Houston Texans running back Joe Mixon (ankle) is not practicing to begin the week on Wednesday. On Monday, head coach DeMeco Ryans said the team still does not know exactly when Mixon will be able to return after he sprained his ankle in the Week 2 win over the Chicago Bears. And now that Mixon has picked up another DNP to begin the week, his status for the Week 6 game against the New England Patriots is firmly up in the air. The good news is the 28-year-old has made some progress, but he still needs to get back on the practice field to have any shot at playing this Sunday. Dameon Pierce (hamstring) hasn't played since the season opener, leaving Cam Akers and Dare Ogunbowale as Houston's primary backfield options each of the last three weeks. Fantasy managers won't have a clearer picture on the Texans' backfield until later this week.

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Buffalo Bills head coach Sean McDermott said that running back James Cook (foot, toe) will not take part in practice on Wednesday after getting injured in the Week 5 loss to the Houston Texans on Sunday. The good news for Cook's fantasy managers is that while he is certainly banged up, he's considered day-to-day. Still, the 25-year-old's status is now up in the air for Week 6's Monday night showdown with the division-rival New York Jets, and if Cooks ends up being questionable to play in that contest, it will make for some tough fantasy decisions this week. Those in need of a RB or that have Cook rostered may want to consider picking up rookie Ray Davis if he's available on the waiver wire. In addition to Davis, Ty Johnson would see a larger role in Buffalo's backfield if Cook's injuries keep him out in Week 6. Check back for status updates on Cook throughout the week.

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Buffalo Bills head coach Sean McDermott said that wide receivers Khalil Shakir (ankle) and Curtis Samuel (foot, toe) will not practice on Wednesday. Samuel's injuries were suffered in the Week 5 loss to the Houston Texans on Sunday, while Shakir was inactive for that game after being hurt the week prior. Shakir is the bigger name to follow for fantasy purposes. The 24-year-old didn't practice at all last week before being inactive, and another DNP to kick off the week isn't a great sign for his availability in Week 6, especially with a matchup against the division-rival New York Jets upcoming on Monday night. Buffalo's offense struggled without quarterback Josh Allen's top target available. Allen spread the ball around to rookie Keon Coleman, Mack Hollins, Samuel and Marquez Valdes-Scantling. Shakir's fantasy outlook remains very cloud this week, and if he does end up playing, he's eyeing a tough matchup against Jets corner Sauce Gardner.

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New York Giants head coach Brian Daboll said that running back Devin Singletary (groin) is trending in the right direction, and he will practice on Wednesday, likely in a limited capacity. Singletary suffered a groin injury in the Week 4 loss to the division-rival Dallas Cowboys and then was inactive for last week's win over the Seattle Seahawks. With Singletary sidelined in Week 5, rookie Tyrone Tracy Jr. filled in and turned some heads with 18 carries for 129 rushing yards in the surprising upset in Seattle. Tracy's performance likely earned him some more run in the G-Men's backfield, even when Singletary is able to return, which could come this Sunday night against the visiting Cincinnati Bengals. In his first year in the Big Apple, Singletary has averaged a career-low 3.9 yards per carry while going for 221 yards and two rushing TDs on 56 attempts. He'll be in play as an RB3/flex if he plays in Week 6.

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New York Giants standout pass-rusher Kayvon Thibodeaux (wrist) suffered a fractured scaphoid bone in his wrist in the Week 5 win over the Seattle Seahawks and had surgery on Wednesday, according to a source. Head coach Brian Daboll described Thibodeaux as "week-to-week." After having surgery, it seems unlikely that Thibodeaux will be able to suit up for Sunday night's game against the visiting Cincinnati Bengals in Week 6. The 23-year-old has been making a big impact for New York's defense so far in 2024, so any time missed will surely be a downgrade for their unit, especially against a Bengals offense that finally appears to be clicking after getting off to a slow start this year. Thibodeaux, the fifth overall pick in 2022 out of Oregon, has 12 tackles (eight solo), two sacks, three tackles for loss and seven QB hits so far through five games.

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New York Giants rookie wide receiver Malik Nabers (concussion) is "doing better," according to head coach Brian Daboll. Nabers will be working on the side with trainers at practice on Wednesday and is considered day-to-day. The impressive 21-year-old pass-catcher from LSU suffered a concussion in the Thursday night loss to the division-rival Dallas Cowboys on Thursday night in Week 4 and sat out of the Week 5 win over the Seattle Seahawks. It sounds like he's making progress with his head injury, but he still has boxes to check in the league's concussion protocol and isn't a lock to play yet in Week 6 against the Cincinnati Bengals. If Nabers is questionable to play, it will make for some tough decisions in fantasy with New York's game being on Sunday night this week. Wan'Dale Robinson and Darius Slayton will have higher fantasy ceilings as flex options again this weekend if Nabers misses his second straight game.

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Indianapolis Colts head coach Shane Steichen said that quarterback Anthony Richardson (oblique) would practice on Wednesday. Richardson injured his oblique in the Week 4 win over the Pittsburgh Steelers but then was inactive for last week's loss to the division-rival Jacksonville Jaguars. However, the 22-year-old second-year signal-caller was limited all of last week in practice, so if he takes a step forward this week, he'll have a legitimate chance to return to action in Week 6 versus the division-rival Tennessee Titans. Steichen said earlier this week that Richardson will reclaim his gig as the team's starting QB once he gets past his oblique injury, sending veteran Joe Flacco back to the bench. If Richardson gets more done in practice this week and returns on Sunday against the Titans, he'll be on the QB1/2 borderline for fantasy managers after a rough start in 2024.

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Indianapolis Colts head coach Shane Steichen said running back Jonathan Taylor (ankle) will not practice on Wednesday after he missed the Week 5 loss to the division-rival Jacksonville Jaguars with a minor high-ankle sprain. Although Taylor's ankle sprain isn't considered too serious, he's no lock to play in Week 6 against the division-rival Tennessee Titans this Sunday, and a DNP to begin the week isn't a great sign. If the 25-year-old doesn't make much progress in practice this week and is unable to play this weekend, Trey Sermon will once again serve as Indy's lead back, with Tyler Goodson backing him up. In the loss to Jacksonville on Sunday, Sermon played 59% of the offensive snaps and had 10 carries for 38 yards and his second touchdown of the year, adding six catches on six targets for an additional 25 yards. At worst, Sermon will be a plug-and-play RB3/flex option again for fantasy managers if Taylor misses another game.

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New England Patriots S Jabrill Peppers was placed on the commissioner's exempt list on Wednesday, Oct. 9.

From TheHuddle

Free-agent QB Trevor Siemian (Jets) was signed to the Tennessee Titans' practice squad on Wednesday, Oct. 9. Also, OT Leroy Watson was promoted from the practice squad to the 53-man roster.

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Jacksonville Jaguars LB Foyesade Oluokun (foot) is expected back in Week 7 or 8, head coach Doug Pederson said on Wednesday, Oct. 9.

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Cleveland Browns QB Deshaun Watson being benched isn't under consideration right now, head coach Kevin Stefanski said on Wednesday, Oct. 9.

Fantasy Spin: Watson has been the definition of a dumpster fire and the Browns insist on continuing to try and justify his contract when everyone can clearly see it's a disaster. That's apparently more important to Cleveland than actually having a chance to win. Watson remains an afterthought for fantasy purposes and his existence destroys any value Browns pass-catchers could've had.

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Arizona Cardinals WR Chris Moore is being released, per source on Wednesday, Oct. 9.

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Houston Texans wide receiver Nico Collins (hamstring) is being placed on the Injured Reserve list on Wednesday, meaning he will have to miss at least the next four games. The star wideout suffered a hamstring injury after catching a 67-yard touchdown pass in the Week 5 win over the Buffalo Bills. Collins was No. 2 in total PPR fantasy points heading into Week 5, so this is obviously a crushing blow for his fantasy managers. He will be ineligible to return until Week 10 against the Detroit Lions. With Collins sidelined, Stefon Diggs could be a top-five fantasy wideout during his absence, and Tank Dell, who has struggled so far, will likely have a WR2/WR3 outlook in most matchups. Deep-league fantasy managers might want to kick tires on veteran Robert Woods, but youngsters Xavier Hutchinson and John Metchie III could become fantasy factors. Tight end Dalton Schultz could also benefit in this situation.

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Las Vegas Raiders wide receiver Davante Adams (hamstring) is unlikely to play against the Pittsburgh Steelers, according to ESPN's Jeremy Fowler. The hamstring issue may be more of an excuse at this point to keep Adams off the field while the Raiders search for a trade partner. A report earlier this week stated that Adams is nearing full health. The Jets, Saints, and Steelers seem to be the teams pursuing Adams the hardest. However, the Saints just lost Derek Carr (oblique) for a few weeks. The Jets fired their head coach. Other teams don't seem as eager to match the Raiders' asking price. This will be the third straight game Adams has missed. He likely won't see the field again until he's on a different roster.

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Las Vegas Raiders WR Davante Adams (hamstring) is expected to be out for Week 6 against the Pittsburgh Steelers.

Fantasy Spin: Jakobi Meyers has turned 19 targets into 11 grabs for 121 yards the last two weeks. He and TE Brock Bowers are really the only Raiders pass-catchers worth using. Meyers is a flex option, and Bowers is a solid TE1.

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Detroit Lions running back Jahmyr Gibbs has failed to catch a pass in the last two games (although he did get 20 yards and a receiving touchdown on a lateral in Week 3). It's the first time in his young career that he's failed to log a reception in back-to-back games. Thankfully for fantasy football, he's averaging 13.5 carries and 71 rushing yards per game and has failed to score a touchdown just once. The Dallas Cowboys have allowed 17 receptions to running backs this season, the fifth-lowest mark in the league. However, the 222 yards they've given up to the position is the sixth-most. Even if Gibbs can't break off a long reception, the Cowboys' defense is banged up and has been susceptible against the run. Gibbs and his counterpart David Montgomery should be viewed as top-12 running backs this week.

From RotoBaller

Detroit Lions running back David Montgomery looks to continue his scoring ways against the Dallas Cowboys defense in Week 6. The veteran runner has scored a touchdown in all four of Detroit's games this season, despite splitting duties with Jahmyr Gibbs. He's averaging 15.75 carries per game. The Cowboys have allowed the seventh-most fantasy points to running backs and surrendered six touchdowns on the ground through five games. The defensive front-seven is banged up and the Lions' elite offensive line should have little issue opening holes for Monty and Gibbs. Both backs are ranked as RB1s this week in what should be a high-scoring affair in Texas.

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Free agent pass rusher Shaq Lawson has signed with the Carolina Panthers. The veteran visited the team on Tuesday and left with a new contract. It's Lawson's first time out of the AFC East. He began his career with Buffalo in 2016, played one season each in New York and Miami, and spent the last two seasons in Buffalo again. The Panthers are desperate for defensive playmakers. Due to injuries and bad play, Carolina is one of the worst defenses in football. They have recorded six sacks in five games in 2024. Lawson logged one sack in 16 games last season.

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San Francisco 49ers linebacker Fred Warner (ankle) was designated a limited participant in Tuesday's walk-through practice. The 49ers travel to Seattle for Thursday Night Football and haven't held a full practice this week. Warner practiced just once last week, and he dealt with this same ankle injury and still played. The expectation is that Warner will be active for the divisional tilt. The 49ers' defense is banged up, the most notable of which is Talanoa Hufanga (wrist), who will miss a few weeks. Warner is the linebacker with the best odds to win NFL Defensive Player of the Year.

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