Green Bay Packers wide receiver Jayden Reed should be targeted plenty in the Packers' upcoming matchup in Week 6 where they'll host the Arizona Cardinals. Reed has been a big play waiting to happen for Green Bay this season and has emerged as the Packers' unquestioned top target and playmaker in their offense. With a four-catch, 78-yard effort along with 19 rushing yards last week against the Los Angeles Rams, that stat line represented his worst game of the three games with Jordan Love starting at quarterback. With other receivers returning to the lineup like Romeo Doubs and potentially Christian Watson (ankle) who is listed as questionable in the injury report, Reed's targets may shift slightly, but Reed is still in a great position heading into Week 6. He's become a must-start wide receiver for fantasy managers and should be universally started.

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New Orleans Saints running back Alvin Kamara (hand, hip) was removed from Friday's final injury report and will play in Week 6 against the division-rival Tampa Bay Buccaneers. Kamara picked up a DNP on Wednesday but was limited in practice on Thursday and Friday. Meanwhile, Kendre Miller (hamstring) practiced in full all week and is questionable to make his season debut. The 29-year-old Kamara played a season-high 90% of the offensive snaps in last week's loss to the Kansas City Chiefs on Monday night and remains a workhorse for this offense. Expect another heavy workload for Kamara in rookie quarterback Spencer Rattler's first career start, which makes Kamara a must-start RB1 for fantasy managers. However, with QB Derek Carr (oblique) out, the Saints' offense could struggle to move the ball effectively, which could be an overall downgrade for Kamara's upside.

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New Orleans Saints wide receiver Rashid Shaheed (hip) was removed from Friday's injury report and will be active on Sunday in Week 6 against the division-rival Tampa Bay Buccaneers. Shaheed did not practice on Wednesday but returned to limited sessions on both Thursday and Friday. The 26-year-old is in the midst of a breakout season in 2024 and enters Week 6 as the No. 14 fantasy wideout in half-PPR scoring thanks to 19 receptions for 338 yards and three touchdowns. He has had some nice chemistry on the deep ball with quarterback Derek Carr (oblique), but with Carr likely out multiple weeks, Shaheed's fantasy value could take a big tumble while taking passes from rookie QB Spencer Rattler, who will be making his first start this weekend. Shaheed should be viewed as a much more volatile WR3/flex in Week 6.

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Tampa Bay Buccaneers wide receiver Sterling Shepard could be asked to take on a bigger role during Sunday's matchup against the New Orleans Saints. The Bucs could be shorthanded at wideout with Jalen McMillan (hamstring) and Trey Palmer (concussion) both uncertain heading into this game. That being said, Shepard could be asked to step in and be the third receiver behind Mike Evans and Chris Godwin. His best performance came in Week 3 when he hauled in three receptions for 51 yards. It's hard to imagine Shepard being a viable streaming option even if he gets the nod as the third wideout.

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Washington Commanders rookie quarterback Jayden Daniels looks to win his fifth straight game on Sunday as he takes on the Baltimore Ravens. After losing his first professional game, Daniels has averaged an impressive 24.2 PPR points per game with 951 total passing yards, 212 rushing yards, and six scores. The LSU standout has only turned the ball over twice and completed a remarkable 78.5% of his passes. This weekend, he faces a Baltimore defense that has allowed the 28th-most points to opposing quarterbacks. Daniels should be locked into all lineups this weekend as this game could become quite high-scoring given the projected 51.5-point total, which is the highest of the slate.

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Washington Commanders running back Austin Ekeler should be viewed as a solid flex option in PPR formats this weekend as they will face the Baltimore Ravens in what could be a very high-scoring affair. After missing Week 4 with a concussion, Ekeler looked strong in Week 5 as he ran for a season-high 67 yards on six carries. He added 30 yards on two receptions. Ekeler has seen at least two targets in every game and ran double-digit routes in three out of the four games he has played in. In addition, Brian Robinson Jr. (knee) is listed as questionable for Sunday's game, which could further increase Ekeler's opportunities. If Robinson is unable to play, Ekeler should be viewed as a high-end RB2.

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Green Bay Packers running back Josh Jacobs looks to keep his solid run going when the Packers host the Arizona Cardinals in Week 6. Jacobs scored his first touchdown as a Packer last week and totaled 94 total yards in their win over the Rams in Week 5. Jacobs should find many more running lanes against the Cardinals, who are a bottom-six defense in EPA/rush attempt on the season. Arizona has given up at least 80 yards rushing to four running backs in the last three weeks, so Jacobs should be in line for a quality day with the safe and solid volume he gets each week. Fantasy managers should feel secure in slotting Jacobs into their lineups as a RB1 option in most weeks and that doesn't change in Week 6.

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Las Vegas Raiders running back Zamir White (groin) is listed as questionable for Sunday's contest against the visiting Pittsburgh Steelers in Week 6. White missed the Week 5 loss to the division-rival Denver Broncos and is in danger of missing his second straight game. The 25-year-old was unable to practice on Wednesday or Thursday before returning to a limited session on Friday. Even if White suits up this weekend against Pittsburgh, fantasy managers should only consider him for a starting lineup spot if they are in dire straights at the RB position. He's been a huge disappointment through the first five weeks of the season, averaging a career-low 3.1 yards per carry on 49 rushing attempts (152 yards and no scores) in four games. Alexander Mattison will see the majority of backfield work for Vegas if White sits out again, putting him in play as an RB3/flex in fantasy in a tough matchup.

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Tampa Bay Buccaneers wide receiver Chris Godwin has slowed down a bit since his impressive start to the season. However, Godwin has still be one of the better fantasy options at wideout this season. Last week, Godwin hauled in five of his six targets for 64 yards in the overtime loss to the Atlanta Falcons. Godwin now has 60 yards or more in four of his first five games this season. He has also seen eight or more targets in every game, but last week's loss. The assumption is that Godwin will continue getting consistent usage especially with Mike Evans likely drawing star defensive back Marshon Lattimore. Fantasy managers should keep Godwin on the WR1 radar in PPR formats for Week 6.

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The Las Vegas Raiders officially ruled out wide receiver Davante Adams (hamstring) for the Week 6 contest against the visiting Pittsburgh Steelers on Sunday. Adams will miss his third straight game with a hamstring injury that isn't believed to be all that serious, but at this point, the 31-year-old isn't expected to play again as he awaits to be traded before the deadline in early November. In addition to Adams being out again, wideout Jakobi Meyers (ankle) is questionable to suit up. It means that quarterback Aidan O'Connell, who is taking over the starting job from Gardner Minshew II, could be down to Tre Tucker and rookie tight end Brock Bowers as his top two receiving targets against a swarming Steelers defense. If Meyers also is inactive on Sunday, DJ Turner and Tyreik McAllister would likely start in three-receiver sets for the Raiders. Adams' fantasy managers hope a trade goes down sooner than later.

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Tampa Bay Buccaneers wide receiver Mike Evans is coming off a strong two-touchdown performance during last week's loss to the Atlanta Falcons. Evans already has five touchdowns as they head into their Week 6 matchup against the New Orleans Saints. Normally, Evans is a strong play as a WR1, but he could run into some trouble this weekend. He'll likely draw star defensive back Marshon Lattimore which could be problematic for Evans. Despite that, Evans should still be able to find success given the high volume of targets he sees on a regular basis. Evans should still be able to carve out low-end WR1 despite a challenging matchup this weekend.

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Green Bay Packers quarterback Jordan Love is set for a great performance this week as he and the Packers host the Arizona Cardinals in Week 6. Love has thrown multiple touchdowns in all three of his games this season and looks to parlay that into a fourth multiple-touchdown effort on Sunday. Love has a couple banged up pass-catchers in Tucker Kraft (groin) and Christian Watson (ankle) but Kraft is off the injury report and Watson is listed as questionable on the team's injury report. Still, with Jayden Reed, Dontayvion Wicks, a returning Romeo Doubs, and the Cardinals' fourth-worst defensive EPA/pass attempt opposing him, Love should be able to post quality numbers for fantasy managers. Lock Love into your lineups as a solid QB1 option in Week 6.

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Las Vegas Raiders wide receiver Jakobi Meyers (ankle) is listed as questionable for the Week 6 game this Sunday at Allegiant Stadium against the Pittsburgh Steelers. Davante Adams (hamstring) has been ruled out for the third straight game, so if Meyers is also unable to gain clearance to play, the Raiders would be down to Tre Tucker, DJ Turner and Tyreik McAllister in three-receiver sets. Rookie first-round Brock Bowers should have a high target floor yet again with Adams out. Meyers missed practice on Wednesday and Thursday before putting in a limited session on Friday. If he's able to play, the 27-year-old will serve as the team's WR1 for the third straight week. In the last two games with Adams out, Meyers has caught 11 of 19 targets for 121 yards and no touchdowns. Right now, he's shaping up as a shaky WR3/flex for fantasy managers because of his questionable status, especially with Vegas' game coming in the later window on Sunday.

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Tampa Bay Buccaneers running back Bucky Irving is trending towards making his first career start during Sunday's game against the New Orleans Saints. Fellow back Rachaad White (foot) has been limited to one practice this week and is considered a game-time decision for Week 6. If White sits, Irving is expected to get a majority of the snaps in the backfield. He has been effective this season with 247 yards on 44 carries, which is 5.6 yards per carry. The Saints defense is middle of the road when it comes to defending against the run. Irving should be to find success and is in the RB2 conversation, assuming White is unable to play.

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Tampa Bay Buccaneers quarterback Baker Mayfield is coming off another strong performance during last week's loss to the Atlanta Falcons. Mayfield threw for 180 yards and tossed three touchdowns as the Bucs took a tough overtime loss. The former first-round pick has thrown 11 touchdowns with only two interceptions through the first five games of the season. He'll now head into a matchup against a tough New Orleans Saints pass defense. Despite that, Mayfield has been able to overcome obstacles all season long and should be in the QB1 conversation for this Week 6 matchup.

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Las Vegas Raiders tight end Michael Mayer (personal) was placed on the reserve/non-football injury and illness list according to Field Yates of ESPN. Mayer has not suited up since Week 3 due to a personal matter and is now expected to miss more time. The Notre Dame product enjoyed a productive rookie campaign as he caught 27 passes for 304 yards and two scores. While Mayer remains away from the team, fantasy managers should expect rookie Brock Bowers to continue to see the vast majority of snaps at the position and remain a high-end option for the foreseeable future.

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Cincinnati Bengals running back Chase Brown (quadriceps) is listed as questionable for Sunday night's game against the New York Giants. Brown appeared on the injury report on Thursday after logging a limited practice session and remained in the same capacity on Friday. Earlier on Friday, head coach Zac Taylor said that Brown is expected to play. Fantasy managers should monitor his status over the weekend in case he faces a set back. Brown has seen double-digit carries in consecutive games and remains a high-upside flex option this weekend facing the New York Giants.

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Tampa Bay Buccaneers running back Rachaad White (foot) is listed as doubtful for Sunday's game according to Adam Schefter of ESPN. White opened the week as a limited participant in Wednesday's practice but was downgraded to a non-participant on Thursday and Friday which does not bode well for his status this weekend. If White is unable to suit up, fourth-round rookie Bucky Irving would get the starting nod. Irving has seen his opportunities increase over the past few weeks due to his strong efficiency as runner. If White is unable to play, fantasy managers should feel confident locking Irving into their lineup as a high-upside RB2.

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Indianapolis Colts quarterback Anthony Richardson (oblique) is expected to play in Week 6 against the Tennessee Titans barring a late-week surprise, according to Jeremy Fowler of ESPN. Richardson suffered an oblique injury in Week 4 against the Pittsburgh Steelers and was sidelined last weekend. This week, Richardson was able to log a limited practice session on Wednesday but was able to upgrade to full participation on Thursday and Friday, which suggests he should be in line to return to action. Fantasy managers should continue to monitor his status over the weekend in case he faces a setback. Richardson has struggled to remain consistent throughout his young career and remains a high-risk, high-upside QB1 against the Titans.

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Green Bay Packers wide receiver Christian Watson (ankle) is listed as questionable for Sunday's game, according to Wes Hodkiewicz. The former first-round selection was unable to suit up last week due to an ankle sprain he suffered in Week 4. This week, Watson was able to log three consecutive limited practice sessions. Fantasy managers should pay close attention to any updates over the weekend. Watson found the end zone in Week 1 but has been relatively quiet and has caught only two passes since Week 2. If Watson is able to suit up, he should be viewed as a flex option with risk given the amount of pass-catchers in the Green Bay offense, which limits his production.

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