San Francisco 49ers running back Isaac Guerendo (hamstring) suffered a hamstring injury at practice Wednesday, significant enough to be visibly upset by it. Guerendo was pick 129 in the fourth round of the 2024 NFL draft by the 49ers, hoping to impact one of the league's best-rushing offenses. The San Francisco 49ers' rushing offense revolves heavily around Christian McCaffrey, who recorded 272 carries in 16 games during the 2023 season, tied for the second-most in the NFL. If McCaffrey were injured, another player would have a significant opportunity to step into the starting running back role. Should Guerendo miss time due to injury, Elijah Mitchell becomes the clear backup and handcuff to McCaffrey, with Jordan Mason likely to regain the third-string role. Guerendo should be off of fantasy radars if injured, but the backup role in San Francisco is one to keep track of all season.

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Buffalo Bills wide receiver Khalil Shakir (lower body) returned to practice Wednesday after missing time due to a lower body injury. Shakir initially suffered the injury during minicamp. His recovery is crucial as he aims to secure a more prominent role in Buffalo's passing game, especially following the offseason departures of Stefon Diggs and Gabe Davis. Shakir stands out as the only returning wide receiver who has caught a pass from quarterback Josh Allen in a game, showcasing his potential to become a key target. Last season, he impressed with 39 receptions for 611 yards and two touchdowns over 17 games. He is competing with rookie Keon Coleman, tight end Dalton Kincaid, and veteran Curtis Samuel for targets in Buffalo's passing game. With minimal competition for targets and established chemistry with Allen, Shakir presents significant value as a late-round pick in fantasy drafts, offering upside for those looking to round out their roster.

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Detroit Lions CB Carlton Davis (undisclosed), WR Donovan Peoples-Jones (undisclosed), CB Amik Robertson (undisclosed) and WR Tre'Quan Smith (undisclosed) passed their physicals Wednesday, July 24, and have been activated from the Active/Non-Football Injury list.

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Houston Texans RB Joe Mixon (undisclosed) did not participate in practice Wednesday, July 24.

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Free-agent WR Laquon Treadwell (Ravens) signed with the Indianapolis Colts Wednesday, July 24. Terms of the contract were not disclosed. The team also waived WR Xavier White.

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Jacksonville DT Arik Armstead (knee) should be fine for the regular season even though he started training camp on the Active/Physically Unable to Perform list, according to head coach Doug Pederson.

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Pittsburgh Steelers running back Najee Harris spoke to the media on Wednesday for the first time since the team declined his fifth-year option in the spring. Harris said he wants to remain in Pittsburgh on a long-term basis but noted that it's "a business" and isn't fretting about the future. In three seasons with the Steelers, Harris has exceeded the 1,000-yard rushing mark in each year, but he's averaged 3.9 yards per attempt on 834 carries over his career. The 26-year-old is set to split carries with the more explosive Jaylen Warren in 2024, but new offensive coordinator Arthur Smith is likely going to ride Harris in early-down spots and goal-line situations. Harris is shaping up as a solid RB2 bet in the middle rounds fantasy drafts as the starter in a run-centric offense with improved quarterback play.

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Green Bay Packers wide receiver Jayden Reed (toe) came off the non-football injury list on Wednesday. After dealing with a minor toe injury, Reed was back at training camp for Wednesday's practice. The Packers sport a packed receiving corps for star quarterback Jordan Love in 2024, but it's Reed who's projecting as the signal-caller's favorite target while holding an ADP of 56 in fantasy drafts this summer, per RotoBaller. The 24-year-old former second-round pick was a standout in Green Bay's offense during his rookie campaign, ranking in the top 10 at his position in both PPR fantasy points per route run (0.56) and fantasy points per target (2.31) while totaling 10 touchdowns in 16 games (94 targets). Reed is an exciting WR2 bet in this upstart offense.

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Cleveland Browns running back Nick Chubb (knee) was officially placed on the Physically Unable to Perform list on Wednesday. Nothing has changed in terms of Chubb's timetable for a return from last year's Week 2 dislocated knee and torn MCL, as there remains no word regarding the likelihood of his Week 1 availability for this season. The 28-year-old Pro Bowl running back is being drafted 134th overall on average in fantasy drafts this summer, per RotoBaller, with the idea that he may not be ready for the outset of the campaign. Entering his age-29 year and coming off his second major knee surgery, Chubb is one of 2024's top wild cards with a wide range of potential outcomes as an RB3/4 gamble. At the moment, Jerome Ford looks like a decent value pick in the later rounds as the likely lead back for the Browns for any games Chubb may be inactive for.

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Los Angeles Chargers head coach Jim Harbaugh said on Wednesday that running back Gus Edwards (undisclosed) had an offseason surgery, and the Chargers are giving him a "longer runway" to be a full participant in practice. Edwards didn't participate in team drills on Wednesday, but he went through individuals. The 29-year-old power back is entering his first year away from the Baltimore Ravens as Los Angeles' presumptive lead back over J.K. Dobbins (knee), but the latter could make his case for a more prominent role if the former is eased back into action this summer. After scoring 13 touchdowns in 17 games with the Ravens last year, Edwards is still fine to draft in fantasy leagues as a touchdown-dependent RB3 until a clearer picture emerges of how the touches will be divvied up in this backfield, but rookie Kimani Vidal also looms as a threat.

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New Orleans Saints running back Kendre Miller (hamstring) left Wednesday's practice with a hamstring injury. Miller strained his hamstring last year during the preseason to start off what was an injury-ruined rookie year. He should be considered day-to-day until more is known, but the Saints could certainly opt to take a cautious approach here. The 22-year-old TCU product was a third-round pick in last year's NFL draft, but he was held to eight just appearances, and he'd be missing out on valuable reps if this turns out to be a significant setback. Jamaal Williams would have a clearer path to No. 2 duties behind starter Alvin Kamara for any time Miller is absent from training camp, with gadget player Taysom Hill likely getting more involved in New Orleans' backfield.

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Denver Broncos running back Javonte Williams took first-team reps in every drill at training camp on Wednesday. Head coach Sean Payton praised Williams, saying he lost weight and is in good shape with noticeably different conditioning. After looking a step slow all year and averaging 3.6 yards per carry over 217 rushing attempts in his first season following ACL, LCL, and PLC ligament tears, Williams is off on the right foot at practice despite rumors circulating that he could be a cut candidate this offseason. Still only 24 years old, Williams will still need to hold off the speedy Jaleel McLaughlin, rookie Audric Estime, and veteran Samaje Perine for a featured role in Denver's crowded backfield. If Perine ends up being a cap casualty, however, Williams' ADP of 115.5 would start to come up. For now, he should continue to be treated as an RB3 option in a weak Broncos offense.

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Baltimore Ravens QB Lamar Jackson returned to practice on Wednesday, July 24, after missing three days due to an unspecified illness.

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New York Jets running back Breece Hall (lower body), who was dealing with an undisclosed lower-body issue during offseason workouts, took part in 11-on-11 drills during training camp practice on Wednesday. It's a great sign for Hall after he was held out as a precaution during OTAs and minicamp earlier this offseason. The 23-year-old former second-round pick (36th overall) in 2022 out of Iowa State tore his ACL in his first year in the NFL but nearly rushed for 1,000 yards on 223 rushing attempts in his sophomore season, adding nine total touchdowns in 17 games (16 starts). With quarterback Aaron Rodgers (Achilles) returning and with an improved offensive line in front of him, the sky is the limit for Hall in 2024 as a high-end RB1 as long as he avoids any serious injuries.

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Philadelphia Eagles defensive end Brandon Graham made it clear at training camp on Wednesday that the 2024 season will be his last year in the league. Graham signed a one-year deal in the offseason with the Eagles for what will be his 15th and final season in the NFL. The 36-year-old veteran was the 13th overall pick by Philly way back in 2010 out of Michigan. He will end up playing all 15 years of his NFL career with the Eagles, which is extremely rare these days. Graham made his only Pro Bowl in 2020 and will enter his 15th season with a total of 467 tackles (344 solo), 73 sacks, 120 tackles for loss, 146 QB hits, 21 forced fumbles and seven fumble recoveries (one returned for a TD) in 195 regular-season games (105 starts). He had his first double-digit-sack season in 2022 but was only able to pick up three sacks in 17 games a year ago.

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Baltimore Ravens quarterback Lamar Jackson (illness) is back on the practice field at training camp on Wednesday. Jackson came down with a pretty serious illness over the weekend and missed a few days of practice, but he's back with the team now and will likely be eased into workouts early in camp. While the 27-year-old two-time MVP was out, veteran Josh Johnson worked with Baltimore's first-team offense. Jackson made the Pro Bowl for the third time in his career in 2023, when he threw for a career-high 3,678 yards with 24 touchdowns and seven interceptions in 16 regular-season games, adding 821 rushing yards and five touchdowns on 148 rushing attempts. Staying healthy is the key for Jackson. Although new running back Derrick Henry could vulture plenty of goal-line touchdowns from Jackson in 2024, he should be a lock to be a top-five fantasy QB if he stays on the field.

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The Athletic's Nick Baumgardner writes that Detroit Lions wide receiver Jameson Williams looks like a completely different player from a year ago early in training camp. Williams looks stronger through the middle and more explosive with better body control in the air and near the sidelines. Head coach Dan Campbell already said earlier this offseason that the 23-year-old former first-rounder looks like "a man on a mission" in 2024. The former 12th overall pick was recovering from a torn ACL heading into his rookie season and missed time due to a suspension in 2023, so he's been a first-round bust to this point. Williams' big-play ability is undeniable, though, and he has a chance to solidify the WR2 role in Detroit this year behind Amon-Ra St. Brown, which would make him an interesting WR4/flex play in standard-scoring fantasy formats.

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Kansas City Chiefs rookie first-round wide receiver Xavier Worthy (illness) is out of training camp practice for the third straight day on Wednesday. Worthy is under the weather and should be back with the Chiefs sooner than later, but any additional time the 21-year-old misses could hurt his chances of starting his first NFL season off strong, especially since he missed a lot of the offseason program due to a hamstring injury. The 28th overall pick in April's NFL draft has a real opportunity to become fantasy relevant in 2024, especially if fellow wideout Rashee Rice opens the year serving a suspension. Speed is Worthy's biggest asset, and if he can stay healthy, he'll be worth at least a late-round flier for wideout depth in fantasy drafts this fall in KC's offense.

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Kansas City Chiefs wide receiver Justin Watson (foot) left training camp practice early on Wednesday with a foot injury, according to multiple reporters on the scene. The 28-year-old wideout is entering his third year with the Chiefs. He finished third on the team in 2023 with 460 yards on 27 receptions while scoring three touchdowns, and he should once again be a key offensive piece for quarterback Patrick Mahomes, especially with second-year pass-catcher Rashee Rice facing a potential lengthy suspension. With rookie first-round wideout Xavier Worthy (illness) missing his third straight practice on Wednesday, the Chiefs are a little short-handed at the position early in camp. While Watson has been reliable when on the field for KC, he can be left to the waiver wire to begin the year in most fantasy leagues.

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Miami Dolphins head coach Mike McDaniel acknowledged that quarterback Tua Tagovailoa's participation level at training camp will be "very fluid," and he's unlikely to fully participate in all practices as contract discussions between the two sides continue. The Dolphins and Tagovailoa have been in talks on a long-term contract extension worth north of $50 million per season. The 26-year-old former first-rounder out of Alabama was a first-time Pro Bowler in 2023 in his fourth year in the NFL, when he threw for a league-high 4,624 yards while tossing a career-high 29 touchdown passes and 14 interceptions in 17 regular-season starts. Tagovailoa deserves a raise after last year's performance, but in terms of fantasy, despite leading the league in passing yards, he barely finished as a top-10 QB. He's extremely accurate and has one of the best one-two punches in the league at receiver, but his lack of rushing prowess makes him merely a low-end QB1/high-end QB2.

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