Buffalo Bills tight end Dawson Knox will be atop the depth chart on Sunday night when the team hosts the San Francisco 49ers. Starter Dalton Kincaid (knee) will be inactive for the second consecutive game. Knox logged a season-high mark in targets (six) and receptions (four) for 40 yards in place of Kincaid before the team's bye week. The 49ers are the sixth-best defense against fantasy football tight ends this season. With all 32 teams in action, Knox is outside of streaming consideration.

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Buffalo Bills running back Ray Davis has remained in a reserve role since Week 6 but holds value as a bench stash entering Week 13. The rookie only averaged five touches per game over the last four contests. If anything happens to starter James Cook, Davis would be the most valuable waiver-wire addition. Fantasy managers, especially those rostering Cook, can get ahead by adding Davis to benches. He should not be started against the San Francisco 49ers.

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San Francisco 49ers wide receiver Deebo Samuel Sr. will attempt to break out of a four-game touchdown-less slump when the team goes to Buffalo to face the Bills in Week 13. The sixth-year pro's performance in Green Bay last week was ugly. Samuel Sr. was targeted four times by backup quarterback Brandon Allen, catching only one pass for 21 yards. Two of those unfulfilled targets should have been caught. He had no rushing attempts. Amid speculation that Samuel Sr. is looking a little "thicker" lately, his most explosive play in recent memory was an 87-yard kick return at Lambeau called back for holding. It could be rough-going again in a loud, cold, and maybe snowy Orchard Park, as the Bills have allowed the eighth-fewest half-PPR points to opposing wide receivers. Significantly, San Francisco's offensive line is banged up, with All-Pro left tackle Trent Williams (ankle) set to miss a second-straight game and starting left guard Aaron Banks (concussion) also out. Still, Samuel Sr. likely offers at least a modest rebound from last week with starting quarterback Brock Purdy (shoulder) expected to play. Samuel Sr. is a WR3/FLEX this week, with a downgrade to WR4 if Purdy can't go.

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Los Angeles Rams running back Kyren Williams began the year by recording at least one touchdown in seven straight contests. However, after not scoring in meetings with the Seahawks, Dolphins, and Patriots, the 24-year-old finally got back in the end zone in the Week 12 loss to the Philadelphia Eagles. With Puka Nacua and Cooper Kupp healthy, Williams has a lot less on his plate. Still, he will remain involved. Although Williams' success for fantasy managers is often contingent on whether he runs it in for six points, his outlook is promising for Sunday's matchup versus a Saints defense that has allowed 12 rushing touchdowns during the 2024-25 campaign, the third-worst mark in the NFL. Keep him starting in Week 13.

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Los Angeles Rams wide receiver Cooper Kupp is coming off another strong performance, catching eight of his 11 targets for 60 yards and a touchdown in the Week 12 loss to the Eagles. Although he missed time this season due to injury, he's been relatively consistent in most of his appearances during the 2024-25 campaign. With a favorable matchup on the horizon versus a Saints defense that has surrendered nearly 2,000 yards to opposing wideouts this season, the fifth-worse mark in the NFL, Kupp's ceiling is higher than usual.

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Los Angeles Rams wide receiver Puka Nacua has been on a roll. Although the 23-year-old only has one touchdown this season, he's combined for 25 catches for 338 yards in his previous three appearances. Without question, Matthew Stafford should continue to look in his direction in the Week 13 showdown against New Orleans, and his outlook is more promising than normal versus a Saints defense that has allowed 1,959 yards to opposing receivers this season, the fifth-worst total in the National Football League.

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Buffalo Bills wide receiver Amari Cooper (wrist) does not carry an injury designation into the weekend after fully participating in practice all week. His route participation may increase against San Francisco. He's been a part-time player since his arrival in Buffalo before Week 7 but had the bye week to better acclimate to the Bills system. Fellow outside wide receiver Keon Coleman (wrist) will be inactive. However, the San Francisco pass defense is above average against fantasy football wide receivers. Sunday Night Football also has weather concerns (snow, wind). Cooper is considered a risky start in Week 13.

From RotoBaller

Buffalo Bills quarterback Josh Allen enters Week 13 as a model of consistency for fantasy football. He's scored at least 20 fantasy points in six straight games and is the QB5 in fantasy points per game this season. In Week 13, the Buffalo Bills host the reeling San Francisco 49ers. The defense is generally strong against quarterbacks but there are injuries to a few key players, including All-Pro pass rusher Nick Bosa. There's a chance of snow in the forecast, which could hamper offensive production. Nevertheless, Allen has been too good to fade and should be in all starting lineups this weekend.

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Buffalo Bills running back James Cook projects to see plenty of usage on Sunday night against the San Francisco 49ers. The 49ers are fairly weak against fantasy football running backs this season, allowing the 10th-most points per game. Most recently, Josh Jacobs ran for 106 yards and three touchdowns against them. Cook can beat defenses on the ground or through the passing game. With the potential for hazardous weather in Buffalo, Cook may hear his name called more often. He's ranked as a high-end RB2 in Week 13.

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Los Angeles Rams quarterback Matthew Stafford has played well in the last month. After tossing only three touchdowns in the Rams' first six games of the 2024-25 campaign, the 36-year-old signal-caller has 12 in the last five contests. Los Angeles needs some wins to keep the team's postseason hopes alive. Fantasy managers will likely see Stafford extra-motivated in Sunday's meeting with the Saints, and he'll have a good chance to produce versus a New Orleans defense that has allowed 23.6 points per game this season, one of the worst marks in the National Football League. With that in mind, Stafford deserves consideration in all fantasy formats, although he's a must-start in two-QB setups.

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Buffalo Bills wide receiver Khalil Shakir has five straight games with at least six receptions as the slot receiver for quarterback Josh Allen. He has 18 more catches than the next Buffalo Bill. As Allen's go-to receiver, Shakir ranks as a WR3 against San Francisco. However, the 49ers are one of the best defenses against slot receivers this season. Plus, Shakir hasn't scored a touchdown since Week 3. Shakir should still see plenty of targets but there are some reasons to be concerned about him matching his typical stat line.

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San Francisco 49ers wide receiver Jauan Jennings faces the Bills in Orchard Park for Week 13's Sunday night matchup. Last week in Green Bay -- and catching passes from backup quarterback Brandon Allen -- Jennings led the 49ers in targets with seven, finishing with five receptions for 40 yards. Fortunately, starter Brock Purdy (shoulder) is expected to play in Buffalo, but the encouraging news ends there. Buffalo's pass defense has been the eighth-toughest on fantasy wide receivers and should have a nice home-field advantage as a significant winter storm is expected to bleed into the first quarter. Most significantly, San Francisco will be missing All-Pro left tackle Trent Williams (ankle) and starting left guard Aaron Banks (concussion). Consider Jennings a risky WR3/FLEX with a significant downgrade into WR4 territory if Purdy is held out again.

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Dynasty | Dolphins tight end Jonnu Smith had ten catches for 113 yards in the Dolphins loss to the Packers on Thanksgiving. Dynasty Analysis: There have been a lot of disappointments on the Miami roster this year, but Smith hasn't been one of them. He now has 25 catches on 30 targets for 301 yards and three touchdowns over the past three weeks, making him a must-start TE1 moving forward. With career highs in catches and yards already, Smith's dynasty value is on the rise, despite him being 29.

From Dynasty League Fantasy

San Francisco 49ers running back Christian McCaffrey is in Buffalo for a Week 13 contest against the Bills on Sunday night. The 2023 touchdown machine has not been himself on the ground since returning from double-Achilles tendinitis three weeks ago, averaging a career-low 3.5 yards per carry. Shockingly, McCaffrey has been held out of the end zone as well. McCaffrey's involvement in the passing game has been steady though, garnering 5.3 targets per game which is right in line with last year's average. Still, fantasy managers hope that Week 12's 6.3 half-PPR dud is the nadir, and there is nowhere to go but up. Besides CMC's obvious track record, there are reasons for hope. First, Buffalo has allowed the fourth-most half-PPR points to opposing running backs. Also, quarterback Brock Purdy (shoulder) is expected to be back, increasing the efficiency of the Niners' offense. However, San Francisco will again be without legendary left tackle Trent Williams (ankle) and left guard Aaron Banks (concussion) who was ruled out in the fourth quarter against Green Bay. The injuries on the line, plus speculation that McCaffrey is not yet at his sharpest, have him as a low-mid RB1 in Week 13.

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Las Vegas Raiders kicker Daniel Carlson nailed two extra points and a field goal of 27 yards, but missed on tries of 55, 56, and 58 yards in a loss to the Kansas City Chiefs on Black Friday. The normally sure-footed kicker stumbled on what turned out to be three separate occasions to add to what would have been an eventual lead, as the Raiders lost 17-19. Ultimately, he didn't have a chance at redemption, as Las Vegas turned the ball over to the Chiefs on a bizarre early snap that turned into a fumble that Kansas City recovered. Still, Carlson will remain the starter, and if he can get back on track, his outlook against a weak Tampa Bay Buccaneers defense could be better in Week 14. The Raiders offense looks much better with O'Connell leading the show, and that could lead to more consistent field goal opportunities for the veteran placekicker.

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Las Vegas Raiders wide receiver Tre Tucker caught just one pass in his team's Week 13 loss to the Kansas City Chiefs, but he made the most of it. On his big play, he streaked across the middle of the field before turning vertical and sped up the sideline, tracking down a moon ball from quarterback Aidan O'Connell and outracing the defender before being tackled and getting the ball into the end zone. He also had one rush for 11 yards. It's not encouraging to see Tucker only targeted one time, though. For fantasy purposes, it would be better to see him more involved, but he's usually the third and sometimes just the fourth option in the passing game. It seems like WR Jakobi Meyers and tight end Brock Bowers are the only two reliable pass-catchers on this team. Tucker will face a porous Tampa Bay Buccaneers secondary in Week 14, though. That could afford him more opportunities for big plays, but it's still too risky to start him in all but the deepest of fantasy football leagues.

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Las Vegas Raiders running back Ameer Abdullah rushed 10 times for 39 yards and caught two passes for 14 yards in his team's Week 13 loss to the Kansas City Chiefs. However, it was in the return game that his presence was most felt, as he logged punt returns of 12 and 18 yards and returned a kickoff 68 yards, leading to a drive that started on the Chiefs 26-yard line. That resulted in a touchdown. Despite the loss, Abdullah impressed as a returner, and may have earned a larger role in that area moving forward. At 31 years old, he still has some juice. Fantasy-wise, though, he didn't have a huge day, and RB Alexander Mattison (ankle), the starter, could return in Week 14, making Abdullah's value extremely questionable as anything more than a handcuff.

From RotoBaller

Las Vegas Raiders wide receiver Jakobi Meyers again had a big day for fantasy managers in Week 13. He caught six of his 11 targets for 97 yards, scoring 15.7 PPR fantasy points. He continues to beat coverages handily with his crisp route running and excellent separation ability. While he wasn't able to haul in nearly half of his targets, he showed chemistry with quarterback Aidan O'Connell, who appears to be a clear upgrade over QB Gardner Minshew II (collarbone). Moving forward, Meyers cannot be benched in PPR fantasy leagues. He's one of the most underrated players at his position in the league, and with tight end Brock Bowers playing at such a high level, defenses are struggling with coverage assignments. Meyers is an easy WR1/WR2 with plenty of upside heading into a Week 14 matchup with the Tampa Bay Buccaneers. They could have a bottom-5 pass defense after dealing with injuries in the secondary.

From RotoBaller

The Jacksonville Jaguars present a great slump-busting chance for Houston Texans quarterback C.J. Stroud, who is a fringe QB1 candidate in the Week 13 matchup. Last year's Offensive Rookie of the Year has been a fantasy disappointment relative to where he was drafted, throwing just 14 touchdowns and ranking behind the likes of Sam Darnold and Bo Nix. To the credit of the second-year quarterback, a poor pass-protecting offensive line that has allowed more yardage lost to sacks than anyone in the NFL certainly has been a major factor. The Jags, however, rank 32nd against fantasy quarterbacks, allow the fourth-most air yards, second-most yards after catch, and have the second-worst pressure percentage in the league. This week is a prime candidate for Stroud to turn things around.

From RotoBaller

Barring anything highly unexpected, Las Vegas Raiders rookie tight end Brock Bowers cemented himself as the single-best player at his position in the league with a monster performance, catching 10 of his 14 targets for 140 yards and a touchdown in Week 13 in a loss to the Chiefs on Black Friday. Like many other defenses, the Kansas City Chiefs had no answer for his ridiculous skillset. He can run routes like a wide receiver, can shake defenders out of their shoes, has excellent hands and football IQ, and is a matchup nightmare one-on-one with any defender in the league. He's an elite fantasy TE1 and will probably finish as this year's TE1 while putting up WR1 numbers. At this rate, he could be a first-round pick in next year's fantasy drafts. He'll face the Tampa Bay Buccaneers in Week 14. Expect more dominance from the Raiders' brightest star.

From RotoBaller