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Wide receiver Kendrick Bourne signed a one-year deal with the San Francisco 49ers on September 9, returning to the team that gave him his start in the NFL in 2017. The signing was in light of injuries sustained in Week 1 by key pass catchers George Kittle (hamstring), who is now on injured reserve, and Jauan Jennings (shoulder), who is questionable for Week 2. Quarterback Brock Purdy (toe, shoulder) is also dealing with injuries and has been ruled out for Sunday's game against the Saints. Taking over the offense will be Mac Jones, who was Bourne's teammate for three years in New England, from 2021 to 2023. Bourne should not be in starting lineups but could be a bench stash in deeper leagues in case he shows renewed chemistry with Jones, given Purdy might be facing a multi-week absence.

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San Francisco 49ers wide receiver Skyy Moore stands little chance of making an impact in Week 2, despite the injury bug biting key players on offense. Even though tight end George Kittle (hamstring) is on injured reserve and wide receiver Jauan Jennings (shoulder) is questionable for Sunday's game against the Saints, veterans Marquez Valdes-Scantling and Kendrick Bourne stand in Moore's way on the depth chart. Moore played just three snaps in Week 1, and even if he does see a greater run on Sunday, the offense will be helmed by Mac Jones and not Brock Purdy (toe, shoulder), who has been ruled out. Moore's only path to fantasy relevance is in leagues that count return yards. Last week against Seattle, he fielded one kickoff and four punts, totaling 63 return yards.

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San Francisco 49ers wide receiver Marquez Valdes-Scantling saw zero targets on 15 routes run in Week 1. With George Kittle (hamstring) now on injured reserve and Jauan Jennings (shoulder) tagged as questionable for San Francisco's Week 2 matchup against the Saints, it is possible that Valdes-Scantling plays a bigger role on Sunday. Unfortunately, Brock Purdy (toe, shoulder) has been ruled out so it will be Mac Jones under center, limiting Valdes-Scantling's upside even if he does see more playing time. MVS does have the ability to stretch the field but Jones' career completion rate on passes of 20 or more air yards is a mere 30%, effectively negating that threat. If it were Purdy running the show, Valdes-Scantling would have more potential but as it is, he has little viability in Week 2.

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New York Giants kicker Graham Gano is a possible fantasy option for Week 2 against the Dallas Cowboys, depending on your league. Gano was responsible for all six of the Giants' points in Week 1, making both of his field goal attempts, including a long of 52 yards, for 8 fantasy points. This puts him in a decent position among fantasy kickers, especially since he has a 100% field goal percentage so far. His opportunities for scoring could increase against a Dallas team that gave up 11 fantasy points to kickers in Week 1 of the 2025 season. Given the Giants' offensive struggles and Gano's reliable leg, he should be considered for Week 2.

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New York Giants quarterback Jaxson Dart is not a recommended fantasy option for Week 2 against the Dallas Cowboys, as he is not expected to play. Although the rookie first-round draft pick has impressed in the preseason and is the team's QB2, head coach Brian Daboll has publicly stated that Russell Wilson will remain the starter for Sunday's game. There is some speculation that Dart could see action if Wilson struggles, but given that he has no regular-season statistics for 2025, his fantasy outlook is entirely dependent on an in-game change. Therefore, Dart should be left on the bench or waiver wire for this matchup.

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New York Giants tight end Theo Johnson is not a recommended fantasy start for Week 2 against the Dallas Cowboys. He was the TE49 in fantasy football for Week 1, securing just one of his three targets for five receiving yards and one fantasy point. This meager production, despite dominating the tight-end snaps with 46, makes him an unreliable option. Furthermore, the Cowboys' defense was a difficult matchup for tight ends in 2024, ranking second in the league by allowing only 7.66 fantasy points per game to the position. Given the tough matchup and Johnson's minimal usage and production in Week 1, he should be left on the bench in all formats.

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New York Giants running back Cam Skattebo is not a recommended fantasy start for Week 2, despite facing a favorable matchup. Skattebo was the RB58 in Week 1, with a minimal role, receiving only two carries for -3 yards and two receptions for 12 yards, totaling just 1.9 fantasy points on an 11.8% timeshare. While the Dallas Cowboys' defense was the 23rd-ranked fantasy defense against running backs in 2024 and gave up 158 rushing yards in Week 1, Skattebo is simply not seeing the volume to capitalize on the opportunity. His primary role appears to be as a depth and short-yardage option behind Tyrone Tracy Jr., which severely caps his fantasy upside.

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Despite heading to the medical tent twice, New Orleans Saints wide receiver Chris Olave led the team with 13 targets, turning them into seven receptions for 54 yards in Sunday's loss to the Arizona Cardinals. Kellen Moore's offense appeared aggressive, as quarterback Spencer Rattler attempted a career-high 46 passes in Week 1. This bodes well for the fourth-year receiver, who looks poised to become a go-to target in the pass-heavy attack. Olave should have plenty of opportunities to build chemistry with Rattler and, as long as he remains healthy, projects as a borderline WR2/WR3 this week against the San Francisco 49ers.

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New Orleans Saints wide receiver Rashid Shaheed was the team's third-most productive pass catcher in Week 1 against the Arizona Cardinals, finishing with six receptions for 33 yards on nine targets. His longest catch was just 17 yards, but his speed and explosiveness give him real big-play potential. With Kellen Moore's offense passing aggressively, Shaheed could turn his volume into a breakout performance and projects as a WR4 with upside this week against the 49ers.

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New York Giants running back Tyrone Tracy Jr. had a lackluster Week 1, but his fantasy outlook improves considerably heading into a favorable Week 2 matchup against the Dallas Cowboys. As the RB39 in Week 1, Tracy managed only 4.5 fantasy points with 24 rushing yards and 11 receiving yards, but he dominated the backfield with a 66.2% timeshare. This heavy workload, combined with the Cowboys' defensive struggles against the run, makes him an intriguing play. Dallas allowed a whopping 158 rushing yards in Week 1, the fifth-most in the NFL, and was the 23rd-ranked fantasy defense against running backs last season, giving up 22.67 fantasy points per game. Given the potential for a high-volume day, Tracy has a chance to deliver RB2 numbers.

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New Orleans Saints kicker Blake Grupe went 2-for-3 on field goals and 1-for-1 on extra points in the Week 1 loss to the Arizona Cardinals. His only miss came in the third quarter on a 37-yard attempt following a 14-play drive, while he converted from 36 and 28 yards. Grupe is a reliable kicker, but the Saints' offense, led by quarterback Spencer Rattler, may struggle to move the ball consistently. He ranks 21st among kickers on RotoBaller this week.

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New Orleans Saints quarterback Spencer Rattler went 27-of-46 for 214 yards with no touchdowns in Week 1 against the Arizona Cardinals, adding 29 rushing yards on four attempts. Despite the volume, his 4.7 yards per pass attempt was inefficient, and the 46 throws marked a career high. He faces a tough matchup at home against the San Francisco 49ers, who allowed just 150 passing yards to Sam Darnold and the Seahawks in Week 1. Rattler remains off fantasy radars for Week 2 and will need a more efficient showing to keep his starting role.

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New York Giants quarterback Russell Wilson had a tough Week 1, but he has an encouraging fantasy outlook heading into his Week 2 matchup against the Dallas Cowboys. Wilson was the QB23 in fantasy after mustering only 12.8 fantasy points against the Commanders, throwing for 168 yards and zero touchdowns. However, the Cowboys' defense allowed 24.4 fantasy points to Jalen Hurts in Week 1 and was the 32nd-ranked fantasy defense against quarterbacks last year, giving up 19.6 fantasy points per game. Wilson's 44 rushing yards in the opener, combined with the Cowboys allowing 62 rushing yards and two rushing touchdowns to Hurts, suggest he has a solid floor and a potential for a major bounce-back performance in this favorable matchup.

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New Orleans Saints running back Alvin Kamara rushed 11 times for 45 yards and one touchdown in Week 1 against the Arizona Cardinals. Surprisingly, he saw limited action in the passing game despite Spencer Rattler's career-high 46 pass attempts, catching just two targets for 12 yards. Despite this, Kamara showed he still has plenty left in the tank. He looks poised to be effective again against the San Francisco 49ers in Week 2 and should see an increased workload as a pass-catcher. He remains a high-upside RB2 this week.

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New Orleans Saints running back Kendre Miller saw limited action in Week 1 but made the most of it, rushing five times for 24 yards. The Saints ran the ball just 22 times while Spencer Rattler threw 46 passes, and Miller was on the field for only 11 offensive snaps. Rookie Devin Neal, who played seven snaps and carried the ball twice, could further limit Miller's role. While he showed flashes of explosiveness against the Cardinals, the Saints' likely pass-heavy approach means Miller can remain on waivers until his usage increases.

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San Francisco 49ers running back Brian Robinson Jr. may see an uptick in usage when the team faces the Saints on Sunday. With quarterback Brock Purdy (toe, shoulder) out, wide receiver Jauan Jennings (shoulder) questionable, and tight end George Kittle (hamstring) on injured reserve, San Francisco is short on playmakers. In Week 2, San Francisco may prefer to grind things out on the ground now that Mac Jones is under center. If that's the case, Robinson should mix in regularly in order to avoid overworking Christian McCaffrey (31 touches in Week 1). Robinson projects as an RB4 in Week 2. While he is not a must-start, he is a viable flex in deeper leagues and should be rostered in most leagues.

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The Philadelphia Eagles just traded for Tank Bigsby on Monday, and the former Jaguar is currently listed as the third running back on the depth chart. He was far outpaced by Travis Etienne Jr. in Jacksonville's first game, and was splitting touches with Bhayshul Tuten as well. Bigsby only managed 12 yards on five carries against the Panthers in Week 1, which clearly didn't impress the Jaguars front office enough to keep him on the roster. Eagles backup RB Will Shipley (rib) is officially out for the upcoming contest against Kansas City, clearing the runway a bit for Bigsby, but probably not enough for any real fantasy production. Shipley and AJ Dillon combined for 13 snaps on offense against Dallas last week, while Saquon Barkley totaled 50. With a star like Barkley ahead of him, Bigsby should not be considered for lineups in Week 2.

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Philadelphia Eagles wide receiver A.J. Brown had fantasy managers second-guessing whether they should have taken him so high in their drafts with his performance against the Cowboys, hauling in just one catch for eight yards on one target. However, with the Chiefs on the horizon in Week 2, Brown looks to cement his spot once again as the top wideout in Philly's offense. Kansas City allowed four players to achieve 50 or more receiving yards last week against the Chargers, and Brown caught a touchdown last time he faced off against this defense in Super Bowl LIX. He's due for a bounceback showing, and despite his lack of looks in Week 1, Brown is still a WR1 in fantasy.

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Eagles wide receiver DeVonta Smith fell victim to a strange week for the Philadelphia passing game against the Cowboys, being targeted just three times for three catches and 16 yards. Saquon Barkley and Dallas Goedert led the team in targets in Week 1, and Jahan Dotson had the most receiving yards in what was a bit of an anomaly. Philly will likely get back to their normal ways eventually, which favors Smith in this upcoming contest against the Chiefs as the Eagles' typical second option in the passing game. In their Super Bowl LIX clash, Smith led his team in receiving yards (69) and caught a touchdown against Kansas City. He's a player that's known to be up-and-down in fantasy, so managers have to bank on this being an up week for Smith in a favorable matchup-especially with Goedert (knee) being unavailable. The Chiefs let the Chargers pass all over them last Friday, so Smith is a solid WR2 for Week 2 in hopes that his offense can do something similar.

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Philadelphia Eagles rookie wide receiver Darius Cooper failed to get any targets in the opening game of the season against the Cowboys. While Cooper did have a solid preseason showing against the Bengals, he was bound to struggle for looks in the regular season with the amount of talent surrounding him. He is currently listed as the fifth wideout on the Philly depth chart and was on the field for only two offensive snaps in Week 1. In an upcoming faceoff against the Chiefs, this undrafted rookie will likely have a similar workload. Cooper isn't worth looking at in fantasy for Week 2.

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