Cleveland Browns running backs Nick Chubb (knee) and Nyheim Hines (knee) have both been ruled out for the Week 6 contest against the Philadelphia Eagles. Both Chubb and Hines opened their 21-day practice windows last week but remain on the Physically Unable to Perform list and will not make their 2024 debuts this weekend. There next chance to return will be in Week 7 versus the division-rival Cincinnati Bengals. The 28-year-old Chubb should be stashed in the majority of fantasy formats, but it's still unclear when exactly he'll return, and when he does, the Browns figure to ease him back in after he suffered a gruesome knee injury in Week 2 of 2023. At least for another week, Jerome Ford will lead the Browns' backfield and will be a low-upside RB2/3 against Philly given how bad Cleveland's offense has looked in 2024.

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Fantasy managers who selected Houston Texans wide receiver Tank Dell haven't seen much production yet, but there's some hope that could change in Week 6 with Houston at New England. The second-year pass-catcher could be in line to improve on a disappointing 71st ranking among fantasy receivers, as team-leading wide receiver Nico Collins (hamstring) is set to miss at least the next month on injured reserve. Dell has at least four targets in every game in which he has appeared and also has carried the ball six times, however, so Houston at least seems committed to keeping him involved. He should be considered a boom-or-bust flex option with the Texans playing a decent New England pass defense.

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Now that Houston Texans wide receiver Nico Collins (hamstring) is on injured reserve, fellow receiver Stefon Diggs figures to be Houston's top pass-catching option ahead of a Week 6 game at New England. The 30-year-old plays a different role than Collins within the Houston offense, but an already good volume play (82% of snaps, 8.2 targets per game) could become even better in the coming weeks. Through five weeks, the Texans rank second in the NFL in passing yards per game. Even though Houston is playing a decent Patriots pass defense, Diggs deserves a starting lineup spot as a regular first read on a top passing offense.

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Houston Texans quarterback C.J. Stroud faces one of the NFL's worst teams on Sunday when the Texans visit New England. There hasn't been anything resembling a sophomore slump for the second-year quarterback, who has been good if not overwhelming for fantasy managers who drafted him as an every-week starter. The Patriots, meanwhile, have been a mess. The New England offense's inability to score has put immense pressure on their defense, which is paying the price. The Patriots rank near the bottom of the league in passing yards allowed (27th), net yards per attempt (29th), pressure percentage (28th), and passer rating allowed (25th). Given the talent advantage Houston enjoys in this matchup, Stroud can be started confidently.

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Houston Texans tight end Dalton Schultz is a playable option with a decent matchup in Week 6 against the New England Patriots. The 28-year-old has had a disappointing fantasy season so far, but the silver lining is that his target percentage has gone up three weeks in a row and he's still an every-down player, averaging nearly 87% of Houston snaps. Further, Houston's targets leader, receiver Nico Collins, is now on injured reserve. At this stage, fantasy managers have to be realistic with their expectations for the former Dallas Cowboy: he'll play most of the game and earn a handful of targets on a good offense, but he's dependent on touchdowns for game-changing weeks.

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Arizona Cardinals head coach Jonathan Gannon said that wide receiver Zay Jones (hamstring) will not suit up in Week 6 at Lambeau Field to take on the Green Bay Packers on Sunday. Jones was reinstated earlier this week after being suspended for the first five games of the season. However, the 29-year-old is nursing a hamstring injury and won't make his 2024 debut until at least Week 7 against the Los Angeles Chargers on Monday night. For now, he belongs on the waiver wire in the majority of fantasy leagues. When healthy, Jones will serve as receiver depth for the Cardinals behind rookie Marvin Harrison Jr., Michael Wilson and Greg Dortch. He'll be battling for playing time with the likes of Zach Pascal and rookie Xavier Weaver. In just nine games with the Jaguars in 2023, Jones had 34 receptions for 321 yards and two touchdown grabs.

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Pittsburgh Steelers head coach Mike Tomlin said that quarterback Justin Fields will make another start in Week 6 against the Las Vegas Raiders, with Russell Wilson (calf) being active on Sunday to back him up. Wilson is recovering from a calf strain that has kept him out all year to this point. He was able to finally return to full practice this week and will serve as Fields' backup on the road in Vegas this weekend. Fields hasn't been amazing as the starter under center, but he's done enough to lead the team to a winning record and has limited the turnovers. The 25-year-old has completed 67.6% of his pass attempts with five touchdowns and one interception while also rushing for 172 yards and three scores on the ground. However, he's going to need to keep playing well to hold off Wilson now that he's past his calf issues. Against the struggling Raiders this weekend, Field has QB1 upside.

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Pittsburgh Steelers running back Jaylen Warren (knee) logged a full practice on Friday and is on the "upswing" with his trajectory. Warren will be listed as questionable to play in Week 6 against the Las Vegas Raiders on Sunday, but the Steelers are optimistic about his status. Earlier in the week, head coach Mike Tomlin considered Warren doubtful to face the Raiders, but apparently he's made good progress with his knee since then. The 25-year-old was unable to play in last week's loss to the Dallas Cowboys on Sunday night. If he's able to return on Sunday on the road at Allegiant Stadium, he'll continue to mix in sparingly behind lead back Najee Harris in what is an excellent matchup. Still, fantasy managers will be hard-pressed to be excited to use Warren as a flex play given what he's done so far in 2024. He's averaging a career-low 3.9 yards per carry on just 14 rushing attempts through three games.

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Indianapolis Colts head coach Shane Steichen confirmed that running back Jonathan Taylor (ankle) will not play in Week 6 against the division-rival Tennessee Titans. It will be Taylor's second straight missed game after he suffered a high-ankle sprain in the Week 4 win over the Pittsburgh Steelers. Although Taylor's ankle sprain is considered to be minor, the 25-year-old was unable to practice all week, and his status will also be in question for Week 7 against the Miami Dolphins. Trey Sermon (collarbone) was also on the injury report this week, but he practiced in full on Thursday and is in line to serve as the team's lead back for the second straight week. Sermon had 10 carries for 38 yards and a touchdown and also caught six passes in last week's loss to the division-rival Jacksonville Jaguars. This Sunday's matchup against Tennessee isn't as strong, but with Taylor out, Sermon will once again be in play as at least an RB3/flex option for fantasy managers.

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Indianapolis Colts head coach Shane Steichen said that quarterback Anthony Richardson (oblique) will be questionable to play on Sunday against the division-rival Tennessee Titans in Week 6. Richardson suffered an oblique injury in the Week 4 win over the Pittsburgh Steelers and was questionable last week before sitting out in the Week 5 loss to the division-rival Jacksonville Jaguars. He's questionable again this weekend, but the fact that Richardson returned to a full practice on Thursday bodes well for his chances of returning. Steichen said earlier this week that the struggling Richardson will be the team's starting QB when healthy. If the 22-year-old is active, he'll be a shaky QB1/2 given his struggles so far in his second season and the fact that the Colts are without running back Jonathan Taylor (ankle) and could be without receivers Michael Pittman Jr. (back) and Josh Downs (toe).

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The Carolina Panthers have ruled out tight end Tommy Tremble (concussion) from their Week 6 game on Sunday against the division-rival Atlanta Falcons. Tremble was unable to practice all week after getting knocked out in the Week 5 loss to the Chicago Bears. The 24-year-old will need to clear the league's concussion protocol next week in order to gain clearance to play in Week 7 against the Washington Commanders. Ian Thomas (calf) is questionable to come off the Injured Reserve this weekend, but if he does, he'll likely play second fiddle to rookie Ja'Tavion Sanders for the team's primary tight end pass-catching role. Sanders now has some deep-league TE2 streaming appeal with Tremble out. The 21-year-old rookie has caught eight of his 11 targets for 41 yards and no touchdowns in the first five games of his NFL career.

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Carolina Panthers rookie running back Jonathon Brooks (knee) said he thinks there's a chance he could open his 21-day practice window next week. Brooks acknowledged there's really no reason to rush back as much as he wants to play. The running game is currently in good hands with Chuba Hubbard. At the very least, Brooks should push Miles Sanders down the RB depth chart in Carolina, and he could force a timeshare with Hubbard in the backfield later on this season once he's up to speed. The 21-year-old is now 11 months removed from a torn ACL, so the Panthers will surely ease him back in, and he won't be a lock to make his NFL debut in Week 7 against the Washington Commanders, even if he resumes practicing next week. For now, Brooks is worth stashing in the majority of fantasy formats after being the first RB taken in this year's draft in April.

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The struggling New England Patriots present a terrific opportunity for the Houston Texans' defense in Week 6. Only the Tua Tagovailoa-less Miami Dolphins have scored fewer points per game than New England, which is officially making a quarterback change this week. Rookie quarterback Drake Maye will make his first start for the Patriots, who are on the short list for worst offensive line in the league. So far, New England ranks 31st in sacks allowed, 30th in completion percentage, 31st in passing first downs, 32nd in net yards per passing attempt, and tied for 31st in fumbles. Fantasy managers holding the Texans or within reach of them should be all over this matchup.

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Carolina Panthers wide receiver Diontae Johnson (ankle) is listed as questionable for Sunday's game. Johnson logged three limited practice sessions this week due to an ankle injury. Johnson was dealing with this same injury last weekend and was able to suit up which is a good sign for his status. Fantasy managers should monitor any updates regarding his status over the weekend. After eclipsing 20.0 PPR points during Weeks 3 and 4, Johnson took a step back last weekend as he caught only three passes for 23 yards. If Johnson is able to suit up he should be viewed as a WR3/flex option facing the Atlanta Falcons.

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Carolina Panthers rookie wide receiver Xavier Legette (shoulder) does not carry an injury designation and is expected to play this weekend. Legette was battling a minor shoulder injury throughout the week but was able to log three consecutive full practice sessions suggesting the injury was not serious. The 23-year-old is coming off one of his worst games of the season as he caught only one pass for eight yards. However, in Weeks 3 and 4, the former first-round pick averaged four catches in each game with a season-high 66 yards in Week 5. Legette remains a low-end flex option on Sunday when he faces the Atlanta Falcons.

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Cincinnati Bengals running backs Zack Moss (foot) and Chase Brown (quadriceps) are both expected to play on Sunday against the New York Giants, according to Kelsey Conway of USA Today. Moss left last weekend's game early with an injury and was unable to practice on Wednesday but did return on Thursday in a limited capacity. Brown was added to the injury report on Thursday. However, both injuries appear minor, and they are expected to play this weekend. Fantasy managers should expect Moss to see the slight majority of carries out of the backfield, but both should be viewed as flex options facing the Giants, who have allowed the 11th-fewest points to opposing running backs.

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New York Giants running back Devin Singletary (groin) is still dealing with his groin injury, according to Jordan Raanan of ESPN. Raanan further reported that head coach Brian Daboll said "we'll see" regarding his running back's status heading into the weekend. Fantasy managers should monitor Friday's injury report, as it should provide clarity on Singletary's status heading into the weekend. Last week in his absence, rookie Tyrone Tracy Jr. ran for an impressive 129 yards on 18 carries. If Singletary were to remain sidelined, Tracy becomes a solid RB2 with upside against the Cincinnati Bengals, who have allowed the 19th-most points to opposing running backs this season.

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Dallas Cowboys running back Ezekiel Elliott could see more opportunities later in the season according to Ari Meirov of The 33rd Team. Meirov reported that Dallas owner Jerry Jones expressed that the team is "saving him" on 1053 The Fan when asked about his lack of opportunities. After seeing double-digit rushing attempts in the opening week of the season, Elliott has yet to that mark since and has averaged just 2.9 yards per carry in this span. Rico Dowdle has begun to emerge as the lead option in the backfield as he has scored in each of the past two games and seen double-digit carries in each of them. Fantasy managers in deeper formats could consider stashing Elliott, but for now, Dowdle has the highest upside on the depth chart.

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New England Patriots running back Rhamondre Stevenson (foot) is not expected to miss a long period of time, according to Mike Reiss of ESPN. Stevenson did not practice earlier in the week and was also not seen at Friday's practice. Fantasy managers should monitor Friday's injury report, as it will likely provide clarity on his status heading into the weekend. However, the fact that Stevenson has not logged a practice session this week does not bode well for his availability on Sunday. After not finding the end zone during Weeks 3 and 4, Stevenson broke out of his slump last weekend and ran for 89 yards and a score. If Stevenson were to sit out this weekend, Antonio Gibson becomes a viable flex option and should see a majority of the opportunities in the backfield.

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Washington Commanders running back Brian Robinson Jr. (knee) will likely be a game-time decision on Sunday, according to Ian Rapoport of the NFL Network. Robinson battled a knee injury heading into last week's game but was able to suit up. This week, he did not practice on Wednesday and Thursday with a similar knee injury and was also not seen during Friday's practice, which is not a promising sign for his status. Fantasy managers should monitor the injury report later on Friday, as the Alabama product will likely carry an injury designation into the weekend. The 25-year-old has enjoyed an excellent start to the season, scoring five touchdowns with 325 rushing yards. If Robinson can suit up, he should be locked into all lineups as an upside RB2. If he cannot play, Austin Ekeler should see the majority of opportunities out of the backfield and would become a must-start option.

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