

| Benched | TE | Travis Kelce KC | Owner | Tue Nov 4 8:02am CT |
| Started | RB | Quinshon Judkins CLE | Owner | Tue Nov 4 8:02am CT |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 4 10:24am CT |
| Benched | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 4 10:24am CT |
| Benched | TE | AJ Barner SEA | Owner | Tue Nov 4 10:24am CT |
| Started | RB | Kenneth Walker III SEA | Owner | Tue Nov 4 10:24am CT |
| Started | WR | A.J. Brown PHI | Owner | Tue Nov 4 10:24am CT |
| Started | TE | T.J. Hockenson MIN | Owner | Tue Nov 4 10:24am CT |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Tue Nov 4 11:11am CT |
| Benched | D/ST | Jacksonville Jaguars JAX | Owner | Tue Nov 4 11:11am CT |
| Started | WR | Tory Horton SEA | Owner | Tue Nov 4 11:02am CT |
| Started | WR | Nico Collins HOU | Owner | Tue Nov 4 11:02am CT |
| Started | RB | Breece Hall NYJ | Owner | Tue Nov 4 11:02am CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 4 11:02am CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 4 11:02am CT |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 4 11:02am CT |
| Benched | RB | Ollie Gordon II MIA | Owner | Tue Nov 4 11:02am CT |
| Benched | QB | Patrick Mahomes KC | Owner | Tue Nov 4 11:02am CT |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | RB | Jacory Croskey-Merritt WAS | Owner | Tue Nov 4 9:04am CT |
| Started | RB | Saquon Barkley PHI | Owner | Tue Nov 4 9:04am CT |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |