Pittsburgh Steelers running back Jaylen Warren (knee) was limited during Wednesday's practice, according to Tom Pelissero of the NFL Network. The 25-year-old has been sidelined since Week 3 after suffering a knee injury early in that game. The 25-year-old was initially deemed doubtful for this weekend's game, according to his head coach, Mike Tomlin, but seeing him participate in practice early in the week is a promising sign. Fantasy managers should continue to monitor his status throughout the week. If Warren can suit up against the Las Vegas Raiders, he should be viewed as a solid flex option in PPR formats, given his pass-catching ability. If he cannot play, Najee Harris should see a heavy workload with Cordarrelle Patterson (ankle) already ruled out.

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Cincinnati Bengals running back Zack Moss (foot) did not practice on Wednesday, according to Mike Petraglia. Petraglia further noted that the running back did walk out in his uniform but could not participate in any drills. The 26-year-old suffered the injury in Sunday's loss to the Baltimore Ravens. Before the injury, Moss logged nine carries for 24 yards and added three catches for 28 yards. Through the early part of the season, Moss has been deployed as the lead back in Cincinnati, with Chase Brown serving as the No.2 option. Fantasy managers should continue to monitor Moss' status during the week, as he could be in danger of missing Sunday's game. After totaling just over 40 yards through the first two weeks of the season, Brown has tallied at least 50 all-purpose yards in each of the past three games and could be a high-end RB2 on Sunday if Moss were to be held out of action.

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Pittsburgh Steelers quarterback Russell Wilson (calf) was a full participant in practice for the first time in over a month on Wednesday, according to Tom Pelissero of the NFL Network. Wilson suffered a calf injury before the season opener, which allowed Justin Fields to take over starting duties. While fantasy managers should still expect Fields to remain the starting QB for the time being, Wilson could eventually take over the job in the coming weeks, given that he is now at full strength. Last week, Fields went 15-for-27 in their loss to the Dallas Cowboys and threw for just 131 yards. Fantasy managers in superflex formats should consider stashing Wilson, as he could move to the top of the depth chart if Fields continues to struggle.

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Houston Texans running back Dameon Pierce (hamstring) is expected to return this weekend, according to Aaron Wilson of KPRC2. The 24-year-old has been sidelined since the opening week of the season with a hamstring injury. Cam Akers took over No.2 duties in his absence and eventually became the starter when Joe Mixon (ankle) suffered an injury following Week 2. Fantasy managers should continue monitoring Joe Mixon's status, as Pierce could be the top option out of the backfield if Mixon is kept out of action. Since breaking out in his rookie campaign with an impressive 939 yards, Pierce has been stuck in a reserve role. However, he is worth a speculative add this week as he could be a solid flex option if he gets the starting nod against the New England Patriots.

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Philadelphia Eagles wide receiver A.J. Brown (hamstring) was seen at Wednesday's practice, according to Brooks Kubena of The Athletic. This is a great sign, as Brown missed the past three games due to a hamstring injury after injuring his hamstring during a Week 2 practice. Fantasy managers should continue to monitor the 27-year-old's status throughout the week, but seeing him at practice early in the week is promising. In the season opener, Brown caught five of his ten targets for 119 yards and a score. If Brown can suit up on Sunday, he should be viewed as a high-end WR1 facing the Cleveland Browns.

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Philadelphia Eagles wide receiver DeVonta Smith (concussion) will practice on Wednesday according to Jeff McLane of the Inquirer. McLane further noted that the 25-year-old is still in concussion protocol but still has time to be cleared before Sunday's game. The former first-round pick suffered a concussion in Week 3 against the New Orleans Saints. Before the injury, Smith caught at least seven passes in the first three weeks and averaged 79.7 yards per game with one total score. Fantasy managers should continue to monitor his status throughout the week. If Smith can suit up, he should be viewed as a low-end WR1 facing the Cleveland Browns, who have allowed the 21st most points to opposing wideouts.

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New York Giants running back Devin Singletary (groin) was a limited participant in Wednesday's practice, according to Dan Salomone of Giants.com. Singletary was held out of action last weekend due to a groin injury. The veteran running back was able to log a limited session last Friday but was ultimately kept sidelined. However, seeing him log a limited session early in the week is a positive sign for his status for this weekend's game. In his absence, fifth-round rookie Tyrone Tracy Jr. led the way last Sunday, totaling 129 yards on the ground in their victory over the Seattle Seahawks. If Singletary can suit up, he should be viewed as a high-floor RB2 facing the Cincinnati Bengals.

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New York Giants rookie wide receiver Malik Nabers (concussion) did not practice on Wednesday as he is still in concussion protocol. Nabers was seen working with the coaching staff earlier on Wednesday but did not participate enough to be deemed limited. Fantasy managers should continue monitoring his status throughout the week, as Thursday's and Friday's injury reports should clarify his availability for this weekend. Before suffering a concussion in Week 4, the LSU standout was enjoying an impressive campaign as averaged 96.5 receiving yards per game with three total touchdowns. If Nabers is able to suit up on Sunday against the Cincinnati Bengals, he should be viewed as a high-end WR1. If not, Wan'Dale Robinson should be in line for increased opportunities.

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Indianapolis Colts wide receiver Josh Downs (toe) was not spotted at Wednesday's practice and is reportedly dealing with a toe injury, according to Colts reporter Nate Atkins. The second-year pass-catcher out of North Carolina missed the first two games of the 2024 campaign with an ankle injury but has heated up in his last two contests with Joe Flacco at quarterback. He posted at least 15.9 PPR points against the Steelers and Jaguars. Downs' status is worth monitoring for the rest of the week, but the Colts are set to face the Tennessee Titans, who have allowed the fewest fantasy points per game to wideouts this season. No wide receiver has eclipsed 67 yards or caught a touchdown against Tennessee's revamped secondary. If Anthony Richardson (oblique) starts on Sunday, all of the Colts' pass-catchers have lower ceilings and floors in fantasy football.

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Las Vegas Raiders quarterback Aidan O'Connell will start against the Pittsburgh Steelers in Week 6, according to ESPN's Paul Gutierrez. Veteran Gardner Minshew has struggled as the team's starter, passing for 1,014 yards, four touchdowns, and five interceptions in five games. The Raiders are out to a 2-3 start and are rumored to be looking to trade All-Pro wideout Davante Adams (hamstring), so things are turning south in the Sin City quickly. O'Connell is now a must-add option in two-QB or Superflex leagues, but it would be surprising if he performs well enough to become a viable starter in single-QB formats. Without Adams, the Las Vegas skill group featuring Jakobi Meyers, Tre Tucker, and Brock Bowers is decent, but it's a bottom-half supporting cast in the NFL. O'Connell played in 11 games last year and posted 2,218 passing yards, 12 touchdowns, and seven interceptions.

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New England Patriots running back Rhamondre Stevenson (calf) did not practice on Wednesday due to a calf injury, according to Patriots beat reporter Taylor Kyles. The 26-year-old didn't appear to be injured following the Week 5 loss to the Miami Dolphins, but nonetheless, his status is now worth monitoring. Last week, head coach Jerod Mayo said the team would start Antonio Gibson at running back following Stevenson's four fumbles in four games, but Stevenson still led the team in touches and rushed 12 times for 89 yards and a touchdown. He should continue to be viewed as the RB1 in New England, but if he can't play on Sunday, Gibson will become an attractive RB2 option. New England faces a Houston Texans' defense that has allowed the ninth-fewest fantasy points per game to running backs this season, but the former Washington Commanders' ball carrier could see 20-plus touches and be leaned on in rookie quarterback Drake Maye's first start. If Stevenson plays, he's a solid RB2 option.

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The Arizona Cardinals released wide receiver Chris Moore on Wednesday, according to NFL.com. This move comes after veteran wideout Zay Jones was reinstated from his five-game suspension for violating the NFL's personal conduct policy. Moore entered the NFL in 2016 with the Baltimore Ravens and has played in games for the Ravens, Houston Texans, and Tennessee Titans. He did not earn a target or catch a pass for the Cardinals this season. Overall, the 31-year-old has caught 138 passes for 1,710 yards, and eight touchdowns in 106 career games. Another franchise might be interested in signing him, but it would be a surprise if he ends up on the fantasy football radar this season.

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Cleveland Browns tight end David Njoku (knee) is expected to practice on Wednesday after suffering a knee injury in the Week 5 loss to the Washington Commanders. The former first-round pick out of Miami worked his way back from a high-ankle sprain to return to the Cleveland lineup but exited Sunday's contest early. However, the Browns just released reserve tight end Blake Whiteheart, an indication that Njoku might be ready to play in Week 6 against the Philadelphia Eagles. Whether Njoku plays in Week 6 or not, he's likely to be somewhat limited by his two lower-body injuries, and the Eagles have allowed the fourth-fewest fantasy points per game to tight ends this season. He still might be worth starting given the scarcity of the tight end position, but his floor and ceiling are low in Deshaun Watson's putrid passing offense.

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Carolina Panthers wide receiver Xavier Legette (shoulder) exited the Week 5 game against the Chicago Bears with a shoulder injury, but he is practicing on Wednesday to begin Week 6 preparation. The rookie first-round pick out of South Carolina had the best performance of his career in Week 4, catching six of his 10 targets for 66 yards and a touchdown. Carolina's offense looked strong under quarterback Andy Dalton against the Raiders and Bengals before being held to just 10 points in the blowout loss to Chicago. If Legette can suit up on Sunday, he'll face an Atlanta Falcons defense that has surrendered the 12th-most fantasy points per game to wideouts. With Adam Thielen (hamstring) on the Injured Reserve list, Legette is a fine flex option, but he has a WR4/WR5 outlook.

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Cleveland Browns running back D'Onta Foreman (ankle) is not practicing on Wednesday due to an ankle injury. The veteran rushed for a season-high 44 yards and caught one pass for 16 yards in the Week 5 loss to the Washington Commanders. He evidently got dinged up. While Foreman is not high on the fantasy football radar, his injury status is notable because Pro Bowl running back Nick Chubb (knee) has a chance to return in Week 6 against the Philadelphia Eagles for the first time since his brutal knee injury a season ago. Whenever Chubb returns, Foreman could be phased out of the offense, but he might keep a small role while Chubb ramps up to a significant workload. Either way, the Browns' offense and offensive line have struggled mightily to begin the season, so Foreman offers very little upside.

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Cleveland Browns running back Nick Chubb (knee) returned to practice last week for the first time since suffering a serious knee injury in last year's Week 2 game against the Pittsburgh Steelers. The four-time Pro Bowler missed all of training camp and began the regular season on the PUP (Physically Unable to Perform) list. He was eligible to return in Week 5, but he did not. On the prospect of activating Chubb to the active roster to face the Philadelphia Eagles in Week 6, head coach Kevin Stefanski was non-committal, but he did not rule it out. "Anything is possible," Stefanski said. "But I don't want to get too far beyond today." This is clearly a situation worth monitoring, as it sounds like there is at least an outside chance Chubb could suit up on Sunday. Even if Chubb makes his 2024 debut in Week 6, expectations should be tempered. The team will likely ease him into action and split backfield work between Chubb, Jerome Ford, and D'Onta Foreman (ankle), so unless you're in a tough spot at running back, he can be left on the bench until we see what he looks like.

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Houston Texans running back Joe Mixon (ankle) is not practicing to begin the week on Wednesday. On Monday, head coach DeMeco Ryans said the team still does not know exactly when Mixon will be able to return after he sprained his ankle in the Week 2 win over the Chicago Bears. And now that Mixon has picked up another DNP to begin the week, his status for the Week 6 game against the New England Patriots is firmly up in the air. The good news is the 28-year-old has made some progress, but he still needs to get back on the practice field to have any shot at playing this Sunday. Dameon Pierce (hamstring) hasn't played since the season opener, leaving Cam Akers and Dare Ogunbowale as Houston's primary backfield options each of the last three weeks. Fantasy managers won't have a clearer picture on the Texans' backfield until later this week.

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Buffalo Bills head coach Sean McDermott said that running back James Cook (foot, toe) will not take part in practice on Wednesday after getting injured in the Week 5 loss to the Houston Texans on Sunday. The good news for Cook's fantasy managers is that while he is certainly banged up, he's considered day-to-day. Still, the 25-year-old's status is now up in the air for Week 6's Monday night showdown with the division-rival New York Jets, and if Cooks ends up being questionable to play in that contest, it will make for some tough fantasy decisions this week. Those in need of a RB or that have Cook rostered may want to consider picking up rookie Ray Davis if he's available on the waiver wire. In addition to Davis, Ty Johnson would see a larger role in Buffalo's backfield if Cook's injuries keep him out in Week 6. Check back for status updates on Cook throughout the week.

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Buffalo Bills head coach Sean McDermott said that wide receivers Khalil Shakir (ankle) and Curtis Samuel (foot, toe) will not practice on Wednesday. Samuel's injuries were suffered in the Week 5 loss to the Houston Texans on Sunday, while Shakir was inactive for that game after being hurt the week prior. Shakir is the bigger name to follow for fantasy purposes. The 24-year-old didn't practice at all last week before being inactive, and another DNP to kick off the week isn't a great sign for his availability in Week 6, especially with a matchup against the division-rival New York Jets upcoming on Monday night. Buffalo's offense struggled without quarterback Josh Allen's top target available. Allen spread the ball around to rookie Keon Coleman, Mack Hollins, Samuel and Marquez Valdes-Scantling. Shakir's fantasy outlook remains very cloud this week, and if he does end up playing, he's eyeing a tough matchup against Jets corner Sauce Gardner.

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New York Giants head coach Brian Daboll said that running back Devin Singletary (groin) is trending in the right direction, and he will practice on Wednesday, likely in a limited capacity. Singletary suffered a groin injury in the Week 4 loss to the division-rival Dallas Cowboys and then was inactive for last week's win over the Seattle Seahawks. With Singletary sidelined in Week 5, rookie Tyrone Tracy Jr. filled in and turned some heads with 18 carries for 129 rushing yards in the surprising upset in Seattle. Tracy's performance likely earned him some more run in the G-Men's backfield, even when Singletary is able to return, which could come this Sunday night against the visiting Cincinnati Bengals. In his first year in the Big Apple, Singletary has averaged a career-low 3.9 yards per carry while going for 221 yards and two rushing TDs on 56 attempts. He'll be in play as an RB3/flex if he plays in Week 6.

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