Kansas City Chiefs tight end Travis Kelce will face the New Orleans Saints on Monday night in Week 5. Kelce was the top target in the Chiefs offense after star receiver Rashee Rice went down with a knee injury in the first quarter. Kelce finished the game with seven catches for 89 yards on nine targets in Week 4. With Kansas City officially placing Rashee Rice on injured reserve, Kelce should regain his role as the top target for Patrick Mahomes. The Saints should be a favorable matchup for the Chiefs passing attack, and Kelce could be in for a big game. Mahomes will likely involve Xavier Worthy and the other receivers, but Kelce should be the favorite to lead the team in targets and receptions this week. Kelce is also without a touchdown through four games, so look for that to change in this primetime matchup. Fantasy managers should feel much more confident about starting Kelce this week.

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San Francisco 49ers wide receiver Trent Taylor has been elevated from the practice squad ahead of the Week 5 matchup against the Arizona Cardinals. Taylor will join the active roster for the first time this season with fellow wideout Jacob Cowing (shoulder) unlikely to play. Taylor will serve as depth at wide receiver, but will likely be used more frequently as a punt and kick returner. He hasn't recorded a reception in an NFL game since 2022. He's unlikely to see much action in the receiving game with a majority of the 49ers wideouts healthy right now. Taylor will likely just return kicks, which means he won't have much fantasy appeal for this weekend.

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Kansas City Chiefs quarterback Patrick Mahomes will take on the New Orleans Saints on Monday night in Week 5. Mahomes will be without his favorite receiver, Rashee Rice, for the foreseeable future as the Chiefs placed him on injured reserve due to a severe knee injury. The remaining Chiefs receiving corps will be asked to step up in his absence. The primary beneficiary figures to be Travis Kelce, who should vacuum up those middle-of-the-field targets that Rice was feasting on. Rookie Xavier Worthy, Justin Watson, Skyy Moore, JuJu Smith-Schuster, and Mecole Hardman all figure to play a role in the passing attack, but their volume is to be determined. Mahomes has not been a great fantasy quarterback by any stretch of the imagination this season, as he has thrown for less than 300 yards and at least one interception in every contest. The loss of his best receiver should also decrease his production, making him an undesirable start in fantasy football most weeks. Despite his poor start and few game-changing pass catchers, Mahomes could find success against the Saints this week. The Saints have given up the ninth-most passing yards to opposing offenses this season but have also given up the fewest passing touchdowns. If Mahomes does not find a way to get it done in this matchup, fantasy managers may need to readjust their expectations for him this season.

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New York Giants wide receiver Isaiah Hodgins has been elevated from the practice squad ahead of the Week 5 matchup against the Seattle Seahawks. Hodgins started with the Giants last season, but failed to make the 53-man roster out of training camp. Despite that, Hodgins decided to remain with the organization and go to the practice squad. He'll be elevated for the first time this season with fellow wideout Malik Nabers (concussion) ruled out. Hodgins hauled in 21 receptions for 230 yards and three touchdowns across 17 games last season. He figures to be a depth option behind Wan'Dale Robinson and Darius Slayton in this offense.

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Las Vegas Raiders defensive end Maxx Crosby (ankle) is expected to return to the field for the Week 5 matchup against the Denver Broncos. The star pass rusher returned to practice on Friday and appears to be in line to play this weekend. Crosby missed his first game of his career last week after playing in 86 straight games. His return to the field is a welcoming sight for this defensive unit. Crosby has 14 tackles and three sacks through three games this season.

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Denver Broncos running back Tyler Badie (back) has been placed on the injured reserve prior to the Week 5 matchup against the Las Vegas Raiders. Badie went down with a back injury during last week's game. It appears the injury is somewhat significant considering the team has placed him on the IR, so Badie will miss at least the next four games. The young back hasn't done a ton this season outside of his 70-yard performance against the Tampa Bay Buccaneers. Javonte Williams and Jaleel McLaughlin figure to split up the workload in the backfield going forward.

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According to ESPN's Jeremy Fowler, Washington Commanders running back Brian Robinson Jr. (knee) will suit up for Sunday's game versus the Browns. He was officially labeled as questionable heading into this contest. However, with Austin Ekeler (concussion) also cleared to play, the Commanders will have their top options out of the backfield. While Robinson's presence should mean fewer touches for Ekeler, the knee injury could still jeopardize the former's volume in Week 5. As a result, both should be considered flex options against Cleveland, although Robinson's ceiling is still considerably higher.

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Washington Commanders quarterback Marcus Mariota (chest) was removed from the injured reserve list on Saturday. The veteran signed a one-year deal with Washington during the offseason. However, he hasn't stepped on the field for the Commanders. For now, Mariota is questionable for the Week 5 meeting with the Browns. Still, Jayden Daniels is the team's starting signal-caller, so anyone behind him will only have fantasy value for insurance purposes.

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The Arizona Cardinals elevated kicker Chad Ryland to the active roster for Sunday's game against the 49ers. The 24-year-old had a rough season in 2023, making only 64% of his field goal attempts. While that type of production won't land him on most fantasy rosters, Saturday's move could mean Matt Prater, who is questionable, (knee) won't be healthy enough to get on the field versus the Niners.

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Indianapolis Colts quarterback Joe Flacco came off the bench to help the Colts in Week 4, completing 16 of his 26 passes for 168 yards and two touchdowns in the team's win. Now, reports suggest that Flacco will get the start again in Week 5, with Anthony Richardson (hip) marked as doubtful. Flacco gets a favorable matchup against Jacksonville, a team that has allowed the most fantasy points to opposing QBs this season and the second most passing yards. Although Flacco doesn't provide the same ceiling as some other potential streaming options, he provides a very safe floor going up against Jacksonville's defense. He is the QB23 in our staff rankings this week.

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Kansas City Chiefs wide receiver Mecole Hardman Jr. (knee) is questionable for Monday's matchup with the Saints. The veteran didn't practice on Friday. However, he was a full-participant on Saturday, so there's a good chance he'll suit up. With that said, despite the absences of Rashee Rice (knee) and Marquise Brown (shoulder), Hardman likely won't get more involved, considering he's primarily used on special teams. As a result, it will likely be business as usual versus New Orleans, with Travis Kelce and Xavier Worthy expected to see the most attention from Patrick Mahomes.

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Kansas City Chiefs running back Kareem Hunt (shoulder) doesn't carry an injury designation heading into Monday's matchup with the Saints. He was limited at practice on Thursday and Friday. However, he logged a full session on Saturday. The veteran looked good in his first game back with the Chiefs, amassing 69 yards off 14 carries, adding two catches for 16 yards in the Week 4 win over the Chargers. With Clyde Edwards-Helaire (illness) doubtful, Hunt should get most of the work out of the backfield in Week 5, so he's worth a start in any fantasy format. The same can't be said for Samaje Perine, who had a touchdown versus Los Angeles, and Carson Steele.

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Kansas City Chiefs running back Clyde Edwards-Helaire (illness) is doubtful for Monday's matchup with the Saints. The 25-year-old has practiced somewhat throughout the week, so he's moving in the right direction. However, fantasy managers must wait a little longer to see him back on the field. With Kareem Hunt (shoulder) off the injury report, he'll absorb most of the carries out of the backfield in Week 5, so he should be considered a starting fantasy option. While Samaje Perine found the end zone in the Week 4 win over the Chargers, he's hard to trust despite the potential for more work.

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Indianapolis Colts running back Trey Sermon hasn't seen much action this season, but that is set to change in Week 5. With starting running back Jonathan Taylor (ankle) confirmed out, Sermon is set to be the starter for Indianapolis in Sunday's matchup against the Jaguars. He also draws a favorable matchup, with the Jaguars allowing the seventh most fantasy points to the position. It's unclear how much of a split there will be between Sermon and RBs Tyler Goodson and Evan Hull, which might hinder Sermon's production in the matchup. Fantasy managers in deeper leagues needing a replacement for Taylor can look to Sermon, but managers with more depth might want to wait to see how the backfield plays out this week. He is the RB20 in our half-PPR rankings.

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New Orleans Saints tight end Taysom Hill (ribs) won't play on Monday night. He hasn't practiced all week due to fractured ribs and was listed as doubtful, so fantasy managers had a feeling things were heading in this direction. The 34-year-old has only two catches this season. However, he has two rushing touchdowns, meaning fantasy managers in multi-tight end setups may need to find a replacement. While Juwan Johnson could see more snaps, he's hard to trust from a fantasy standpoint.

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Indianapolis Colts wide receiver Josh Downs had his best game of the season in Week 4, grabbing eight catches for 82 yards and a touchdown in the team's win. Since returning from injury, Downs immediately went back into a starting role in the offense, offering a deep-threat ability with his speed. Downs is in for a favorable Week 5 matchup against the Jaguars, a team allowing the fifth-most fantasy points to the position and the second-most receiving yards this season. Jacksonville's defense has also been below-average against slot receivers, allowing the 11th most points to the position. The starting QB for Indy in Week 5 has yet to be confirmed, but Downs' value would see a slight uptick if QB Joe Flacco is named the starter for Sunday. With the favorable matchup and his big-play ability, fantasy managers can view Downs as a solid WR3 option. He is the WR34 in our half-PPR rankings.

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New Orleans Saints running back Alvin Kamara (hip, ribs) practiced in full on Saturday and doesn't carry an injury designation heading into Monday night's meeting with the Chiefs. Kamara is battling multiple ailments. However, the 29-year-old will likely continue to play through the pain barring any setbacks. He looked great in the Saints' first four contests, amassing 362 yards and five touchdowns off 80 carries, adding 17 catches for 174 yards and a touchdown. He's a must-start despite a challenging matchup with a Chiefs defense that has allowed the fewest fantasy points to opposing running backs in 2024-25. His presence versus Kansas City will mean fewer snaps for Jamaal Williams, who would have been in line for more work.

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Pittsburgh Steelers kicker Chris Boswell is tied for second in the NFL in field goals made so far this season and will look to stay involved against the Dallas Cowboys in Week 5. The Cowboys, dealing with numerous injuries to key defensive starters, have allowed 26 points per contest through the first four weeks. This should be a competitive affair in which the Steelers can effectively move the ball. Although Boswell has not been nearly as prolific for fantasy purposes since his six-for-six showing in Week 1, he remains a reliable option with a handful of opportunities every week. The 33-year-old can be deployed in starting lineups by fantasy managers without an elite-level option.

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Indianapolis Colts wide receiver Michael Pittman Jr. had his best performance of the season in Week 4, grabbing six targets for 113 yards. He now gears up for a favorable matchup against the Jacksonville Jaguars in Week 5. The Jaguars have allowed the fifth most points to the position this season and the second-most receiving yards. No. 1 WR options have succeeded against Jacksonville this season, most recently in Week 4 when WR Nico Collins grabbed 12 catches for 151 yards and a touchdown. While there is still uncertainty at the QB position for Indy with Anthony Richardson (hip) doubtful, Pittman makes for a strong start regardless of the starting QB. Fantasy managers can prioritize him as a WR2 in Week 5. He is the WR27 in our half-PPR rankings.

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Pittsburgh Steelers tight end Pat Freiermuth found the end zone in Week 4 and hopes to be similarly productive in a Week 5 bout with the Dallas Cowboys. Freiermuth is enjoying a prominent role in new offensive coordinator Arthur Smith's system as the only tight end in the NFL with at least four receptions in all four weeks this season. Although the Cowboys have been stout against opposing tight ends in 2024, Freiermuth's consistent utilization gives him a floor that many players at the position cannot provide for fantasy purposes. He is essential to Pittsburgh's success as a preferred weapon in the passing game second only to receiver George Pickens. Freiermuth may have trouble repeating his success of last week on Sunday night, but fantasy managers can rely on him as a low-end TE1 nonetheless.

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