

| No starting lineup changes performed this week. |
| Benched | RB | Tyjae Spears TEN | Owner | Wed Nov 5 12:43pm ET |
| Started | WR | A.J. Brown PHI | Owner | Wed Nov 5 12:43pm ET |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 4 2:56pm ET |
| Benched | RB | Chase Brown CIN | Owner | Tue Nov 4 2:56pm ET |
| Benched | WR | Chimere Dike TEN | Owner | Tue Nov 4 2:56pm ET |
| Started | QB | Sam Darnold SEA | Owner | Tue Nov 4 2:56pm ET |
| Started | RB | Rachaad White TB | Owner | Tue Nov 4 2:56pm ET |
| Started | WR | Rashid Shaheed SEA | Owner | Tue Nov 4 2:56pm ET |
| Started | K | Nick Folk NYJ | Owner | Thu Nov 6 5:23pm ET |
| Benched | QB | Justin Herbert LAC | Owner | Tue Nov 4 10:47pm ET |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 4 10:47pm ET |
| Benched | WR | Rashod Bateman BAL | Owner | Tue Nov 4 10:47pm ET |
| Benched | D/ST | Houston Texans HOU | Owner | Tue Nov 4 10:47pm ET |
| Started | QB | Caleb Williams CHI | Owner | Tue Nov 4 10:47pm ET |
| Started | RB | Saquon Barkley PHI | Owner | Tue Nov 4 10:47pm ET |
| Started | WR | Garrett Wilson NYJ | Owner | Tue Nov 4 10:47pm ET |
| Started | D/ST | Buffalo Bills BUF | Owner | Tue Nov 4 10:47pm ET |
| Benched | QB | C.J. Stroud HOU | Owner | Tue Nov 4 7:41pm ET |
| Benched | WR | Rashee Rice KC | Owner | Tue Nov 4 7:41pm ET |
| Started | QB | Baker Mayfield TB | Owner | Tue Nov 4 7:41pm ET |
| Started | WR | D.J. Moore CHI | Owner | Tue Nov 4 7:41pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Chris Olave NO | Owner | Thu Nov 6 5:30pm ET |
| Started | WR | Michael Pittman Jr. IND | Owner | Thu Nov 6 5:30pm ET |
| Benched | WR | Michael Pittman Jr. IND | Owner | Tue Nov 4 3:34pm ET |
| Started | WR | Emeka Egbuka TB | Owner | Tue Nov 4 3:34pm ET |
| Benched | QB | Daniel Jones IND | Owner | Thu Nov 6 9:28am ET |
| Benched | WR | Quentin Johnston LAC | Owner | Thu Nov 6 9:28am ET |
| Benched | TE | Jake Ferguson DAL | Owner | Thu Nov 6 9:28am ET |
| Benched | D/ST | New England Patriots NE | Owner | Thu Nov 6 9:28am ET |
| Started | QB | Jalen Hurts PHI | Owner | Thu Nov 6 9:28am ET |
| Started | RB | J.K. Dobbins DEN | Owner | Thu Nov 6 9:28am ET |
| Started | TE | Mark Andrews BAL | Owner | Thu Nov 6 9:28am ET |
| Started | D/ST | Pittsburgh Steelers PIT | Owner | Thu Nov 6 9:28am ET |
| Benched | RB | Tyler Allgeier ATL | Owner | Wed Nov 5 12:45pm ET |
| Started | RB | Breece Hall NYJ | Owner | Wed Nov 5 12:45pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Ja'Marr Chase CIN | Owner | Wed Nov 5 3:32pm ET |
| Benched | WR | CeeDee Lamb DAL | Owner | Wed Nov 5 3:32pm ET |
| Benched | TE | Travis Kelce KC | Owner | Wed Nov 5 3:32pm ET |
| Started | WR | Drake London ATL | Owner | Wed Nov 5 3:32pm ET |
| Started | WR | Parker Washington JAX | Owner | Wed Nov 5 3:32pm ET |
| Started | TE | Brock Bowers LV | Owner | Wed Nov 5 3:32pm ET |
| No starting lineup changes performed this week. |