

| Started | QB | Jared Goff DET | Owner | Wed Nov 12 8:17pm CT |
| Benched | QB | Jared Goff DET | Owner | Tue Nov 11 7:35pm CT |
| Benched | RB | Terrell Jennings NE | Owner | Tue Nov 11 7:35pm CT |
| Benched | WR | Christian Kirk HOU | Owner | Tue Nov 11 7:35pm CT |
| Started | QB | Joe Flacco CIN | Owner | Tue Nov 11 7:35pm CT |
| Started | RB | Chase Brown CIN | Owner | Tue Nov 11 7:35pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 11 7:35pm CT |
| Benched | WR | Marvin Harrison Jr. ARI | Owner | Wed Nov 12 12:45pm CT |
| Started | WR | Stefon Diggs NE | Owner | Wed Nov 12 12:45pm CT |
| Benched | TE | Luke Musgrave GB | Owner | Wed Nov 12 12:04am CT |
| Started | TE | Travis Kelce KC | Owner | Wed Nov 12 12:04am CT |
| Started | RB | Tyler Allgeier ATL | Owner | Wed Nov 12 8:26pm CT |
| Benched | RB | J.K. Dobbins DEN | Owner | Wed Nov 12 8:26pm CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 11 9:55pm CT |
| Started | WR | Rashee Rice KC | Owner | Tue Nov 11 9:55pm CT |
| Started | WR | Matthew Golden GB | Owner | Tue Nov 11 9:55pm CT |
| Started | QB | C.J. Stroud HOU | Owner | Tue Nov 11 9:55pm CT |
| Benched | WR | Chris Olave NO | Owner | Tue Nov 11 9:55pm CT |
| Benched | WR | Dyami Brown JAX | Owner | Tue Nov 11 9:55pm CT |
| Benched | WR | Jack Bech LV | Owner | Tue Nov 11 9:55pm CT |
| Benched | RB | Tyler Allgeier ATL | Owner | Tue Nov 11 9:55pm CT |
| No starting lineup changes performed this week. |
| Benched | RB | Jonathan Taylor IND | Owner | Tue Nov 11 5:53pm CT |
| Started | WR | DeVonta Smith PHI | Owner | Tue Nov 11 5:53pm CT |
| Benched | RB | Rhamondre Stevenson NE | Owner | Wed Nov 12 5:13pm CT |
| Started | WR | Calvin Ridley TEN | Owner | Wed Nov 12 5:13pm CT |
| Started | RB | Rhamondre Stevenson NE | Owner | Tue Nov 11 6:19pm CT |
| Benched | QB | Sam Darnold SEA | Owner | Tue Nov 11 2:45pm CT |
| Benched | WR | Michael Pittman Jr. IND | Owner | Tue Nov 11 2:45pm CT |
| Benched | TE | Juwan Johnson NO | Owner | Tue Nov 11 2:45pm CT |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 11 2:45pm CT |
| Started | TE | Jake Ferguson DAL | Owner | Tue Nov 11 2:45pm CT |
| Benched | QB | Jaxson Dart NYG | Owner | Thu Nov 13 3:22pm CT |
| Started | QB | J.J. McCarthy MIN | Owner | Thu Nov 13 3:22pm CT |
| Benched | WR | Jerry Jeudy CLE | Owner | Tue Nov 11 9:52pm CT |
| Benched | WR | Cedric Tillman CLE | Owner | Tue Nov 11 9:52pm CT |
| Started | WR | Tee Higgins CIN | Owner | Tue Nov 11 9:52pm CT |
| Started | WR | Xavier Worthy KC | Owner | Tue Nov 11 9:52pm CT |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Started | WR | Mack Hollins NE | Owner | Wed Nov 12 11:21pm CT |
| Benched | WR | Kendrick Bourne SF | Owner | Wed Nov 12 11:21pm CT |
| Started | TE | George Kittle SF | Owner | Tue Nov 11 5:52pm CT |
| Started | WR | Kendrick Bourne SF | Owner | Tue Nov 11 5:52pm CT |
| Started | WR | Calvin Austin III PIT | Owner | Tue Nov 11 5:52pm CT |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 11 5:52pm CT |
| Benched | TE | Oronde Gadsden II LAC | Owner | Tue Nov 11 5:52pm CT |
| Benched | TE | Tyler Warren IND | Owner | Tue Nov 11 7:42am CT |
| Benched | WR | Kendrick Bourne SF | Owner | Tue Nov 11 7:42am CT |
| Benched | WR | Calvin Austin III PIT | Owner | Tue Nov 11 7:42am CT |
| Benched | QB | Trevor Lawrence JAX | Owner | Wed Nov 12 8:17pm CT |
| Started | QB | Joe Flacco CIN | Owner | Wed Nov 12 8:17pm CT |
| Benched | QB | Daniel Jones IND | Owner | Tue Nov 11 8:30am CT |
| Benched | WR | Jaylin Lane WAS | Owner | Tue Nov 11 8:30am CT |
| Started | QB | Geno Smith LV | Owner | Tue Nov 11 8:30am CT |
| Started | WR | CeeDee Lamb DAL | Owner | Tue Nov 11 8:30am CT |
| Benched | WR | Rashid Shaheed SEA | Owner | Wed Nov 12 7:11pm CT |
| Started | TE | Cade Otton TB | Owner | Wed Nov 12 7:11pm CT |