New York Giants wide receiver Malik Nabers (concussion) has been ruled out ahead of the Week 5 matchup against the Seattle Seahawks. This doesn't come as much of a surprise given Nabers hasn't been able to practice this week. He continues to work his way back from a head injury he suffered in Week 4. The loss of Nabers is a significant hit to this Giants offense considering he has 35 receptions on 52 targets this season. Wan'Dale Robinson will likely gain the most value out of anyone on this offense with Nabers out. Robinson finished with 11 receptions on 14 targets with 71 yards last week. He figures to be a focal point in the passing game, especially with Nabers out.

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Tampa Bay Buccaneers quarterback Baker Mayfield continued his effective play during Thursday's game against the Atlanta Falcons. Mayfield looked solid as he completed 19-of-24 passing attempts for 180 yards and three touchdowns in the overtime loss. Mayfield was accurate in this one as he only had a handful of incompletions with zero turnovers. He also added 42 yards on the ground on six carries as Mayfield looked good with his legs. Mayfield will now head into a tougher challenge against the New Orleans Saints defense in Week 6. Despite that, Mayfield has done enough to put himself in the QB1 conversation for that game.

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Miami Dolphins tight end Jonnu Smith will not be a viable fantasy option in Week 5 when his team lines up for a road tilt against their division-rival New England Patriots. The 29-year-old had a productive outing -- for a TE, anyway -- in Week 2 against the Buffalo Bills when he reeled in 6-of-7 targets for 53 yards but has seen his production decline since then. Most recently, posting a goose egg on one target in the team's 31-12 loss against the Tennessee Titans. The Dolphins' offensive woes aside, it's unclear whether or not Smith is still the TE1 on this team, as teammate Julian Hill has out-snapped him each of the last two weeks and 125-to-100 on the season. The former still leads Hill in every statistical category. Still, the veteran tight end can't be a trusted source of consistent production as the fourth option at best in Miami's passing attack. He's RotoBaller's PPR TE26 ahead of Week 5.

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Houston Texans running back Joe Mixon (ankle) is not expected to suit up for the Week 5 matchup against the Buffalo Bills. Mixon hasn't played since Week 2 and it looks like he'll miss at least one more game. Mixon hasn't been able to practice this week, which puts him in the wrong direction ahead of Sunday's game. That being said, Cam Akers and Dare Ogunbowale figure to split up the backfield duties for at least one more week. Akers is looking like a low-end flex option after posting 53 yards on the ground on 13 attempts last week.

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Buffalo Bills wide receiver Khalil Shakir (ankle) has been ruled out ahead of the Week 5 matchup against the Houston Texans. Shakir was pulled early during last week's game due to an ankle issue. It doesn't seem to be improving too well as he hasn't practiced this week. As a result, Shakir will sit out this week and will hopefully return in Week 6. His absence should mean increased roles for Keon Coleman and Mack Hollins. Also, tight end Dalton Kincaid should see more targets in the passing game with Shakir sidelined. Kincaid saw a season-high seven targets and finished with 47 yards last week.

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Miami Dolphins wide receiver Jaylen Waddle has an enticing Week 5 matchup in a road tilt against the New England Patriots. Waddle -- along with the other Dolphins skill players -- has been one of the more disappointing fantasy assets through the first month of the season as his team works through their offensive challenges down their starting (Tua Tagovailoa [concussion]) and backup (Skylar Thompson [ribs]) quarterbacks. However, New England's defense presents as an excellent opportunity for a bounce-back effort. The Patriots have been porous against opposing passing attacks through four weeks, allowing the fourth-most pass yards per play. Additionally, the Dolphins could be forced into a pass-heavy script, as New England has been one of the better teams at stopping the run. While it hasn't translated to on-field production, the 25-year-old has been one of the better separators in the league, garnering an "OPEN" score of 76 per ESPN analytics -- a top-six score in the NFL and ten points better than his running-mate Tyreek Hill. Waddle is RotoBaller's PPR WR44 in this week's rankings.

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Miami Dolphins wide receiver Tyreek Hill has a juicy matchup lined up this Sunday when his team hits the road to square off against their division-rival New England Patriots. The veteran speedster has seen his production dip over the last few outings since a massive seven-catch, 130-yard performance in the team's season opener. Not only has Hill had his offensive woes with quarterbacks Tua Tagovailoa (concussion) and Skylar Thompson (ribs) shelved due to injury. Also, Miami has faced three top-six defenses regarding net passing yards per play since then. Everything is working against the 30-year-old wideout, but he'll have an opportunity to get right against a New England defense that has been beaten by the pass all season. Touchdowns might be tough to come by, with the Pats allowing 21.8 points per outing, but the 1,016 passing yards they've let up are the sixth-most in the NFL. Hill is the WR28 this week in RotoBaller's Week 5 PPR rankings, with as good a chance as any to bounce back before Miami's Week 6 bye.

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Buffalo Bills running back Ray Davis remains one of the best running back bench stashes across the league as the NFL enters Week 5. Under offensive coordinator Joe Brady, the Bills lean on James Cook and the running game. The rookie has been called upon to spell Cook on early downs. Veteran Ty Johnson would command the passing downs work if Cook suffered an injury. Blowouts have given Davis several opportunities, averaging over eight carries per game over the last three contests. In a closer game, his touches are likely cut in half. Keep Davis on fantasy football benches against Houston.

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The Buffalo Bills defense/special teams draws the Houston Texans in Week 5. The Texans are averaging a shade under 20 points per game, and their offense has taken a step back with Joe Mixon (ankle) sidelined. He's trending toward missing another game, which should slow down the Houston offense. However, Nico Collins and Stefon Diggs are one of the best wide receiver duos in football, and C.J. Stroud has little issues connecting with them. Stroud also limits his turnovers (two interceptions). The Texans' quarterback is sixth in the league in sacks taken (13). However, one of Buffalo's best pass rushers, Von Miller, is suspended for four games and will miss this contest. There are better DST options on the waiver wire this week. Fantasy managers can pass on Buffalo.

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Buffalo Bills tight end Dalton Kincaid is the TE7 on the season, despite an up-and-down campaign so far. Kincaid hasn't topped 50 yards in any game and has only finished as a TE1 once. Fantasy managers can trust Kincaid's floor, especially given the state of the tight-end landscape. Josh Allen should throw the ball more often in what projects to be a more competitive matchup between Buffalo and Houston. Kincaid could see more targets if Khalil Shakir (ankle) is forced to miss the contest. The Texans surrendered the third-fewest fantasy points to the position through four weeks, but the competition (Kylen Granson, Cole Kmet, Johnny Mundt, and Brenton Strange) isn't of Kincaid's caliber.

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Buffalo Bills wide receiver Curtis Samuel has played the fewest snaps of any Buffalo wide receiver this season but that could change in Week 5. Khalil Shakir (ankle) is in danger of missing the contest. Offensive coordinator Joe Brady stated to the media that he wants Samuel to be on the field more often. The veteran is averaging just 12 yards per game and secured three receptions or more just once. Samuel shouldn't be added to rosters in any standard-sized fantasy football league, but he's a name worth monitoring on Sunday, especially if Shakir is sidelined.

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Miami Dolphins running back De'Von Achane will have his work cut out for him this week when the team takes on the New England Patriots in Foxborough. The second-year back started the season off hot with back-to-back seven-catch games and 20+ fantasy-point outings. However, he's cooled over the last few weeks, with Miami posting just 15 total points combined over the two contests. New England has been one of the more stout defenses against opposing rushing attacks thus far, allowing just 4.0 YPC -- the seventh-best mark in the league. Despite this, the Texas A&M product could still leave his mark on this game if he can recapture his work in the passing game from early September. The Patriots' D has been easier to throw on this year, letting up the sixth-most yards and fourth-most yards per play (7.1) through the air, and that's likely where Miami will have to beat them to succeed. Achane is RotoBaller's PPR RB17 in this week's rankings and projects as an RB2 with upside.

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Buffalo Bills running back James Cook suffered through the worst fantasy performance of his season in Week 4 but should bounce back against the Houston Texans. Cook was removed from the game due to a negative game script against the Ravens. He logged just 10 touches for under 50 yards. The game script on Sunday versus Houston should fare better for Cook's fantasy production. However, the Texans' defense is stronger against the run than the pass, and they've allowed the fewest passing yards to opposing running backs. The Bills shouldn't have many issues moving the football on offense, setting up more high-value opportunities for the lead running back. Start Cook across the board.

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Los Angeles Rams wide receiver Tutu Atwell has now posted back-to-back weeks with WR3 finishes and even boasted a 90% snap share in their Week 4 loss against the Chicago Bears. Atwell hauled in four of his six targets for 82 yards in that contest while receiving a 21% target share. Since Cooper Kupp (ankle) has already been ruled out again, Atwell will look to capitalize on more opportunities against a Green Bay Packers secondary that has been quite generous to opposing receivers. In fact, the Packers give up the ninth-most fantasy points to receiver groups in half-PPR formats with an average of 30.3 fantasy points per game. That gives Atwell some nice flex appeal for fantasy managers in half or full-PPR formats that might be dealing with some injuries or bye weeks.

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Buffalo Bills wide receiver Keon Coleman could be called upon more often against the Houston Texans on Sunday. Top wide receiver Khalil Shakir (ankle) did not practice on Wednesday and Thursday and is at risk of missing the game. If he does, Coleman and Dalton Kincaid should see a target bump. Still, it would be risky for fantasy football managers to trust the rookie in starting lineups. He'll see a lot of cornerback Derek Stingley Jr. on the outside and hasn't garnered enough target volume to be relied upon. Coleman is in the WR5 range against the Texans.

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Miami Dolphins quarterback Tyler Huntley will line up for his second start of the season this Sunday when the team hits the road to take on the New England Patriots. With quarterback Skylar Thompson (ribs) still tending to an injury that forced him from Miami's Week 3 matchup, the dual-threat 26-year-old will again be at the helm for the Dolphins. His last time out, the former Raven failed to throw a score -- or interception -- leading Miami to 12 total points against the Tennessee Titans. He did add 40 yards rushing on eight carries but was largely ineffective in his first action since Week 18 of last season. This week, Huntley and Miami will get an easier matchup against a Patriots squad that is vulnerable to the pass -- allowing the fourth-most net yards per pass attempt to opposing offenses. It's possible the fifth-year QB keeps himself in the fantasy conversation with his work on the ground. Still, he'll be hard to trust outside of superflex and 2QB formats, based on what we've seen thus far.

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Los Angeles Rams running back Kyren Williams had some question marks surrounding his role entering the season, but after four weeks it's clear to see he remains the bell cow of this backfield. Williams has 23 touches compared to Ronnie Rivers' six in their Week 4 loss to the Chicago Bears, and he's seen no fewer than 16 total touches in each game this year. While the receiving corps is still banged up, the Rams will likely continue to lean on Williams and Matthew Stafford will undoubtedly look to throw his way out of the backfield as well. The Green Bay Packers are right in the middle of the pack when it comes to fantasy points allowed to opposing backfields while they average 20.1 fantasy points allowed per game. Fantasy managers can be confident starting Williams again this week.

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Buffalo Bills quarterback Josh Allen has ping-ponged between being the top fantasy football quarterback and an unstartable asset (QB28) over the past four weeks. Blowouts have been to blame. The Bills won two games by an average of 29 points and then lost in Week 4 by 25. A (hopefully) more competitive tilt against the Houston Texans will keep Allen aggressive and throwing for four quarters. Buffalo's signal caller is on the injury report with a left hand injury but he's practicing in full this week. He could be without his top wide receiver Khalil Shakir, who is dealing with an ankle injury. Through all the tribulations, Allen is the QB4 on the season and should be started in all leagues in Week 5.

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Los Angeles Rams quarterback Matthew Stafford hasn't posted the best start to the season in terms of fantasy football, but he continues to rack up yards and completions. Despite clocking in as the QB29, he has the highest completion percentage of his career this season while averaging 244.5 yards per game. This is all while Cooper Kupp (ankle) and Puka Nacua (knee) have been out for two and a half of the four weeks so far. In Week 5, Stafford takes on the Green Bay Packers who have given up the 13th-most fantasy points to opposing quarterbacks with an average of 17.1 per game. For fantasy managers dealing with byes, Stafford could be a sneaky streaming option since the Packers' offense is likely to put up some big points turning this into a shootout.

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Tampa Bay Buccaneers tight end Cade Otton continued his success during Thursday's game against the Atlanta Falcons. Otton hauled in three of his four targets for 44 yards during the overtime loss. This now marks three straight games that Otton has surpassed 40 receiving yards. This is nice to see after Otton had one total reception through the first two weeks of the season. It's worth noting that Otton is going to remain third on the pecking order, so fantasy managers shouldn't expect huge games from him. However, Otton should be able to do enough on a weekly basis to hold TE2 value.

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