

| Benched | RB | Jordan Mason MIN | Owner | Thu Nov 6 5:58pm ET |
| Started | QB | Jacoby Brissett ARI | Owner | Thu Nov 6 5:58pm ET |
| Benched | QB | Kyler Murray ARI | Owner | Tue Nov 4 5:12pm ET |
| Started | RB | Jordan Mason MIN | Owner | Tue Nov 4 5:12pm ET |
| Benched | QB | Jayden Daniels WAS | Owner | Tue Nov 4 4:34pm ET |
| Benched | RB | Chase Brown CIN | Owner | Tue Nov 4 4:34pm ET |
| Started | QB | Kyler Murray ARI | Owner | Tue Nov 4 4:34pm ET |
| Started | RB | Jacory Croskey-Merritt WAS | Owner | Tue Nov 4 4:34pm ET |
| Started | QB | Marcus Mariota WAS | Owner | Wed Nov 5 8:09pm ET |
| Benched | WR | D.J. Moore CHI | Owner | Tue Nov 4 8:58am ET |
| Started | RB | Breece Hall NYJ | Owner | Tue Nov 4 8:58am ET |
| Benched | TE | T.J. Hockenson MIN | Owner | Tue Nov 4 11:13am ET |
| Started | TE | Dallas Goedert PHI | Owner | Tue Nov 4 11:13am ET |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 4 11:13am ET |
| Benched | K | Evan McPherson CIN | Owner | Tue Nov 4 11:13am ET |
| Benched | D/ST | Indianapolis Colts IND | Owner | Tue Nov 4 11:13am ET |
| Started | RB | Rachaad White TB | Owner | Tue Nov 4 11:13am ET |
| Started | K | Eddy Pineiro SF | Owner | Tue Nov 4 11:13am ET |
| Started | D/ST | Pittsburgh Steelers PIT | Owner | Tue Nov 4 11:13am ET |
| Started | RB | Bhayshul Tuten JAX | Owner | Fri Nov 7 12:16pm ET |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Fri Nov 7 12:16pm ET |
| Started | TE | Harold Fannin Jr. CLE | Owner | Wed Nov 5 8:34pm ET |
| Started | WR | Xavier Hutchinson HOU | Owner | Wed Nov 5 8:34pm ET |
| Benched | RB | Bhayshul Tuten JAX | Owner | Wed Nov 5 8:34pm ET |
| Started | WR | Chris Godwin TB | Owner | Wed Nov 5 5:31pm ET |
| Benched | WR | Kayshon Boutte NE | Owner | Wed Nov 5 5:31pm ET |
| Started | K | Cam Little JAX | Owner | Wed Nov 5 3:33pm ET |
| Benched | K | Andres Borregales NE | Owner | Wed Nov 5 3:33pm ET |
| Started | WR | Emeka Egbuka TB | Owner | Wed Nov 5 12:45am ET |
| Started | RB | Bhayshul Tuten JAX | Owner | Wed Nov 5 12:45am ET |
| Started | RB | Tyler Allgeier ATL | Owner | Wed Nov 5 12:45am ET |
| Benched | TE | Tucker Kraft GB | Owner | Wed Nov 5 12:45am ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Wed Nov 5 12:45am ET |
| Benched | RB | Tyjae Spears TEN | Owner | Wed Nov 5 12:45am ET |
| Benched | K | Brandon Aubrey DAL | Owner | Wed Nov 5 5:10am ET |
| Started | K | Chase McLaughlin TB | Owner | Wed Nov 5 5:10am ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 5 5:08am ET |
| Started | RB | Nick Chubb HOU | Owner | Wed Nov 5 5:08am ET |
| Benched | QB | Tyler Shough NO | Owner | Wed Nov 5 5:07am ET |
| Started | QB | Baker Mayfield TB | Owner | Wed Nov 5 5:07am ET |
| No starting lineup changes performed this week. |
| Benched | QB | Patrick Mahomes KC | Owner | Wed Nov 5 6:16pm ET |
| Benched | RB | Kareem Hunt KC | Owner | Wed Nov 5 6:16pm ET |
| Benched | WR | Rashee Rice KC | Owner | Wed Nov 5 6:16pm ET |
| Started | QB | Justin Fields NYJ | Owner | Wed Nov 5 6:16pm ET |
| Started | RB | David Montgomery DET | Owner | Wed Nov 5 6:16pm ET |
| Started | WR | Garrett Wilson NYJ | Owner | Wed Nov 5 6:16pm ET |
| Started | WR | Parker Washington JAX | Owner | Wed Nov 5 7:44pm ET |
| Benched | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 4 6:07pm ET |
| Started | WR | Matthew Golden GB | Owner | Tue Nov 4 6:07pm ET |
| Benched | QB | Jordan Love GB | Owner | Tue Nov 4 10:37am ET |
| Benched | WR | CeeDee Lamb DAL | Owner | Tue Nov 4 10:37am ET |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 4 10:37am ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 4 10:37am ET |
| Started | TE | Zach Ertz WAS | Owner | Thu Nov 6 11:35am ET |
| Benched | TE | David Njoku CLE | Owner | Thu Nov 6 11:35am ET |
| Started | WR | Alec Pierce IND | Owner | Thu Nov 6 11:35am ET |
| Benched | WR | Kendrick Bourne SF | Owner | Thu Nov 6 11:35am ET |
| Started | TE | David Njoku CLE | Owner | Wed Nov 5 10:22am ET |
| Benched | TE | Zach Ertz WAS | Owner | Wed Nov 5 10:22am ET |
| Started | D/ST | Cleveland Browns CLE | Owner | Wed Nov 5 10:22am ET |
| Benched | D/ST | Minnesota Vikings MIN | Owner | Wed Nov 5 10:22am ET |
| Started | RB | Quinshon Judkins CLE | Owner | Wed Nov 5 10:22am ET |
| Benched | RB | Ollie Gordon II MIA | Owner | Wed Nov 5 10:22am ET |
| Benched | WR | George Pickens DAL | Owner | Tue Nov 4 9:48am ET |
| Started | WR | Tre Tucker LV | Owner | Tue Nov 4 9:48am ET |
| Benched | WR | Chimere Dike TEN | Owner | Tue Nov 4 8:04am ET |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 4 8:04am ET |
| Started | WR | Nico Collins HOU | Owner | Tue Nov 4 8:04am ET |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 4 8:04am ET |
| Benched | QB | Dak Prescott DAL | Owner | Tue Nov 4 7:29pm ET |
| Started | WR | DeVonta Smith PHI | Owner | Tue Nov 4 7:29pm ET |
| Started | WR | A.J. Brown PHI | Owner | Tue Nov 4 7:29pm ET |
| Started | RB | Saquon Barkley PHI | Owner | Tue Nov 4 7:29pm ET |
| Started | QB | Daniel Jones IND | Owner | Tue Nov 4 7:29pm ET |
| Benched | TE | Travis Kelce KC | Owner | Tue Nov 4 7:29pm ET |
| Benched | WR | Cooper Kupp SEA | Owner | Tue Nov 4 7:29pm ET |
| Benched | WR | Marquise Brown KC | Owner | Tue Nov 4 7:29pm ET |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 4 7:29pm ET |
| Started | TE | Colston Loveland CHI | Owner | Tue Nov 4 7:29pm ET |