

| Benched | RB | Chase Brown CIN | Owner | Thu Nov 6 5:20am ET |
| Benched | RB | Isiah Pacheco KC | Owner | Thu Nov 6 5:20am ET |
| Started | RB | Terrell Jennings NE | Owner | Thu Nov 6 5:20am ET |
| Started | WR | Jalen Coker CAR | Owner | Thu Nov 6 5:20am ET |
| Started | D/ST | Carolina Panthers CAR | Owner | Thu Nov 6 5:20am ET |
| Benched | RB | Michael Carter ARI | Owner | Wed Nov 5 8:04pm ET |
| Benched | WR | Chimere Dike TEN | Owner | Wed Nov 5 8:04pm ET |
| Started | RB | Quinshon Judkins CLE | Owner | Wed Nov 5 8:04pm ET |
| Started | RB | Isiah Pacheco KC | Owner | Wed Nov 5 8:04pm ET |
| Benched | RB | Javonte Williams DAL | Owner | Wed Nov 5 8:45pm ET |
| Started | TE | David Njoku CLE | Owner | Wed Nov 5 8:45pm ET |
| Benched | RB | TreVeyon Henderson NE | Owner | Tue Nov 4 7:20am ET |
| Started | RB | Breece Hall NYJ | Owner | Tue Nov 4 7:20am ET |
| Benched | WR | Kayshon Boutte NE | Owner | Tue Nov 4 7:20am ET |
| Started | WR | Alec Pierce IND | Owner | Tue Nov 4 7:20am ET |
| Benched | RB | Zach Charbonnet SEA | Owner | Wed Nov 5 8:21pm ET |
| Benched | WR | Demario Douglas NE | Owner | Wed Nov 5 8:21pm ET |
| Started | WR | A.J. Brown PHI | Owner | Wed Nov 5 8:21pm ET |
| Started | WR | Emeka Egbuka TB | Owner | Wed Nov 5 8:21pm ET |
| Benched | D/ST | Los Angeles Chargers LAC | Owner | Tue Nov 4 8:35pm ET |
| Started | D/ST | Cleveland Browns CLE | Owner | Tue Nov 4 8:35pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | RB | Samaje Perine CIN | Owner | Wed Nov 5 11:06pm ET |
| Benched | WR | George Pickens DAL | Owner | Wed Nov 5 11:06pm ET |
| Started | RB | D'Andre Swift CHI | Owner | Wed Nov 5 11:06pm ET |
| Started | WR | Troy Franklin DEN | Owner | Wed Nov 5 11:06pm ET |
| Benched | WR | Kendrick Bourne SF | Owner | Thu Nov 6 10:00am ET |
| Started | WR | Olamide Zaccheaus CHI | Owner | Thu Nov 6 10:00am ET |
| Started | D/ST | Baltimore Ravens BAL | Owner | Thu Nov 6 12:05am ET |
| Benched | QB | Dak Prescott DAL | Owner | Tue Nov 4 7:00am ET |
| Benched | RB | Jordan Mason MIN | Owner | Tue Nov 4 7:00am ET |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 4 7:00am ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 4 7:00am ET |
| Started | RB | Saquon Barkley PHI | Owner | Tue Nov 4 7:00am ET |
| Started | WR | Garrett Wilson NYJ | Owner | Tue Nov 4 7:00am ET |
| Benched | RB | Chuba Hubbard CAR | Owner | Thu Nov 6 1:50pm ET |
| Started | WR | Jerry Jeudy CLE | Owner | Thu Nov 6 1:50pm ET |
| Benched | TE | Tucker Kraft GB | Owner | Thu Nov 6 1:47pm ET |
| Started | RB | Chuba Hubbard CAR | Owner | Thu Nov 6 1:47pm ET |
| Benched | K | Ka'imi Fairbairn HOU | Owner | Thu Nov 6 1:46pm ET |
| Started | K | Matt Prater BUF | Owner | Thu Nov 6 1:46pm ET |
| Benched | RB | Kareem Hunt KC | Owner | Tue Nov 4 9:34am ET |
| Benched | WR | Rashee Rice KC | Owner | Tue Nov 4 9:34am ET |
| Benched | K | Chad Ryland ARI | Owner | Tue Nov 4 9:34am ET |
| Started | RB | Bhayshul Tuten JAX | Owner | Tue Nov 4 9:34am ET |
| Started | WR | Jauan Jennings SF | Owner | Tue Nov 4 9:34am ET |
| Started | K | Chase McLaughlin TB | Owner | Tue Nov 4 9:34am ET |
| No starting lineup changes performed this week. |
| Benched | D/ST | Kansas City Chiefs KC | Owner | Thu Nov 6 12:36pm ET |
| Started | D/ST | Atlanta Falcons ATL | Owner | Thu Nov 6 12:36pm ET |
| Benched | QB | Patrick Mahomes KC | Owner | Tue Nov 4 8:15am ET |
| Started | QB | Michael Penix Jr. ATL | Owner | Tue Nov 4 8:15am ET |
| Benched | QB | Drake Maye NE | Owner | Wed Nov 5 7:00pm ET |
| Started | QB | Bo Nix DEN | Owner | Wed Nov 5 7:00pm ET |
| Benched | TE | Noah Fant CIN | Owner | Wed Nov 5 7:00pm ET |
| Started | WR | DeVonta Smith PHI | Owner | Wed Nov 5 7:00pm ET |