

| No starting lineup changes performed this week. |
| Started | QB | Davis Mills HOU | Owner | Thu Nov 6 12:17am ET |
| Benched | QB | C.J. Stroud HOU | Owner | Wed Nov 5 11:11pm ET |
| Benched | QB | Joe Flacco CIN | Owner | Wed Nov 5 12:41am ET |
| Benched | TE | Travis Kelce KC | Owner | Wed Nov 5 12:41am ET |
| Started | RB | Saquon Barkley PHI | Owner | Wed Nov 5 12:41am ET |
| Started | WR | Chris Godwin TB | Owner | Wed Nov 5 12:41am ET |
| Benched | QB | Jayden Daniels WAS | Owner | Tue Nov 4 7:36am ET |
| Started | QB | Marcus Mariota WAS | Owner | Tue Nov 4 7:36am ET |
| Benched | QB | Patrick Mahomes KC | Owner | Tue Nov 4 3:02pm ET |
| Benched | RB | LeQuint Allen JAX | Owner | Tue Nov 4 3:02pm ET |
| Benched | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 4 3:02pm ET |
| Benched | TE | Oronde Gadsden II LAC | Owner | Tue Nov 4 3:02pm ET |
| Started | QB | Trevor Lawrence JAX | Owner | Tue Nov 4 3:02pm ET |
| Started | RB | Breece Hall NYJ | Owner | Tue Nov 4 3:02pm ET |
| Started | RB | Quinshon Judkins CLE | Owner | Tue Nov 4 3:02pm ET |
| Started | WR | Garrett Wilson NYJ | Owner | Tue Nov 4 3:02pm ET |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 4 7:40pm ET |
| Started | TE | Dallas Goedert PHI | Owner | Tue Nov 4 7:40pm ET |
| Benched | QB | Aaron Rodgers PIT | Owner | Tue Nov 4 7:40pm ET |
| Benched | WR | CeeDee Lamb DAL | Owner | Tue Nov 4 7:40pm ET |
| Started | QB | Baker Mayfield TB | Owner | Tue Nov 4 7:40pm ET |
| Started | WR | A.J. Brown PHI | Owner | Tue Nov 4 7:40pm ET |
| Benched | QB | Dak Prescott DAL | Owner | Tue Nov 4 5:23pm ET |
| Started | WR | Keon Coleman BUF | Owner | Tue Nov 4 5:23pm ET |
| Started | WR | Calvin Austin III PIT | Owner | Tue Nov 4 5:23pm ET |
| Started | RB | Rachaad White TB | Owner | Tue Nov 4 5:23pm ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 4 5:23pm ET |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 4 5:23pm ET |
| Benched | WR | Kayshon Boutte NE | Owner | Tue Nov 4 5:23pm ET |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 4 5:23pm ET |
| Benched | RB | Samaje Perine CIN | Owner | Tue Nov 4 5:23pm ET |
| Started | TE | Evan Engram DEN | Owner | Tue Nov 4 5:23pm ET |
| Benched | QB | Tyler Shough NO | Owner | Tue Nov 4 7:03am ET |
| Benched | RB | Brashard Smith KC | Owner | Tue Nov 4 7:03am ET |
| Benched | WR | George Pickens DAL | Owner | Tue Nov 4 7:03am ET |
| Benched | TE | Noah Fant CIN | Owner | Tue Nov 4 7:03am ET |
| Started | QB | Justin Fields NYJ | Owner | Tue Nov 4 7:03am ET |
| Started | RB | D'Andre Swift CHI | Owner | Tue Nov 4 7:03am ET |
| Started | WR | DeVonta Smith PHI | Owner | Tue Nov 4 7:03am ET |
| Started | TE | David Njoku CLE | Owner | Tue Nov 4 7:03am ET |
| Benched | QB | Geno Smith LV | Owner | Thu Nov 6 5:46pm ET |
| Started | QB | Michael Penix Jr. ATL | Owner | Thu Nov 6 5:46pm ET |
| Started | TE | Dalton Schultz HOU | Owner | Thu Nov 6 5:04pm ET |
| Benched | RB | Kareem Hunt KC | Owner | Tue Nov 4 12:10pm ET |
| Benched | WR | Rashee Rice KC | Owner | Tue Nov 4 12:10pm ET |
| Started | RB | Chuba Hubbard CAR | Owner | Tue Nov 4 12:10pm ET |
| Started | WR | Tez Johnson TB | Owner | Tue Nov 4 12:10pm ET |
| Benched | TE | Juwan Johnson NO | Owner | Fri Nov 7 4:16am ET |
| Started | TE | Luke Musgrave GB | Owner | Fri Nov 7 4:16am ET |
| Benched | RB | Kyle Monangai CHI | Owner | Fri Nov 7 3:48am ET |
| Started | WR | Josh Downs IND | Owner | Fri Nov 7 3:48am ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 4 7:14am ET |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 4 7:14am ET |
| Benched | RB | Javonte Williams DAL | Owner | Wed Nov 5 5:26pm ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Wed Nov 5 5:26pm ET |
| Started | WR | Quentin Johnston LAC | Owner | Wed Nov 5 5:26pm ET |
| Started | WR | Jameson Williams DET | Owner | Wed Nov 5 5:26pm ET |
| Benched | WR | Chimere Dike TEN | Owner | Tue Nov 4 9:36am ET |
| Started | WR | Emeka Egbuka TB | Owner | Tue Nov 4 9:36am ET |