After an up-and-down start to the season, Buffalo Bills quarterback Josh Allen (left hand) has thrown at least two touchdowns in his last four games. That could continue against the Indianapolis Colts on Sunday. The Colts' secondary has allowed 14 touchdown passes this season, which is good for ninth-most in the league. The Bills have also shifted to a more pass-happy approach to their offense. Allen's attempted 33, 34, and 39 passes in the last three games. Those attempts could decline if Amari Cooper (questionable, wrist) and Keon Coleman (out, wrist) aren't in the lineup on Sunday. As has been the case for the last several weeks, Allen's left hand injury is not keeping him from practicing. Allen is a high-end QB1, once again, against the Colts.

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Jacksonville Jaguars quarterback Trevor Lawrence (shoulder) is listed as questionable for Sunday's game against the Minnesota Vikings according to Tom Pelissero of the NFL Network. Lawrence sustained this injury last weekend in their loss to the Philadelphia Eagles. During the week, the former first-overall pick remained a limited participant in practice. Earlier in the week, it was reported that Lawrence was trending toward not playing but seeing him listed as questionable does keep the door open for his availability. Fantasy managers should continue to monitor his status over the weekend. If the Clemson product is unable to suit up, Mac Jones would get the starting nod and should be viewed as a low-end QB2 facing a tough Minnesota defense.

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Buffalo Bills running back James Cook has underwhelming rushing totals (12 and 10 carries) in two of his last three games. However, he is seeing an uptick in his passing game involvement. The Bills have transitioned from a run-heavy approach to a pass-happy offense. Cook has logged eight catches in his last two games. He had 11 catches in the six prior contests. If wide receivers Amari Cooper (questionable, wrist) and Keon Coleman (out, wrist) can't play on Sunday, Cook could see his number called more, both on the ground and through the air. Cook is a high-end RB1 in the rankings against the bottom-dweller Indianapolis rush defense.

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Buffalo Bills wide receiver Khalil Shakir has scored at least 10 PPR fantasy points in all but one game this season, which happened to be his first game back from an ankle injury. Shakir's role is safe, regardless of the situation around him. He commands the slot role on the Buffalo offense and he's only missed three targets this season. Shakir's utilization mixes well with the defense that Indianapolis tends to run. He could also see increased target volume if Amari Cooper (wrist) can't play on Sunday. Keon Coleman (wrist) has already been ruled out. Shakir is a safe WR3/flex for Week 10.

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Detroit Lions offensive tackle Taylor Decker (shoulder) has been ruled out for Sunday's tilt against the Houston Texans. Decker appeared on the injury report on Thursday with a shoulder and was listed as a limited participant. However, he was downgraded to a non-participant on Friday and will now set his sights on returning in Week 11 to face the Jacksonville Jaguars. Decker has served as a starting tackle all season but will likely cede those duties to Dan Skipper on Sunday evening. However, fantasy managers should not be overly concerned with inserting both Detroit running backs David Montgomery and Jahmyr Gibbs into their lineup with a depleted offensive line. Both running backs should be viewed as matchup-proof for the remainder of the season.

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Washington Commanders running back Brian Robinson Jr. (hamstring) has been ruled out for this Sunday's matchup against the Pittsburgh Steelers according to Ian Rapoport of the NFL Network. Robinson will now miss his second-straight contest and set his sights on returning in Week 11 for a pivotal divisional matchup against the Philadelphia Eagles. This week Robinson remained a limited participant in practice. As a result, fantasy managers should expect Austin Ekeler to operate as the lead option out of the backfield with Chris Rodriguez Jr. and Jeremy McNichols serving as change-of-pace options. Last week, Ekeler scored a season-high 17.3 PPR points and should be in a good position to produce solid RB2 numbers again this weekend. Fantasy managers in deeper formats could consider Rodriguez a desperation flex option as he logged 11 carries for 52 yards last weekend.

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Arizona Cardinals wide receiver Marvin Harrison Jr. is a boom-or-bust wide receiver when the Cardinals host the New York Jets in Week 10. Harrison Jr. led the team in targets in the Week 9 victory over the Chicago Bears; however, he only caught two of his targets. The Cardinals shifted to a run-first game plan and cruised to victory, not needing much production from the passing game to secure the win. In Week 10, the Cardinals will be underdogs against the Jets and will likely have to throw the ball more to get a victory, which creates a better game script for Harrison Jr. and the rest of the Cardinals' pass-catchers. Harrison Jr.'s inconsistency has made him a boom-or-bust player, but he could be due for a boom. Unless your roster has better options, Harrison Jr. will likely be a wide receiver two or flex in Week 10 when the Cardinals host the Jets.

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Atlanta Falcons running back Bijan Robinson was held out of the end zone in Week 9 for the first time since Week 5 but is in prime position to find paydirt again in Week 10. The second-year pro has scored four rushing TDs and one receiving TD on the year, while the Falcons' Week 10 opponent, the Saints, has allowed 5.1 yards per carry (second-worst) and 12 rushing TDs (third-most) thus far. The 22-year-old is a consistent force in the ground game, but what is somewhat surprising is his increased work in the passing game, recording seven catches in two consecutive weeks, which led the entire receiving corps. That makes him even more valuable in PPR, but the former first-round draft pick projects as a high-end RB1 in Week 10 regardless of format.

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New Orleans Saints running back Jamaal Williams (groin) is not expected to play on Sunday against the division-rival Atlanta Falcons in Week 10 after aggravating his groin injury in practice on Friday, according to interim head coach Darren Rizzi. With Williams likely to be inactive this weekend, it will mean an elevated role for Jordan Mims as the team's No. 2 RB behind workhorse Alvin Kamara. Mims will be unlikely to see many backfield touches as long as Kamara remains healthy, and the Saints also figure to utilize tight end Taysom Hill more as a wild-card offensive player with receiver Chris Olave (concussion) already ruled out. Williams has had 32 rushing attempts for 124 yards and one touchdown in eight games in 2024, adding four catches for 21 yards, so he hasn't had any real standalone fantasy appeal behind Kamara.UPDATE: Williams has been officially ruled out for Week 10.

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New Orleans Saints wide receiver Chris Olave (concussion) has officially been ruled out for the Week 10 game against the division-rival Atlanta Falcons this Sunday. Olave suffered his second concussion of the season and fourth of his career in the Week 9 loss to the Dallas Cowboys and could still land on Injured Reserve, which would require him to miss a minimum of four games. He visited with head specialists this week and is probably going to miss several games at the very least. Fantasy managers should plan for the worst, which would be a trip to IR. Rashid Shaheed (knee) and rookie Bub Means (ankle) are both out for the season, leaving rookie Mason Tipton, Cedrick Wilson Jr. (shoulder) and Marquez Valdes-Scantling as the team's starters at wideout this weekend. The Saints will be leaning more on tight ends Taysom Hill and Juwan Johnson and running back Alvin Kamara much more.

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Pittsburgh Steelers quarterback Justin Fields (hamstring) has been removed from the injury report ahead of the Week 10 matchup against the Washington Commanders. Fields should be active this weekend after sitting out during the Week 8 win over the New York Giants. Despite being active, Fields is now the backup to Russell Wilson. Head coach Mike Tomlin has mentioned that he wants to get Fields involved as the backup. It's possible that Fields does see the field this weekend, but he remains avoidable in fantasy formats while Wilson is the starter.

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Atlanta Falcons wide receiver Darnell Mooney has topped 80 yards receiving and scored in two consecutive games, continuing to earn consistent looks in the Falcon passing attack. Some of his production last week could be attributed to Drake London's absence after the first quarter, but he's been getting attention whether London has been on the field or not. The 27-year-old has six or more targets in three straight and seven of nine games this season, good for a 23.94% target share compared to 24.65% for Drake London, and Mooney actually has a higher percentage of the team's air yards compared to London (37.76% vs. 33.59%). All of this gives him a decent floor for fantasy, especially in PPR leagues, and with five touchdowns on the season, the fifth-year pro has a fairly high ceiling as well. The Saints are without Paulson Adebo (leg) and Marshon Lattimore (traded), so Mooney's 3-56-0 line from Week 4 should look a bit better this time around. The former fifth-round draft pick projects as a back-end WR2 this week, but keep an eye on London's status for Sunday, because if he doesn't suit up, the Atlanta receiving corps will have some additional targets to go around.

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Pittsburgh Steelers running back Cordarrelle Patterson (ankle) has been removed from the injury report ahead of the Week 10 matchup against the Washington Commanders. The veteran back appears to be finally ready to make his return to the field. Patterson hasn't played since Week 4, but appears to be ready after getting in full practice sessions this week. Patterson is unlikely to have much fantasy value as the third string option behind Najee Harris and Jaylen Warren in the backfield. Patterson gives the Steelers depth in the backfield and at kick/punt returner, but isn't a viable fantasy option right now.

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Buffalo Bills wide receiver Amari Cooper (wrist) has been tagged as questionable ahead of the Week 10 matchup against the Indianapolis Colts. The veteran wideout was unable to play last week due to the wrist issue, but appears to be trending towards playing this weekend. Cooper has been limited in practice all week, but that might just be the Bills being cautious with him. The Bills are already going to be without Keon Coleman (wrist) which means Cooper should have a bigger role. If active, Cooper should be a fine WR3 for this Week 10 matchup.

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The Los Angeles Chargers defense is projected to be one of the top defensive units in fantasy football for Week 10. The Bolts will take on the Tennessee Titans, who will have quarterback Will Levis returning to the starting lineup. In his five games this season, Levis has thrown five touchdowns and seven interceptions. The Chargers defense has finished as a top-three fantasy defense in both of the past two weeks, and they have a good chance to end up in or near that tier once again this time around. Start them with confidence as a high-floor and even higher-ceiling DST.

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Los Angeles Chargers kicker Cameron Dicker is a solid fantasy option for a Week 10 matchup against the Tennessee Titans. Dicker has been about as consistent as fantasy kickers can be this season, scoring double digit fantasy points in four of the Chargers' eight games, peaking with 21 points in Week 7. This week, he faces a Tennessee Titans team that has been very generous to opposing fantasy kickers. With the Chargers offense expected to do well in this game, Dicker should be given at least a few chances to kick. He's a top-10 option at fantasy's least projectable position.

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Philadelphia Eagles wide receiver DeVonta Smith (hamstring) said on Friday that he'll be fine for the Week 10 matchup against the Dallas Cowboys. Smith appears to have suffered a minor hamstring injury during last week's win over the Jacksonville Jaguars. He was a non-participant during Wednesday's practice before getting in a limited session on Thursday. Smith doesn't seem to be worried about the injury, so fantasy managers should expect to see him out there. He can be plugged in as a solid WR2 for this divisional matchup with Dallas

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Los Angeles Chargers tight end Will Dissly is unlikely to make a significant fantasy impact in a Week 10 game against the Tennessee Titans. Dissly was heavily involved in the Chargers passing game between Weeks 6 and 8, drawing 23 targets across the three games, but that was mostly due to other Chargers pass catchers missing time with injuries. In Week 9, with several pass catchers returning, Dissly saw just three targets and made two catches for a total of nine yards. He has yet to score a touchdown this season and shouldn't be relied upon as anything more than a non-zero floor tight end option. Most leagues will likely have at least one higher upside option on the waiver wire for this week.

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Arizona Cardinals quarterback Kyler Murray is valued as a mid-tier QB1 when the Cardinals host the New York Jets in Week 10. Murray delivered a quiet fantasy outing last week in the 29-9 victory over the Chicago Bears, but that shouldn't concern fantasy managers, as he is still playing his best football of the season recently. The Cardinals took an early lead and shifted to a run-first approach en route to victory, which was the primary contributor to Murray's low fantasy output. However, the Cardinals are currently underdogs to the Jets, and a closely contested matchup will likely lead to higher fantasy numbers for Murray. The Cardinals' offensive line has been great in pass protection and will be equipped to handle the Jets' solid pass rush. There is no reason to bench Murray heading into the Week 10 matchup against the Jets.

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Carolina Panthers running back Jonathon Brooks (knee) was recently activated off the reserve list. The rookie back hasn't played this season while he recovers from an ACL tear he suffered in college. Brooks was able to get through three full practice sessions this week. That is good news heading into the Week 10 matchup against the New York Giants. The Panthers are listing Brooks as questionable for this weekend, but three full practices is a good sign that he'll play. He figures to be the primary backup to Chuba Hubbard for now. That being said, Brooks probably won't be a reliable fantasy option out of the gate, but should earn a bigger role as the season goes on.

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