Guest of the League
| Away | Home | Time | Away Probable | Home Probable | Status | |||
|---|---|---|---|---|---|---|---|---|
 | Pirates | at |  | Tigers | 11:40am CT | Jones R (3-4) | Skubal L (6-1) | |
 | Cardinals | at |  | Reds | 12:10pm CT | Pallante R (0-1) | Montas R (2-3) | |
 | Diamondbacks | at |  | Rangers | 1:35pm CT | Nelson R (3-3) | Dunning R (3-3) | 1:35pm |
 | Phillies | at |  | Giants | 2:45pm CT | Sanchez L (2-3) | Harrison L (4-1) | 2:45pm |
 | Dodgers | at |  | Mets | 3:10pm CT | Paxton L (5-0) | Peterson L (0-0) | 3:10pm |
 | Marlins | at |  | Padres | 3:10pm CT | Garrett L (1-0) | Darvish R (4-2) | 3:10pm |
| Pirates | at | | Tigers | 3:10pm CT | Skenes R (1-0) | Montero R (0-0) | 3:10pm |
 | Red Sox | at |  | Orioles | 5:35pm CT | Crawford R (2-3) | Burnes R (4-2) | 5:35pm |
 | Athletics | at |  | Rays | 5:50pm CT | Estes R (1-1) | Pepiot R (3-2) | 5:50pm |
 | Nationals | at |  | Braves | 6:20pm CT | Gore L (3-4) | - | 6:20pm |
 | Blue Jays | at |  | White Sox | 6:40pm CT | Manoah R (1-2) | Flexen R (2-4) | 6:40pm |
 | Royals | at |  | Twins | 6:40pm CT | Lugo R (8-1) | Ober R (5-2) | 6:40pm |
 | Cubs | at |  | Brewers | 6:40pm CT | Imanaga L (5-0) | Wilson R (3-1) | 6:40pm |
 | Guardians | at |  | Rockies | 7:40pm CT | Allen L (6-2) | Blach L (1-2) | 7:40pm |
 | Yankees | at |  | Angels | 8:38pm CT | Gil R (6-1) | Anderson L (5-4) | 8:38pm |
 | Astros | at |  | Mariners | 8:40pm CT | Verlander R (3-2) | Kirby R (4-5) | 8:40pm |
