Buffalo Bills wide receiver Amari Cooper (wrist) has been tagged as questionable ahead of the Week 10 matchup against the Indianapolis Colts. The veteran wideout was unable to play last week due to the wrist issue, but appears to be trending towards playing this weekend. Cooper has been limited in practice all week, but that might just be the Bills being cautious with him. The Bills are already going to be without Keon Coleman (wrist) which means Cooper should have a bigger role. If active, Cooper should be a fine WR3 for this Week 10 matchup.

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The Los Angeles Chargers defense is projected to be one of the top defensive units in fantasy football for Week 10. The Bolts will take on the Tennessee Titans, who will have quarterback Will Levis returning to the starting lineup. In his five games this season, Levis has thrown five touchdowns and seven interceptions. The Chargers defense has finished as a top-three fantasy defense in both of the past two weeks, and they have a good chance to end up in or near that tier once again this time around. Start them with confidence as a high-floor and even higher-ceiling DST.

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Los Angeles Chargers kicker Cameron Dicker is a solid fantasy option for a Week 10 matchup against the Tennessee Titans. Dicker has been about as consistent as fantasy kickers can be this season, scoring double digit fantasy points in four of the Chargers' eight games, peaking with 21 points in Week 7. This week, he faces a Tennessee Titans team that has been very generous to opposing fantasy kickers. With the Chargers offense expected to do well in this game, Dicker should be given at least a few chances to kick. He's a top-10 option at fantasy's least projectable position.

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Philadelphia Eagles wide receiver DeVonta Smith (hamstring) said on Friday that he'll be fine for the Week 10 matchup against the Dallas Cowboys. Smith appears to have suffered a minor hamstring injury during last week's win over the Jacksonville Jaguars. He was a non-participant during Wednesday's practice before getting in a limited session on Thursday. Smith doesn't seem to be worried about the injury, so fantasy managers should expect to see him out there. He can be plugged in as a solid WR2 for this divisional matchup with Dallas

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Los Angeles Chargers tight end Will Dissly is unlikely to make a significant fantasy impact in a Week 10 game against the Tennessee Titans. Dissly was heavily involved in the Chargers passing game between Weeks 6 and 8, drawing 23 targets across the three games, but that was mostly due to other Chargers pass catchers missing time with injuries. In Week 9, with several pass catchers returning, Dissly saw just three targets and made two catches for a total of nine yards. He has yet to score a touchdown this season and shouldn't be relied upon as anything more than a non-zero floor tight end option. Most leagues will likely have at least one higher upside option on the waiver wire for this week.

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Arizona Cardinals quarterback Kyler Murray is valued as a mid-tier QB1 when the Cardinals host the New York Jets in Week 10. Murray delivered a quiet fantasy outing last week in the 29-9 victory over the Chicago Bears, but that shouldn't concern fantasy managers, as he is still playing his best football of the season recently. The Cardinals took an early lead and shifted to a run-first approach en route to victory, which was the primary contributor to Murray's low fantasy output. However, the Cardinals are currently underdogs to the Jets, and a closely contested matchup will likely lead to higher fantasy numbers for Murray. The Cardinals' offensive line has been great in pass protection and will be equipped to handle the Jets' solid pass rush. There is no reason to bench Murray heading into the Week 10 matchup against the Jets.

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Carolina Panthers running back Jonathon Brooks (knee) was recently activated off the reserve list. The rookie back hasn't played this season while he recovers from an ACL tear he suffered in college. Brooks was able to get through three full practice sessions this week. That is good news heading into the Week 10 matchup against the New York Giants. The Panthers are listing Brooks as questionable for this weekend, but three full practices is a good sign that he'll play. He figures to be the primary backup to Chuba Hubbard for now. That being said, Brooks probably won't be a reliable fantasy option out of the gate, but should earn a bigger role as the season goes on.

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Kansas City Chiefs wide receiver JuJu Smith-Schuster (hamstring) has been ruled out ahead of the Week 10 matchup against the Denver Broncos. The veteran wideout will now miss his third game in a row due to a lingering hamstring issue. Smith-Schuster was unable to practice all week, so the fact he has been ruled out shouldn't come as a surprise. His role is likely to decrease in the offense once he is back to full health. DeAndre Hopkins has stepped up and become the No. 1 wideout for this offense. Also, Xavier Worthy is still going to be involved, so Smith-Schuster is unlikely to be reliable once he does return.

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Atlanta Falcons quarterback Kirk Cousins has thrown for 498 yards and seven touchdowns with no interceptions over his last two games, but in Week 10 the 36-year-old will take on the Saints, a team who held him to 238 yards passing, zero touchdowns, and one interception back in Week 4. That contest was at home, this one will be on their divisional foe's turf. Be that as it may, this time around the Saints will be without Paulson Adebo (leg), who led the team in tackles in that Week 4 matchup, and without 4x Pro Bowler Marshon Lattimore after he was traded to the Commanders this past week. If Drake London (hip) suits up, the Falcons will have a full complement of receivers. Working against Cousins is the fact that the Saints just allowed Carolina's Chuba Hubbard to run for 72 yards and two scores last week, so the run game may get a boost in this matchup. Nevertheless, the veteran signal caller projects as a back-end QB1 and is a viable bye week filler for Jordan Love and Geno Smith managers.

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Atlanta Falcons tight end Kyle Pitts (hamstring) has been upgraded to a full participant ahead of the Week 10 matchup against the New Orleans Saints. Pitts was limited on Wednesday and Thursday, but a full session on Friday means he should be ready for this weekend. The young tight end posted four straight games of 65 receiving yards or more before his 11-yard dud against the Dallas Cowboys last week. Fantasy managers should expect a bounce back outing this weekend. Pitts should be on the fantasy radar as a TE1 for Week 10.

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Atlanta Falcons wide receiver Drake London (hip), who suffered a hip pointer in the Week 9 win over the Dallas Cowboys, was limited in practice all week and is officially listed as questionable to suit up on Sunday against the division-rival New Orleans Saints in Week 10. London could be a true game-time decision this weekend, but the good news for fantasy managers is we'll know early on Sunday as to whether the 23-year-old will play. If active, he should be put back into starting fantasy lineups as the team's top wideout. If London misses the contest against New Orleans, both Darnell Mooney and Ray-Ray McCloud III will be more attractive flex plays with upside against a Saints defense that just traded top cornerback Marshon Lattimore to the Commanders. In addition to Mooney and McCloud, tight end Kyle Pitts should see more volume as he looks to bounce back from a poor showing in Week 9.

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The New York Giants listed kicker Graham Gano (hamstring) as questionable for their Week 10 game in Germany this Sunday against the Carolina Panthers after he was limited in practice. Gano is eligible to be activated from Injured Reserve and kick this weekend, but the Giants have yet to officially make the move. The 37-year-old veteran kicker has been sidelined due to a right-hamstring injury since Week 2, so he'll be a pretty risky fantasy option if he's activated on Saturday and plays this Sunday. If the G-Men decide to wait another week on Gano, expect Jude McAtamney to kick for the team again against Carolina. Whenever Gano does return, he'll merely be a deep-league streaming option at the position. In the first two games of the year before getting injured, Gano made both of his field-goal tries and didn't attempt an extra point.

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Los Angeles Chargers wide receiver Joshua Palmer remains a risky fantasy option in Week 10 against the Tennessee Titans. Palmer scored his first touchdown of the season in Week 9, but ended up totaling just two catches on four targets. That seems to be the role Palmer has settled into in this Chargers offense. He could occasionally come up with big plays but it won't be consistent enough to make him a reliable fantasy option. With D.J. Chark (groin) expected to return this week, Palmer could have even more competition in the passing game going forward.

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Tennessee Titans quarterback Will Levis (shoulder) will return as the starter for the Week 10 contest on the road against the Los Angeles Chargers, according to head coach Brian Callahan. The writing was on the wall for Levis to return to action this weekend after he returned to a full practice participant on Thursday. A sprained AC joint in his right throwing shoulder kept Levis out of action for the team's last three games. With the 25-year-old returning under center against LA, Mason Rudolph will revert to the backup role in Tennessee. Levis is going to need to play better down the stretch to avoid being benched for Rudolph, though. The former second-round pick last year out of Kentucky completed 66.4% of his passes for 699 yards, five TDs and seven picks in his five starts in 2024 while making lots of questionable decisions that led to game-changing turnovers. He's a low-end QB2 in Week 10 against the Bolts.

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Tennessee Titans running back Tyjae Spears (hamstring) is "trending in the right direction" to play in Week 10 versus the Los Angeles Chargers, according to FOX Sports' Ben Arthur. Spears has been sidelined for each of the team's last three games due to a hamstring injury, but he's on track to return this Sunday on the road after returning to a full practice session on Thursday. In addition, lead back Tony Pollard (foot) was downgraded from a full-go on Wednesday to limited on Thursday, so he could be in danger of missing Sunday's game. The Titans already said they'd like to limit Pollard's workload after he saw a season-high 31 touches in last week's overtime loss to the New England Patriots. Spears will probably be an RB3/flex, at best, in fantasy in a tough matchup if both he and Pollard are active. But if Pollard is out, Spears will become a plug-and-play option in fantasy.

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Cincinnati Bengals quarterback Joe Burrow (arm) is dealing with some soreness after he was hit hard a few times in the 35-34 Thursday night loss to the division-rival Baltimore Ravens, according to head coach Zac Taylor. Burrow was seen wincing when trying to move his left arm on the sidelines on Thursday evening after taking a few hard hits, but he never came out of the game and had another fantastic performance for his fantasy managers in the one-point loss, throwing for a season-high 428 yards on a season-high 56 pass attempts while tossing four touchdown passes and no interception. The former first overall pick out of LSU appears to be hitting his stride in the middle of the season and has now gone 61-for-95 for 679 passing yards, nine TDs and one interception the last two weeks. He'll be a no-brainer TE1 in Week 11, albeit in a tough matchup against the Los Angeles Chargers.

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Indianapolis Colts wide receiver Michael Pittman Jr. (back) has officially been ruled out for the Week 10 contest on Sunday versus the visiting Buffalo Bills after missing practice all week, according to head coach Shane Steichen. Pittman has been battling a back injury in recent weeks but hasn't missed any game action until now. He will now look to rest up so that he can hopefully return for a Week 11 clash on the road against the New York Jets. With Pittman now out this weekend, it essentially makes receiver Josh Downs a must-start as quarterback Joe Flacco's likely go-to passing target in a game in which the Colts will likely have to throw often to keep up on the scoreboard. In addition to Downs seeing more targets, the flex-play appeal of both Alec Pierce and rookie Adonai Mitchell goes up for those in deeper leagues.

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Philadelphia Eagles quarterback Jalen Hurts (ankle) is reportedly dealing with a potential ankle injury, according to Brandon Lee Gowton. Hurts was sidelined during Wednesday's practice due to rest, but head coach Nick Sirianni expressed he was dealing with an ankle injury while talking to the media. However, Sirianni then quickly clarified his statement and emphasized that he misunderstood the question and his absence was strictly rest-related. Seeing that Hurts returned to a full participant on Thursday suggests that this injury is very minor. Fantasy managers should expect Hurts to suit up on Sunday to face the Dallas Cowboys. The 26-year-old should be viewed as a high-end QB1, as he has scored over 30 PPR points in each of his past two games.

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Carolina Panthers tight end Tommy Tremble (back) is officially listed as questionable to play in Week 10 against the New York Giants on Sunday in Munich, Germany. Tremble practiced in full on Wednesday and Friday while being limited on Thursday. Meanwhile, rookie Ja'Tavion Sanders (ankle, wrist) was cleared to play after popping up on the injury report on Thursday. The 24-year-old Tremble has missed four of the last five games due to injury, but he appears to be on the right track to suit up overseas this weekend. Still, fantasy managers desperate at the tight end position should be able to find better streaming options in deep leagues. Tremble will probably take a back seat to Sanders, who has become a bigger part of the offense in recent weeks. In his five games played in 2024, Tremble has nine grabs on 12 targets for just 72 yards and no touchdowns.

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New Washington Commanders cornerback Marshon Lattimore (hamstring) will not make his debut with the team in Week 10 on Sunday against the Pittsburgh Steelers after being acquired in a trade from the New Orleans Saints at the deadline on Tuesday. While Lattimore's injury isn't all that serious, it also kept him from playing in the Saints' Week 9 loss to the division-rival Carolina Panthers. The 28-year-old defensive back's next chance to make his debut with Washington will come next Thursday night in a big divisional clash against the Philadelphia Eagles in primetime. When healthy, Lattimore, a four-time Pro Bowler, should be a starter in a secondary that has been the weakness of their defense this year. In seven starts with the Saints before getting hurt, he had 30 tackles (22 solo) and two pass breakups.

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