

| No starting lineup changes performed this week. |
| Benched | RB | Tony Pollard TEN | Owner | Wed Nov 5 12:22am ET |
| Benched | TE | Jake Ferguson DAL | Owner | Wed Nov 5 12:22am ET |
| Started | RB | Blake Corum LAR | Owner | Wed Nov 5 12:22am ET |
| Started | WR | Stefon Diggs NE | Owner | Wed Nov 5 12:22am ET |
| Benched | RB | Chase Brown CIN | Owner | Tue Nov 4 8:42am ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 4 8:42am ET |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 4 8:42am ET |
| Started | WR | Tez Johnson TB | Owner | Tue Nov 4 8:42am ET |
| Started | WR | Parker Washington JAX | Owner | Tue Nov 4 8:42am ET |
| Started | WR | Jameson Williams DET | Owner | Tue Nov 4 8:42am ET |
| Benched | QB | Dak Prescott DAL | Owner | Tue Nov 4 1:39pm ET |
| Benched | RB | Michael Carter ARI | Owner | Tue Nov 4 1:39pm ET |
| Started | WR | Malik Washington MIA | Owner | Tue Nov 4 1:39pm ET |
| Started | TE | Dallas Goedert PHI | Owner | Tue Nov 4 1:39pm ET |
| Benched | RB | Samaje Perine CIN | Owner | Tue Nov 4 7:36pm ET |
| Benched | WR | Jayden Higgins HOU | Owner | Tue Nov 4 7:36pm ET |
| Benched | WR | CeeDee Lamb DAL | Owner | Tue Nov 4 7:36pm ET |
| Benched | TE | AJ Barner SEA | Owner | Tue Nov 4 7:36pm ET |
| Started | QB | Marcus Mariota WAS | Owner | Tue Nov 4 7:36pm ET |
| Started | RB | Rachaad White TB | Owner | Tue Nov 4 7:36pm ET |
| Started | WR | A.J. Brown PHI | Owner | Tue Nov 4 7:36pm ET |
| Started | WR | Emeka Egbuka TB | Owner | Tue Nov 4 7:36pm ET |
| Benched | QB | Patrick Mahomes KC | Owner | Tue Nov 4 10:33am ET |
| Benched | WR | George Pickens DAL | Owner | Tue Nov 4 10:33am ET |
| Benched | WR | Rashee Rice KC | Owner | Tue Nov 4 10:33am ET |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 4 10:33am ET |
| Started | RB | D'Andre Swift CHI | Owner | Tue Nov 4 10:33am ET |
| Started | WR | Jerry Jeudy CLE | Owner | Tue Nov 4 10:33am ET |
| Benched | RB | Ray Davis BUF | Owner | Tue Nov 4 10:51pm ET |
| Benched | WR | Matthew Golden GB | Owner | Tue Nov 4 10:51pm ET |
| Started | RB | Travis Etienne JAX | Owner | Tue Nov 4 10:51pm ET |
| Started | WR | Garrett Wilson NYJ | Owner | Tue Nov 4 10:51pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 4 9:37pm ET |
| Started | RB | Jaylen Warren PIT | Owner | Tue Nov 4 9:37pm ET |
| Benched | QB | Jacoby Brissett ARI | Owner | Tue Nov 4 9:17am ET |
| Benched | RB | TreVeyon Henderson NE | Owner | Tue Nov 4 9:17am ET |
| Benched | RB | Jaylen Warren PIT | Owner | Tue Nov 4 9:17am ET |
| Benched | TE | Travis Kelce KC | Owner | Tue Nov 4 9:17am ET |
| Started | WR | DeVonta Smith PHI | Owner | Tue Nov 4 9:17am ET |
| Started | TE | Jonnu Smith PIT | Owner | Tue Nov 4 9:17am ET |
| Benched | RB | Chuba Hubbard CAR | Owner | Tue Nov 4 7:23am ET |
| Started | WR | Kyle Williams NE | Owner | Tue Nov 4 7:23am ET |
| Benched | TE | Theo Johnson NYG | Owner | Tue Nov 4 7:22am ET |
| Started | TE | Mason Taylor NYJ | Owner | Tue Nov 4 7:22am ET |
| Benched | WR | Jaylin Noel HOU | Owner | Tue Nov 4 7:21am ET |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 4 7:21am ET |
| Benched | WR | Elic Ayomanor TEN | Owner | Tue Nov 4 9:35am ET |
| Benched | TE | Tucker Kraft GB | Owner | Tue Nov 4 9:35am ET |
| Started | WR | DeAndre Hopkins BAL | Owner | Tue Nov 4 9:35am ET |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 4 9:35am ET |