The Buffalo Bills are ranked as a top-10 fantasy football defense for their matchup against the Indianapolis Colts. Colts quarterback Joe Flacco has committed a turnover in each of his three starts and the team averages under 21 points per game this season. They'll also be without one of their top weapons in wide receiver Michael Pittman Jr. (back/finger). The Bills DST is 10th in average fantasy points per game and worthy of a start in all leagues this weekend.

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Philadelphia Eagles wide receiver A.J. Brown (knee) is off the injury report and good to go for Sunday's divisional battle against the Dallas Cowboys. Brown left last weekend's game early with a knee injury and logged a limited practice session on Wednesday. However, he was then upgraded to full participation on Thursday and remained in the same status on Friday. During Weeks 6 through 8, Brown found the back of the end zone twice and averaged an impressive 96.3 yards and 19.0 PPR points per game during this stretch. Fantasy managers should lock the former Ole Miss product into their lineups as a high-end WR1 this weekend facing a Dallas defense who has allowed the 16th-most PPR points to opposing wideouts this season.

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Houston Texans tight end Dalton Schultz should be considered a TE2 in Week 10 with a difficult matchup on Sunday against the Detroit Lions. Detroit ranks No. 1 against fantasy tight ends going into this week, and the former Dallas Cowboy hasn't exactly been lighting it up this season anyway. Through nine games, the veteran tight end has zero top-15 finishes at his position and has not caught a regular-season touchdown since Week 11 of 2023. But due to his high snap count and injuries to Houston's receivers, he's still playable as a bye-week fill-in or in formats that play more than one tight end.

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Minnesota Vikings wide receiver Jordan Addison will face off against the Jacksonville Jaguars this Sunday in Week 10. It's been a bit of a sophomore slump for Addison this season, as he is averaging just over three catches and 45.5 yards per game with two touchdowns in six contests. He had a nice outing last weekend, reeling in all five of his targets for 42 yards and a touchdown against a porous Colts defense. He may do so again in another intriguing matchup against a lowly Jaguars defensive unit that's given up the third-most fantasy points to wide receivers in 2024. Still, as the matchup does not project to be a shootout with quarterback Trevor Lawrence (shoulder) trending in the wrong direction, fantasy managers could be disappointed with Addison's performance if he doesn't hit pay dirt. The 22-year-old is RotoBaller's PPR WR33 heading into Week 10.

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The 7-1 Detroit Lions present a challenge for the Houston Texans in Week 10, but Texans running back Joe Mixon has been so effective that he should still be considered an RB1 candidate. The veteran has gone for 100-plus yards and a touchdown four weeks in a row, and he now ranks 15th among fantasy running backs in PPR formats despite missing three entire games and half of another. Detroit ranks fifth against fantasy running backs, but Mixon is drawing so much opportunity in the Houston offense that he still belongs in starting lineups despite the tough draw.

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Philadelphia Eagles tight end Dallas Goedert (hamstring) is off the injury report and expected to return to action in Week 10 to face the Dallas Cowboys. Goedert has been sidelined since sustaining a hamstring injury in the opening quarter during their Week 6 tilt against the Cleveland Browns. In his absence, Grant Calcaterra has been deployed as the No.1 tight end. Before the injury, Goedert averaged an impressive 75.3 yards and 13.5 PPR points per game throughout the first four weeks. Fantasy managers should feel confident inserting Goedert back into their lineup as a safe TE1.

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Minnesota Vikings wide receiver Justin Jefferson gets another enticing matchup this Sunday when his team takes on the Jacksonville Jaguars in a road tilt. The 25-year-old superstar is averaging 97.9 receiving yards per contest in 2024 and stands an excellent chance to match or surpass that total against a woeful Jaguars pass defense. Jacksonville is the second-worst team against the pass on a per-play basis, letting up 7.3 yards per attempt to their opponents. Additionally, they've allowed 19 touchdowns through the air while intercepting just two passes on the season. The former LSU Tiger is again an elite WR option and should challenge as the WR1 overall on the week. He's RotoBaller's top PPR play at the position in Week 10.

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Houston Texans wide receiver Tank Dell (back) was added to the injury report on Friday and is now listed as questionable for Sunday's game according to Tom Pelissero of the NFL Network. This is not a positive sign for his status for this weekend's game as the sophomore wideout practiced in full earlier in the week. Fantasy managers should pay close attention to his status over the weekend as he may end up being a game-time decision. The Texans are also listing top wideout Nico Collins (hamstring) as questionable as well. If both wideouts are unable to play, fantasy managers should look to find an alternative option over quarterback C.J. Stroud. Last week, Dell enjoyed his best outing of the season as he brought in a season-high 126 yards and should be viewed as a solid WR2 if he is able to play.

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Minnesota Vikings running back Aaron Jones is set to square off against the Jacksonville Jaguars this Sunday in Week 10. The long-time Packer has been excellent during his first stint in Vikings Purple, piling up 810 yards from scrimmage through the team's first eight games. The only stat lacking is his touchdowns, as he has just three on the season. While Jacksonville has been solid against their opponents in the rushing department (4.4 YPC), they're tied for the second-most receptions allowed to the running back position (55). The 29-year-old has seen his yards per carry wane over the last two contests, so it might be tough sledding for him again. However, his work in the passing game should continue to keep his fantasy floor high. He ranks as RotoBaller's PPR RB11 ahead of Week 10's slate.

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Houston Texans wide receiver Nico Collins (hamstring) is listed as questionable for Sunday's tilt against the Detroit Lions. Collins has been on the injured reserve since Week 5 but was designated to return to practice earlier on Friday. During the practice session, Collins participated in a limited capacity. Fantasy managers should continue to monitor his status over the weekend as he may be a game-time decision on Sunday evening. Before sustaining the hamstring injury, Collins was enjoying a fantastic start to his season as he averaged a stellar 21.3 PPR points in each game across the first five weeks. During this span, Collins saw nine targets per game and tallied an impressive 113.4 yards per game. If Collins suits up, fantasy managers should lock him into their lineups as a high-end WR1.

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Despite his appearance on the injury report, Buffalo Bills tight end Dalton Kincaid (knee) is one of the team's healthy receiving options entering Week 10. He's practiced in full every day this week and has no injury designation this weekend. The same can't be said for Amari Cooper (wrist), Keon Coleman (wrist), and Curtis Samuel (pectoral). Coleman has been ruled out, while the other two are questionable. Kincaid saw a season-high in targets (10) with Cooper out of the lineup last week and could also see more usage against the Colts. Unfortunately, he's securing under 60% of targets thrown in his direction. With an easier matchup (Indianapolis allows the third-most fantasy points to tight ends), Kincaid may convert more opportunities. He's a low-end TE1 this week.

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Dallas Cowboys wide receiver CeeDee Lamb (shoulder) is off the injury report and expected to play on Sunday against the Philadelphia Eagles according to Adam Schefter of ESPN. Lamb sustained this shoulder injury last weekend during their loss to the Atlanta Falcons and logged two limited practice sessions on Wednesday and Thursday before upgrading to full participation on Friday. This season, Lamb has continued to operate as the clear No.1 option in the Dallas offense and has averaged 18.5 PPR points with 82.5 yards per game. Even though Lamb will not be catching passes from Dak Prescott (hamstring) for the time being, Lamb should still be locked into all fantasy lineups as a high-end wide receiver.

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Buffalo Bills running back Ray Davis has established himself as one of the best insurance running backs in fantasy football entering Week 10. Despite averaging just six touches per game since his Week 6 explosion, the rookie has scored in two of the last three contests. The Buffalo backfield still belongs to James Cook. Davis would be the most valuable waiver-wire addition if anything happens to Cook. Savvy fantasy managers can get ahead by adding Davis to benches now. Desperate fantasy managers hope Davis (a low-end RB3) can continue his efficient play in limited opportunities against a leaky Indianapolis run defense.

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Minnesota Vikings quarterback Sam Darnold will line up against the Jacksonville Jaguars this Sunday in a road matchup. Darnold has been overall solid this season, compiling 16 or more fantasy points in all but two outings. The 27-year-old is currently tied for fourth in the league with 17 passing scores and gets a gift of a matchup in Week 10. Jacksonville's defense presents as one of the worst against opposing passing attacks, allowing the second most yards (2,379), touchdowns (19), and yards per attempt (7.3) to their opponents. The only thing that could stop him from having a strong outing is if the game is not competitive, which is in the range of outcomes with Jaguars quarterback Trevor Lawrence (shoulder) trending toward not playing. Darnold is RotoBaller's QB7 in this week's ranks.

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After an up-and-down start to the season, Buffalo Bills quarterback Josh Allen (left hand) has thrown at least two touchdowns in his last four games. That could continue against the Indianapolis Colts on Sunday. The Colts' secondary has allowed 14 touchdown passes this season, which is good for ninth-most in the league. The Bills have also shifted to a more pass-happy approach to their offense. Allen's attempted 33, 34, and 39 passes in the last three games. Those attempts could decline if Amari Cooper (questionable, wrist) and Keon Coleman (out, wrist) aren't in the lineup on Sunday. As has been the case for the last several weeks, Allen's left hand injury is not keeping him from practicing. Allen is a high-end QB1, once again, against the Colts.

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Jacksonville Jaguars quarterback Trevor Lawrence (shoulder) is listed as questionable for Sunday's game against the Minnesota Vikings according to Tom Pelissero of the NFL Network. Lawrence sustained this injury last weekend in their loss to the Philadelphia Eagles. During the week, the former first-overall pick remained a limited participant in practice. Earlier in the week, it was reported that Lawrence was trending toward not playing but seeing him listed as questionable does keep the door open for his availability. Fantasy managers should continue to monitor his status over the weekend. If the Clemson product is unable to suit up, Mac Jones would get the starting nod and should be viewed as a low-end QB2 facing a tough Minnesota defense.

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Buffalo Bills running back James Cook has underwhelming rushing totals (12 and 10 carries) in two of his last three games. However, he is seeing an uptick in his passing game involvement. The Bills have transitioned from a run-heavy approach to a pass-happy offense. Cook has logged eight catches in his last two games. He had 11 catches in the six prior contests. If wide receivers Amari Cooper (questionable, wrist) and Keon Coleman (out, wrist) can't play on Sunday, Cook could see his number called more, both on the ground and through the air. Cook is a high-end RB1 in the rankings against the bottom-dweller Indianapolis rush defense.

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Buffalo Bills wide receiver Khalil Shakir has scored at least 10 PPR fantasy points in all but one game this season, which happened to be his first game back from an ankle injury. Shakir's role is safe, regardless of the situation around him. He commands the slot role on the Buffalo offense and he's only missed three targets this season. Shakir's utilization mixes well with the defense that Indianapolis tends to run. He could also see increased target volume if Amari Cooper (wrist) can't play on Sunday. Keon Coleman (wrist) has already been ruled out. Shakir is a safe WR3/flex for Week 10.

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Detroit Lions offensive tackle Taylor Decker (shoulder) has been ruled out for Sunday's tilt against the Houston Texans. Decker appeared on the injury report on Thursday with a shoulder and was listed as a limited participant. However, he was downgraded to a non-participant on Friday and will now set his sights on returning in Week 11 to face the Jacksonville Jaguars. Decker has served as a starting tackle all season but will likely cede those duties to Dan Skipper on Sunday evening. However, fantasy managers should not be overly concerned with inserting both Detroit running backs David Montgomery and Jahmyr Gibbs into their lineup with a depleted offensive line. Both running backs should be viewed as matchup-proof for the remainder of the season.

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Washington Commanders running back Brian Robinson Jr. (hamstring) has been ruled out for this Sunday's matchup against the Pittsburgh Steelers according to Ian Rapoport of the NFL Network. Robinson will now miss his second-straight contest and set his sights on returning in Week 11 for a pivotal divisional matchup against the Philadelphia Eagles. This week Robinson remained a limited participant in practice. As a result, fantasy managers should expect Austin Ekeler to operate as the lead option out of the backfield with Chris Rodriguez Jr. and Jeremy McNichols serving as change-of-pace options. Last week, Ekeler scored a season-high 17.3 PPR points and should be in a good position to produce solid RB2 numbers again this weekend. Fantasy managers in deeper formats could consider Rodriguez a desperation flex option as he logged 11 carries for 52 yards last weekend.

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