Indianapolis Colts head coach Shane Steichen confirmed that running back Jonathan Taylor (ankle) will not play in Week 6 against the division-rival Tennessee Titans. It will be Taylor's second straight missed game after he suffered a high-ankle sprain in the Week 4 win over the Pittsburgh Steelers. Although Taylor's ankle sprain is considered to be minor, the 25-year-old was unable to practice all week, and his status will also be in question for Week 7 against the Miami Dolphins. Trey Sermon (collarbone) was also on the injury report this week, but he practiced in full on Thursday and is in line to serve as the team's lead back for the second straight week. Sermon had 10 carries for 38 yards and a touchdown and also caught six passes in last week's loss to the division-rival Jacksonville Jaguars. This Sunday's matchup against Tennessee isn't as strong, but with Taylor out, Sermon will once again be in play as at least an RB3/flex option for fantasy managers.

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Indianapolis Colts head coach Shane Steichen said that quarterback Anthony Richardson (oblique) will be questionable to play on Sunday against the division-rival Tennessee Titans in Week 6. Richardson suffered an oblique injury in the Week 4 win over the Pittsburgh Steelers and was questionable last week before sitting out in the Week 5 loss to the division-rival Jacksonville Jaguars. He's questionable again this weekend, but the fact that Richardson returned to a full practice on Thursday bodes well for his chances of returning. Steichen said earlier this week that the struggling Richardson will be the team's starting QB when healthy. If the 22-year-old is active, he'll be a shaky QB1/2 given his struggles so far in his second season and the fact that the Colts are without running back Jonathan Taylor (ankle) and could be without receivers Michael Pittman Jr. (back) and Josh Downs (toe).

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The Carolina Panthers have ruled out tight end Tommy Tremble (concussion) from their Week 6 game on Sunday against the division-rival Atlanta Falcons. Tremble was unable to practice all week after getting knocked out in the Week 5 loss to the Chicago Bears. The 24-year-old will need to clear the league's concussion protocol next week in order to gain clearance to play in Week 7 against the Washington Commanders. Ian Thomas (calf) is questionable to come off the Injured Reserve this weekend, but if he does, he'll likely play second fiddle to rookie Ja'Tavion Sanders for the team's primary tight end pass-catching role. Sanders now has some deep-league TE2 streaming appeal with Tremble out. The 21-year-old rookie has caught eight of his 11 targets for 41 yards and no touchdowns in the first five games of his NFL career.

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Carolina Panthers rookie running back Jonathon Brooks (knee) said he thinks there's a chance he could open his 21-day practice window next week. Brooks acknowledged there's really no reason to rush back as much as he wants to play. The running game is currently in good hands with Chuba Hubbard. At the very least, Brooks should push Miles Sanders down the RB depth chart in Carolina, and he could force a timeshare with Hubbard in the backfield later on this season once he's up to speed. The 21-year-old is now 11 months removed from a torn ACL, so the Panthers will surely ease him back in, and he won't be a lock to make his NFL debut in Week 7 against the Washington Commanders, even if he resumes practicing next week. For now, Brooks is worth stashing in the majority of fantasy formats after being the first RB taken in this year's draft in April.

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The struggling New England Patriots present a terrific opportunity for the Houston Texans' defense in Week 6. Only the Tua Tagovailoa-less Miami Dolphins have scored fewer points per game than New England, which is officially making a quarterback change this week. Rookie quarterback Drake Maye will make his first start for the Patriots, who are on the short list for worst offensive line in the league. So far, New England ranks 31st in sacks allowed, 30th in completion percentage, 31st in passing first downs, 32nd in net yards per passing attempt, and tied for 31st in fumbles. Fantasy managers holding the Texans or within reach of them should be all over this matchup.

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Carolina Panthers wide receiver Diontae Johnson (ankle) is listed as questionable for Sunday's game. Johnson logged three limited practice sessions this week due to an ankle injury. Johnson was dealing with this same injury last weekend and was able to suit up which is a good sign for his status. Fantasy managers should monitor any updates regarding his status over the weekend. After eclipsing 20.0 PPR points during Weeks 3 and 4, Johnson took a step back last weekend as he caught only three passes for 23 yards. If Johnson is able to suit up he should be viewed as a WR3/flex option facing the Atlanta Falcons.

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Carolina Panthers rookie wide receiver Xavier Legette (shoulder) does not carry an injury designation and is expected to play this weekend. Legette was battling a minor shoulder injury throughout the week but was able to log three consecutive full practice sessions suggesting the injury was not serious. The 23-year-old is coming off one of his worst games of the season as he caught only one pass for eight yards. However, in Weeks 3 and 4, the former first-round pick averaged four catches in each game with a season-high 66 yards in Week 5. Legette remains a low-end flex option on Sunday when he faces the Atlanta Falcons.

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Cincinnati Bengals running backs Zack Moss (foot) and Chase Brown (quadriceps) are both expected to play on Sunday against the New York Giants, according to Kelsey Conway of USA Today. Moss left last weekend's game early with an injury and was unable to practice on Wednesday but did return on Thursday in a limited capacity. Brown was added to the injury report on Thursday. However, both injuries appear minor, and they are expected to play this weekend. Fantasy managers should expect Moss to see the slight majority of carries out of the backfield, but both should be viewed as flex options facing the Giants, who have allowed the 11th-fewest points to opposing running backs.

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New York Giants running back Devin Singletary (groin) is still dealing with his groin injury, according to Jordan Raanan of ESPN. Raanan further reported that head coach Brian Daboll said "we'll see" regarding his running back's status heading into the weekend. Fantasy managers should monitor Friday's injury report, as it should provide clarity on Singletary's status heading into the weekend. Last week in his absence, rookie Tyrone Tracy Jr. ran for an impressive 129 yards on 18 carries. If Singletary were to remain sidelined, Tracy becomes a solid RB2 with upside against the Cincinnati Bengals, who have allowed the 19th-most points to opposing running backs this season.

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Dallas Cowboys running back Ezekiel Elliott could see more opportunities later in the season according to Ari Meirov of The 33rd Team. Meirov reported that Dallas owner Jerry Jones expressed that the team is "saving him" on 1053 The Fan when asked about his lack of opportunities. After seeing double-digit rushing attempts in the opening week of the season, Elliott has yet to that mark since and has averaged just 2.9 yards per carry in this span. Rico Dowdle has begun to emerge as the lead option in the backfield as he has scored in each of the past two games and seen double-digit carries in each of them. Fantasy managers in deeper formats could consider stashing Elliott, but for now, Dowdle has the highest upside on the depth chart.

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New England Patriots running back Rhamondre Stevenson (foot) is not expected to miss a long period of time, according to Mike Reiss of ESPN. Stevenson did not practice earlier in the week and was also not seen at Friday's practice. Fantasy managers should monitor Friday's injury report, as it will likely provide clarity on his status heading into the weekend. However, the fact that Stevenson has not logged a practice session this week does not bode well for his availability on Sunday. After not finding the end zone during Weeks 3 and 4, Stevenson broke out of his slump last weekend and ran for 89 yards and a score. If Stevenson were to sit out this weekend, Antonio Gibson becomes a viable flex option and should see a majority of the opportunities in the backfield.

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Washington Commanders running back Brian Robinson Jr. (knee) will likely be a game-time decision on Sunday, according to Ian Rapoport of the NFL Network. Robinson battled a knee injury heading into last week's game but was able to suit up. This week, he did not practice on Wednesday and Thursday with a similar knee injury and was also not seen during Friday's practice, which is not a promising sign for his status. Fantasy managers should monitor the injury report later on Friday, as the Alabama product will likely carry an injury designation into the weekend. The 25-year-old has enjoyed an excellent start to the season, scoring five touchdowns with 325 rushing yards. If Robinson can suit up, he should be locked into all lineups as an upside RB2. If he cannot play, Austin Ekeler should see the majority of opportunities out of the backfield and would become a must-start option.

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San Francisco 49ers running back Jordan Mason (shoulder) is believed to have suffered a sprained AC joint during Thursday's night game, according to Adam Schefter of ESPN. Schefter further noted that the 25-year-old will undergo further testing later on Friday. Mason left Thursday's game in the first half and was only able to see one rushing attempt during the entire second half due to the injury. This opened the door for fourth-round rookie Isaac Guerendo to see a season-high 10 carries for 99 yards. Fantasy managers should continue to monitor Mason's status ahead of their Week 7 matchup against the Kansas City Chiefs. If Mason were to miss an extended period of time, Guerendo becomes a priority waiver-wire target and a must-start option.

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New York Giants rookie wide receiver Malik Nabers (concussion) will not play on Sunday according to Pat Leonard of NYDN Sports. The LSU standout suffered a concussion in their Week 4 loss to the Dallas Cowboys and has not returned to the field since. Nabers did not return to practice this week and also did not show any significant progress through the concussion protocol. Fantasy managers should continue to monitor his status heading into next week as he could return to face the Pittsburgh Steelers. Last weekend, Wan'Dale Robinson and Darius Slayton led the Giant passing attack and should be expected to do so again on Sunday night against the Cincinnati Bengals. Both are high-upside flex options this weekend as the Bengals have allowed the 18th-most points to opposing wideouts this season.

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Seattle Seahawks wide receiver DK Metcalf had a poor game on Thursday night against the San Francisco 49ers. Metcalf finished the game with three receptions for 48 yards. Metcalf had been cruising this season and entered the game as the WR11 in fantasy. However, the 49ers more or less dominated the Seahawks and limited Metcalf's upside. Metcalf also had a couple of near-miss touchdowns in this game. Unfortunately, Metcalf's performance will set fantasy managers back heading into the weekend. However, there should be no panic or concern over his performance. Quarterback Geno Smith still threw for over 300 yards and Metcalf earned eleven targets. His catch rate was abysmal, but that kind of volume is sure to continue to translate to fantasy points. Metcalf will look to get back on track in Week 7 against the Atlanta Falcons.

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Dallas Cowboys kicker Brandon Aubrey remains the top kicker heading into Week 6's matchup with the Detroit Lions. Aubrey missed a kick last week, going 2-for-3 on field goals and 2-for-2 on extra points. He will look to bounce back this week in a dome environment in Dallas in what projects to be a high-flying offensive battle. The 29-year-old is the top kicker option this week and offers week-winning potential. Start him in all leagues that utilize kickers.

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Seattle Seahawks tight end Noah Fant matched his season-high catch total of six on Thursday night against the San Francisco 49ers. He also set a new season-high in receiving yards with 63. Fant has been a useless fantasy asset all season but if you happened to stream him this week then you were likely pleasantly surprised by the outcome. The Seahawks wound up throwing the ball 52 times, so it is no surprise that so many pass catchers were able to receive solid volume in this game. Even with a nice game from Fant, he is still too inconsistent to trust in fantasy football. However, if this trend continues then he would be worth an add off waivers.

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Seattle Seahawks running back Kenneth Walker III was inefficient on the ground in Week 6 against the San Francisco 49ers. However, Walker earned eight targets for the second straight game. Walker is not known as a pass catcher. That is a role that typically falls to backup running back Zach Charbonnet. Even so, the new Seahawks regime seems to be changing that narrative. Walker has earned 24 targets in 2024 which is 13 off of a career high. The Seahawks have also found themselves trailing quite a bit over the last three weeks which could contribute to Walker's volume in the passing game. Still, the passing game work is giving Walker a nice floor in fantasy and propelling him into the high-end RB1 conversation. If this trend continues in Week 7, then it may be safe to say that Walker will see solid passing game volume all season.

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Seattle Seahawks quarterback Geno Smith had a rough outing on Thursday against the San Francisco 49ers. Smith threw for 312 yards and continued his 2024 trend of throwing for exactly one touchdown. However, he threw two costly interceptions as the Seahawks were unable to keep pace with a 49ers team that was opportunistic on turnovers throughout the game. The outing was disappointing for Smith as he was coming off two straight games with at least 22.56 fantasy points. However, Smith has now thrown for at least 312 yards in three of six games in 2024. At some point, the touchdown numbers should increase. Unfortunately, the Seahawks find themselves in a rut as they have lost three straight games. Smith often plays better when the Seahawks can play with a lead, which has not been the case lately. Hopefully, Smith can get back on track in Week 7 against the Atlanta Falcons.

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Seattle Seahawks wide receiver Jaxon Smith-Njigba's target share continues to remain high. He seems to have found some consistency as Thursday's game against the San Francisco 49ers marked his third straight with at least seven targets. He has consistently kept pace with the targets earned by DK Metcalf and Tyler Lockett. Smith-Njigba's only issue is that he has not scored many touchdowns. Quarterback Geno Smith has only thrown six touchdowns on the season and has thrown exactly one in every game so there have not been a lot of touchdowns to go around. Still, Seattle's offense continues to have to throw at a high rate to keep up with more challenging opponents as the season progresses. That will bode well for Smith-Njigba's volume throughout 2024.

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