

| PLAYER | POS | NFL | BYE | INJ | OPP | DATE | LINEUP | PTS | SCORING |
|---|---|---|---|---|---|---|---|---|---|
| Brock Purdy | QB | SF | 14 | CAR | Mon 8:15pm ET | Starter | 0 | ||
| James Cook | RB | BUF | 7 | @HOU | Thu 8:15pm ET | Starter | 0 | ||
| Sean Tucker | RB | TB | 9 | @LAR | Sun 8:20pm ET | Starter | 0 | ||
| Justin Jefferson | WR | MIN | 6 | @GB | Sun 1:00pm ET | Starter | 0 | ||
| Jerry Jeudy | WR | CLE | 9 | @LV | Sun 4:05pm ET | Starter | 0 | ||
| Tre Tucker | WR | LV | 8 | CLE | Sun 4:05pm ET | Starter | 0 | ||
| Tennessee Titans | K | TEN | 10 | SEA | Sun 1:00pm ET | Starter | 0 | ||
| Pittsburgh Steelers | D/ST | PIT | 5 | @CHI | Sun 1:00pm ET | Starter | 0 | ||
| Dillon Gabriel | QB | CLE | 9 | Q | @LV | Sun 4:05pm ET | Bench | 0 | |
| Justin Herbert | QB | LAC | 12 | bye | Bench | 0 | |||
| Mac Jones | QB | SF | 14 | CAR | Mon 8:15pm ET | Bench | 0 | ||
| Nick Chubb | RB | HOU | 6 | BUF | Thu 8:15pm ET | Bench | 0 | ||
| Woody Marks | RB | HOU | 6 | BUF | Thu 8:15pm ET | Bench | 0 | ||
| Chris Rodriguez Jr. | RB | WAS | 12 | bye | Bench | 0 | |||
| Quentin Johnston | WR | LAC | 12 | Q | bye | Bench | 0 | ||
| Courtland Sutton | WR | DEN | 12 | bye | Bench | 0 | |||
| Oronde Gadsden II | TE | LAC | 12 | bye | Bench | 0 | |||
| J.K. Dobbins | RB | DEN | 12 | X | bye | IR | 0 | ||
| Bucky Irving | RB | TB | 9 | Q | @LAR | Sun 8:20pm ET | IR | 0 |
| WEEK | SCORE | HIGH SCORER | OPPONENT | SCORE | RESULT | |||
|---|---|---|---|---|---|---|---|---|
| Week 1 | 236 409 | Justin Herbert (194) Best Roster | vs | Show me your TDs | 238 | LOSS WIN | ||
| Week 2 | 403 485 | Mac Jones (145) Best Roster | vs | Connection | 302 | WIN | ||
| Week 3 | 471 669 | Tre Tucker (190) Best Roster | vs | RBL | 398 | WIN | ||
| Week 4 | 589 660 | Bucky Irving (172) Best Roster | vs | k-dawg | 369 | WIN | ||
| Week 5 | 210 368 | Mac Jones (149) Best Roster | vs | Tigertalzz | 379 | LOSS | ||
| Week 6 | 217 288 | Mac Jones (125) Best Roster | vs | Daa Bears! | 193 | WIN | ||
| Week 7 | 373 404 | Justin Herbert (272) Best Roster | vs | Devtime | 473 | LOSS | ||
| Week 8 | 446 456 | James Cook (251) Best Roster | vs | The Tall Toddler | 414 | WIN | ||
| Week 9 | 374 403 | Justin Herbert (129) Best Roster | vs | The Godfather | 258 | WIN | ||
| Week 10 | 90 216 | Mac Jones (150) Best Roster | vs | Who Dat? | 324 | LOSS | ||
| Week 11 | 283 533 | Sean Tucker (177) Best Roster | vs | Make Alvin Kamara Great Again | 248 | WIN | ||
| Week 12 | vs | Gone Postal | ||||||
| Week 13 | vs | Feed The Freak | ||||||
| Week 14 | vs | Show me your TDs | ||||||
| Playoff Week 1 | -- No Game Scheduled -- | |||||||
| Playoff Week 2 | -- No Game Scheduled -- | |||||||
| Playoff Week 3 | -- No Game Scheduled -- | |||||||
| Acquired | Jerry Jeudy WR CLE | Owner | Week 11 | Sat Nov 15 2:02am ET |
| Released | Kendrick Bourne WR SF | Owner | Week 11 | Sat Nov 15 2:02am ET |
| Off I/R | Brock Purdy QB SF | Owner | Week 11 | Sat Nov 15 1:57am ET |
| On I/R | J.K. Dobbins RB DEN | Owner | Week 11 | Sat Nov 15 1:57am ET |
| Acquired | Chris Rodriguez Jr. RB WAS | Waiver Wire | Week 11 | Thu Nov 13 12:02am ET |
| Released | Green Bay Packers K GB | Waiver Wire | Week 11 | Thu Nov 13 12:02am ET |
| Released | Kansas City Chiefs K KC | Waiver Wire | Week 10 | Thu Nov 6 12:02am ET |
| Acquired | Green Bay Packers K GB | Waiver Wire | Week 10 | Thu Nov 6 12:02am ET |
| Acquired | Oronde Gadsden II TE LAC | Waiver Wire | Week 9 | Thu Oct 30 12:02am ET |
| Released | Jerry Jeudy WR CLE | Waiver Wire | Week 9 | Thu Oct 30 12:02am ET |
| Released | Jeremy McNichols RB WAS | Owner | Week 6 | Thu Oct 9 5:37pm ET |
| Released | Tampa Bay Buccaneers D/ST TB | Owner | Week 6 | Thu Oct 9 5:37pm ET |
| Acquired | Kendrick Bourne WR SF | Owner | Week 6 | Thu Oct 9 5:37pm ET |
| Acquired | Woody Marks RB HOU | Owner | Week 6 | Thu Oct 9 5:37pm ET |
| Acquired | Sean Tucker RB TB | Owner | Week 5 | Fri Oct 3 7:59pm ET |
| On I/R | Bucky Irving RB TB | Owner | Week 5 | Fri Oct 3 7:58pm ET |
| Acquired | Mac Jones QB SF | Owner | Week 5 | Thu Oct 2 12:23pm ET |
| On I/R | Brock Purdy QB SF | Owner | Week 5 | Thu Oct 2 12:22pm ET |
| Acquired | Dillon Gabriel QB CLE | Owner | Week 5 | Thu Oct 2 12:22pm ET |
| Released | Cam Ward QB TEN | Owner | Week 5 | Thu Oct 2 12:22pm ET |
| Acquired | Tampa Bay Buccaneers D/ST TB | Waiver Wire | Week 5 | Thu Oct 2 12:02am ET |
| Released | Hunter Renfrow WR CAR | Waiver Wire | Week 5 | Thu Oct 2 12:02am ET |
| Off I/R | Brock Purdy QB SF | Owner | Week 4 | Fri Sep 26 10:12pm ET |
| Released | Mac Jones QB SF | Owner | Week 4 | Fri Sep 26 10:12pm ET |
| Released | Tank Bigsby RB PHI | Owner | Week 4 | Thu Sep 25 12:06pm ET |
| Acquired | Jeremy McNichols RB WAS | Owner | Week 4 | Thu Sep 25 12:06pm ET |
| Acquired | Hunter Renfrow WR CAR | Owner | Week 3 | Thu Sep 18 12:03pm ET |
| Released | Mark Andrews TE BAL | Owner | Week 3 | Thu Sep 18 12:03pm ET |
| Acquired | Tennessee Titans K TEN | Waiver Wire | Week 3 | Thu Sep 18 12:02am ET |
| Released | Xavier Legette WR CAR | Waiver Wire | Week 3 | Thu Sep 18 12:02am ET |
| Acquired | Mac Jones QB SF | Owner | Week 2 | Fri Sep 12 4:28am ET |
| On I/R | Brock Purdy QB SF | Owner | Week 2 | Fri Sep 12 4:23am ET |
| Acquired | Tre Tucker WR LV | Owner | Week 2 | Fri Sep 12 3:47am ET |
| Released | Adam Thielen WR MIN | Owner | Week 2 | Fri Sep 12 3:47am ET |
| Acquired | Kansas City Chiefs K KC | Waiver Wire | Week 2 | Thu Sep 11 12:02am ET |
| Released | Washington Commanders K WAS | Waiver Wire | Week 2 | Thu Sep 11 12:02am ET |
| Acquired | Quentin Johnston WR LAC | Owner | Week 1 | Thu Sep 4 4:11pm ET |
| Released | Amari Cooper WR --- | Owner | Week 1 | Thu Sep 4 4:11pm ET |
| Acquired | Amari Cooper WR --- | Owner | Week 1 | Tue Aug 26 3:48am ET |
| Released | Jalen Tolbert WR DAL | Owner | Week 1 | Tue Aug 26 3:48am ET |
| Traded | Drake Maye QB NE | to Who Dat? | Justin Herbert QB LAC | Week 1 | Approved Wed Aug 27 4:14am ET |