Willy Adames delivered a walk-off single in the bottom of the 10th inning to give the host Milwaukee Brewers a 4-3 comeback victory over Chicago on Saturday, handing the White Sox their 10th consecutive defeat.

William Contreras opened the 10th as the automatic runner against Michael Kopech (1-5). Christian Yelich was walked intentionally to open and both runners advanced on a wild pitch. Adames then lined a grounder to the left side that shortstop Zach Remillard knocked down but couldn't corral, allowing Contreras to score.

Hoby Milner (3-0) tossed a perfect 10th inning for the victory.

Chicago, off to the worst 58-game start in franchise history, has lost 14 of its past 15 games and 16 of its past 19.

Pirates 8, Blue Jays 1

Ke'Bryan Hayes and Bryan Reynolds hit two-run homers, right-hander Mitch Keller struck out eight and visiting Pittsburgh defeated Toronto. Pittsburgh gained a split of the first two games of a three-game series in ending Toronto's four-game winning streak.

Jared Triolo had three hits for the Pirates, who are 2-2 on a five-game road trip. Keller (7-3) allowed one run, five hits and one walk in six innings. Luis L. Ortiz allowed one hit in three innings to earn his first career save.

Toronto left-hander Yusei Kikuchi (2-5) allowed six runs (five earned), nine hits and one walk while striking out four in 5 1/3 innings.

Mariners 9, Angels 0

J.P. Crawford hit a grand slam and Bryce Miller pitched six scoreless innings as Seattle blanked visiting Los Angeles.

Luke Raley also homered and Julio Rodriguez went 3-for-4 with two RBIs for the American League West-leading Mariners, who won for the sixth time in their past seven games. Miller (5-5) allowed three hits, walked one and struck out nine, one shy of his career-high.

The highlight for the last-place Angels, who have lost seven of eight, was backup infielder Cole Tucker pitching a scoreless inning of relief. Starter Reid Detmers (3-6) lost his sixth straight decision. The left-hander allowed five runs on four hits in 3 2/3 innings, with four walks and three strikeouts.

Orioles 9, Rays 5

Ryan Mountcastle blasted a pair of two-run home runs as Baltimore beat visiting Tampa Bay in a game that featured plenty of early offense.

Anthony Santander and Jordan Westburg also homered as the Orioles won for the eighth time in nine games. Mountcastle hadn't homered since May 8, and he had only six RBIs in all of May.

Yandy Diaz had three RBIs for the Rays, who have lost nine of their past 12. Jacob Webb (1-3) got the win with 2 1/3 innings of scoreless relief. Four more relievers followed Webb, and they combined to blank the Rays over the final four innings.

Athletics 11, Braves 9

Miguel Andujar and Brent Rooker both homered and drove in four runs to help visiting Oakland outslug Atlanta and even the three-game series.

Andujar was 4-for-5, scored three runs and hit his second homer, and Rooker was 2-for-5 with his 12th homer. Max Schuemann went 4-for-4 and the A's recorded 16 hits. The winning pitcher was Michael Kelly (3-2) and Dany Jimenez pitched the ninth to earn his first save.

Atlanta's Marcell Ozuna went 2-for-5 with a home run and four RBIs. He has reached base in 25 straight games and leads the National League with 17 homers and 53 RBIs. Atlanta starter Chris Sale pitched only four innings and allowed season highs in runs (eight) and hits (nine), walked one and struck out four.

Red Sox 6, Tigers 3

Enmanuel Valdez recorded the second multi-homer game in as many days for Boston as the Red Sox used a stretch of five unanswered runs to move past visiting Detroit. Valdez finished 3-for-4 with three RBIs and three runs scored to lead Boston to its second consecutive win in the four-game series.

Jarren Duran added two hits and two runs, while Red Sox right-hander Cooper Criswell (3-2) held up his end of the effort on the mound, striking out five while allowing just one run on four hits across the first five innings.

Matt Vierling hit two doubles while Riley Greene and Gio Urshela (two-run home run) were all 2-for-4 for Detroit, which was outhit 10-7. Reese Olson (1-6) was charged with five runs and six hits in 5 1/3 innings.

Guardians 3, Nationals 2

Jose Ramirez had two infield singles and scored the decisive run with some aggressive baserunning as surging Cleveland won its ninth straight home game, beating Washington.

Ben Lively (5-2) continued his surprise season by allowing two runs over 5 2/3 innings. The 32-year-old right-hander combined with four relievers to hold the Nationals to six hits for the AL Central-leading Guardians. Cleveland has won 15 of 18 overall.

Cleveland led 2-0 entering the third when Ramirez reached on his second infield hit. He stole second, and with two outs, scored from second on rookie Mitchell Parker's wild pitch that catcher Riley Adams initially couldn't find. Joey Meneses and Jesse Winker delivered RBIs for Washington.

Padres 7, Royals 3

Ha-Seong Kim's bases-clearing double led visiting San Diego past Kansas City. With one out in the fourth and the Padres trailing by a run, Kim drilled Alec Marsh's sweeper to the center-field wall, plating three for a 5-3 advantage.

Kim also tripled as San Diego pounded Marsh (4-3) for five runs on seven hits, including four for extra bases. Marsh walked Manny Machado three times and hit a batter, completing five innings with three strikeouts.

San Diego starter Randy Vasquez (1-3) finished five innings, allowing three runs on four hits and a walk with five strikeouts to earn his first win since Aug. 11.

Astros 5, Twins 2

Framber Valdez carried a no-hitter into the seventh inning while Yordan Alvarez produced his first multi-homer game in five weeks as Houston slugged four home runs in a win over visiting Minnesota.

Valdez (4-3) recorded his fifth quality start by working seven innings for the fourth time this season. He faced the minimum through six innings and had 65 pitches on his ledger entering the seventh. Twins right fielder Manuel Margot ended the no-hit bid with a leadoff single in the seventh.

Alvarez clubbed both of his homers off Twins starter Joe Ryan (4-4). Alvarez spotted the Astros a 2-0 lead in the first when he followed a Kyle Tucker walk with a 403-foot blast to right field for his 10th homer. Astros first baseman Jose Abreu slugged his first homer an inning later, an opposite-field shot to right-center that extended the lead to 3-0.

Rangers 7, Marlins 0

Michael Lorenzen logged 6 1/3 scoreless innings and Texas blanked host Miami.

Corey Seager went 3-for-4 with a run and a walk to headline the Rangers' offense. He increased his hitting streak to 14 and has reached base in 24 straight appearances.

Josh Bell had the only extra-base hit for the Marlins, a double in the ninth. Miami scored 17 runs while winning its previous two games.

Diamondbacks 10, Mets 5

Christian Walker hit a third-inning grand slam for visiting Arizona, which rolled past New York in the third game of a four-game series.

Blaze Alexander, Randal Grichuk, Jake McCarthy and Kevin Newman had two hits apiece for the Diamondbacks, who have collected 19 runs in their past two games -- their most in consecutive contests since April 19-20, when Arizona beat the San Francisco Giants 17-1 before falling to the Giants 7-3.

Mark Vientos and Pete Alonso homered for the Mets, who were trying to win three straight games for the first time since a six-game winning streak from April 14-20.

Phillies 6, Cardinals 1

Bryce Harper hit a two-run homer and scored three times to power Philadelphia past visiting St. Louis.

Alec Bohm drove in two runs and scored another as Philadelphia won its third straight. Phillies starting pitcher Ranger Suarez retired the six batters he faced. But he did not come out for the third inning due to a left-hand contusion he sustained when he was hit by Alec Burleson's line drive to end the second inning.

That forced Philadelphia to deploy a string of relievers to get through the game. Jose Ruiz allowed one run on two hits in one inning, then Spencer Turnbull (1-0) blanked the Cardinals for three innings while striking out six. Orion Kerkering, Seranthony Dominguez and Gregory Soto each threw a scoreless inning to close out the victory.

Yankees 7, Giants 3

Aaron Judge homered for the third straight game, Giancarlo Stanton added a two-run insurance shot and New York beat host San Francisco.

New York starter Cody Poteet (2-0) combined with four relievers on a five-hitter, helping the Yankees clinch a third consecutive series win on their Western swing. New York can complete a three-game sweep of San Francisco on Sunday.

Casey Schmitt, promoted from Triple-A Sacramento on Friday, had two of the Giants' five hits.

Dodgers 4, Rockies 1

Yoshinobu Yamamoto went six strong innings to rebound from his first loss in over two months and Los Angeles went on to a victory over visiting Colorado.

Jason Heyward and Will Smith each had an RBI double and Enrique Hernandez added an RBI single as the Dodgers won one day after the Rockies took the opener of the three-game series.

Ezequiel Tovar had three hits for the second consecutive game, with Colorado still in line for a possible third consecutive series victory. After a standout May in which he posted a 1.71 ERA in five starts, Colorado right-hander Cal Quantrill (4-4) gave up four runs on nine hits in 4 1/3 innings.

Cubs 7, Reds 5

Dansby Swanson hit a tiebreaking home run in the eighth inning to lift Chicago over visiting Cincinnati.

Seiya Suzuki went 2-for-4 with a grand slam for the Cubs and reliever Mark Leiter Jr. (2-3) tossed a scoreless eighth for the win. Hector Neris struck out a pair in the ninth for his seventh save.

Spencer Steer went 3-for-5 and Jeimer Candelario went 2-for-5 with an RBI for the Reds.