Kansas City Chiefs running back Clyde Edwards-Helaire (illness) is doubtful for Monday's matchup with the Saints. The 25-year-old has practiced somewhat throughout the week, so he's moving in the right direction. However, fantasy managers must wait a little longer to see him back on the field. With Kareem Hunt (shoulder) off the injury report, he'll absorb most of the carries out of the backfield in Week 5, so he should be considered a starting fantasy option. While Samaje Perine found the end zone in the Week 4 win over the Chargers, he's hard to trust despite the potential for more work.

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Indianapolis Colts running back Trey Sermon hasn't seen much action this season, but that is set to change in Week 5. With starting running back Jonathan Taylor (ankle) confirmed out, Sermon is set to be the starter for Indianapolis in Sunday's matchup against the Jaguars. He also draws a favorable matchup, with the Jaguars allowing the seventh most fantasy points to the position. It's unclear how much of a split there will be between Sermon and RBs Tyler Goodson and Evan Hull, which might hinder Sermon's production in the matchup. Fantasy managers in deeper leagues needing a replacement for Taylor can look to Sermon, but managers with more depth might want to wait to see how the backfield plays out this week. He is the RB20 in our half-PPR rankings.

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New Orleans Saints tight end Taysom Hill (ribs) won't play on Monday night. He hasn't practiced all week due to fractured ribs and was listed as doubtful, so fantasy managers had a feeling things were heading in this direction. The 34-year-old has only two catches this season. However, he has two rushing touchdowns, meaning fantasy managers in multi-tight end setups may need to find a replacement. While Juwan Johnson could see more snaps, he's hard to trust from a fantasy standpoint.

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Indianapolis Colts wide receiver Josh Downs had his best game of the season in Week 4, grabbing eight catches for 82 yards and a touchdown in the team's win. Since returning from injury, Downs immediately went back into a starting role in the offense, offering a deep-threat ability with his speed. Downs is in for a favorable Week 5 matchup against the Jaguars, a team allowing the fifth-most fantasy points to the position and the second-most receiving yards this season. Jacksonville's defense has also been below-average against slot receivers, allowing the 11th most points to the position. The starting QB for Indy in Week 5 has yet to be confirmed, but Downs' value would see a slight uptick if QB Joe Flacco is named the starter for Sunday. With the favorable matchup and his big-play ability, fantasy managers can view Downs as a solid WR3 option. He is the WR34 in our half-PPR rankings.

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New Orleans Saints running back Alvin Kamara (hip, ribs) practiced in full on Saturday and doesn't carry an injury designation heading into Monday night's meeting with the Chiefs. Kamara is battling multiple ailments. However, the 29-year-old will likely continue to play through the pain barring any setbacks. He looked great in the Saints' first four contests, amassing 362 yards and five touchdowns off 80 carries, adding 17 catches for 174 yards and a touchdown. He's a must-start despite a challenging matchup with a Chiefs defense that has allowed the fewest fantasy points to opposing running backs in 2024-25. His presence versus Kansas City will mean fewer snaps for Jamaal Williams, who would have been in line for more work.

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Pittsburgh Steelers kicker Chris Boswell is tied for second in the NFL in field goals made so far this season and will look to stay involved against the Dallas Cowboys in Week 5. The Cowboys, dealing with numerous injuries to key defensive starters, have allowed 26 points per contest through the first four weeks. This should be a competitive affair in which the Steelers can effectively move the ball. Although Boswell has not been nearly as prolific for fantasy purposes since his six-for-six showing in Week 1, he remains a reliable option with a handful of opportunities every week. The 33-year-old can be deployed in starting lineups by fantasy managers without an elite-level option.

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Indianapolis Colts wide receiver Michael Pittman Jr. had his best performance of the season in Week 4, grabbing six targets for 113 yards. He now gears up for a favorable matchup against the Jacksonville Jaguars in Week 5. The Jaguars have allowed the fifth most points to the position this season and the second-most receiving yards. No. 1 WR options have succeeded against Jacksonville this season, most recently in Week 4 when WR Nico Collins grabbed 12 catches for 151 yards and a touchdown. While there is still uncertainty at the QB position for Indy with Anthony Richardson (hip) doubtful, Pittman makes for a strong start regardless of the starting QB. Fantasy managers can prioritize him as a WR2 in Week 5. He is the WR27 in our half-PPR rankings.

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Pittsburgh Steelers tight end Pat Freiermuth found the end zone in Week 4 and hopes to be similarly productive in a Week 5 bout with the Dallas Cowboys. Freiermuth is enjoying a prominent role in new offensive coordinator Arthur Smith's system as the only tight end in the NFL with at least four receptions in all four weeks this season. Although the Cowboys have been stout against opposing tight ends in 2024, Freiermuth's consistent utilization gives him a floor that many players at the position cannot provide for fantasy purposes. He is essential to Pittsburgh's success as a preferred weapon in the passing game second only to receiver George Pickens. Freiermuth may have trouble repeating his success of last week on Sunday night, but fantasy managers can rely on him as a low-end TE1 nonetheless.

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Pittsburgh Steelers wide receiver George Pickens had his best showing of the campaign in Week 4 and will look to carry positive momentum into a primetime showdown against the Dallas Cowboys. Through the first four weeks of the season, Pickens has earned over 28% of the team's targets with quarterback Justin Fields at the helm. Fields has been steady as a passer in 2024 and consistently displays trust in Pickens as his go-to receiver. Dallas' defense has been solid against opposing wideouts but did allow rookie sensation Malik Nabers to post 12 receptions for 115 yards last week. The Cowboys are a bit banged up defensively, with linebacker Micah Parsons (ankle) out and defensive back Trevon Diggs (ankle) questionable for Sunday night's contest. Although Diggs is expected to suit up, Pickens could benefit from any limitations faced by the former All-Pro corner. Pickens is yet to find the end zone this season but continues to offer fantasy managers plenty of upside due to his ability to make plays down the field. The 23-year-old should be locked into lineups as a WR2 this week.

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Jacksonville Jaguars tight end Evan Engram (hamstring) is not expected to play on Sunday against the Indianapolis Colts. Engram has been sidelined since Week 1 but returned to practice this week, participating in a limited capacity each day. He suffered the hamstring injury during pregame warmups in Week 2 and could miss a fourth consecutive game as a result. Unless something changes unexpectedly, the Jaguars will attempt to secure their first win of the season without this crucial target. In Engram's absence, Brenton Strange has stepped up as the clear starter, recording eight receptions for 96 yards and a touchdown on 14 targets. However, his target share has declined over the past two weeks. While Strange can be considered a risky streaming option, he may still provide value in a pinch this week.

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Pittsburgh Steelers running back Najee Harris was underwhelming for fantasy purposes last week but will hope to capitalize on an enticing matchup against the Dallas Cowboys in Week 5. The Steelers will once again be without Jaylen Warren (knee), and with Cordarrelle Patterson (ankle) also sidelined, Harris is poised to amass a large volume of touches. Dallas's defense has struggled to stop the run this season and has surrendered the third-most fantasy points to running backs through the first four weeks. In addition to his utilization on the ground, Harris has been extremely involved in the passing game over the past two weeks, recording eight receptions on 11 targets. Pittsburgh lacks proven depth in the backfield, and although Aaron Shampklin is likely to mix in, Harris should operate in a workhorse role on Sunday night. He can remain in fantasy lineups as a solid RB2.

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The Green Bay Packers have placed wide receiver Romeo Doubs on the reserve/suspended list for one game due to conduct detrimental to the team. Reports indicate that Doubs missed practice this week out of frustration with his role in the offense. Although he participated in practice on Wednesday, he did not attend on Thursday. Concerned for his well-being, team representatives visited him at home. Doubs currently ranks second on the team in receiving yards and receptions, trailing only Jayden Reed in those categories. He has recorded 12 catches for 169 yards this season but has yet to score a touchdown. With fellow receiver Christian Watson also expected to miss tomorrow's game against the Rams, the Packers will rely on Reed and Dontayvion Wicks to step up in a more significant capacity for Sunday's matchup in Los Angeles.

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The Arizona Cardinals have downgraded tight end Trey McBride (ribs) to questionable for Sunday's game due to a rib injury. McBride had cleared concussion protocol earlier this week after missing Week 4 against the Commanders, but he has now appeared on the injury report with this new issue. This season, McBride has recorded 14 receptions on 21 targets for a total of 122 yards. In his last outing against San Francisco in Week 15 of 2023, he caught 10 passes for 102 yards. Backup tight end Elijah Higgins saw an increase in playing time last week, managing two receptions for 12 yards against Washington. However, it's difficult to project his future role, especially since the Cardinals had effectively lost that game by halftime. More updates on McBride's injury are expected before Sunday's 4:05 p.m. ET kickoff against the 49ers.

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The San Francisco 49ers defense/special teams unit hosts the Arizona Cardinals in a Week 5 divisional matchup on Sunday. The Niners rank as the fourth-most productive D/ST in football so far, propelled by a big performance against New England last week. San Francisco sacked quarterback Jacoby Brissett six times, recovered two fumbles, and intercepted one pass which was taken to the house by linebacker Fred Warner. Arizona's offense has been decent so far, ranking 13th in both yards per game and points per game. They're relatively healthy, though tight end Trey McBride (ribs) was tagged as questionable on Saturday after clearing concussion protocol, and starting right tackle Kelvin Beachum (hamstring) is also questionable. On the other side, the 49ers are a bit beat up on defense with tackle Javon Hargrave (triceps) still on Injured Reserve and Warner (ankle) questionable. A few backups are also unavailable, which could make things more difficult in Santa Clara's predicted 99-degree weather. The 49ers D/ST is RotoBaller's seventh-ranked option in Week 5, with a bit of a boost if Warner plays.

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Pittsburgh Steelers quarterback Justin Fields is coming off a three-touchdown performance and will hope to keep rolling against the Dallas Cowboys in Week 5. This should be a favorable matchup for Fields as Dallas has surrendered the 11th-most fantasy points and sixth-most rushing yards to opposing quarterbacks through the first four weeks of the season. Fields' fantasy potential will additionally benefit from the absence of star linebacker Micah Parsons (ankle), who the Cowboys have ruled out for Sunday night. Although the Steelers are favored at home, Dallas' offense has plenty of firepower and should be able to put up points. This bodes well for Fields, who proved in Week 4 that he can effectively command Pittsburgh's offense when trailing. The 25-year-old signal-caller can be started as a low-end QB1 with upside this week.

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Indianapolis Colts quarterback Anthony Richardson (oblique) and center Ryan Kelly (neck) have both been downgraded from questionable to doubtful to play in Week 5 against the division-rival Jacksonville Jaguars. Richardson suffered an oblique injury in the Week 4 win over the Pittsburgh Steelers and was relieved by veteran Joe Flacco, who now appears to be in line for his first start in Indy in 2024. Fantasy managers were probably already considering benching Richardson this week after his disappointing start to his sophomore season, and now you can officially move him to the bench for Week 5. The 39-year-old Flacco becomes a clear QB2 streamer in superflex leagues against a Jaguars defense that has allowed the second-most fantasy points per game to QBs so far this year. Flacco went 16-for-26 for 168 yards and two touchdowns in relief of Richardson last week against Pittsburgh.

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San Francisco 49ers kicker Jake Moody has a home matchup in Week 5 against the Arizona Cardinals. Last week versus New England hit all three field goal attempts -; from 22, 26, and 41 yards -; and made all three extra-point tries. Moody is tied with Dallas' Brandon Aubrey for the second-most kicker fantasy points per game in Yahoo default scoring. Last year San Francisco's red zone offense was hyper-efficient, which meant that Moody only attempted 25 field goals in his rookie year while leading the league in extra points. In 2024 however, Moody is already nearly halfway to that field goal attempt total with 12 through four games. The Cardinals' defense is allowing 26.5 points per game to opposing offenses -- fourth worst in the NFL -- so Moody's floor is safe even if it turns into one of his patented extra-point games. Moody is a top-5 option in Week 5.

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The Indianapolis Colts elevated running back Evan Hull and cornerback David Long Jr. to the active roster from the practice squad on Saturday. The team also signed cornerback Alex Johnson to the practice squad and released running back Trent Pennix from the practice squad. Hull will provide more backfield insurance with Jonathan Taylor (ankle) ruled out for the Week 5 divisional contest against the Jacksonville Jaguars this weekend. With Taylor sidelined for at least one week, Trey Sermon is expected to operate as Indy's lead back, with Tyler Goodson backing him up. The Colts' offense is likely to be without quarterback Anthony Richardson (oblique), too, with veteran Joe Flacco expected to make his first start in 2024. Hull had one carry for one yard and caught his only target for a six-yard pickup in one game in his rookie season with the Colts in 2023.

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Green Bay Packers wide receiver Romeo Doubs skipped practices on Thursday and Friday because he is upset with his opportunities in the passing game through the first four weeks of the 2024 season, according to sources. Because of Doubs' skipped practices, he's now doubtful to play in Week 5 against the Los Angeles Rams due to personal reasons. "It's still day-to-day," head coach Matt LaFleur said after Friday's practice. Doubs is third on the team with 20 targets, only two behind Jayden Reed and Dontayvion Wicks, who have 22 apiece. Last year, he had a team-high 96 targets -- two more than Reed and well ahead of Wicks (58) and Christian Watson (53). Green Bay didn't throw as much with quarterback Jordan Love (knee) missing two games due to injury. With Watson (ankle) and Doubs doubtful to play in Week 5, Reed and Wicks and tight end Tucker Kraft will be more attractive in fantasy.

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New England Patriots safety Jabrill Peppers (shoulder) has been downgraded to out for the Week 5 divisional contest on Sunday against the visiting Miami Dolphins. Peppers put in a few limited practices this week after injuring his shoulder in the Week 4 loss to the San Francisco 49ers and will now have to miss at least one game. The 29-year-old figures to have a good shot at returning in Week 6 to face the Houston Texans, barring a setback. It's a big loss for the Patriots' secondary in a plus matchup against a Dolphins offense that is currently being led by backup quarterback Tyler Huntley. With Peppers sidelined on Sunday, expect the Patriots to deploy Dell Pettus and Jaylinn Hawkins more. Defensive back Kyle Dugger (ankle) is also listed as questionable for New England. Peppers has 23 tackles (11 solo) and an interception through the first four games of 2024 in his third year in New England.

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