed (collarbone) is scheduled for surgery early next week. The hope is that he will be able to return this season, with the team looking at November as a possible timeline. Reed broke his collarbone making a touchdown grab on a play that was negated by a holding penalty. The play came on the Packers' opening drive and was Reed's first look in a game that ultimately saw seven other Green Bay pass catchers targeted. On a day that saw Jordan Love throw for nearly 300 yards and two scores, only tight end Tucker Kraft looked like a reliable option moving forward, with Romeo Doubs' fantasy day kept afloat by an early touchdown. With Reed now sidelined until at least mid-season, the silver lining could be added clarity amongst the Packers' pass catchers, but until rookie Matthew Golden can demonstrate an established chemistry with Love, Kraft will remain the only weekly start.

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Las Vegas Raiders running back Ashton Jeanty had a tough Week 1 against the Patriots, managing just 40 yards from scrimmage but salvaging his day with a three-yard touchdown run. Encouragingly, Jeanty dominated the backfield workload, logging 86% of snaps and handling 19 of the team's 22 rushing attempts, cementing himself as the clear lead back. Week 2 presents another challenge, as the Chargers limited the Chiefs to just 98 rushing yards in their opener. If Los Angeles sells out to stop the run the way New England did, the Raiders may lean more on Geno Smith and the passing game, potentially capping Jeanty's ceiling. Still, his elite usage keeps him firmly in the RB2 mix with touchdown upside.

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In his first career NFL game, rookie tight end Tyler Warren led the Colts in targets and receptions, chipping in 76 yards through the air. Impressively, his impact on Shane Steichen's offense went beyond the numbers he was able to put on the stat sheet. Michael Pittman Jr.'s 27-yard touchdown in the second quarter was the direct result of space created along the sideline when Dolphins' safety Ifeatu Melifonwu chose to carry Warren down the seam. In the running game, Warren at times looked like a 6th offensive lineman, clearing space for Jonathan Taylor, DJ Giddens, and Daniel Jones on a day where the Colts put up 156 yards on the ground. The Colts invested a first-round draft pick in Warren, and through one week, it appears they have a clear plan to run the offense through him. Week 1 was arguably the most successful game of the Shane Steichen era, and it should not be a surprise to see Warren rewarded for his dirty work with more fantasy-friendly opportunities.

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Detroit Lions wide receiver Kalif Raymond played ahead of rookie wideout Isaac TeSlaa in Week 1, recording two catches for 16 yards on three targets against the Green Bay Packers. That may not be the case in Week 2 against the Chicago Bears after TeSlaa's highlight-reel touchdown grab against Green Bay. Raymond has worked in a gadget/downfield role for the Lions over the past couple of seasons, which may not be as effective under new Detroit play-caller John Morton as it was under former offensive coordinator and current Bears head coach Ben Johnson. Raymond is an explosive player with the ball in his hands due to his speed, but he's not a fantasy-viable wide receiver unless the Lions suffer multiple injuries at the position.

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Detroit Lions rookie wide receiver Isaac TeSlaa only saw one target in Week 1, but he made it count with a highlight-reel, one-handed touchdown grab. Lions offensive coordinator John Morton said after the game that the team plans to get TeSlaa more involved going forward, which could start with Detroit's Week 2 matchup against the Chicago Bears. Between wide receivers Amon-Ra St. Brown and Jameson Williams, as well as tight end Sam LaPorta and running back Jahmyr Gibbs, the Lions still have multiple pass-catchers above TeSlaa in the pecking order for targets and touches. That makes TeSlaa more of a long-term stash in deep leagues than a viable fantasy starter at wide receiver in Week 2.

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Detroit Lions wide receiver Amon-Ra St. Brown was held in check by the Green Bay Packers in Week 1, recording four catches for 45 yards on six targets. As a player who typically does his best work out of the slot, St. Brown has an easier matchup on paper in Week 2 against the Chicago Bears, who could be without starting nickel corner Kyler Gordon (hamstring). The Lions could be without starting left tackle Taylor Decker (shoulder), which may incentivize quarterback Jared Goff to prioritize St. Brown as a short-area target. In eight career games against Chicago, St. Brown has recorded 46 catches for 515 yards and two touchdowns. He profiles as a must-start fantasy wide receiver in Week 2.

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Las Vegas Raiders quarterback Geno Smith (hamstring) practiced in full on Thursday and did not appear on the injury report ahead of a Week 2 matchup with the Chargers. Smith opened the year strong, finishing as the QB11 in standard formats after throwing for 362 yards while leading all quarterbacks in yards per completion (15.1). Chip Kelly's creative offense appears to be unlocking the best in Smith, positioning him as a steady low-end QB1/high-end backup option moving forward. This week's matchup offers upside, as the Chargers surrendered the 11th-most passing yards in Week 1, giving Smith a prime opportunity to exploit an underwhelming secondary.

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Detroit Lions wide receiver Jameson Williams was quiet in Week 1, hauling in four of five targets for just 23 receiving yards in his team's 27-13 loss to the Green Bay Packers. Williams will now face the Chicago Bears in Week 2, whom he recorded 10 catches for 171 yards and a touchdown against across two games last season. However, there's reason to think this Sunday could be a struggle for Williams. For one, Chicago is likely to get star corner Jaylon Johnson (calf/groin) back in the lineup after Johnson missed Week 1. Secondly, Detroit could be without starting left tackle Taylor Decker, which could speed up quarterback Jared Goff's time-to-throw and make it difficult for Williams to earn downfield targets. Williams still has big-play potential, but he profiles as a boom/bust low-end WR3/flex option in Week 2.

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Detroit Lions kicker Jake Bates held up his end of the bargain in Week 1 against the Green Bay Packers, nailing both of his field goal attempts and an extra-point try in his team's 27-13 loss. Bates will not have to worry about any potential weather issues in Week 2, as the Lions return home to the domed Ford Field to take on the Chicago Bears. Bates has more career points scored (21) against Chicago than any other NFL team. The Lions should also have an easier time moving the football and generating scoring opportunities against the Bears than they did against the Packers. Bates profiles as a low-end top-12 fantasy kicker in Week 2 against Chicago.

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Las Vegas Raiders rookie wide receiver Dont'e Thornton Jr. was quiet in the team's Week 1 win over New England, logging just two catches on four targets for 45 yards while playing 60% of the snaps. Encouragingly, he drew more targets than Tre Tucker despite fewer snaps, and the Raiders leaned on the passing game as Geno Smith threw for 362 yards. With Chip Kelly determined to stretch the field, Thornton's speed keeps him in play as a stash with big-play potential. The Week 2 matchup adds intrigue, as the Chargers just allowed the 10th-most fantasy points to opposing wide receivers in Week 1, giving Thornton an outside chance to make noise if he sees increased usage. Until his role grows, he's best kept on benches, but the upside is worth monitoring.

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Cleveland Browns rookie second-round running back Quinshon Judkins is officially listed as questionable to make his NFL debut in Week 2 versus the division-rival Baltimore Ravens on Sunday, according to Tony Grossi. The Browns think Judkins is in good shape, but the 21-year-old practiced with the team on Thursday for the first time since mandatory minicamp in the spring due to a domestic-violence incident. Even if Judkins is active on Sunday, he'll likely work as the team's RB3 behind Jerome Ford and fellow rookie Dylan Sampson, making him one to fade in all fantasy formats. Although nothing is official yet, there are rumblings that the NFL could come down hard on Judkins and suspend him for two to four games, even though he wasn't formally charged in his domestic-violence case. The Browns have until Saturday afternoon to officially activate him and put him on the 53-man roster.

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Las Vegas Raiders wide receiver Jakobi Meyers cemented himself as the offense's most reliable option in Week 1, drawing 10 targets and converting eight into 97 yards. As the veteran presence in a young receiving corps, Meyers has quickly earned the trust of Geno Smith, thriving as a chain-mover while Tre Tucker and Dont'e Thornton Jr. stretch the field vertically. His high-volume role makes him a consistent fantasy asset, and if Brock Bowers (knee) is sidelined, Meyers could see an even larger workload as the Raiders lean on his reliability. Ranked as RotoBaller's WR22 for Week 2, Meyers should be locked into starting lineups across all formats.

From RotoBaller

Detroit Lions tight end Sam LaPorta was one of the few Lions who delivered a decent fantasy performance in Week 1, hauling in six of his nine targets for 79 yards against the Green Bay Packers. LaPorta will now face the Chicago Bears in Week 2, a team he has scored three touchdowns against in four career games played. Chicago allowed just three catches and 15 yards to Minnesota Vikings tight end T.J. Hockenson in Week 1. LaPorta's Lions have health and productivity questions along their offensive line, but that could actually help LaPorta's outlook by forcing Jared Goff to target the short and intermediate areas of the field more often. LaPorta is a must-start fantasy tight end against Chicago in Week 2.

From RotoBaller

Detroit Lions quarterback Jared Goff averaged just 5.8 yards per pass attempt in Week 1 against the Green Bay Packers. He was also sacked four times, and could now be without starting left tackle Taylor Decker (shoulder) in Week 2. Goff does have an easier matchup on paper this Sunday against the Chicago Bears, whom he torched for 523 passing yards and five touchdowns across two games in 2024. However, particularly if Decker cannot play, Detroit's offensive line looks significantly worse in 2025 and may prevent Goff from consistently pushing the ball downfield. He profiles as a mid-tier fantasy QB2 in Week 2 against the Bears.

From RotoBaller