New Orleans Saints running back Alvin Kamara (hip/hand) was listed as a DNP in practice on Wednesday. Kamara is the No. 1 running back in fantasy and his absence from practice is a huge concern for fantasy managers. Kamara came out of Week 5's tilt with the Kansas City Chiefs banged up and it appears to have carried over into this week. Kamara has rushed for 388 yards and a whopping five touchdowns in 2024. He has added 23 receptions for 214 yards and a receiving touchdown as well. He has looked like the vintage Kamara that fantasy managers know and love. Fantasy managers should monitor the situation closely to see if Kamara's status for Week 6 is in jeopardy. The Saints offense as a whole is banged up with quarterback Derek Carr (oblique) expected to miss multiple weeks and wide receiver Rashid Shaheed (hip) joining Kamara on the sidelines on Wednesday.

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Indianapolis Colts wide receiver Michael Pittman Jr. (back) is expected to miss multiple weeks. The Colts have also suggested that Pittman may be placed on injured reserve. Pittman was a non-participant in practice on Wednesday and is listed as doubtful heading into this weekend. This is unfortunate news for fantasy managers as Pittman had just started to come alive. He had at least 113 receiving yards or a touchdown in his last two games. That may be attributed to the presence of quarterback Joe Flacco in the lineup rather than a struggling Anthony Richardson. However, it could be some time before fantasy managers find out if Pittman is able to build on that momentum. Pittman has recorded 22 receptions for 238 yards and a touchdown in 2024. For now, fantasy managers will have to stick him in their IR spot and hope for the best.

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New Orleans Saints wide receiver Rashid Shaheed (hip) did not practice on Wednesday. This is worth monitoring for fantasy managers as Shaheed has been excellent in 2024. Shaheed has 19 receptions for 338 yards and three touchdowns this season. That includes a game in which he recorded a zero in the box score. Veterans are often provided rest days on Wednesdays, especially if they have an existing ailment so this could be precautionary. However, fantasy managers will need to pay close attention to this situation leading up to the weekend.

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Carolina Panthers tight end Tommy Tremble (concussion) was held out of the first practice of the week on Wednesday. Tremble suffered a scary-looking concussion in the Week 5 loss to the Chicago Bears and is in the league's concussion protocol this week. He still has two more days to improve, but just based on how he looked on Sunday, it would be a surprise if he suited up this weekend against the division-rival Atlanta Falcons. Tremble being inactive in Week 6 would open up more playing time for rookie Ja'Tavion Sanders, but fantasy managers should be able to find better TE2 streaming options. Ian Thomas (calf) practiced in full on Wednesday and could come off Injured Reserve to play this weekend, but he, too, should be avoided in fantasy. In four games in 2024, Tremble has only seven receptions for 59 yards. He's off the fantasy radar.

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Carolina Panthers wide receiver Diontae Johnson (ankle) was listed as a limited participant in the first practice of the week on Wednesday. Johnson was also limited with his ankle injury last week but still played in the Week 5 loss to the Chicago Bears and caught only three passes for 23 yards against a strong Bears defense. Unless the 28-year-old suffers a setback later this week, he should be fine to play in a Week 6 tilt against the division-rival Atlanta Falcons. Ever since quarterback Andy Dalton took over for Bryce Young in Week 3, Johnson has a total of 18 receptions on 33 targets for 228 yards and two touchdowns. Despite his disappointing showing in Week 5, Johnson should be trusted as a solid WR2 for fantasy managers this Sunday in a much better matchup against the Falcons defense.

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Indianapolis Colts running back Trey Sermon (collarbone) popped on the Week 6 injury report after not practicing on Wednesday. In addition to Sermon, Jonathan Taylor (ankle) also missed practice and could be in danger of missing his second straight game in Week 6 against the division-rival Tennessee Titans. If Sermon is indeed in danger of missing this weekend's game, the Colts could be down to Tyler Goodson and Evan Hull in their backfield against Tennessee if both Taylor and Sermon cannot suit up. The 25-year-old Sermon was a great plug-and-play flex for fantasy managers that threw him into their lineups in the Week 5 loss to the division-rival Jacksonville Jaguars, as he saw a season-high 10 carries for 38 yards and his second touchdown of the year while adding six receptions for 25 yards through the air. Fantasy managers will want to keep a close eye on the practices statuses of both Sermon and Taylor the rest of the week.

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Dynasty | The Patriots are starting quarterback Drake Maye this week. Dynasty Analysis: The Patriots chose to start the season with Jacoby Brissett at the helm and the results turned out to be about as expected. New England is 1-4 and have a real chance of seeing their season spiral out of control, so they're turning to the rookie. It's a best-case scenario for Maye as he shouldn't be under too much pressure as the team has simply looked anemic. Still, there is a real lack of offensive talent on this team, so it's fair to wonder just how this is going to go. Maye's dynasty value should rise with some solid performances.

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Dynasty | The Texans have placed wide receiver Nico Collins on injured reserve. Dynasty Analysis: Collins has gone from an afterthought, to a serviceable receiver, to a possible lineup staple, to a WR1, to perhaps the best receiver in fantasy leagues over the past three years. This is a major buzzkill as he has been flat-out dominant. Savvy owners who aren't competing right now could make a "buy low" play for his services to a team desperate to win, but you're not likely to get him. Unfortunately, he's going to be out for at least four weeks and that should open up targets for Tank Dell, Stefon Diggs, Dalton Schultz and others.

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Dynasty | The Raiders will replace Gardner Minshew at quarterback with Aidan O'Connell. Dynasty Analysis: The Raiders are 2-3 and while Minshew hasn't been awful, he also hasn't done anything to make anyone believe this looks like a playoff team. With Davante Adams likely on the way out, this is starting to look a little like a lost season for Las Vegas, so it makes sense for them to see if O'Connell can provide a spark. In his 11 games last year, he threw for 2,218 yards with 12 touchdowns and seven interception looking relatively average most Sundays. At this point, the Raiders are likely going to be scouting the college scene pretty hard in search of who may be their next signal caller. If O'Connell falls on his face, they could also scour the trade market (Russell Wilson could be available). Minshew can be dropped in dynasty leagues while O'Connell is back on the map.

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Indianapolis Colts wide receiver Michael Pittman Jr. (back) was listed as a non-participant in Wednesday's practice. In addition to Pittman, Josh Downs (toe) also popped on the Week 6 injury report and didn't practice. It's not a great start to the week for Pittman and Downs, but they still have two days left to get back onto the practice field. Given his injury and the fact that we still don't know if quarterback Anthony Richardson (oblique) will play this Sunday against the division-rival Tennessee Titans, Pittman's fantasy outlook is a bit up in the air. He had 11 receptions for 88 yards and no touchdowns in the first three weeks with Richardson at the helm but has exploded for 11 catches for 150 yards and his first touchdown of the year in the last two weeks with Richardson injured. Pittman's fantasy upside may actually be higher if Richardson misses another week.

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San Francisco 49ers tight end George Kittle (ribs) is good to go on Thursday night, according to Tom Pelissero of the NFL Network. Kittle was a limited participant during the first two practice sessions of the week but was able to upgrade to full participation on Wednesday. The 31-year-old should be locked into all starting lineups as he faces a Seattle defense that has allowed the 19th-most points to opposing tight ends. Kittle has found the end zone in each of the past three games he has played in and averaged 61.7 yards and 6.3 receptions during this span. He should be viewed as a TE1 and should also be considered as a solid flex option in all DFS formats on Thursday evening.

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Pittsburgh Steelers running back Jaylen Warren (knee) was limited during Wednesday's practice, according to Tom Pelissero of the NFL Network. The 25-year-old has been sidelined since Week 3 after suffering a knee injury early in that game. The 25-year-old was initially deemed doubtful for this weekend's game, according to his head coach, Mike Tomlin, but seeing him participate in practice early in the week is a promising sign. Fantasy managers should continue to monitor his status throughout the week. If Warren can suit up against the Las Vegas Raiders, he should be viewed as a solid flex option in PPR formats, given his pass-catching ability. If he cannot play, Najee Harris should see a heavy workload with Cordarrelle Patterson (ankle) already ruled out.

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Cincinnati Bengals running back Zack Moss (foot) did not practice on Wednesday, according to Mike Petraglia. Petraglia further noted that the running back did walk out in his uniform but could not participate in any drills. The 26-year-old suffered the injury in Sunday's loss to the Baltimore Ravens. Before the injury, Moss logged nine carries for 24 yards and added three catches for 28 yards. Through the early part of the season, Moss has been deployed as the lead back in Cincinnati, with Chase Brown serving as the No.2 option. Fantasy managers should continue to monitor Moss' status during the week, as he could be in danger of missing Sunday's game. After totaling just over 40 yards through the first two weeks of the season, Brown has tallied at least 50 all-purpose yards in each of the past three games and could be a high-end RB2 on Sunday if Moss were to be held out of action.

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Pittsburgh Steelers quarterback Russell Wilson (calf) was a full participant in practice for the first time in over a month on Wednesday, according to Tom Pelissero of the NFL Network. Wilson suffered a calf injury before the season opener, which allowed Justin Fields to take over starting duties. While fantasy managers should still expect Fields to remain the starting QB for the time being, Wilson could eventually take over the job in the coming weeks, given that he is now at full strength. Last week, Fields went 15-for-27 in their loss to the Dallas Cowboys and threw for just 131 yards. Fantasy managers in superflex formats should consider stashing Wilson, as he could move to the top of the depth chart if Fields continues to struggle.

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Houston Texans running back Dameon Pierce (hamstring) is expected to return this weekend, according to Aaron Wilson of KPRC2. The 24-year-old has been sidelined since the opening week of the season with a hamstring injury. Cam Akers took over No.2 duties in his absence and eventually became the starter when Joe Mixon (ankle) suffered an injury following Week 2. Fantasy managers should continue monitoring Joe Mixon's status, as Pierce could be the top option out of the backfield if Mixon is kept out of action. Since breaking out in his rookie campaign with an impressive 939 yards, Pierce has been stuck in a reserve role. However, he is worth a speculative add this week as he could be a solid flex option if he gets the starting nod against the New England Patriots.

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Philadelphia Eagles wide receiver A.J. Brown (hamstring) was seen at Wednesday's practice, according to Brooks Kubena of The Athletic. This is a great sign, as Brown missed the past three games due to a hamstring injury after injuring his hamstring during a Week 2 practice. Fantasy managers should continue to monitor the 27-year-old's status throughout the week, but seeing him at practice early in the week is promising. In the season opener, Brown caught five of his ten targets for 119 yards and a score. If Brown can suit up on Sunday, he should be viewed as a high-end WR1 facing the Cleveland Browns.

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Philadelphia Eagles wide receiver DeVonta Smith (concussion) will practice on Wednesday according to Jeff McLane of the Inquirer. McLane further noted that the 25-year-old is still in concussion protocol but still has time to be cleared before Sunday's game. The former first-round pick suffered a concussion in Week 3 against the New Orleans Saints. Before the injury, Smith caught at least seven passes in the first three weeks and averaged 79.7 yards per game with one total score. Fantasy managers should continue to monitor his status throughout the week. If Smith can suit up, he should be viewed as a low-end WR1 facing the Cleveland Browns, who have allowed the 21st most points to opposing wideouts.

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New York Giants running back Devin Singletary (groin) was a limited participant in Wednesday's practice, according to Dan Salomone of Giants.com. Singletary was held out of action last weekend due to a groin injury. The veteran running back was able to log a limited session last Friday but was ultimately kept sidelined. However, seeing him log a limited session early in the week is a positive sign for his status for this weekend's game. In his absence, fifth-round rookie Tyrone Tracy Jr. led the way last Sunday, totaling 129 yards on the ground in their victory over the Seattle Seahawks. If Singletary can suit up, he should be viewed as a high-floor RB2 facing the Cincinnati Bengals.

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New York Giants rookie wide receiver Malik Nabers (concussion) did not practice on Wednesday as he is still in concussion protocol. Nabers was seen working with the coaching staff earlier on Wednesday but did not participate enough to be deemed limited. Fantasy managers should continue monitoring his status throughout the week, as Thursday's and Friday's injury reports should clarify his availability for this weekend. Before suffering a concussion in Week 4, the LSU standout was enjoying an impressive campaign as averaged 96.5 receiving yards per game with three total touchdowns. If Nabers is able to suit up on Sunday against the Cincinnati Bengals, he should be viewed as a high-end WR1. If not, Wan'Dale Robinson should be in line for increased opportunities.

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Indianapolis Colts wide receiver Josh Downs (toe) was not spotted at Wednesday's practice and is reportedly dealing with a toe injury, according to Colts reporter Nate Atkins. The second-year pass-catcher out of North Carolina missed the first two games of the 2024 campaign with an ankle injury but has heated up in his last two contests with Joe Flacco at quarterback. He posted at least 15.9 PPR points against the Steelers and Jaguars. Downs' status is worth monitoring for the rest of the week, but the Colts are set to face the Tennessee Titans, who have allowed the fewest fantasy points per game to wideouts this season. No wide receiver has eclipsed 67 yards or caught a touchdown against Tennessee's revamped secondary. If Anthony Richardson (oblique) starts on Sunday, all of the Colts' pass-catchers have lower ceilings and floors in fantasy football.

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