

| Started | K | Chase McLaughlin TB | Owner | Thu Nov 6 4:28am ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Wed Nov 5 4:36pm ET |
| Benched | K | Brandon Aubrey DAL | Owner | Wed Nov 5 4:36pm ET |
| Started | WR | Justin Jefferson MIN | Owner | Wed Nov 5 4:36pm ET |
| Started | TE | Sam LaPorta DET | Owner | Wed Nov 5 4:36pm ET |
| No starting lineup changes performed this week. |
| Benched | QB | Jordan Love GB | Owner | Wed Nov 5 3:00pm ET |
| Benched | WR | Romeo Doubs GB | Owner | Wed Nov 5 3:00pm ET |
| Benched | TE | Mark Andrews BAL | Owner | Wed Nov 5 3:00pm ET |
| Started | QB | J.J. McCarthy MIN | Owner | Wed Nov 5 3:00pm ET |
| Started | WR | Khalil Shakir BUF | Owner | Wed Nov 5 3:00pm ET |
| Started | TE | AJ Barner SEA | Owner | Wed Nov 5 3:00pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 4 9:40am ET |
| Started | WR | Romeo Doubs GB | Owner | Tue Nov 4 9:40am ET |
| Benched | RB | RJ Harvey DEN | Owner | Thu Nov 6 7:39pm ET |
| Started | RB | Breece Hall NYJ | Owner | Thu Nov 6 7:39pm ET |
| Started | D/ST | Cleveland Browns CLE | Owner | Thu Nov 6 12:11am ET |
| Benched | WR | Rashod Bateman BAL | Owner | Wed Nov 5 11:52am ET |
| Started | TE | Cade Otton TB | Owner | Wed Nov 5 11:52am ET |
| Benched | RB | Kareem Hunt KC | Owner | Tue Nov 4 7:42pm ET |
| Benched | TE | Noah Fant CIN | Owner | Tue Nov 4 7:42pm ET |
| Started | WR | Rashod Bateman BAL | Owner | Tue Nov 4 7:42pm ET |
| Started | TE | Dallas Goedert PHI | Owner | Tue Nov 4 7:42pm ET |
| Benched | WR | Malik Washington MIA | Owner | Tue Nov 4 9:16pm ET |
| Started | WR | A.J. Brown PHI | Owner | Tue Nov 4 9:16pm ET |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 4 3:10pm ET |
| Benched | WR | CeeDee Lamb DAL | Owner | Tue Nov 4 3:10pm ET |
| Started | RB | D'Andre Swift CHI | Owner | Tue Nov 4 3:10pm ET |
| Started | WR | Ricky Pearsall SF | Owner | Tue Nov 4 3:10pm ET |
| Benched | WR | Rome Odunze CHI | Owner | Thu Nov 6 9:35pm ET |
| Started | WR | Emeka Egbuka TB | Owner | Thu Nov 6 9:35pm ET |
| Started | D/ST | Pittsburgh Steelers PIT | Owner | Thu Nov 6 7:35am ET |
| Benched | QB | Mac Jones SF | Owner | Tue Nov 4 10:05am ET |
| Benched | RB | Chase Brown CIN | Owner | Tue Nov 4 10:05am ET |
| Benched | WR | Matthew Golden GB | Owner | Tue Nov 4 10:05am ET |
| Benched | TE | Juwan Johnson NO | Owner | Tue Nov 4 10:05am ET |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 4 10:05am ET |
| Started | RB | J.K. Dobbins DEN | Owner | Tue Nov 4 10:05am ET |
| Started | WR | DeVonta Smith PHI | Owner | Tue Nov 4 10:05am ET |
| Started | TE | Brock Bowers LV | Owner | Tue Nov 4 10:05am ET |
| Benched | RB | Jeremy McNichols WAS | Owner | Wed Nov 5 2:07pm ET |
| Benched | WR | Chimere Dike TEN | Owner | Wed Nov 5 2:07pm ET |
| Benched | WR | Tory Horton SEA | Owner | Wed Nov 5 2:07pm ET |
| Started | RB | Bhayshul Tuten JAX | Owner | Wed Nov 5 2:07pm ET |
| Started | WR | Tez Johnson TB | Owner | Wed Nov 5 2:07pm ET |
| Started | TE | Elijah Arroyo SEA | Owner | Wed Nov 5 2:07pm ET |
| Benched | QB | Patrick Mahomes KC | Owner | Tue Nov 4 9:12am ET |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 4 9:12am ET |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 4 9:12am ET |
| Benched | K | Harrison Butker KC | Owner | Tue Nov 4 9:12am ET |
| Benched | D/ST | Jacksonville Jaguars JAX | Owner | Tue Nov 4 9:12am ET |
| Started | QB | Aaron Rodgers PIT | Owner | Tue Nov 4 9:12am ET |
| Started | RB | Saquon Barkley PHI | Owner | Tue Nov 4 9:12am ET |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 4 9:12am ET |
| Started | D/ST | Buffalo Bills BUF | Owner | Tue Nov 4 9:12am ET |
| Benched | TE | Travis Kelce KC | Owner | Tue Nov 4 8:37am ET |
| Started | TE | T.J. Hockenson MIN | Owner | Tue Nov 4 8:37am ET |