

| Benched | WR | Christian Watson GB | Owner | Tue Nov 11 8:18am ET |
| Benched | TE | Tyler Warren IND | Owner | Tue Nov 11 8:18am ET |
| Started | RB | Aaron Jones MIN | Owner | Tue Nov 11 8:18am ET |
| Started | WR | Tee Higgins CIN | Owner | Tue Nov 11 8:18am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Devin Singletary NYG | Owner | Tue Nov 11 7:21am ET |
| Benched | D/ST | Denver Broncos DEN | Owner | Tue Nov 11 7:21am ET |
| Started | RB | Chase Brown CIN | Owner | Tue Nov 11 7:21am ET |
| Started | D/ST | Cleveland Browns CLE | Owner | Tue Nov 11 7:21am ET |
| Benched | RB | J.K. Dobbins DEN | Owner | Thu Nov 13 12:36pm ET |
| Benched | WR | Quentin Johnston LAC | Owner | Thu Nov 13 12:36pm ET |
| Benched | TE | Dalton Kincaid BUF | Owner | Thu Nov 13 12:36pm ET |
| Benched | D/ST | Indianapolis Colts IND | Owner | Thu Nov 13 12:36pm ET |
| Started | RB | Rachaad White TB | Owner | Thu Nov 13 12:36pm ET |
| Started | WR | Jameson Williams DET | Owner | Thu Nov 13 12:36pm ET |
| Started | TE | Travis Kelce KC | Owner | Thu Nov 13 12:36pm ET |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Thu Nov 13 12:36pm ET |
| Benched | WR | Tre Tucker LV | Owner | Thu Nov 13 12:40pm ET |
| Started | WR | Jauan Jennings SF | Owner | Thu Nov 13 12:40pm ET |
| Benched | RB | Zach Charbonnet SEA | Owner | Thu Nov 13 3:36pm ET |
| Started | RB | Brashard Smith KC | Owner | Thu Nov 13 3:36pm ET |
| Benched | RB | Jonathan Taylor IND | Owner | Wed Nov 12 7:54am ET |
| Started | RB | Zach Charbonnet SEA | Owner | Wed Nov 12 7:54am ET |
| Benched | QB | Trevor Lawrence JAX | Owner | Wed Nov 12 8:00pm ET |
| Benched | RB | Tyler Allgeier ATL | Owner | Wed Nov 12 8:00pm ET |
| Benched | WR | Malik Washington MIA | Owner | Wed Nov 12 8:00pm ET |
| Started | QB | Joe Flacco CIN | Owner | Wed Nov 12 8:00pm ET |
| Started | RB | Kareem Hunt KC | Owner | Wed Nov 12 8:00pm ET |
| Started | WR | George Pickens DAL | Owner | Wed Nov 12 8:00pm ET |
| Benched | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 13 12:51am ET |
| Started | K | Harrison Butker KC | Owner | Thu Nov 13 12:51am ET |
| Started | D/ST | Dallas Cowboys DAL | Owner | Thu Nov 13 12:51am ET |
| Benched | D/ST | Carolina Panthers CAR | Owner | Tue Nov 11 2:49pm ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Tue Nov 11 2:49pm ET |
| Benched | WR | Chris Olave NO | Owner | Tue Nov 11 10:44am ET |
| Benched | WR | Michael Pittman Jr. IND | Owner | Tue Nov 11 10:44am ET |
| Started | WR | Stefon Diggs NE | Owner | Tue Nov 11 10:44am ET |
| Started | WR | Khalil Shakir BUF | Owner | Tue Nov 11 10:44am ET |
| Benched | WR | D.J. Moore CHI | Owner | Tue Nov 11 11:29am ET |
| Benched | WR | Parker Washington JAX | Owner | Tue Nov 11 11:29am ET |
| Started | RB | Javonte Williams DAL | Owner | Tue Nov 11 11:29am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 11 11:29am ET |
| No starting lineup changes performed this week. |
| Benched | QB | Jaxson Dart NYG | Owner | Wed Nov 12 9:51pm ET |
| Benched | WR | Garrett Wilson NYJ | Owner | Wed Nov 12 9:51pm ET |
| Benched | TE | Juwan Johnson NO | Owner | Wed Nov 12 9:51pm ET |
| Started | QB | Patrick Mahomes KC | Owner | Wed Nov 12 9:51pm ET |
| Started | WR | Rashee Rice KC | Owner | Wed Nov 12 9:51pm ET |
| Started | TE | AJ Barner SEA | Owner | Wed Nov 12 9:51pm ET |
| No starting lineup changes performed this week. |