

| Benched | D/ST | Detroit Lions DET | Owner | Wed Nov 12 7:41pm ET |
| Started | D/ST | Chicago Bears CHI | Owner | Wed Nov 12 7:41pm ET |
| Benched | RB | Kenneth Walker III SEA | Owner | Wed Nov 12 2:58am ET |
| Benched | TE | Jake Tonges SF | Owner | Wed Nov 12 2:58am ET |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 12 2:58am ET |
| Started | TE | Travis Kelce KC | Owner | Wed Nov 12 2:58am ET |
| No starting lineup changes performed this week. |
| Started | QB | Patrick Mahomes KC | Owner | Wed Nov 12 4:44pm ET |
| Benched | QB | Baker Mayfield TB | Owner | Wed Nov 12 4:44pm ET |
| Started | WR | A.J. Brown PHI | Owner | Wed Nov 12 4:43pm ET |
| Benched | WR | Jauan Jennings SF | Owner | Wed Nov 12 4:43pm ET |
| Started | TE | Jake Ferguson DAL | Owner | Wed Nov 12 4:42pm ET |
| Started | WR | Quentin Johnston LAC | Owner | Wed Nov 12 4:42pm ET |
| Started | WR | Jauan Jennings SF | Owner | Wed Nov 12 4:42pm ET |
| Benched | TE | Pat Freiermuth PIT | Owner | Wed Nov 12 4:42pm ET |
| Benched | WR | Michael Pittman Jr. IND | Owner | Wed Nov 12 4:42pm ET |
| Benched | WR | A.J. Brown PHI | Owner | Wed Nov 12 4:42pm ET |
| Started | K | Joey Slye TEN | Owner | Thu Nov 13 12:24am ET |
| Benched | WR | Marvin Harrison Jr. ARI | Owner | Wed Nov 12 11:49am ET |
| Started | WR | Jordan Addison MIN | Owner | Wed Nov 12 11:49am ET |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 11 9:56am ET |
| Benched | TE | Colston Loveland CHI | Owner | Tue Nov 11 9:56am ET |
| Benched | K | Michael Badgley IND | Owner | Tue Nov 11 9:56am ET |
| Started | WR | CeeDee Lamb DAL | Owner | Tue Nov 11 9:56am ET |
| Started | TE | Cade Otton TB | Owner | Tue Nov 11 9:56am ET |
| No starting lineup changes performed this week. |
| Benched | RB | D'Andre Swift CHI | Owner | Wed Nov 12 6:16pm ET |
| Started | RB | TreVeyon Henderson NE | Owner | Wed Nov 12 6:16pm ET |
| Benched | RB | TreVeyon Henderson NE | Owner | Tue Nov 11 4:31pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 11 4:31pm ET |
| No starting lineup changes performed this week. |
| Started | K | Nick Folk NYJ | Owner | Thu Nov 13 6:34am ET |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 11 7:26am ET |
| Benched | WR | Garrett Wilson NYJ | Owner | Tue Nov 11 7:26am ET |
| Started | WR | Tez Johnson TB | Owner | Tue Nov 11 7:26am ET |
| Started | WR | George Pickens DAL | Owner | Tue Nov 11 7:26am ET |
| Benched | RB | J.K. Dobbins DEN | Owner | Tue Nov 11 9:52pm ET |
| Benched | K | Jake Bates DET | Owner | Tue Nov 11 9:52pm ET |
| Benched | D/ST | Indianapolis Colts IND | Owner | Tue Nov 11 9:52pm ET |
| Started | RB | Javonte Williams DAL | Owner | Tue Nov 11 9:52pm ET |
| Started | K | Brandon Aubrey DAL | Owner | Tue Nov 11 9:52pm ET |
| Started | D/ST | Pittsburgh Steelers PIT | Owner | Tue Nov 11 9:52pm ET |
| Benched | D/ST | Carolina Panthers CAR | Owner | Wed Nov 12 11:04am ET |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Wed Nov 12 11:04am ET |
| Benched | RB | Jonathan Taylor IND | Owner | Tue Nov 11 9:15am ET |
| Benched | WR | Cedric Tillman CLE | Owner | Tue Nov 11 9:15am ET |
| Started | WR | Tee Higgins CIN | Owner | Tue Nov 11 9:15am ET |
| Started | WR | Rashee Rice KC | Owner | Tue Nov 11 9:15am ET |
| Benched | QB | Justin Fields NYJ | Owner | Wed Nov 12 2:56pm ET |
| Benched | WR | Deebo Samuel WAS | Owner | Wed Nov 12 2:56pm ET |
| Started | QB | Joe Flacco CIN | Owner | Wed Nov 12 2:56pm ET |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 12 2:56pm ET |